Abstract:
:A 63-year-old man was admitted to the National Cancer Center Hospital on December 20, 1983 for a close examination of the abnormal shadows found in chest roentgenograms. Chest radiographs showed a massive right pleural effusion, a large tumor in the right hilar region and swelling of the left hilar nodes. Transcutaneous needle biopsy revealed the tumor's cytological type to be adenocarcinoma. The clinical stage was considered to be T3N2M1 (American joint committee (AJC) stage III M1), and his performance status was 4, so he was given etoposide (VP-16) alone as the initial chemotherapy treatment. He showed a partial response upon two courses of VP-16 therapy. Subsequently, one course of cisplatin (80 mg/m2) + vindesine (3.3 mg/m2), two courses of VP-16 (80 mg/m2 D1-4), five courses of cyclophosphamide (80 mg/m2) + adriamycin (50 mg/m2) + vincristine (1.4 mg/m2) and two courses of VP-16 (100 mg/m2 D1, 3, 5) were administered sequentially until May 31, 1985. No radiation therapy was given and, up to March 31, 1987, no sign of recurrence had been observed.
journal_name
Jpn J Clin Oncoljournal_title
Japanese journal of clinical oncologyauthors
Akiba T,Saijo N,Miyamoto K,Sakurai M,Tamura T,Sasaki Y,Eguchi K,Shinkai T,Uei Y,Fujiwara Ysubject
Has Abstract,Author List Incompletepub_date
1987-06-01 00:00:00pages
165-72issue
2eissn
0368-2811issn
1465-3621journal_volume
17pub_type
杂志文章abstract:OBJECTIVE:The cell cycle profile test is suggested to be an independent prognostic indicator for breast cancer patients. To further clarify the prognostic value, we applied this to breast cancer patients treated with postoperative 5-fluorouracil-based chemotherapy. METHODS:A total of 153 breast cancer patients, who we...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyr042
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:Emotional distress is considered to be higher in patients with head and neck cancer than other types of cancer. The present study aimed to identify predictors of the postoperative levels of depression in patients with head and neck cancer who have undergone surgery. METHODS:Postoperative levels of depression...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyu002
更新日期:2014-04-01 00:00:00
abstract:Objectives:In performing an open biopsy of a neck mass, an incisional biopsy may increase the risk of cancer cell seeding and dissemination that, ultimately, worsens a patient's survival. The aim of this study was to compare the impact of incisional and excisional biopsies of cervical lymph node metastases of solid tum...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyy056
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:This phase I/II study determined the recommended dose of FOLFIRI (irinotecan, infusional 5-fluorouracil and leucovorin) for Japanese patients with advanced colorectal cancer, and evaluated safety at the recommended dose in patients without the UDP-glucuronosyltransferase 1A1*28 allele which caused reduced enz...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyq197
更新日期:2011-02-01 00:00:00
abstract:Background:Shorter duration of infusion of monoclonal antibody treatments may reduce treatment burden and improve healthcare resource utilization. Methods:This phase II study recruited Japanese patients with previously untreated CD20+ B-cell non-Hodgkin lymphoma. Patients received intravenous obinutuzumab 1000 mg by r...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,多中心研究
doi:10.1093/jjco/hyy087
更新日期:2018-08-01 00:00:00
abstract::A post hoc analysis of interim results from PREVAIL, a Phase III, double-blind, placebo-controlled trial of men with metastatic castration-resistant prostate cancer, demonstrated that the treatment effects, safety and pharmacokinetics of enzalutamide in Japanese patients were generally consistent with those of the ove...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyw187
更新日期:2017-03-01 00:00:00
abstract::A randomized Phase II/III trial commenced in Japan in December 2013. Carboplatin plus etoposide is the current standard treatment for elderly extensive-disease small-cell lung cancer. The purpose of this study is to confirm the superiority of carboplatin plus irinotecan in terms of overall survival over carboplatin pl...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/jjco/hyu166
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Patients with end-stage renal disease are suggestive to have a higher risk for the development of some kinds of cancer. The aim of this study is to evaluate the possible association between malignancy and end-stage renal disease in Taiwan. METHODS:We used the data of the National Health Insurance system of T...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyr051
