Regulatory changes after the enforcement of the new Clinical Trials Act in Japan.

abstract：:A case of prostatic phyllodes tumor which developed in a 78-yr-old man is reported. Histologically, the tumor comprised myxomatous and cellular portions with a proliferation of atypical stromal cells. Multinucleated giant cells were occasionally present, but mitoses were rare. Fibroblastic differentiation of the tumor...

journal_title：Japanese journal of clinical oncology

authors： Ito H,Ito M,Mitsuhata N,Tahara E

更新日期：1989-09-01 00:00:00

abstract：:In order to determine whether the epidemiological characteristics of lung cancer have changed within a certain period of time in Taiwan and to propose some causative factors for its rapid rate of increase we performed chronological and epidemiological studies based on the analysis of: (1) available vital statistics an...

journal_title：Japanese journal of clinical oncology

authors： Yang SP,Luh KT,Kuo SH,Lin CC

更新日期：1984-03-01 00:00:00

abstract：:A post hoc analysis of interim results from PREVAIL, a Phase III, double-blind, placebo-controlled trial of men with metastatic castration-resistant prostate cancer, demonstrated that the treatment effects, safety and pharmacokinetics of enzalutamide in Japanese patients were generally consistent with those of the ove...

journal_title：Japanese journal of clinical oncology

authors： Kimura G,Ueda T

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:Human papillomavirus vaccines are being introduced worldwide and are expected to reduce the incidence of cervical cancer. Here we report a cross-sectional study using a validated human papillomavirus genotyping method to reveal the human papillomavirus prevalence and genotype distribution in Japanese women wi...

journal_title：Japanese journal of clinical oncology

authors： Azuma Y,Kusumoto-Matsuo R,Takeuchi F,Uenoyama A,Kondo K,Tsunoda H,Nagasaka K,Kawana K,Morisada T,Iwata T,Aoki D,Kukimoto I

更新日期：2014-10-01 00:00:00

abstract：:Nude mice bearing the human oral cavity carcinoma cell line OCC-1, and the lung cancer cell line LC-1, developed a triple paraneoplastic syndrome consisting of hypercalcemia, cachexia and leukocytosis. All of these abnormalities disappeared rapidly after surgical resection of the tumors, suggesting their ectopic humor...

journal_title：Japanese journal of clinical oncology

authors： Tanaka R,Okada M,Kajimura N,Otsubo K,Gyotoku M,Nagasaki K,Ekimoto H,Yamaguchi K

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:We aimed to assess the potency and efficacy of tropisetron, a 5-HT3 receptor antagonist, in the prevention of nausea and emesis observed in the pediatric patient population taking various chemotherapy protocols. METHODS:Tropisetron (Navoban) was given to 100 children (62 boys and 38 girls aged 6 months to 1...

journal_title：Japanese journal of clinical oncology

authors： Ozkan A,Yildiz I,Yüksel L,Apak H,Celkan T

更新日期：1999-02-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to specifically investigate the clinicopathological role of expression of vascular endothelial growth factor-C (VEGF-C) as well as the correlation with clinical outcomes in esophageal squamous cell carcinomas (ESCCs). METHODS:Seventy-three patients with ESCC resected in our inst...

journal_title：Japanese journal of clinical oncology

authors： Liu P,Chen W,Zhu H,Liu B,Song S,Shen W,Wang F,Tucker S,Zhong B,Wang D

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:The detection of prostate-specific antigen (PSA) molecular forms such as free PSA and PSA-ACT and the use of PSA molecular ratios, especially the percentage of free to total PSA, have been reported to improve the diagnostic accuracy of prostate cancer in the patients with slightly elevated serum PSA values. ...

journal_title：Japanese journal of clinical oncology

authors： Kuriyama M,Uno H,Ueno K,Hamamoto Y,Vihn PQ,Ban Y

更新日期：1999-06-01 00:00:00

abstract：:The incidence of follicular lymphoma in Japan is far lower than that in western countries, and no large-scale clinicopathologic studies on this neoplasm have been conducted in Japan. We reviewed histopathological specimens from 118 of 135 patients who had been diagnosed as having follicular lymphoma between 1968 and 1...

journal_title：Japanese journal of clinical oncology

authors： Katsumata N,Matsuno Y,Nakayama H,Takenaka T,Kobayashi Y,Takeyama K,Narabayashi M,Fukushima T,Yokozawa T,Nakata M,Tajima K,Ikeda H,Tobinai K

更新日期：1996-12-01 00:00:00

abstract：:The main purpose of the study was to evaluate quality of life (QOL) among cancer patients using the WHOQOL-100 instrument and to see if any significant differences were seen in cancer stages, treatment status and prognosis. This study consisted of two parts; qualitative and quantitative. For the qualitative study, two...

journal_title：Japanese journal of clinical oncology

authors： Tazaki M,Nakane Y,Endo T,Kakikawa F,Kano K,Kawano H,Kuriyama K,Kuroko K,Miyaoka E,Ohta H,Okamoto N,Shiratori S,Takamiya S,Tanemura K,Tsuchiya R

