Low-level Ki-67 expression as an independent predictor of bladder tumour recurrence in patients with primary upper tract urothelial carcinoma after radical nephroureterectomy.

Abstract:

OBJECTIVE:To evaluate the association of molecular markers and conventional clinicopathological factors with bladder tumour recurrence in patients with primary upper tract urothelial carcinoma after radical nephroureterectomy. METHODS:The expressions of Ki-67 and P53 were measured by immunohistochemical staining prospectively in 115 consecutive patients with primary upper tract urothelial carcinoma from March 2004 to February 2014. The Cox proportional hazards regression model was used to identify independent predictors. The association between Ki-67 expression and clinicopathological variables was assessed by the χ(2) test. RESULTS:Intravesical recurrence occurred in 13 out of 115 (11.3%) patients with a mean follow-up of 54.2 months (range: 7-130). Low-level Ki-67 expression (P = 0.010), older age (>65, P = 0.040) and lower ureter tumour (P = 0.001) were independent predictors of bladder tumour recurrence in Cox regression analysis. Ki-67 expression was elevated with the progression of tumour grade (P = 0.004) but not with stage (P = 0.186). Ki-67 overexpression was also significantly higher in aggressive pathological types (P = 0.008), but only shows an inclination towards poor oncologic outcomes in the cancer-specific survival rate (P = 0.107) and the overall survival rate (P = 0.063). CONCLUSIONS:Low-level Ki-67 expression was an independent predictor for bladder tumour recurrence, while Ki-67 overexpression was associated with adverse clinicopathological parameters and poor prognosis in patients with primary upper tract urothelial carcinoma after radical nephroureterectomy.

journal_name

Jpn J Clin Oncol

authors

Wu P,Liu S,Zhang W,Zhang Y,Zhu G,Wei D,Wan B,Wang J

doi

10.1093/jjco/hyv139

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

1175-81

issue

12

eissn

0368-2811

issn

1465-3621

pii

hyv139

journal_volume

45

pub_type

杂志文章
  • Detecting circulating cancer cells using reverse transcriptase-polymerase chain reaction for cytokeratin mRNA in peripheral blood from patients with gastric cancer.

    abstract:BACKGROUND:Cytokeratins (CKs) 19 and 20 have been used as targets for detecting cancer cells. We attempted to detect circulating cancer cells in patients with gastric cancer using a high-sensitivity reverse transcriptase-polymerase chain reaction (RT-PCR) assay for CK transcripts. METHODS:RT-PCR for CK 19 and CK 20 wa...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyd130

    authors: Majima T,Ichikura T,Takayama E,Chochi K,Mochizuki H

    更新日期:2000-11-01 00:00:00

  • Troubles and hardships faced by psychologists in cancer care.

    abstract:OBJECTIVE:The aim of this study was to identify problems experienced by psychologists involved in cancer and palliative care and consider an education system for psychologists. METHODS:We conducted a questionnaire survey of psychologists involved in cancer care and palliative care. At the 403 facilities, 419 psycholog...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hys232

    authors: Iwamitsu Y,Oba A,Hirai K,Asai M,Murakami N,Matsubara M,Kizawa Y

    更新日期:2013-03-01 00:00:00

  • Ovarian cyst formation in patients using tamoxifen for breast cancer.

    abstract:OBJECTIVE:The purpose of this study was to evaluate patient-related parameters that determine ovarian cyst formation in women using tamoxifen for breast cancer. METHODS:A retrospective review of tamoxifen-treated women with breast cancer who were followed up in the outpatient clinic at Ankara Oncology Hospital between...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyi165

    authors: Metindir J,Aslan S,Bilir G

    更新日期:2005-10-01 00:00:00

  • Chemoradiotherapy for limited-disease small-cell lung cancer in elderly patients aged 75 years or older.

