当前位置： SCI文献检索 > JAPANESE JOURNAL OF CLINICAL ONCOLOGY期刊下所有文献 > Characteristics of lymph node metastases defining the outcome after radical cystectomy of urothelial bladder carcinoma.

Characteristics of lymph node metastases defining the outcome after radical cystectomy of urothelial bladder carcinoma.

Abstract：

OBJECTIVE:The aim of this study was to identify clinicopathological variables associated with the clinical outcomes of patients with lymph node metastasis-positive urothelial bladder carcinoma after radical cystectomy. METHODS:Forty-six patients who underwent radical cystectomy without preoperative chemotherapy and had histologically proven nodal metastasis were included in the study. The status of lymph nodes and primary lesion was analyzed in terms of disease-specific survival and recurrence-free survival. RESULTS:The 5-year disease-specific survival and recurrence-free survival for the 46 patients overall were 41.3 and 32.2%, respectively. Univariate analysis showed that pN status, the total number of involved lymph nodes, lymph node density and extranodal invasion were statistically significant variables predictive of disease-specific survival. Multivariate analysis revealed that the total number of involved lymph nodes, extranodal invasion and diameter of the metastatic lesion were statistically significant variables predictive of disease-specific survival. Interestingly, the diameter of metastatic lesions was inversely correlated with poorer survival. Patients with large (≥10 mm) metastatic lesions and no extranodal invasion (expansive growth) had significantly better disease-specific survival than those with multiple small (<10 mm) metastatic lesions and no extranodal invasion (highly spreading) (P=0.0156) or those with extranodal invasion (infiltrative growth) (P=0.0181). CONCLUSIONS:Our data indicate that the clinical outcome of node-positive patients is not only stratified according to the tumor burden reflected in the total number of involved lymph nodes, but also affected by tumor biology including invasiveness and potential for metastasis, which is reflected in pathological characteristics such as extranodal invasion and the diameter of metastatic lesions.

journal_name

Jpn J Clin Oncol

journal_title

Japanese journal of clinical oncology

authors

Nakagawa T,Kanai Y,Nakanishi H,Komiyama M,Fujimoto H

doi

10.1093/jjco/hys136

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

1066-72

issue

eissn

0368-2811

issn

1465-3621

pii

hys136

journal_volume

pub_type

杂志文章

在线工具

Characteristics of lymph node metastases defining the outcome after radical cystectomy of urothelial bladder carcinoma.