Analysis of 13 postmortem examinations with regard to the effect of chemotherapy on neuroblastoma patients.

Abstract:

:Thirteen postmortem examinations on neuroblastoma patients were reviewed clinicopathologically. Commonly found metastatic sites were bone, liver and lung. The introduction of massive doses of cyclophosphamide and cisplatinum into chemotherapy protocol markedly reduced the tumor burden: no tumor focus in liver or lung, small tumor burden in bone. Lymph node metastasis remained, however, and was refractory to the chemotherapy. The intensive chemotherapy caused severe side effects: interstitial or bacterial pneumonia and intrathecal bleeding, which sometimes proved fatal. Such side effects must, therefore, be carefully controlled in order to maximize the survival rate.

journal_name

Jpn J Clin Oncol

authors

Naito H,Sasaki M,Takeda T,Nakadate H,Fujita M

keywords:

subject

Has Abstract

pub_date

1992-06-01 00:00:00

pages

204-9

issue

3

eissn

0368-2811

issn

1465-3621

journal_volume

22

pub_type

杂志文章
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    doi:

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    更新日期:1997-08-01 00:00:00

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    doi:10.1093/jjco/hyq181

    authors: Shi A,Li S,Xu N,Nie G,Li X,Zhang T,Fan Z

    更新日期:2011-02-01 00:00:00

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    doi:10.1093/jjco/hyr169

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    更新日期:2012-01-01 00:00:00

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    pub_type: 杂志文章,多中心研究

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