    abstract:BACKGROUND:As clinical trials for limited-disease small-cell lung cancer often exclude elderly patients due to comorbidities and a decline in organ function, the most suitable treatment for limited-disease small-cell lung cancer patients aged 75 years or older still remains unclear. METHODS:From July 2002 to June 2011...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hys197

    authors: Shukuya T,Takahashi T,Harada H,Ono A,Akamatsu H,Taira T,Kenmotsu H,Naito T,Murakami H,Endo M,Takahashi K,Yamamoto N

    更新日期:2013-02-01 00:00:00

  • Expression of VEGF-C correlates with a poor prognosis based on analysis of prognostic factors in 73 patients with esophageal squamous cell carcinomas.

    abstract:OBJECTIVE:The purpose of this study was to specifically investigate the clinicopathological role of expression of vascular endothelial growth factor-C (VEGF-C) as well as the correlation with clinical outcomes in esophageal squamous cell carcinomas (ESCCs). METHODS:Seventy-three patients with ESCC resected in our inst...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyp079

    authors: Liu P,Chen W,Zhu H,Liu B,Song S,Shen W,Wang F,Tucker S,Zhong B,Wang D

    更新日期:2009-10-01 00:00:00

  • Adjuvant and neoadjuvant treatment for pancreatic adenocarcinoma.

    abstract::The prognosis of pancreatic adenocarcinoma is dismal. Hence, advances in multidisciplinary treatment strategies, including surgery, are urgently needed. Early recurrence of distant organ metastases suggests that there are occult metastases even in cases with resectable disease. Several randomized controlled trials on ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/hyaa018

    authors: Motoi F,Unno M

    更新日期:2020-05-05 00:00:00

  • Preoperative level of depression is a predictor of postoperative levels of depression in patients with head and neck cancer.

    abstract:OBJECTIVE:Emotional distress is considered to be higher in patients with head and neck cancer than other types of cancer. The present study aimed to identify predictors of the postoperative levels of depression in patients with head and neck cancer who have undergone surgery. METHODS:Postoperative levels of depression...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyu002

    authors: Adachi Y,Kimura H,Sato N,Nagashima W,Nakamura K,Aleksic B,Yoshida K,Fujimoto Y,Nakashima T,Ozaki N

    更新日期:2014-04-01 00:00:00

  • Risk factors for para-aortic lymph node metastasis of gastric cancer from a randomized controlled trial of JCOG9501.

    abstract:BACKGROUND:No risk factor has been confirmed for para-aortic lymph node (PAN) metastasis from gastric cancer. To identify the risk factors and the most frequent route of metastasis to PAN, we analyzed the prospective data from a phase III trial. METHODS:In JCOG9501 comparing D2 and D2 + PAN dissection, 260 patients wi...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/jjco/hym067

    authors: Nomura E,Sasako M,Yamamoto S,Sano T,Tsujinaka T,Kinoshita T,Furukawa H,Shimizu T,Hiratsuka M,Kobayashi O,Kurokawa Y,Tanigawa N,Gastric Cancer Surgical Study Group of the Japan Clinical Oncology Group.

    更新日期:2007-06-01 00:00:00

  • Uterine inversion caused by uterine sarcoma: a case report.

    abstract::Uterine inversion caused by uterine sarcoma is a rare condition with 12 reported cases to date according to a MEDLINE search. We report two cases of this rare condition. A 71- and a 72-year-old woman presented with uterine sarcomas rapidly extruded into the vagina. In both cases, magnetic resonance imaging (MRI) scans...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hye002

    authors: Takano K,Ichikawa Y,Tsunoda H,Nishida M

    更新日期:2001-01-01 00:00:00

  • Co-deletions of the retinoblastoma gene and Wilms' tumor gene and rearrangement of the Krev-1 gene in a human insulinoma.

    abstract::We found deletions of both alleles of the retinoblastoma gene (Rb) and the candidate Wilms' tumor gene (WT33) in a surgically resected human insulinoma by blot hybridization. Rearrangement of Krev-1, a transformation suppressor gene, was also detected in this case. The clinical and histological findings suggested that...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Iwamura Y,Futagawa T,Kaneko M,Nakagawa K,Kawai K,Yamashita K,Nakamura T,Hayashi H

