The localization of human keratin proteins at cytological and histological levels in carcinomatous and sarcomatous lesions.

abstract：:A Phase II study was started in Japan to evaluate the efficacy and safety of concurrent chemoradiotherapy with S-1 plus cisplatin in patients with unresectable locally advanced squamous cell carcinoma of the head and neck. This study began in July 2008, and a total of 45 patients will be accrued from 13 institutions w...

journal_title：Japanese journal of clinical oncology

authors： Nakamura K,Tahara M,Kiyota N,Hayashi R,Akimoto T,Fukuda H,Fujii M,Boku N

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:To investigate the prognostic value of interleukin-11 receptor α chain in patients with early-stage clear-cell renal cell carcinoma. Interleukin-11 receptor α chain, a member of the gp130-dependent receptors, exerts pleiotropic oncogenic activities by promoting proliferation, angiogenesis and metastasis in ma...

journal_title：Japanese journal of clinical oncology

authors： Pan D,Xu L,Liu H,Zhang W,Zhu Y,Xu J,Gu J

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:Transcatheter arterial embolization (TAE) with gelatin sponge particles and iodized oil often yields poor results when used to treat unresectable multifocal hepatocellular carcinoma (HCC). The present study retrospectively investigated the utility of a novel combination chemotherapy regimen for treating multi...

journal_title：Japanese journal of clinical oncology

authors： Ishida K,Hirooka M,Hiraoka A,Kumagi T,Uehara T,Hiasa Y,Horiike N,Onji M

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to identify clinicopathological variables associated with the clinical outcomes of patients with lymph node metastasis-positive urothelial bladder carcinoma after radical cystectomy. METHODS:Forty-six patients who underwent radical cystectomy without preoperative chemotherapy and ha...

journal_title：Japanese journal of clinical oncology

authors： Nakagawa T,Kanai Y,Nakanishi H,Komiyama M,Fujimoto H

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:Study aims include determination of nationwide structural characteristics of radiation oncology facilities, types of radiation therapy equipment, availability of human resources and trends and comparisons with previous surveys. METHODS:An annual nationwide survey was conducted to collect the statistics of in...

journal_title：Japanese journal of clinical oncology

authors： Ji YH,Jung H,Yang K,Cho CK,Yoo SY,Yoo HJ,Kim KB,Kim MS

更新日期：2010-05-01 00:00:00

abstract：:Thirteen postmortem examinations on neuroblastoma patients were reviewed clinicopathologically. Commonly found metastatic sites were bone, liver and lung. The introduction of massive doses of cyclophosphamide and cisplatinum into chemotherapy protocol markedly reduced the tumor burden: no tumor focus in liver or lung,...

journal_title：Japanese journal of clinical oncology

authors： Naito H,Sasaki M,Takeda T,Nakadate H,Fujita M

更新日期：1992-06-01 00:00:00

abstract：:The rise in the incidence of lung cancer has been associated with shifts in histologic distribution. A study was conducted to investigate changes in the cell type distribution in lung cancer in relation to age, sex, and smoking history, based on a retrospective analysis of 10,910 proven cases of lung cancer at the Vet...

journal_title：Japanese journal of clinical oncology

authors： Perng DW,Perng RP,Kuo BI,Chiang SC

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:It has been reported that prognosis is less favorable in poorly (G3) differentiated endometrioid adenocarcinoma than in well (G1) or moderately (G2) differentiated endometrioid adenocarcinoma. The goal of this study is therefore to analyze the prognosis of G3 endometrioid adenocarcinoma and various factors t...

journal_title：Japanese journal of clinical oncology

authors： Kuwabara Y,Susumu N,Banno K,Hirao T,Kawaguchi M,Yamagami W,Suzuki N,Aoki D,Nozawa S

更新日期：2005-01-01 00:00:00

abstract：:A simple and effective method for concentrating sputum in the preparation of smears for cytodiagnosis of lung cancer was developed. The procedure, which utilizes a fixative consisting of 2,3-dihydroxy-1,4-dithiol-butane, 3,5-ditert-butyl-4-hydroxy-toluene, polyoxyethylene-cetyl-ether, polyethylene glycol 1540, and eth...

journal_title：Japanese journal of clinical oncology

authors： Yamagishi K,Koketsu H,Tajima M,Suemasu K

更新日期：1985-06-01 00:00:00

abstract：BACKGROUND:In an interim analysis of a Phase II trial in Japanese patients with pancreatic neuroendocrine tumors (panNETs), sunitinib demonstrated antitumor activity with an objective response rate (ORR) of 50% (95% confidence interval [CI], 21-79) and a median progression-free survival (PFS) of 16.8 months (95% CI, 9....

journal_title：Japanese journal of clinical oncology

authors： Ito T,Tori M,Hashigaki S,Kimura N,Sato K,Ohki E,Sawaki A,Okusaka T

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:In a tumor, increased deubiquitination of cyclins by a protein gene product gene, PGP9.5, could contribute to the uncontrolled growth of somatic cells that is a hallmark of cancer. We hypothesized that PGP9.5 may be expressed in tumors of patients with non-small cell lung cancer (NSCLC). METHODS:Expression ...

