Abstract:
:The occurrence of multiple primary malignant neoplasms in 9,191 consecutive cases of primary gastrointestinal (GI) tract cancer from 1962 to 1981 at the National Cancer Center was analyzed. The person-years of the cases totaled 28,399.4: 185 second cancers were diagnosed clinically and 85 were first diagnosed at autopsy. The overall frequency was 2.01% for clinically recognizable cancers and 2.94% including those discovered at autopsy. The overall observed/expected ratio was 0.96 for clinical cancers and 1.33 including autopsy cases. However, a significant association between the first and second cancers was present in the oro-pharynx and esophagus; esophagus, stomach and colon; stomach and all other parts of the GI tract; and the colon and rectum. The mode of appearance was also analyzed to clarify the organ relationship.
journal_name
Jpn J Clin Oncoljournal_title
Japanese journal of clinical oncologyauthors
Watanabe S,Kodama T,Shimosato Y,Arimoto H,Suemasu Ksubject
Has Abstractpub_date
1985-04-01 00:00:00pages
171-82eissn
0368-2811issn
1465-3621journal_volume
15 Suppl 1pub_type
杂志文章abstract:BACKGROUND:A self-administered quantitative food frequency questionnaire (Qx) was developed for a population-based cohort study on cancer in Takayama, Japan. METHODS:The Qx was tested among 58 male and 59 female volunteers. Average daily nutrient intakes for the previous year calculated from the Qx were compared with ...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/29.1.38
更新日期:1999-01-01 00:00:00
abstract::Human lymphoblastoid interferon-alpha was administered intramuscularly at a dose of 5 x 10(6) units/day to 20 metastatic renal cell carcinoma patients. For potentiating the antitumor effect of interferon, cimetidine was also given to them orally at a dose of 800 mg/day. The combination therapy obtained a complete resp...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1991-02-01 00:00:00
abstract:BACKGROUND:Duodenal carcinoma is very rare and its culture cell lines have rarely been established. METHODS:Tumor cells separated from a surgically resected primary tumor of duodenal carcinoma were put into culture. The patient was an 81-year-old female and had metastatic lymph nodes. We investigated the biological ch...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/29.12.596
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor C (VEGF-C) and D (VEGF-D) are considered to be potentially lymphangiogenic and can selectively induce hyperplasia of the lymphatic vasculature. In this study, we aimed to clarify the relation between expression of VEGF-C and -D and lymphatic metastasis in early gastric canc...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyg008
更新日期:2003-01-01 00:00:00
abstract::Human gastrin-releasing peptide (GRP) mRNA was detected in the tumor tissues of medullary thyroid carcinomas and small cell lung carcinomas using synthetic oligodeoxyribonucleotides as hybridization probes. The amount of GRP mRNA was estimated by radiodensitometric hybridization assay. A good correlation was found bet...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1987-06-01 00:00:00
abstract::A 56-year-old housewife was incidentally discovered to have an abnormal shadow in the right B6 area upon a chest X-ray film being taken. A transcutaneous lung biopsy of the mass revealed adenocarcinoma of the lung (WHO classification). A brain computed tomography (CT) scan demonstrated multiple brain metastasis. Follo...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1987-06-01 00:00:00
abstract::In Japan, lateral lymph node dissection (LLND) is generally performed for the treatment of T3-4 lower rectal carcinoma, and not for T1 lower rectal carcinoma, because of a low positive rate in patients with T1 lesion. We experienced a rare case of lateral pelvic lymph node recurrence after total mesorectal resection f...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyn011
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:Oral fluoropyrimidine plus cisplatin is a standard treatment for advanced gastric cancer, but patients with severe peritoneal metastasis often cannot tolerate this regimen. The aim of this study was to assess the feasibility of fluorouracil, l-leucovorin and paclitaxel therapy in such patients. METHODS:In th...
journal_title:Japanese journal of clinical oncology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1093/jjco/hys111
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:Studies have suggested that bevacizumab has shown activity against various pediatric solid tumors. We, therefore, conducted a Phase I study of bevacizumab plus irinotecan in Japanese children with recurrent, progressive or refractory solid tumors. METHODS:The starting dose was bevacizumab 10 mg/kg over 60-90...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyt124
更新日期:2013-11-01 00:00:00
abstract::Age-adjusted incidence rates for malignant lymphomas in eastern Asian countries except for the Kyushu district of Japan are lower than those in northern European, North and South American and Oceanian countries. Particularly, the incidence rates for Hodgkin's disease and follicular lymphoma are remarkably low in easte...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1983-09-01 00:00:00
abstract:BACKGROUND:Angiogenesis is required for growth and metastasis of colorectal cancer (CRC), and several positive regulators of tumor angiogenesis have been identified. Cyclooxygenase-2 (COX-2), known to be elevated in several human cancers, regulates angiogenesis by inducing angiogenic factors. The aim of this study was ...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hym080
更新日期:2007-09-01 00:00:00
abstract::Although recent progress in multi-drug chemotherapy has increased the median survival of patients with extensive Small cell lung cancer (SCLC) to 7 months, 2-year survivors are still exceptional. We describe a 40-year-old man with extensive SCLC involving the lungs and systemic nodes who was initially treated with 6 c...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1995-10-01 00:00:00
abstract::Multiple endocrine neoplasia (MEN) 2A is an inherited disease characterized by the development of medullary thyroid carcinoma, pheochromocytoma and hyperparathyroidism. It has recently been shown to be associated with germ-line mutations in the RET proto-oncogene. We describe a 21-year-old man from a MEN 2A family who...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/27.1.42
更新日期:1997-02-01 00:00:00
abstract:BACKGROUND:Recent studies reported that hospital procedure volume (i.e. volume of patients per hospital receiving a particular treatment)was directly proportional to cancer survival; however the degree of association might be different according to the primary tumor site, extent of disease and year of diagnosis. We per...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hym052