    更新日期:1992-02-01 00:00:00

  • A phase 2 study of abiraterone acetate in Japanese men with metastatic castration-resistant prostate cancer who had received docetaxel-based chemotherapy.

    abstract:OBJECTIVE:In this Phase 2 multicenter study the efficacy and safety of oral abiraterone acetate (1000 mg/once daily) plus prednisolone (5 mg/twice daily) was evaluated in metastatic castration-resistant prostate cancer patients from Japan who had previously received docetaxel-based chemotherapy. METHODS:Men (aged ≥20 ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/jjco/hyu148

    authors: Satoh T,Uemura H,Tanabe K,Nishiyama T,Terai A,Yokomizo A,Nakatani T,Imanaka K,Ozono S,Akaza H

    更新日期:2014-12-01 00:00:00

  • Hematogenous metastatic patterns of curatively resected colon cancer were different from those of stage IV and autopsy cases.

    abstract::The hematogenous metastases of colon cancer have primarily been explained by the cascade hypothesis based on the cadaveric study. However, we experienced several cases with isolated lung metastasis. The metastatic patterns of a total of 982 patients with colon cancer who underwent surgery were reviewed. The incidence ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyt002

    authors: Sadahiro S,Suzuki T,Tanaka A,Okada K,Kamata H

    更新日期:2013-04-01 00:00:00

  • Rapid reconstruction of three dimensional images from ultrasonography using a linearly moving mirror.

    abstract::A system for reconstructing three dimensional (3-D) images from ultrasonography using a linearly moving mirror was modified. The device could display the 3-D structure of objects in real time by employing an on-line system. In a case of hepatocellular carcinoma, structures of the tumor and blood vessels were selective...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Kawabata M,Mochida S,Fujiwara K,Yamanaka R,Yamamoto K,Yoshikura H

    更新日期:1992-02-01 00:00:00

  • Fibulin-1 functions as a prognostic factor in lung adenocarcinoma.

    abstract:OBJECTIVE:Fibulin-1 is a member of the fibulin gene family, characterized by tandem arrays of epidermal growth factor-like domains and a C-terminal fibulin-type module. Fibulin-1 plays important roles in a range of cellular functions including morphology, growth, adhesion and mobility. It acts as a tumor suppressor gen...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyv094

    authors: Cui Y,Liu J,Yin HB,Liu YF,Liu JH

    更新日期:2015-09-01 00:00:00

  • Post-marketing observational study of everolimus in patients with unresectable or metastatic renal cell carcinoma in Japan.

    abstract:OBJECTIVE:To confirm the safety and efficacy of everolimus in patients with unresectable or metastatic RCC. METHODS:Patients with unresectable or metastatic RCC were included and were followed for up to 1 year from the start of everolimus. The study was conducted at 618 investigational sites in Japan from March 2010 t...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyz081

    authors: Akaza H,Kurihara R,Katsura A,Harumiya M,Ushida N

    更新日期:2019-10-01 00:00:00

  • Locally recurrent rectal cancer successfully treated by total pelvic exenteration with combined ischiopubic rami resection: report of a case.

    abstract::A combined ischiopubic rami resection is extremely rare in the field of gastroenterologic surgery. We report a case of a locally recurrent rectal cancer that was successfully treated by total pelvic exenteration with combined ischiopubic rami resection. A 58-year-old male with locally recurrent rectal cancer and liver...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyr169

    authors: Uehara K,Yoshioka Y,Taguchi Y,Igami T,Ebata T,Yokoyama Y,Sugawara G,Tsukushi S,Nishida Y,Yoshino Y,Nagino M

    更新日期:2012-01-01 00:00:00

  • Revised staging system for malignant lymphoma based on the Lugano classification.

    abstract::The Lugano classification was published in 2014 to form the basis for revising the recommendations regarding anatomic staging and evaluation of disease before and after therapy. This staging system was adopted by the eighth edition of the Cancer Staging Manual of the American Joint Committee on Cancer. In this review,...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/hyz111

    authors: Munakata W,Terauchi T,Maruyama D,Nagai H

    更新日期:2019-10-01 00:00:00

  • Impact of intracranial extension on survival in stage IV nasopharyngeal carcinoma: identification of a subset of patients with better prognosis.

