The cell cycle profile test is a prognostic indicator for breast cancer patients treated with postoperative 5-fluorouracil-based chemotherapy.

Abstract:

OBJECTIVE:The cell cycle profile test is suggested to be an independent prognostic indicator for breast cancer patients. To further clarify the prognostic value, we applied this to breast cancer patients treated with postoperative 5-fluorouracil-based chemotherapy. METHODS:A total of 153 breast cancer patients, who were treated with postoperative 5-fluorouracil-based chemotherapies, were randomly selected. Specific activities of cyclin-dependent kinases 1 and 2 in the tumor samples were analyzed. Patients were divided into three categories (low, intermediate or high risk) based on cell cycle profile analysis. RESULTS:The proportions of the cell cycle profile categories were 39% for low risk, 10% for intermediate risk and 45% for high risk, respectively. Although the cell cycle profile test did not show a significant predictive power for relapse-free survival (high vs. low risk; P = 0.052), the cell cycle profile categories were significant prognostic factors in a subgroup of 98 patients with fewer than three involved nodes (high vs. low risk, P = 0.004). Multivariate analyses also indicated that a cell cycle profile parameter (high vs. low risk) was an independent prognostic indicator from the number of involved nodes and clinical stage in this subgroup (hazard ratio = 2.46, P = 0.01). Interestingly, the prognostic power of the cell cycle profile test was significant in 75 patients treated with oral 5-fluorouracil derivatives alone (hazard ratio = 6.29 for high vs. low risk, P = 0.02). CONCLUSIONS:These findings suggest that the cell cycle profile test is useful for predicting a higher risk of relapse in patients treated with postoperative 5-fluorouracil-based chemotherapy.

journal_name

Jpn J Clin Oncol

authors

Kurebayashi J,Kanomata N,Kozuka Y,Moriya T,Kikukawa N,Kawasaki Y,Harada S,Tamura S,Nakayama S,Ishihara H,Noguchi S,Sonoo H

doi

10.1093/jjco/hyr042

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

739-46

issue

6

eissn

0368-2811

issn

1465-3621

pii

hyr042

journal_volume

41

pub_type

杂志文章
  • Retroperitoneal schwannoma mimicking hepatic tumor in the caudate lobe.

    abstract::We report a 41-year-old woman with a retroperitoneal schwannoma mimicking hepatic tumor in the caudate lobe. Dynamic computed tomography in the early phase showed an enhanced tumor (2.7 cm in diameter) in the Spiegel lobe of the liver, which compressed the inferior vena cava (IVC). We also performed left hepatic angio...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/27.4.282

    authors: Nakamura M,Takayama T,Takayasu K,Shimada K,Yamamoto J,Kosuge T,Sakamoto M,Yamasaki S,Shimizu S,Makuuchi M

    更新日期:1997-08-01 00:00:00

  • Risk and prognostic factors for multiple primary carcinomas in patients with head and neck cancer.

    abstract:Background:Unexpected multiple primary carcinomas (MPCs) that develop in patients with head and neck carcinomas complicate approaches to their management. We therefore investigated the clinical factors associated with survival outcomes after the treatment of MPCs. Methods:We performed a retrospective review of records...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyx178

    authors: Hosokawa S,Takahashi G,Okamura J,Imai A,Mochizuki D,Takizawa Y,Yamatodani T,Misawa K,Mineta H

    更新日期:2018-02-01 00:00:00

  • A preliminary study of preoperative chemotherapy combining irinotecan and cisplatin in patients with gastric cancer with unresectable para-aortic lymph node metastases.

    abstract:BACKGROUND:A high response rate has been reported for chemotherapy combining irinotecan (CPT-11) and cisplatin (CDDP) against advanced gastric cancer. The strong anti-tumor activity of this regimen makes it very attractive as a preoperative chemotherapy. We conducted a preliminary study on preoperative chemotherapy wit...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyh046

    authors: Yamao T,Ohta K,Ohyama S,Ishihara S,Chin K,Maruyama M,Takahashi T,Nakajima T

    更新日期:2004-05-01 00:00:00

  • Dynamic computed tomography and color Doppler ultrasound of renal parenchymal neoplasms: correlations with histopathological findings.