journal_title：Japanese journal of clinical oncology

authors： Sasaki H,Yukiue H,Moriyama S,Kobayashi Y,Nakashima Y,Kaji M,Fukai I,Kiriyama M,Yamakawa Y,Fujii Y

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:This study was conducted to evaluate the efficacy and safety of pegylated liposomal doxorubicin (PLD) in Japanese patients with Müllerian carcinoma having a therapeutic history of platinum-based chemotherapy. METHODS:Patients who were diagnosed with Müllerian carcinoma (epithelial ovarian carcinoma, primary ...

journal_title：Japanese journal of clinical oncology

authors： Katsumata N,Fujiwara Y,Kamura T,Nakanishi T,Hatae M,Aoki D,Tanaka K,Tsuda H,Kamiura S,Takehara K,Sugiyama T,Kigawa J,Fujiwara K,Ochiai K,Ishida R,Inagaki M,Noda K

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Usually, total and filtered platinum concentrations in plasma are monitored after cisplatin administration. However, these concentrations represent a mixture of unchanged cisplatin and metabolites. In this work, we studied population pharmacokinetic analysis based on these platinum concentrations. METHODS:T...

journal_title：Japanese journal of clinical oncology

authors： Hanada K,Nishijima K,Ogata H,Atagi S,Kawahara M

更新日期：2001-05-01 00:00:00

abstract：:Many psychosocial factors have been reported to influence the duration of survival of breast cancer patients. We have studied how family members, hobbies and habits of the patients may alter their psychosocial status. Female patients with surgically treated breast cancer diagnosed between 1986 and 1995 at the Tochigi ...

journal_title：Japanese journal of clinical oncology

authors： Tominaga K,Andow J,Koyama Y,Numao S,Kurokawa E,Ojima M,Nagai M

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:Trop-1/Ep-CAM modulates growth and survival of transformed cells, and it is highly expressed in most carcinomas including breast cancer. Only membranous staining is typically considered in evaluating Trop-1/epithelial cell adhesion molecule (Ep-CAM) expression in tumor cells. However, there is evidence of ret...

journal_title：Japanese journal of clinical oncology

authors： Alberti S,Ambrogi F,Boracchi P,Fornili M,Querzoli P,Pedriali M,La Sorda R,Lattanzio R,Tripaldi R,Piantelli M,Biganzoli E,Coradini D

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:To assess the resectability rate of patients with initially unresectable liver-only metastases from colorectal cancer (CRC) after treatment with irinotecan/capecitabine. METHODS:Patients received irinotecan (240 mg/m(2)) as a 30 min intravenous infusion on day 1 and capecitabine (1000 mg/m(2)) orally bid for...

journal_title：Japanese journal of clinical oncology

authors： Zhao R,Zhu J,Ji X,Cai J,Wan F,Li Q,Zhong B,Tucker S,Wang D

更新日期：2010-01-01 00:00:00

abstract：:Squamous cell carcinoma of the head and neck is characterized by an immunosuppressive environment and evades immune responses through multiple resistance mechanisms. A breakthrough in cancer immunotherapy employing immune checkpoint inhibitors has evolved into a number of clinical trials with antibodies against progra...

journal_title：Japanese journal of clinical oncology

authors： Yokota T,Homma A,Kiyota N,Tahara M,Hanai N,Asakage T,Matsuura K,Ogawa T,Saito Y,Sano D,Kodaira T,Motegi A,Yasuda K,Takahashi S,Tanaka K,Onoe T,Okano S,Imamura Y,Ariizumi Y,Hayashi R,Japan Clinical Oncology Group (

更新日期：2020-09-28 00:00:00

abstract：BACKGROUND:In recent times, the possibility of detecting lung cancer using microsatellite alterations (microsatellite instability and loss of heterozygosity) in DNA of bronchial washings has been explored. However, no data regarding the presence of microsatellite alterations in lung cancer are available from India, a c...

journal_title：Japanese journal of clinical oncology

authors： Malhotra P,Behera D,Srinivasan R,Majumdar S,Wali A,Mir S,Kaur R

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Allogeneic hematopoietic stem cell transplantation is the treatment of choice in young patients with severe aplastic anemia. The main causes of failure after this procedure are graft versus host disease, infections and graft failure, often exacerbated by large numbers of transfusions and prolonged disease du...

journal_title：Japanese journal of clinical oncology

authors： Rzepecki P,Sarosiek T,Szczylik C

更新日期：2006-01-01 00:00:00

abstract：:AMG 337, a selective small-molecule MET inhibitor, was evaluated in Asian patients with advanced solid tumors. Eligible patients orally self-administered AMG 337; the initial dose of 150 mg once daily (QD) was escalated to 300 mg QD (modified 3+3+3 design). Treatment continued until disease progression, intolerability...

