Antitumor effect and survival benefit of chemotherapy for unresectable advanced gastric cancer.

Abstract:

:The "Criteria for Evaluating the Efficacy of Chemotherapy/Radiation Therapy in the Treatment of Gastric Cancer" are now widely used in Japan. To assess the validity of the criteria, the relation between the antitumor effect evaluated by the criteria and the survival of patients with gastric cancer was analyzed. The subjects were 169 patients with unresectable advanced gastric cancer who were entered into a randomized comparative trial of tegafur plus mitomycin C, or UFT (a combination of uracil and tegafur in a 4:1 molar ratio) plus mitomycin C. Irrespective of their performance status, disease extent and chemotherapy regimen, responding patients showed improved survival over non-responding patients. If the primary gastric lesion responded to chemotherapy, prolongation of survival was noted in patients with a measurable gastric lesion as well as in those with a non-measurable but evaluable gastric lesion. No improvement in survival was recognized among patients having a primary gastric lesion which did not respond to chemotherapy, even if the metastases showed a response. The results obtained in the present study indicate the validity of the criteria, except for diffusely infiltrating gastric lesions.

journal_name

Jpn J Clin Oncol

authors

Kiyohashi A,Kurihara M,Yoshida S,Ohkubo T,Suga S

subject

Has Abstract

pub_date

1993-02-01 00:00:00

pages

41-5

issue

1

eissn

0368-2811

issn

1465-3621

journal_volume

23

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • Descriptive epidemiology of subsites of cancers of the liver, biliary tract and pancreas in Japan.

    abstract::Recent time trends (1979-1987) and geographical distributions in mortalities from subsites of cancers of the hepato-biliary-pancreatic system have been investigated on the basis of the vital statistics of Japan. The corrected age-adjusted mortality rates (CAAMRs) were calculated to eliminate the influence of the propo...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Kato I,Kuroishi T,Tominaga S

    更新日期:1990-09-01 00:00:00

  • Adenoid basal carcinoma of the uterine cervix: immunohistochemical study and literature review.

    abstract::Adenoid basal carcinoma of the uterine cervix is rare and its cell origin is still obscure. We report a case of adenoid basal carcinoma of the uterine cervix discovered incidentally in a 69-year-old woman who had been hysterectomized due to endometrial adenocarcinoma of the uterine corpus. Histologically, small round-...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/27.6.437

    authors: Senzaki H,Osaki T,Uemura Y,Kiyozuka Y,Ogura E,Okamura A,Tsubura A

    更新日期:1997-12-01 00:00:00

  • Practical patterns for stereotactic body radiotherapy to hepatocellular carcinoma in Korea: a survey of the Korean Stereotactic Radiosurgery Group.

    abstract:OBJECTIVE:To investigate practical patterns for stereotactic body radiotherapy to hepatocellular carcinoma in Korea. METHODS:In June 2013, the Korean Stereotactic Radiosurgery Group of the Korean Society for Radiation Oncology conducted a national patterns-of-care survey about stereotactic body radiotherapy to the liv...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/jjco/hyv209

    authors: Bae SH,Kim MS,Jang WI,Kay CS,Kim W,Kim ES,Kim JH,Kim JH,Yang KM,Lee KC,Chang AR,Jo S

    更新日期:2016-04-01 00:00:00

  • Initial experience of robotic anatomical segmentectomy for non-small cell lung cancer.

    abstract:OBJECTIVE:Anatomical segmentectomy has the potential to replace lobectomy as the standard procedure for early stage non-small cell lung cancer. We investigated the safety and feasibility of robotic anatomical segmentectomy for non-small cell lung cancer. METHODS:Overall 20 patients underwent robotic anatomical segment...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyz199

    authors: Kagimoto A,Tsutani Y,Izaki Y,Handa Y,Mimae T,Miyata Y,Okada M

    更新日期:2020-04-07 00:00:00

  • A 12-mm carcinoid tumor of the minor duodenal papilla with lymph node metastases.