更新日期：1998-02-01 00:00:00

abstract：:Adenoid basal carcinoma of the uterine cervix is rare and its cell origin is still obscure. We report a case of adenoid basal carcinoma of the uterine cervix discovered incidentally in a 69-year-old woman who had been hysterectomized due to endometrial adenocarcinoma of the uterine corpus. Histologically, small round-...

journal_title：Japanese journal of clinical oncology

authors： Senzaki H,Osaki T,Uemura Y,Kiyozuka Y,Ogura E,Okamura A,Tsubura A

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:There have been few reports of sarcoid reaction in the regional lymph nodes associated with lung cancer. The purpose of this study was to analyze the surgical results of lung cancer with sarcoid reaction. METHODS:Of 1733 lung cancer patients undergoing surgical treatment in our institute from 1990 to 2004, ...

journal_title：Japanese journal of clinical oncology

authors： Tomimaru Y,Higashiyama M,Okami J,Oda K,Takami K,Kodama K,Tsukamoto Y

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:To report the results of radiotherapy for patients with failure, adverse reactions or relative contraindications to the use of steroids or immunosuppressants, by using newly developed quantitative indexes. METHODS:Fourteen female and six male patients with Graves' ophthalmopathy were treated with radiothera...

journal_title：Japanese journal of clinical oncology

authors： Sakata K,Hareyama M,Oouchi A,Shidou M,Nagakura H,Morita K,Osanai H,Ohtsuka K,Hinoda Y

更新日期：1998-06-01 00:00:00

abstract：:We report the development of a unique enzyme-linked immunosorbent assay (ELISA) which makes possible the detection of leukemia-associated P24 antigen, utilizing its ability to bind the Ricinus communis agglutinin (RCA1) and a monoclonal antibody, SJ-9A4 simultaneously. Using the RCA1/SJ-9A4-ELISA, P24 antigen, as few ...

journal_title：Japanese journal of clinical oncology

authors： Komada Y,Ochiai H,Shimizu K,Azuma E,Kamiya H,Sakurai M

更新日期：1987-12-01 00:00:00

abstract：:Advanced esophageal cancer patients with extensive lymph node metastases show extremely poor prognosis and the long-term outcome is poorer with the involvement of more lymph nodes. We report here a long-surviving case of advanced esophageal cancer with histologically 34 lymph node metastases, in which surgical resecti...

journal_title：Japanese journal of clinical oncology

authors： Shigemitsu K,Naomoto Y,Shirakawa Y,Haisa M,Gunduz M,Tanaka N

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Stage III colorectal cancer is an indication for adjuvant chemotherapy; however, there is no definite view on the selection of regimen. If the recurrence can be predicted, it can serve as the indicator of regimen selection. The present study aimed to predict the recurrence of stage III colorectal cancer by c...

journal_title：Japanese journal of clinical oncology

authors： Ishikawa S,Sawayama H,Matsuo A,Uchino R,Honda S,Hirota M,Baba H

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:In a tumor, increased deubiquitination of cyclins by a protein gene product gene, PGP9.5, could contribute to the uncontrolled growth of somatic cells that is a hallmark of cancer. We hypothesized that PGP9.5 may be expressed in tumors of patients with non-small cell lung cancer (NSCLC). METHODS:Expression ...

journal_title：Japanese journal of clinical oncology

authors： Sasaki H,Yukiue H,Moriyama S,Kobayashi Y,Nakashima Y,Kaji M,Fukai I,Kiriyama M,Yamakawa Y,Fujii Y

更新日期：2001-11-01 00:00:00

abstract：Background and purpose:The objective of this study is to investigate the predictors of critical weight loss in cancer patients receiving particle therapy, and build a prediction model based on its predictive factors. Materials and methods:Patients receiving particle therapy were enroled between June 2015 and June 2016...

journal_title：Japanese journal of clinical oncology

authors： Zhang Z,Zhu Y,Zhang L,Wang Z,Wan H

更新日期：2018-01-01 00:00:00

abstract：:Information of prefectural cancer incidence in Japan is an important resource to plan an effective regional cancer control program. In order to obtain accurate prefectural cancer incidence, we have to adjust for both of completeness of regional cancer registries and regional dispersion, simultaneously, Then, we develo...

journal_title：Japanese journal of clinical oncology

authors： Tanabe R,Kamo KI,Fukui K,Imori S

更新日期：2019-05-01 00:00:00

abstract：:Rupture of irradiated arteries in patients with head and neck cancer is an uncommon complication. We present the first case of a pseudoaneurysm of the external carotid artery branch that developed after irradiation of nasopharyngeal carcinoma and was successfully treated by microcoil embolization therapy. Clinicians s...

journal_title：Japanese journal of clinical oncology

authors： Li SH,Hsu SW,Wang SL,Chen HC,Huang CH

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:The aims of this randomized, controlled study were to investigate the efficacy and safety of long-term monotherapy with the luteinizing hormone-releasing hormone agonist goserelin acetate compared with both short- and long-term combined androgen blockade. METHODS:Patients with advanced prostate cancer (n = 3...