    abstract:BACKGROUND:We evaluated whether color Doppler ultrasound (US) had diagnostic accuracy equal to dynamic computed tomography (CT) and whether performing dynamic CT and Doppler US together would be more informative in preoperative diagnosis of renal solid tumors. METHODS:A total of 110 renal solid tumors smaller than 7 c...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyh013

    authors: Kitamura H,Fujimoto H,Tobisu K,Mizuguchi Y,Maeda T,Matsuoka N,Komiyama M,Nakagawa T,Kakizoe T

    更新日期:2004-02-01 00:00:00

  • Results of a qualitative and field study using the WHOQOL instrument for cancer patients.

    abstract::The main purpose of the study was to evaluate quality of life (QOL) among cancer patients using the WHOQOL-100 instrument and to see if any significant differences were seen in cancer stages, treatment status and prognosis. This study consisted of two parts; qualitative and quantitative. For the qualitative study, two...

    journal_title:Japanese journal of clinical oncology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1093/jjco/28.2.134

    authors: Tazaki M,Nakane Y,Endo T,Kakikawa F,Kano K,Kawano H,Kuriyama K,Kuroko K,Miyaoka E,Ohta H,Okamoto N,Shiratori S,Takamiya S,Tanemura K,Tsuchiya R

    更新日期:1998-02-01 00:00:00

  • Genetic alterations of androgen receptor gene in Japanese human prostate cancer.

    abstract::In order to determine the significance of androgen receptor (AR) gene mutations for Japanese prostate cancers, we examined the entire coding region, from exon A to H, in 36 primary lesions. Five in stage A, 12 in stage B, six in stage C and 13 in stage D were subjected to PCR-SSCP analysis for genomic DNA and nucleoti...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/27.6.389

    authors: Watanabe M,Ushijima T,Shiraishi T,Yatani R,Shimazaki J,Kotake T,Sugimura T,Nagao M

    更新日期:1997-12-01 00:00:00

  • Post-marketing observational study of everolimus in patients with unresectable or metastatic renal cell carcinoma in Japan.

    abstract:OBJECTIVE:To confirm the safety and efficacy of everolimus in patients with unresectable or metastatic RCC. METHODS:Patients with unresectable or metastatic RCC were included and were followed for up to 1 year from the start of everolimus. The study was conducted at 618 investigational sites in Japan from March 2010 t...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyz081

    authors: Akaza H,Kurihara R,Katsura A,Harumiya M,Ushida N

    更新日期:2019-10-01 00:00:00

  • Perinephric invasion as a prognostic factor in non-metastatic renal cell carcinoma: analysis of a nation-wide registry program.

    abstract:OBJECTIVES:Perinephric fat invasion (PFI) of renal cell carcinoma (RCC) is known to be associated with adverse pathological features and poor prognosis. We analyzed these associations using a sub-group of the RCC registry of The Cancer Registration Committee of the Japanese Urological Association. METHODS:The study co...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyz054

    authors: Kume H,Homma Y,Shinohara N,Obara W,Kondo T,Kimura G,Fujimoto H,Nonomura N,Hongo F,Sugiyama T,Takahashi M,Kanayama HO,Fukumori T,Eto M

    更新日期:2019-08-01 00:00:00

  • Techniques and clinical effect of aseptic procedures on patients with acute leukemia in laminar airflow rooms.

    abstract::The techniques of aseptic procedures in the laminar airflow room (LAF) were evaluated in 110 adult patients undergoing antileukemic chemotherapy for remission induction. The patients were divided into three groups according to the regimens: Group A, consisting of 20 patients who stayed in the LAF and received the gown...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Takeo H,Sakurai T,Amaki I

    更新日期:1983-01-01 00:00:00

  • Cancer epidemiology and control in Taiwan: a brief review.

    abstract::Malignant neoplasm has become the leading cause of death in Taiwan since 1982. There has been a decreasing trend for cancers of the stomach and cervix uteri, while an increasing trend has been observed for cancers of the lung, liver, oral cavity, colon and rectum, breast and prostate. International comparison and migr...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/hye138

    authors: Chen CJ,You SL,Lin LH,Hsu WL,Yang YW

    更新日期:2002-03-01 00:00:00

  • Second primary cancers in patients with gastrointestinal cancers.

