Successful treatment of pulmonary artery sarcoma by a two-drug combination chemotherapy consisting of ifosfamide and epirubicin.

abstract：:Of the patients with colorectal cancer, there are some with hereditary disorders such as familial polyposis coli, Gardner's syndrome, Turcot's syndrome, and cancer family syndrome in which colorectal adenocarcinoma develops at a significantly high frequency, and these hereditary diseases are very important and interes...

journal_title：Japanese journal of clinical oncology

authors： Ushio K

更新日期：1985-04-01 00:00:00

abstract：:A Phase II study was started in Japan to evaluate the efficacy and safety of concurrent chemoradiotherapy with S-1 plus cisplatin in patients with unresectable locally advanced squamous cell carcinoma of the head and neck. This study began in July 2008, and a total of 45 patients will be accrued from 13 institutions w...

journal_title：Japanese journal of clinical oncology

authors： Nakamura K,Tahara M,Kiyota N,Hayashi R,Akimoto T,Fukuda H,Fujii M,Boku N

更新日期：2009-07-01 00:00:00

abstract：:The proband was a 32-year-old man with sparse type of familial adenomatous polyposis with fundic gland and duodenal polyps and congenital hypertrophy of the retinal pigment epithelium without osteoma, dental abnormalities and desmoid tumors. Direct DNA sequencing did not detect germline mutations in any APC exon. Howe...

journal_title：Japanese journal of clinical oncology

authors： Yamaguchi T,Koizumi K,Arai M,Tamura K,Iijima T,Horiguchi S,Miyaki M

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:We evaluated whether color Doppler ultrasound (US) had diagnostic accuracy equal to dynamic computed tomography (CT) and whether performing dynamic CT and Doppler US together would be more informative in preoperative diagnosis of renal solid tumors. METHODS:A total of 110 renal solid tumors smaller than 7 c...

journal_title：Japanese journal of clinical oncology

authors： Kitamura H,Fujimoto H,Tobisu K,Mizuguchi Y,Maeda T,Matsuoka N,Komiyama M,Nakagawa T,Kakizoe T

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:The importance of quality assurance in cancer screening has recently gained increasing attention in Japan. To evaluate and improve quality, checklists and process indicators have been developed. To explore effective methods of enhancing quality in cancer screening, we started a randomized control study of the...

journal_title：Japanese journal of clinical oncology

authors： Machii R,Saika K,Higashi T,Aoki A,Hamashima C,Saito H

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:It is critical to obtain informed consent from eligible patients to complete clinical trials. We investigated the factors that affect the participation rates of eligible patients. PATIENTS AND METHODS:Patients with metastatic breast cancer who were eligible for SELECT BC or SELECT BC-CONFIRM trials, randomi...

journal_title：Japanese journal of clinical oncology

authors： Ohsumi S,Mukai H,Takahashi M,Hozumi Y,Akabane H,Park Y,Tokunaga E,Takashima T,Watanabe T,Sagara Y,Kaneko T,Ohashi Y

更新日期：2020-08-04 00:00:00

abstract：BACKGROUND:To determine the maximum tolerated dose and recommended dose of cisplatin and docetaxel administered by three consecutive weekly infusions in both non-elderly (< or =74 years) and elderly (> or =75 years) patients, we conducted two independent phase I studies for nonelderly and elderly patients with non-smal...

journal_title：Japanese journal of clinical oncology

authors： Ohe Y,Niho S,Kakinuma R,Kubota K,Matsumoto T,Ohmatsu H,Goto K,Kunitoh H,Saijo N,Nishiwaki Y

更新日期：2001-03-01 00:00:00

abstract：:A post hoc analysis of interim results from PREVAIL, a Phase III, double-blind, placebo-controlled trial of men with metastatic castration-resistant prostate cancer, demonstrated that the treatment effects, safety and pharmacokinetics of enzalutamide in Japanese patients were generally consistent with those of the ove...

journal_title：Japanese journal of clinical oncology

authors： Kimura G,Ueda T

更新日期：2017-03-01 00:00:00

abstract：:Recent time trends (1979-1987) and geographical distributions in mortalities from subsites of cancers of the hepato-biliary-pancreatic system have been investigated on the basis of the vital statistics of Japan. The corrected age-adjusted mortality rates (CAAMRs) were calculated to eliminate the influence of the propo...

journal_title：Japanese journal of clinical oncology

authors： Kato I,Kuroishi T,Tominaga S

更新日期：1990-09-01 00:00:00

abstract：:A histopathologic study was made on 1,095 thyroid specimens which had been removed surgically under various diagnoses at Seoul National University Hospital during the six-year period, 1976-1981. Among the 1,095 surgically removed thyroids, adenomatous goiter was the most common single disease, accounting for 43% of al...

journal_title：Japanese journal of clinical oncology

authors： Park SH,Suh EH,Chi JG

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:A combination of cisplatin and vinorelbine chemotherapy is effective in cases of advanced non-small cell lung cancer, but the optimum administration schedule for both drugs has not yet been defined. The aim of this study was to determine the maximum dose of vinorelbine that can be tolerated while receiving a...