journal_title：Japanese journal of clinical oncology

authors： Yasui H,Go N,Yang H,Amore BM,Jung AS,Doi T

更新日期：2017-08-01 00:00:00

abstract：:Bone marrow transplantation (BMT) was started in Hokkaido in 1985. In the present report we have reviewed the clinical outcome of patients treated with BMT for hematological diseases in Hokkaido. Fifty-eight allogeneic and 19 autologous transplants were registered by December 1991. The underlying diseases consisted of...

journal_title：Japanese journal of clinical oncology

authors： Hashino S,Imamura M,Kasai M,Higa T,Naohara T,Sakamaki S,Matsunaga T,Kohgo Y,Kohda K,Nakazawa O

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:This retrospective study aimed to evaluate the efficacy of a 3.6-mg dose of pegfilgrastim for primary prophylaxis in Japanese breast cancer patients receiving dose-dense chemotherapy. METHODS:Patients treated with adjuvant or neoadjuvant chemotherapy for early-stage breast cancer at the Tokyo-West Tokushuka...

journal_title：Japanese journal of clinical oncology

authors： Mizuno Y,Fuchikami H,Takeda N,Iwai M,Sato K

更新日期：2017-01-01 00:00:00

abstract：:Adult extrarenal nephroblastomas (Wilms' tumor) are extremely rare tumors. They show a higher incidence of non-seminomatous elements and these so-called 'teratoid' Wilms' tumors are suggested to be of germ cell origin. To date, however, the number of reported cases with gonadal teratoma containing nephroblastoma is ve...

journal_title：Japanese journal of clinical oncology

authors： Keskin S,Ekenel M,Başaran M,Aksu C,Kiliçaslan I,Tunç M,Bavbek S

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:The importance of quality assurance in cancer screening has recently gained increasing attention in Japan. To evaluate and improve quality, checklists and process indicators have been developed. To explore effective methods of enhancing quality in cancer screening, we started a randomized control study of the...

journal_title：Japanese journal of clinical oncology

authors： Machii R,Saika K,Higashi T,Aoki A,Hamashima C,Saito H

更新日期：2012-02-01 00:00:00

abstract：:We reviewed 1074 surgically treated patients with biliary tract cancer (gallbladder 564, bile duct 510) in Niigata prefecture in the five-year period from 1982 to 1986. Analyses of regional distributions revealed the incidence of gallbladder cancer to be highest in the Ka-etsu district (northern part of prefecture) an...

journal_title：Japanese journal of clinical oncology

authors： Kato K,Akai S

更新日期：1990-03-01 00:00:00

abstract：:Rupture of irradiated arteries in patients with head and neck cancer is an uncommon complication. We present the first case of a pseudoaneurysm of the external carotid artery branch that developed after irradiation of nasopharyngeal carcinoma and was successfully treated by microcoil embolization therapy. Clinicians s...

journal_title：Japanese journal of clinical oncology

authors： Li SH,Hsu SW,Wang SL,Chen HC,Huang CH

更新日期：2007-04-01 00:00:00

abstract：:Recently total body irradiation has been used as a method of preparation for the bone marrow transplantation. However, it has become apparent that total body irradiation is one of the causes of interstitial pneumonia. There are several factors in total body irradiation that may induce interstitial pneumonia. 1) Total ...

journal_title：Japanese journal of clinical oncology

authors： Mori T,Ohizumi Y,Maezawa H,Murayama C,Tsuda M,Ando F

更新日期：1984-12-01 00:00:00

abstract：BACKGROUND:Angiogenesis is required for growth and metastasis of colorectal cancer (CRC), and several positive regulators of tumor angiogenesis have been identified. Cyclooxygenase-2 (COX-2), known to be elevated in several human cancers, regulates angiogenesis by inducing angiogenic factors. The aim of this study was ...

journal_title：Japanese journal of clinical oncology

authors： Nakamoto RH,Uetake H,Iida S,Kolev YV,Soumaoro LT,Takagi Y,Yasuno M,Sugihara K

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:Renal cell carcinoma (RCC) is refractory to conventional therapy, including chemotherapy and radiation. However, because RCC is sensitive to cytokine therapy, an immunotherapeutic approach such as hematopoietic stem cell transplantation (HSCT) might lead to a cure. We performed an institutional clinical study...

journal_title：Japanese journal of clinical oncology

authors： Ishiyama K,Takami A,Suzuki S,Konaka H,Namiki M,Ooi A,Nakao S

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess clinically the adequacy of vessel-contouring-based pelvic radiotherapy with regard to nodal coverage for uterine cervical cancer. METHODS:Fifty patients with Stages I-III cervical cancer, treated with vessel-contouring-based three-dimensional radiotherapy since August 2002...

journal_title：Japanese journal of clinical oncology

authors： Uno T,Isobe K,Ueno N,Kobayashi H,Sanayama Y,Mitsuhashi A,Shozu M,Ito H

更新日期：2009-06-01 00:00:00