    abstract::The occurrence of multiple primary malignant neoplasms in 9,191 consecutive cases of primary gastrointestinal (GI) tract cancer from 1962 to 1981 at the National Cancer Center was analyzed. The person-years of the cases totaled 28,399.4: 185 second cancers were diagnosed clinically and 85 were first diagnosed at autop...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Watanabe S,Kodama T,Shimosato Y,Arimoto H,Suemasu K

    更新日期:1985-04-01 00:00:00

  • Rectum dose analysis employing a multi-purpose brachytherapy phantom.

    abstract:PURPOSE:It is difficult to reproduce a brachytherapy measurement because of changes in the rectal shape during inter-fraction. We constructed a multi-purpose brachytherapy phantom (MPBP) and reproduced the same conditions found in actual therapy. We further attempted to apply the measured optimal dose to reduce rectal ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hym032

    authors: Huh H,Kim W,Loh JJ,Lee S,Kim CY,Lee S,Shin D,Shin D,Cho S,Jang J,Lim S,Cho KH,Kwon S,Kim S

    更新日期:2007-05-01 00:00:00

  • Validation of the Integrated Palliative care Outcome Scale (IPOS) - Japanese Version.

    abstract:BACKGROUND:To improve palliative care practice, the need for patients-reported outcome measures is increasing globally. The Integrated Palliative care Outcome Scale (IPOS) is a streamlined outcome scale developed to comprehensively evaluate patients' distress. The goal of this study is to assess the reliability and val...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/jjco/hyy203

    authors: Sakurai H,Miyashita M,Imai K,Miyamoto S,Otani H,Oishi A,Kizawa Y,Matsushima E

    更新日期:2019-03-01 00:00:00

  • Interleukin-11 receptor predicts post-operative clinical outcome in patients with early-stage clear-cell renal cell carcinoma.

    abstract:OBJECTIVE:To investigate the prognostic value of interleukin-11 receptor α chain in patients with early-stage clear-cell renal cell carcinoma. Interleukin-11 receptor α chain, a member of the gp130-dependent receptors, exerts pleiotropic oncogenic activities by promoting proliferation, angiogenesis and metastasis in ma...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyu194

    authors: Pan D,Xu L,Liu H,Zhang W,Zhu Y,Xu J,Gu J

    更新日期:2015-02-01 00:00:00

  • External-beam radiotherapy for localized or locally advanced prostate cancer in Japan: a multi-institutional outcome analysis.

    abstract:BACKGROUND:The outcomes of patients with localized or locally advanced prostate cancer treated with external-beam radiotherapy are not well known in Japan. METHODS:Thirty-four institutions combined data on 679 patients with localized or locally advanced prostate cancer treated with a total dose >/=60 Gy between 1995 a...

    journal_title:Japanese journal of clinical oncology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1093/jjco/hyn008

    authors: Nakamura K,Mizowaki T,Imada H,Karasawa K,Uno T,Onishi H,Nihei K,Sasaki S,Ogura M,Akimoto T

    更新日期:2008-03-01 00:00:00

  • Phyllodes tumor of the prostate: a case report.

    abstract::A case of prostatic phyllodes tumor which developed in a 78-yr-old man is reported. Histologically, the tumor comprised myxomatous and cellular portions with a proliferation of atypical stromal cells. Multinucleated giant cells were occasionally present, but mitoses were rare. Fibroblastic differentiation of the tumor...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:

    authors: Ito H,Ito M,Mitsuhata N,Tahara E

    更新日期:1989-09-01 00:00:00

  • Disconnection of a venous Port-A-Cath followed by embolization after saline flush: rare case report.