    abstract:OBJECTIVE:T-stage is an imperfect prognostic indicator for patients with nasopharyngeal carcinoma. We evaluated the effect of extent of intracranial involvement on survival after conventional radiotherapy in patients with Stage T4 nasopharyngeal carcinoma. METHODS:We conducted a retrospective analysis of the results o...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyq171

    authors: Hu YC,Chang CH,Chen CH,Ger LP,Liu WS,Lin LC,Leung CM,Chang KC

    更新日期:2011-01-01 00:00:00

  • Levels of beta-human chorionic gonadotropin in cerebrospinal fluid of patients with malignant germ cell tumor can be used to detect early recurrence and monitor the response to treatment.

    abstract:BACKGROUND:Tumor marker-producing germ cell tumors of the central nervous system are malignant and require radiation and/or chemotherapy. Although serum beta-human chorionic gonadotropin (hCG) has been used to monitor the course of treatment, the levels of beta-hCG in the cerebrospinal fluid (CSF) have not been measure...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyd076

    authors: Fujimaki T,Mishima K,Asai A,Tabuchi K,Kobayashi M,Suzuki I,Kirino T

    更新日期:2000-07-01 00:00:00

  • Long-term outcomes of dynamic conformal arc irradiation combined with neoadjuvant hormonal therapy in Japanese patients with T1c-T2N0M0 prostate cancer: case series study.

    abstract:OBJECTIVE:There are few reports of the outcomes of external beam radiotherapy in Asian males with localized prostate cancer. The aim of this study is to evaluate the long-term outcomes of external beam irradiation using three-dimensional two-dynamic conformal arc therapy, combined with neoadjuvant hormonal therapy, in ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyt197

    authors: Ikeda I,Mizowaki T,Norihisa Y,Takayama K,Kamba T,Inoue T,Nakamura E,Kamoto T,Ogawa O,Hiraoka M

    更新日期:2014-02-01 00:00:00

  • Initial experience of robotic anatomical segmentectomy for non-small cell lung cancer.

    abstract:OBJECTIVE:Anatomical segmentectomy has the potential to replace lobectomy as the standard procedure for early stage non-small cell lung cancer. We investigated the safety and feasibility of robotic anatomical segmentectomy for non-small cell lung cancer. METHODS:Overall 20 patients underwent robotic anatomical segment...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyz199

    authors: Kagimoto A,Tsutani Y,Izaki Y,Handa Y,Mimae T,Miyata Y,Okada M

    更新日期:2020-04-07 00:00:00

  • A case of amelanotic malignant melanoma of the female urethra.

    abstract::We report a case of amelanotic malignant melanoma of the female urethra. The clinical course was unusually long and complicated by asynchronous resectable metastases to the lung and the brain. The patient died of generalized metastasis in spite of successful resection of the metastatic lesions and post-operative chemo...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Sugaya K,Yazaki T,Ishikawa S,Kanoh S

    更新日期:1983-06-01 00:00:00

  • Prognostic value of surgical margin status for biochemical recurrence following radical prostatectomy.

    abstract:OBJECTIVE:We evaluated the preoperative parameters to predict a positive surgical margin (SM) at radical prostatectomy for patients with prostate cancer. In addition, the prognostic factors for biochemical recurrence were determined in patients with positive SMs. METHODS:We retrospectively analysed 238 patients with p...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hym135

    authors: Hashimoto K,Masumori N,Takei F,Fukuta F,Takahashi A,Itoh N,Hasegawa T,Tsukamoto T

    更新日期:2008-01-01 00:00:00

  • The possibility of clinical sequencing in the management of cancer.

    abstract::Comprehensive genomic profiling using next-generation sequencing technologies provides insights into understanding the genomic architecture of human cancer. This new understanding of the cancer genome allows us to identify many more genomic alterations occurring within tumors than before, some of which could be potent...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/hyw018

    authors: Kou T,Kanai M,Matsumoto S,Okuno Y,Muto M

    更新日期:2016-05-01 00:00:00

  • Immunohistochemical localization of acidic and basic fibroblast growth factors in human benign and malignant thyroid lesions.