更新日期:2011-06-01 00:00:00
abstract::The efficacy of combination therapy with cis-diammine-dichloroplatinum (II) (CDDP) and o-(chloroacetyl-carbamoyl) fumagillol (AGM-1470) was evaluated experimentally using a transplantable rat osteosarcoma line, previously established in our laboratory, with a high potential for metastasis. Tumor-bearing male Fischer 3...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/27.4.236
更新日期:1997-08-01 00:00:00
abstract::Pelvic lymphadenectomy is generally performed to treat early-stage cervical cancer, and pelvic ± para-aortic lymphadenectomy is performed in patients with endometrial cancer confined to the uterus. However, systematic lymphadenectomy is frequently associated with sequelae including lymphocele, lymphedema and celluliti...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1093/jjco/hyz062
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:The value of postmastectomy radiation therapy for breast cancer patients with T1-2 tumor and one to three positive nodes remains controversial. The purpose of this retrospective study was to compare the clinical outcomes of breast cancer patients with T1-2 and one to three positive nodes with and without post...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hys080
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor C (VEGF-C) and D (VEGF-D) are considered to be potentially lymphangiogenic and can selectively induce hyperplasia of the lymphatic vasculature. In this study, we aimed to clarify the relation between expression of VEGF-C and -D and lymphatic metastasis in early gastric canc...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyg008
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:Alpha-fetoprotein (AFP) is an important tumor marker for non-seminomatous germ cell tumors (NSGCTs) that greatly affects diagnosis and the evaluations of therapy and therapeutic policy. However, it is sometimes very difficult to make the distinction between tumors and falsely elevated AFP levels due to benign...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyf094
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:To compare outcome results for squamous cell carcinoma of the uterine cervix between patients treated in a single facility [single facility therapy: (SFT)] and others combined with external beam irradiation (EBRT) in a small facility and intracavitary brachytherapy in a central facility (combined facilities t...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyh024
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVE:In 2009, the TNM classification of malignant tumors was revised, and the renewal of the T2-4 stage in renal cell carcinoma was adopted. To date, however, the staging of ipsilateral solitary adrenal involvement in renal cell carcinoma has not been sufficiently evaluated. METHODS:We retrospectively reviewed th...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,多中心研究
doi:10.1093/jjco/hyr031
更新日期:2011-06-01 00:00:00
abstract::Germline deletion of the 3' portion of the Epithelial Cell Adhesion Molecule (EPCAM) gene located 5' upstream of MutS Homolog 2 (MSH2) is a novel mechanism for its inactivation in Lynch syndrome. However, its contribution in Japanese Lynch syndrome patients is poorly understood. Moreover, somatic events inactivating t...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyv172
更新日期:2016-02-01 00:00:00
abstract:Introduction:Since June 2005, the University Hospital Medical Information Network-Clinical Trial Registry (UMIN-CTR) has been an International Committee of Medical Journal Editors (ICMJE)-approved clinical trial registry in Japan. The number of clinical trials registered in the UMIN-CTR has increased annually. To date,...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyy131
更新日期:2018-11-01 00:00:00
abstract::Recently total body irradiation has been used as a method of preparation for the bone marrow transplantation. However, it has become apparent that total body irradiation is one of the causes of interstitial pneumonia. There are several factors in total body irradiation that may induce interstitial pneumonia. 1) Total ...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1984-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the association of molecular markers and conventional clinicopathological factors with bladder tumour recurrence in patients with primary upper tract urothelial carcinoma after radical nephroureterectomy. METHODS:The expressions of Ki-67 and P53 were measured by immunohistochemical staining prosp...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyv139