journal_title：Japanese journal of clinical oncology

authors： Kotake T,Usami M,Akaza H,Koiso K,Homma Y,Kawabe K,Aso Y,Orikasa S,Shimazaki J,Isaka S,Yoshida O,Hirao Y,Okajima E,Naito S,Kumazawa J,Kanetake H,Saito Y,Ohi Y,Ohashi Y

更新日期：1999-11-01 00:00:00

abstract：:Exciting recent advancements in deep-sequencing technology have enabled a rapid and cost-effective molecular characterization of patient-derived tumor samples. Incorporating these innovative diagnostic technologies into early clinical trials could significantly propel implementation of precision medicine by identifyin...

journal_title：Japanese journal of clinical oncology

authors： Bando H,Takebe N

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:Trop-1/Ep-CAM modulates growth and survival of transformed cells, and it is highly expressed in most carcinomas including breast cancer. Only membranous staining is typically considered in evaluating Trop-1/epithelial cell adhesion molecule (Ep-CAM) expression in tumor cells. However, there is evidence of ret...

journal_title：Japanese journal of clinical oncology

authors： Alberti S,Ambrogi F,Boracchi P,Fornili M,Querzoli P,Pedriali M,La Sorda R,Lattanzio R,Tripaldi R,Piantelli M,Biganzoli E,Coradini D

更新日期：2012-12-01 00:00:00

abstract：:The development of PD-1 pathway inhibitors has dramatically altered the treatment of advanced/recurrent non-small-cell lung cancer patients. However, the prognostic significance of their ongoing usage is controversial, especially for patients who have not progressed for a period of time. If discontinuation has no nega...

journal_title：Japanese journal of clinical oncology

authors： Nomura S,Goto Y,Mizutani T,Kataoka T,Kawai S,Okuma Y,Murakami H,Tanaka K,Ohe Y

更新日期：2020-07-09 00:00:00

abstract：OBJECTIVE:Since there is now growing interest in the incorporation of patient-reported outcome measures in cancer clinical trials, a patient-based questionnaire, the Patient Neurotoxicity Questionnaire (PNQ) was developed to quantify the symptoms and severity of chemotherapy-induced peripheral neuropathy (CIPN). The ai...

journal_title：Japanese journal of clinical oncology

authors： Kuroi K,Shimozuma K,Ohashi Y,Takeuchi A,Aranishi T,Morita S,Ohsumi S,Watanabe T,Bain S,Hausheer FH

更新日期：2008-11-01 00:00:00

abstract：:To elucidate the relationship between the clinical features and pathologic findings of primary pulmonary lymphoma, we reviewed 24 patients with this disease. The pulmonary lymphomas were divided into four groups: (1) B-cell lymphoma composed of small to medium-sized lymphoid cells (19 cases); (2) B-cell lymphoma compo...

journal_title：Japanese journal of clinical oncology

authors： Tamura A,Komatsu H,Yanai N,Homma J,Nagase A,Nemoto E,Hirai T,Hashizume T,Kawata K,Ishikawa S

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:The disease status of axillary lymph nodes at diagnosis is the most powerful predictor of prognosis for patients with breast cancer. Axillary lymph node dissection (ALND) has been the standard treatment. Recently, lymphatic mapping and sentinel lymph node biopsy (SNB) have been suggested as alternatives to A...

journal_title：Japanese journal of clinical oncology

authors： Koizumi M,Makita M,Yoshimoto M,Kasumi F,Sakamoto G,Ogata E

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:The outcomes of patients with localized or locally advanced prostate cancer treated with external-beam radiotherapy are not well known in Japan. METHODS:Thirty-four institutions combined data on 679 patients with localized or locally advanced prostate cancer treated with a total dose >/=60 Gy between 1995 a...

journal_title：Japanese journal of clinical oncology

authors： Nakamura K,Mizowaki T,Imada H,Karasawa K,Uno T,Onishi H,Nihei K,Sasaki S,Ogura M,Akimoto T

更新日期：2008-03-01 00:00:00

abstract：:A case of primary malignant lymphoma of the skull base is reported. A 62-year-old man was admitted with headache and diplopia. Computed tomography and magnetic resonance imaging showed an abnormal mass in the right parasellar region. The final diagnosis after surgery was primary malignant lymphoma of the skull base. P...

journal_title：Japanese journal of clinical oncology

authors： Oyama H,Nagane M,Shibui S,Nomura K,Mukai K

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:Infusional fluorouracil (5-FU) and leucovorin (LV) with oxaliplatin is one of the current standard regimens for the treatment of patients with metastatic colorectal cancer. Weekly bolus 5-FU with high-dose LV (Roswell Park Memorial Institute Regimen: RPMI) is the most commonly used regimen in Japan. The obje...

journal_title：Japanese journal of clinical oncology

authors： Yamada Y,Ohtsu A,Boku N,Miyata Y,Shimada Y,Doi T,Muro K,Muto M,Hamaguchi T,Mera K,Yano T,Tanigawara Y,Shirao K

更新日期：2006-04-01 00:00:00