Patient with extensive small cell lung cancer given moderately dose-intensified chemotherapy and peripheral blood stem cell support.

Abstract:

:Although recent progress in multi-drug chemotherapy has increased the median survival of patients with extensive Small cell lung cancer (SCLC) to 7 months, 2-year survivors are still exceptional. We describe a 40-year-old man with extensive SCLC involving the lungs and systemic nodes who was initially treated with 6 cycles of an alternating combination regimen consisting of cyclophosphamide, doxorubicin, vincristine, cisplatin and etoposide. After the second cycle of the regimen, Peripheral blood stem cells (PBSC) were harvested and frozen. The patient then received a moderately dose-intensified regimen consisting of cisplatin (80 mg/m2) and etoposide (500 mg/m2 X 3), followed by infusion of the thawed PBSC. Hematopoietic recovery was rapid, and the patient remained tumor free for 12 months until multiple tumor recurrence.

journal_name

Jpn J Clin Oncol

authors

Shimizu E,Takaue Y,Yamamoto A,Ogura T,Sone S

subject

Has Abstract

pub_date

1995-10-01 00:00:00

pages

213-7

issue

5

eissn

0368-2811

issn

1465-3621

journal_volume

25

pub_type

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