journal_title：Japanese journal of clinical oncology

authors： Hotta K,Sekine I,Tamura T,Sawada M,Watanabe H,Kusaba H,Akiyama Y,Inoue A,Shimoyama T,Nokihara H,Ueda Y,Yamamoto N,Kunitoh H,Ohe Y,Kodama T,Saijo N

更新日期：2001-12-01 00:00:00

abstract：:Due to the rapid aging of Japan's population, clinical research focusing on older patients with cancer is urgently needed. The Japan Clinical Oncology Group (JCOG) has conducted several such clinical trials, but there has been no formal policy for geriatric research. We have therefore established a JCOG policy for ger...

journal_title：Japanese journal of clinical oncology

authors： Mizutani T,Nakamura K,Fukuda H,Ogawa A,Hamaguchi T,Nagashima F,Geriatric Study Committee\/Japan Clinical Oncology Group.

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:To investigate the prognostic value of interleukin-11 receptor α chain in patients with early-stage clear-cell renal cell carcinoma. Interleukin-11 receptor α chain, a member of the gp130-dependent receptors, exerts pleiotropic oncogenic activities by promoting proliferation, angiogenesis and metastasis in ma...

journal_title：Japanese journal of clinical oncology

authors： Pan D,Xu L,Liu H,Zhang W,Zhu Y,Xu J,Gu J

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:Most cancer patients become increasingly anxious toward the end of their life. The objective of this study was to identify predictors of increased opioid dosage in the last week of a terminal cancer patient's life. METHODS:We retrospectively reviewed charts of patients who died in our palliative care unit. W...

journal_title：Japanese journal of clinical oncology

authors： Miura T,Matsumoto Y,Motonaga S,Hasuo H,Abe K,Kinoshita H

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:This retrospective study aimed to evaluate the efficacy of a 3.6-mg dose of pegfilgrastim for primary prophylaxis in Japanese breast cancer patients receiving dose-dense chemotherapy. METHODS:Patients treated with adjuvant or neoadjuvant chemotherapy for early-stage breast cancer at the Tokyo-West Tokushuka...

journal_title：Japanese journal of clinical oncology

authors： Mizuno Y,Fuchikami H,Takeda N,Iwai M,Sato K

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The purpose of the present study is to verify the treatment effects of boron neutron capture therapy (BNCT) in ectopic tumors implanted in the thoracic cavity mimicking malignant pleural mesothelioma (MPM). METHODS:The tumor model was created by implanting murine squamous cell carcinoma cells into the thora...

journal_title：Japanese journal of clinical oncology

authors： Suzuki M,Sakurai Y,Masunaga S,Kinashi Y,Nagata K,Maruhashi A,Ono K

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Programmed death-ligand 1 is an immune modulator that promotes immunosuppression by binding to programmed death-1 of T-lymphocytes. Whereas programmed death-ligand 1 expression has been shown to be associated with the clinical response to anti-programmed death-ligand 1 antibody, the association of tumor prog...

journal_title：Japanese journal of clinical oncology

authors： Inamura K,Yokouchi Y,Sakakibara R,Kobayashi M,Subat S,Ninomiya H,Nagano H,Nomura K,Okumura S,Ishikawa Y

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor C (VEGF-C) and D (VEGF-D) are considered to be potentially lymphangiogenic and can selectively induce hyperplasia of the lymphatic vasculature. In this study, we aimed to clarify the relation between expression of VEGF-C and -D and lymphatic metastasis in early gastric canc...

journal_title：Japanese journal of clinical oncology

authors： Ishikawa M,Kitayama J,Kazama S,Nagawa H

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:This study was performed to review retrospectively the clinical course of chronic rectal bleeding as a complication of external beam radiation therapy for localized prostate cancer and to analyze the relationship between technical parameters of radiation therapy and the complications. METHODS:Seventy-one pa...

journal_title：Japanese journal of clinical oncology

authors： Kitamura K,Shirato H,Suzuki K,Shinohara N,Demura T,Harabayashi T,Nishioka T,Kagei K,Takayama N,Shinno Y,Kawakura K,Koyanagi T,Miyasaka K

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVE:We evaluated the preoperative parameters to predict a positive surgical margin (SM) at radical prostatectomy for patients with prostate cancer. In addition, the prognostic factors for biochemical recurrence were determined in patients with positive SMs. METHODS:We retrospectively analysed 238 patients with p...

journal_title：Japanese journal of clinical oncology

authors： Hashimoto K,Masumori N,Takei F,Fukuta F,Takahashi A,Itoh N,Hasegawa T,Tsukamoto T

更新日期：2008-01-01 00:00:00

abstract：Background:Leiomyosarcoma (LMS) is one of most aggressive mesenchymal malignancies that differentiate towards smooth muscle. The clinical outcome of LMS patients is poor; as such, there is an urgent need for novel therapeutic approaches. Experimental models such as patient-derived cell lines are invaluable tools for pr...