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVE:Nasopharyngeal carcinoma is one of the leading malignancies with obscure etiology. Circulating tumor cells have been showed to intimately correlate with characteristics in different kinds of cancer. But links between circulating tumor cells and nasopharyngeal carcinoma were still lacking. Therefore, we explor...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyw046
更新日期:2016-07-01 00:00:00
abstract::A 56-year-old man, tentatively diagnosed as having cardiomegaly, was found to have a large cyst in the left anterior mediastinum. At thoracotomy a multilocular cystic mass containing a colorless serous fluid was found and resected. Histologically, the cyst was lined with flattened epithelial cells, and thymic tissue w...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1991-10-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess clinically the adequacy of vessel-contouring-based pelvic radiotherapy with regard to nodal coverage for uterine cervical cancer. METHODS:Fifty patients with Stages I-III cervical cancer, treated with vessel-contouring-based three-dimensional radiotherapy since August 2002...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyp029
更新日期:2009-06-01 00:00:00
abstract::The localization of acidic fibroblast growth factor (aFGF) and basic fibroblast growth factor (bFGF) was investigated immunohistochemically in human benign and malignant thyroid lesions. Immunostaining for aFGF and bFGF displayed diffuse or granular deposits of the reaction products in the cytoplasm of neoplastic cell...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
abstract:Background:Advanced gastric cancer (AGC) and systemic chemotherapy are some of the risk factors for venous thromboembolism (VTE). However, the cumulative incidence, risk factors and prognostic impact of VTE have not been evaluated in Japanese patients with AGC. Methods:This retrospective study included patients who re...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyx107
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:Endobronchial ultrasound-guided transbronchial needle aspiration is widely used for mediastinal and hilar lesions. Histologic specimens from this procedure are important for specific diagnosis and targeted therapy. Studies on the traditional endobronchial ultrasound-guided transbronchial needle aspiration nee...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyu095
更新日期:2014-09-01 00:00:00
abstract::Castleman's disease is a rare disorder characterized by benign proliferation of lymphoid tissue. Most cases occur as a mediastinal mass, although extrathoracic involvement including nodal and extranodal locations has been reported. The left suprarenal location of this localized disease may be mistaken for an adrenal t...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyi092
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:We evaluated the efficacy of our quality assurance (QA) program of radiation therapy (RT) in a prospective phase II study. This is the first description of the experience of the Japan Radiation Oncology Group (JAROG) with this program. METHODS:Clinical records, all diagnostic radiological films or color pho...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyl129
更新日期:2007-02-01 00:00:00
abstract::A 72-year-old man was found to have a 12 mm solid lesion in the pancreatic tail and an 8 mm cystic lesion in the body of the pancreas by computed tomography carried out during a routine follow-up study of his adult-onset diabetes mellitus. A distal pancreatectomy was performed revealing the pancreas to have an adenoca...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1991-12-01 00:00:00
abstract:OBJECTIVE:The aim of the present study is to compare the accuracy in using laboratory data or clinical factors, or both, in predicting probability of dying within 7 days of hospice admission in terminal cancer patients. METHODS:We conducted a prospective cohort study of 727 patients with terminal cancer. Three models ...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyp188
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:We evaluated the feasibility of combination chemotherapy with paclitaxel, doxorubicin and cisplatin without prophylactic granulocyte colony-stimulating factor injection for intermediate-to-high-risk or recurrent endometrial cancer. METHODS:Women with histologically confirmed FIGO Stages I-II with >1/2 myomet...
journal_title:Japanese journal of clinical oncology
pub_type: 临床试验,杂志文章
doi:10.1093/jjco/hyu124
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to identify clinicopathological variables associated with the clinical outcomes of patients with lymph node metastasis-positive urothelial bladder carcinoma after radical cystectomy. METHODS:Forty-six patients who underwent radical cystectomy without preoperative chemotherapy and ha...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hys136
更新日期:2012-11-01 00:00:00
abstract:Background:Many patients with colorectal cancer are elderly with competing comorbidities. When constructing nomogram for assessing survival, we should consider the influence of competing risk. A competing-risks nomogram was developed to estimate the probability of death due to colorectal cancer for patients after curat...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyy136
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:To compare outcome results for squamous cell carcinoma of the uterine cervix between patients treated in a single facility [single facility therapy: (SFT)] and others combined with external beam irradiation (EBRT) in a small facility and intracavitary brachytherapy in a central facility (combined facilities t...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyh024
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVE:To investigate the regulative effect of microRNA-338-3p on colorectal carcinoma cell invasion and migration. METHODS:The microRNA-338-3p expression pattern of colorectal carcinoma tissues and cell lines was detected by real-time reverse transcriptase polymerase chain reaction. The protein level of smoothened...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyt181
更新日期:2014-01-01 00:00:00
abstract::Expression of carcinoembryonic antigen (CEA) and nonspecific cross-reacting antigen (NCA) mRNAs were observed in malignant and nonmalignant colon tissues by Northern blot analysis. CEA mRNA was detected together with NCA mRNA in nine cultured cell lines, with the exception of the lung carcinoma A549 cell line, and in ...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.jjco.a039449
更新日期:1991-04-01 00:00:00