    abstract::A 77-year-old man presented with painful swelling of his Port-A-Cath insertion site soon after flushing with normal saline. No discomfort or abnormality was found during the saline flush. A chest roentgenogram showed that the disconnected catheter had separated from the disc and was absent from its original location. ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/29.12.643

    authors: Lam AW,Chen YM,Yang KY,Tsai CM,Perng RP

    更新日期:1999-12-01 00:00:00

  • Nasopharyngeal carcinoma: immunohistochemical study for keratin, secretory component and leukocyte common antigen.

    abstract::Immunohistochemical studies using antisera to keratin and secretory component (SC) and monoclonal antibody against leukocyte common antigen (LCA) were performed on 92 biopsy and autopsy specimens taken from 65 patients with nasopharyngeal carcinoma. Five biopsy specimens from malignant lymphoma of the nasopharynx and ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Nomori H,Kameya T,Shimosato Y,Saito H,Ebihara S,Ono I

    更新日期:1985-03-01 00:00:00

  • Safety, tolerability and pharmacokinetics of shorter duration of infusion of obinutuzumab in Japanese patients with B-cell non-Hodgkin lymphoma: final results of the phase II GATS study.

    abstract:Background:Shorter duration of infusion of monoclonal antibody treatments may reduce treatment burden and improve healthcare resource utilization. Methods:This phase II study recruited Japanese patients with previously untreated CD20+ B-cell non-Hodgkin lymphoma. Patients received intravenous obinutuzumab 1000 mg by r...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/jjco/hyy087

    authors: Ohmachi K,Ando K,Kinoshita T,Kumagai K,Hatake K,Ishikawa T,Teshima T,Kato K,Izutsu K,Ueda E,Nakai K,Kuriki H,Tobinai K

    更新日期:2018-08-01 00:00:00

  • Risk factors for para-aortic lymph node metastasis of gastric cancer from a randomized controlled trial of JCOG9501.

    abstract:BACKGROUND:No risk factor has been confirmed for para-aortic lymph node (PAN) metastasis from gastric cancer. To identify the risk factors and the most frequent route of metastasis to PAN, we analyzed the prospective data from a phase III trial. METHODS:In JCOG9501 comparing D2 and D2 + PAN dissection, 260 patients wi...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/jjco/hym067

    authors: Nomura E,Sasako M,Yamamoto S,Sano T,Tsujinaka T,Kinoshita T,Furukawa H,Shimizu T,Hiratsuka M,Kobayashi O,Kurokawa Y,Tanigawa N,Gastric Cancer Surgical Study Group of the Japan Clinical Oncology Group.

    更新日期:2007-06-01 00:00:00

  • Malignant soft tissue sarcoma of the hypopharynx successfully treated by radiotherapy alone.

    abstract::Sarcoma of the hypopharynx has been reported very rarely in the literature, only six cases having been found among all head and neck malignancies reported to SEER (Surveillance, Epidemiology, and End Results) during 1973-1987. We report a 14-year-old boy with a huge malignant soft tissue sarcoma arising from the hypop...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.jjco.a023203

    authors: Lin JC,Hsu CY,Kwan PC,Shen WC,Jan JS,Ho WL

    更新日期:1996-06-01 00:00:00

  • Sentinel node navigation surgery in cervical and endometrial cancer: a review.

    abstract::Pelvic lymphadenectomy is generally performed to treat early-stage cervical cancer, and pelvic ± para-aortic lymphadenectomy is performed in patients with endometrial cancer confined to the uterus. However, systematic lymphadenectomy is frequently associated with sequelae including lymphocele, lymphedema and celluliti...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/hyz062

    authors: Niikura H,Tsuji K,Tokunaga H,Shimada M,Ishikawa M,Yaegashi N

    更新日期:2019-06-01 00:00:00

  • Study of paclitaxel and dose escalation of cisplatin in patients with advanced non-small cell lung cancer.

    abstract:BACKGROUND:We conducted a dose-finding and feasibility study in which we administered a fixed dose 3-h infusion of paclitaxel and an escalating dose of cisplatin in Japanese patients with advanced non-small cell lung cancer. METHODS:Chemotherapy consisted of fixed dose (210 mg/m(2)) paclitaxel given over 3 h on day 1 ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyg116

    authors: Watanabe H,Yamamoto N,Tamura T,Shimoyama T,Hotta K,Inoue A,Sawada M,Akiyama Y,Kusaba H,Nokihara H,Sekine I,Kunitoh H,Ohe Y,Kodama T,Saijo N