journal_title：Japanese journal of clinical oncology

authors： Sakumoto M,Takahashi M,Oyama R,Takai Y,Kito F,Shiozawa K,Qiao Z,Yoshida A,Endo M,Kawai A,Kondo T

更新日期：2017-10-01 00:00:00

abstract：:A 56-year-old housewife was incidentally discovered to have an abnormal shadow in the right B6 area upon a chest X-ray film being taken. A transcutaneous lung biopsy of the mass revealed adenocarcinoma of the lung (WHO classification). A brain computed tomography (CT) scan demonstrated multiple brain metastasis. Follo...

journal_title：Japanese journal of clinical oncology

authors： Akiba T,Saijo N,Miyamoto K,Taguchi J,Taito H,Sakurai M,Tamura T,Sasaki Y,Eguchi K,Shinkai T

更新日期：1987-06-01 00:00:00

abstract：OBJECTIVE:Despite the clinical similarities triple-negative and basal-like breast cancer are not synonymous. Indeed, not all basal-like cancers are negative for estrogen receptor, progesterone receptor and HER2 expression while triple-negative also encompasses other cancer types. P53 protein appears heterogeneously exp...

journal_title：Japanese journal of clinical oncology

authors： Biganzoli E,Coradini D,Ambrogi F,Garibaldi JM,Lisboa P,Soria D,Green AR,Pedriali M,Piantelli M,Querzoli P,Demicheli R,Boracchi P,Nenci I,Ellis IO,Alberti S

更新日期：2011-02-01 00:00:00

abstract：:Pure red cell aplasia (PRCA) rarely occurs in non-thymic lymphoproliferative disorders. The present article describes a patient with non-Hodgkin's lymphoma (follicular, mixed type), who concurrently developed PRCA and warm type autoimmune hemolytic anemia during the clinical course. The PRCA and hemolytic anemia were ...

journal_title：Japanese journal of clinical oncology

authors： Suzuki A,Takahashi T,Taniguchi A,Kotake C,Seo T,Toda T,Kobayashi K,Tsukamoto N,Fukumoto M

更新日期：1991-10-01 00:00:00

abstract：OBJECTIVE:We evaluated the results of imatinib dose escalation in patients with advanced gastrointestinal stromal tumors (GISTs) after disease progression on standard-dose imatinib. METHODS:Clinical data from patients with metastatic or unresectable GISTs whose dose of imatinib was increased after disease progression ...

journal_title：Japanese journal of clinical oncology

authors： Park I,Ryu MH,Sym SJ,Lee SS,Jang G,Kim TW,Chang HM,Lee JL,Lee H,Kang YK

更新日期：2009-02-01 00:00:00

abstract：:AMG 337, a selective small-molecule MET inhibitor, was evaluated in Asian patients with advanced solid tumors. Eligible patients orally self-administered AMG 337; the initial dose of 150 mg once daily (QD) was escalated to 300 mg QD (modified 3+3+3 design). Treatment continued until disease progression, intolerability...

journal_title：Japanese journal of clinical oncology

authors： Yasui H,Go N,Yang H,Amore BM,Jung AS,Doi T

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:The objective of this study was to evaluate the relationship of HIF-1alpha expression and tumor angiogenesis, recurrence/distant metastasis, and its value in the prediction of aggressive behavior of gastrointestinal stromal tumor (GIST). METHODS:Paraffin-embedded specimens from 62 patients with GIST were di...

journal_title：Japanese journal of clinical oncology

authors： Chen WT,Huang CJ,Wu MT,Yang SF,Su YC,Chai CY

更新日期：2005-04-01 00:00:00

abstract：:The "Criteria for Evaluating the Efficacy of Chemotherapy/Radiation Therapy in the Treatment of Gastric Cancer" are now widely used in Japan. To assess the validity of the criteria, the relation between the antitumor effect evaluated by the criteria and the survival of patients with gastric cancer was analyzed. The su...

journal_title：Japanese journal of clinical oncology

authors： Kiyohashi A,Kurihara M,Yoshida S,Ohkubo T,Suga S

更新日期：1993-02-01 00:00:00

abstract：Background:Malignant pleural effusion is a commonly seen complication of malignancies such as lung and breast cancers. In Western countries, talc is frequently used as a standard therapeutic agent (pleurodesis agent) with the aim of alleviating symptoms including dyspnea and chest pain. Talc is not recognized as a pleu...

journal_title：Japanese journal of clinical oncology

authors： Saka H,Oki M,Kitagawa C,Kogure Y,Kojima Y,Saito AM,Ishida A,Miyazawa T,Takeda K,Nakagawa K,Sasada S,Negoro S

更新日期：2018-04-01 00:00:00

abstract：:Myxoid liposarcoma can frequently metastasize to extrapulmonary sites. We present two cases of myxoid liposarcoma metastatic to the epidural space. Both patients complained of back pain, but plain radiography revealed no abnormality. MR imaging clearly demonstrated metastatic tumors in the epidural space, but no invol...

journal_title：Japanese journal of clinical oncology

authors： Ogose A,Hotta T,Inoue Y,Sakata S,Takano R,Yamamura S

更新日期：2001-09-01 00:00:00