更新日期:2015-12-01 00:00:00
abstract:Backgrounds:Stereotactic ablative radiotherapy (SABR) is one of the newly developed innovative radiotherapy and of which optimal dose prescription needs to be standardized. We aimed to investigate the dose-response relationship for patients with SABR. Methods:Fifty-three patients with Stage I non-small cell lung cance...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyx172
更新日期:2018-02-01 00:00:00
abstract::In order to determine whether the epidemiological characteristics of lung cancer have changed within a certain period of time in Taiwan and to propose some causative factors for its rapid rate of increase we performed chronological and epidemiological studies based on the analysis of: (1) available vital statistics an...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1984-03-01 00:00:00
abstract::Human lymphoblastoid interferon-alpha was administered intramuscularly at a dose of 5 x 10(6) units/day to 20 metastatic renal cell carcinoma patients. For potentiating the antitumor effect of interferon, cimetidine was also given to them orally at a dose of 800 mg/day. The combination therapy obtained a complete resp...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1991-02-01 00:00:00
abstract::Seventy metastatic breast adenocarcinoma patients, pretreated with standard hormonotherapy or chemotherapy, received continuous UFT at 10 mg/kg/day, orally, for at least two months. There were one complete response (1.5%), 12 partial responses (17%), one minor response and 37 disease stabilizations. The median duratio...
journal_title:Japanese journal of clinical oncology
pub_type: 临床试验,杂志文章
doi:
更新日期:1993-12-01 00:00:00
abstract::There have been no reports describing acute exacerbations of idiopathic pulmonary fibrosis after particle radiotherapy for non-small cell lung cancer. The present study describes the case of a 76-year-old Japanese man with squamous cell carcinoma of the lung that relapsed in the left upper lobe 1 year after right uppe...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hys115
更新日期:2012-10-01 00:00:00
abstract::In order to determine the significance of androgen receptor (AR) gene mutations for Japanese prostate cancers, we examined the entire coding region, from exon A to H, in 36 primary lesions. Five in stage A, 12 in stage B, six in stage C and 13 in stage D were subjected to PCR-SSCP analysis for genomic DNA and nucleoti...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/27.6.389
更新日期:1997-12-01 00:00:00
abstract::A case of primary malignant lymphoma of the skull base is reported. A 62-year-old man was admitted with headache and diplopia. Computed tomography and magnetic resonance imaging showed an abnormal mass in the right parasellar region. The final diagnosis after surgery was primary malignant lymphoma of the skull base. P...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
doi:
更新日期:1992-04-01 00:00:00
abstract:OBJECTIVE:We evaluated the feasibility of combination chemotherapy with paclitaxel, doxorubicin and cisplatin without prophylactic granulocyte colony-stimulating factor injection for intermediate-to-high-risk or recurrent endometrial cancer. METHODS:Women with histologically confirmed FIGO Stages I-II with >1/2 myomet...
journal_title:Japanese journal of clinical oncology
pub_type: 临床试验,杂志文章
doi:10.1093/jjco/hyu124
更新日期:2014-11-01 00:00:00
abstract::Low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT-type lymphoma) is a rare thymic tumor, with only seven previous cases described worldwide to date. We describe the only case to have presented with pulmonary amyloid nodules. A 63-year-old Japanese female was found to have an anterior mediastinal tum...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1093/jjco/hyd096
更新日期:2000-08-01 00:00:00
abstract::The positive correlation between smoking and cancer risk is well estimated in sporadic colorectal cancer, whereas little is known with regard to Lynch syndrome-associated colorectal cancer. A total of 118 familial colorectal cancer patients from the Hereditary Nonpolyposis Colorectal Cancer Registry and Genetic Testin...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyu218
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:The natural history and posttherapeutic outcome of adenomatous hyperplasia and early hepatocellular carcinoma have rarely been analyzed. METHODS:Fifty-three hepatic tumors diagnosed as adenomatous hyperplasia or early hepatocellular carcinoma and followed up for more than 6 months and 141 patients with sing...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/28.10.604
更新日期:1998-10-01 00:00:00