    更新日期:2003-12-01 00:00:00

  • One-hundred-and-two 5-year survivors of esophageal carcinoma after resective surgery.

    abstract::Among 492 patients with esophageal carcinoma who received resective surgery, 102 survived over 5 years. These 5-year survivors were analyzed according to many factors. Females had a better prognosis than males, and patients without lymph-node metastasis had a better 5-year survival rate than those with it. Ten patient...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Iizuka T,Kato H,Watanabe H

    更新日期:1985-06-01 00:00:00

  • Indications for sentinel lymph node biopsy in patients with breast cancer: retrospective and simulation analyses.

    abstract:BACKGROUND:The disease status of axillary lymph nodes at diagnosis is the most powerful predictor of prognosis for patients with breast cancer. Axillary lymph node dissection (ALND) has been the standard treatment. Recently, lymphatic mapping and sentinel lymph node biopsy (SNB) have been suggested as alternatives to A...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyf105

    authors: Koizumi M,Makita M,Yoshimoto M,Kasumi F,Sakamoto G,Ogata E

    更新日期:2002-12-01 00:00:00

  • Cytoplasmic Trop-1/Ep-CAM overexpression is associated with a favorable outcome in node-positive breast cancer.

    abstract:OBJECTIVE:Trop-1/Ep-CAM modulates growth and survival of transformed cells, and it is highly expressed in most carcinomas including breast cancer. Only membranous staining is typically considered in evaluating Trop-1/epithelial cell adhesion molecule (Ep-CAM) expression in tumor cells. However, there is evidence of ret...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hys159

    authors: Alberti S,Ambrogi F,Boracchi P,Fornili M,Querzoli P,Pedriali M,La Sorda R,Lattanzio R,Tripaldi R,Piantelli M,Biganzoli E,Coradini D

    更新日期:2012-12-01 00:00:00

  • Modified and bilateral retroperitoneal lymph node dissection for testicular cancer: peri- and postoperative complications and therapeutic outcome.

    abstract:OBJECTIVE:To characterize surgical invasiveness and morbidity and to verify therapeutic efficacy, we reviewed perioperative and postoperative courses and therapeutic outcomes of patients who underwent retroperitoneal lymph node dissection (RPLND) for testicular germ cell cancers. METHODS:The study included 31 patients...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyl026

    authors: Tanaka T,Kitamura H,Kunishima Y,Takahashi S,Takahashi A,Masumori N,Itoh N,Tsukamoto T

    更新日期:2006-06-01 00:00:00

  • The JPHC study: design and some findings on the typical Japanese diet.

    abstract::The Japan Public Health Center-based prospective Study conducted a baseline survey for 140 000 registered residents aged 40-69 years within 11 public health center areas nationwide in 1990-94. Five- and 10-year follow-up surveys were conducted to update information on lifestyle habits and health conditions. In total, ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyu096

    authors: Tsugane S,Sawada N

    更新日期:2014-09-01 00:00:00

  • Body mass index and risk of gastric cancer: a meta-analysis.

    abstract:OBJECTIVE:Overweight and obesity, indicated as increased body mass index, are associated with the risk of some cancers. We carried out a meta-analysis on published cohort and case-control studies to assess the strength of association between body mass index and gastric cancer. METHODS:Relevant studies were identified ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,meta分析

    doi:10.1093/jjco/hyu082

    authors: Lin XJ,Wang CP,Liu XD,Yan KK,Li S,Bao HH,Zhao LY,Liu X

    更新日期:2014-09-01 00:00:00

  • A case of amelanotic malignant melanoma of the female urethra.

    abstract::We report a case of amelanotic malignant melanoma of the female urethra. The clinical course was unusually long and complicated by asynchronous resectable metastases to the lung and the brain. The patient died of generalized metastasis in spite of successful resection of the metastatic lesions and post-operative chemo...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Sugaya K,Yazaki T,Ishikawa S,Kanoh S

    更新日期:1983-06-01 00:00:00