    abstract::The localization of acidic fibroblast growth factor (aFGF) and basic fibroblast growth factor (bFGF) was investigated immunohistochemically in human benign and malignant thyroid lesions. Immunostaining for aFGF and bFGF displayed diffuse or granular deposits of the reaction products in the cytoplasm of neoplastic cell...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Kodama M,Daa T,Kashima K,Yokoyama S,Nakayama I,Noguchi S

    更新日期:1994-04-01 00:00:00

  • Trends for the past 10 years and international comparisons of the structure of Korean radiation oncology.

    abstract:OBJECTIVE:Study aims include determination of nationwide structural characteristics of radiation oncology facilities, types of radiation therapy equipment, availability of human resources and trends and comparisons with previous surveys. METHODS:An annual nationwide survey was conducted to collect the statistics of in...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyq001

    authors: Ji YH,Jung H,Yang K,Cho CK,Yoo SY,Yoo HJ,Kim KB,Kim MS

    更新日期:2010-05-01 00:00:00

  • Long-term follow-up of a randomized Phase II study of cisplatin/5-FU concurrent chemoradiotherapy for esophageal cancer (KROSG0101/JROSG021).

    abstract:OBJECTIVE:Long-term survival and late toxicities of a randomized Phase II study of chemoradiotherapy for esophageal cancer were analyzed. METHODS:Eligible patients were <75 years old and performance status 0-2, and had Stages II-IVA esophageal cancer. For arm A (short-term infusion), cisplatin 70 mg/m(2) Days 1 and 29...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/jjco/hys112

    authors: Nishimura Y,Hiraoka M,Koike R,Nakamatsu K,Itasaka S,Kawamura M,Negoro Y,Araki N,Ishikawa H,Fujii T,Mitsuhashi N

    更新日期:2012-09-01 00:00:00

  • Phase II trial of S-1 plus cisplatin combined with bevacizumab for advanced non-squamous non-small cell lung cancer (TCOG LC-1202).

    abstract:BACKGROUND:S-1 plus cisplatin is a standard chemotherapy regimen for advanced non-small cell lung cancer (NSCLC). The addition of bevacizumab has been shown to significantly improve overall survival (OS) in patients with advanced non-squamous (NSq) NSCLC who received carboplatin plus paclitaxel, however, failed to show...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/jjco/hyz064

    authors: Miyanaga A,Kubota K,Hosomi Y,Okuma Y,Minato K,Fujimoto S,Okamoto H,Satouchi M,Isobe H,Aono H,Takiguchi Y,Gemma A,Tokyo Cooperative Oncology Group.

    更新日期:2019-08-01 00:00:00

  • A case of estrogen receptor positive secretory carcinoma in a 9-Year-old girl with ETV6-NTRK3 fusion gene.

    abstract::The patient was a 9-year-old premenarcheal pediatric female, whose chief complaint was a well-circumscribed palpable right breast mass without nipple discharge. Although the patient had noticed the lump 2 years prior to hospital admission, its size (1.5 × 1.3 cm) had been stable. There was no family history or previou...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyr187

    authors: Yorozuya K,Takahashi E,Kousaka J,Mouri Y,Yoshida M,Fujii K,Akizuki M,Nakano S,Fukutomi T,Umemoto Y,Yokoi T,Imai H

    更新日期:2012-03-01 00:00:00

  • Prediction model of critical weight loss in cancer patients during particle therapy.

    abstract:Background and purpose:The objective of this study is to investigate the predictors of critical weight loss in cancer patients receiving particle therapy, and build a prediction model based on its predictive factors. Materials and methods:Patients receiving particle therapy were enroled between June 2015 and June 2016...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyx145

    authors: Zhang Z,Zhu Y,Zhang L,Wang Z,Wan H

    更新日期:2018-01-01 00:00:00