    abstract::Carcinoid tumors located in the minor duodenal papilla are extremely rare, with only a few cases reported in the literature. Herein, we report the case of a 71-year-old man with a 12-mm carcinoid tumor at the minor duodenal papilla with lymph node metastases. Multidetector-row computed tomography with contrast enhance...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hys185

    authors: Fukami Y,Kurumiya Y,Mizuno K,Sekoguchi E,Kobayashi S,Ito A,Tomida A,Onishi S,Shirotsuki R,Okubo K,Narita M

    更新日期:2013-01-01 00:00:00

  • Real-time elastography for the diagnosis of prostate cancer: evaluation of elastographic moving images.

    abstract:OBJECTIVE:Elastography is a technique for detecting the stiffness of tissues. We applied elastography for the diagnosis of prostate cancer and evaluated the usefulness of elastography for prostate biopsy. METHODS:The subjects of this study were 311 patients who underwent elastography during prostate needle biopsy at H...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyp026

    authors: Miyagawa T,Tsutsumi M,Matsumura T,Kawazoe N,Ishikawa S,Shimokama T,Miyanaga N,Akaza H

    更新日期:2009-06-01 00:00:00

  • A Phase II study of systemic chemotherapy with docetaxel, cisplatin, and S-1 (DCS) followed by surgery in gastric cancer patients with extensive lymph node metastasis: Japan Clinical Oncology Group study JCOG1002.

    abstract::A Phase II trial was initiated in Japan to evaluate the efficacy and safety of preoperative chemotherapy with docetaxel, cisplatin and S-1 for gastric cancer with extensive lymph node metastasis. Patients are eligible to participate in the study if they have para-aortic lymph node metastases (stations no. 16a2/16b1) a...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/jjco/hys054

    authors: Katayama H,Ito S,Sano T,Takahari D,Mizusawa J,Boku N,Tsuburaya A,Terashima M,Sasako M,Stomach Cancer Study Group of the Japan Clinical Oncology Group.

    更新日期:2012-06-01 00:00:00

  • Cumulative incidence, risk factors and prognostic impact of venous thromboembolism in Japanese patients with advanced gastric cancer.

    abstract:Background:Advanced gastric cancer (AGC) and systemic chemotherapy are some of the risk factors for venous thromboembolism (VTE). However, the cumulative incidence, risk factors and prognostic impact of VTE have not been evaluated in Japanese patients with AGC. Methods:This retrospective study included patients who re...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyx107

    authors: Arai H,Hironaka S,Minashi K,Denda T,Shimokawa M,Yamaguchi T

    更新日期:2017-10-01 00:00:00

  • Late recurrence and second primary malignancy among 139 patients with germ cell tumors: long-term outcome of the disease in a single-center experience.

    abstract:OBJECTIVE:We retrospectively evaluated long-term oncological outcomes in patients with germ cell tumors (GCTs) primarily treated at our institution and assessed late recurrence and second primary malignancies. METHODS:This study included a total of 139 males with newly diagnosed GCTs of the testis or extragonadal orig...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyp142

    authors: Sato S,Tanaka T,Takahashi A,Sasai M,Kitamura H,Masumori N,Tsukamoto T

    更新日期:2010-02-01 00:00:00

  • Chronological observation of epidemiological characteristics of lung cancer in Taiwan with etiological consideration--a 30-year consecutive study.

    abstract::In order to determine whether the epidemiological characteristics of lung cancer have changed within a certain period of time in Taiwan and to propose some causative factors for its rapid rate of increase we performed chronological and epidemiological studies based on the analysis of: (1) available vital statistics an...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Yang SP,Luh KT,Kuo SH,Lin CC

    更新日期:1984-03-01 00:00:00

  • Physical activity and colorectal cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population.

    abstract:OBJECTIVE:Higher levels of physical activity have been consistently associated with a decreased risk of colon cancer, but not rectal cancer, in Western populations. The present study systematically evaluated epidemiologic evidence on the association between physical activity and colorectal cancer risk among the Japanes...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/hyr160

    authors: Pham NM,Mizoue T,Tanaka K,Tsuji I,Tamakoshi A,Matsuo K,Ito H,Wakai K,Nagata C,Sasazuki S,Inoue M,Tsugane S,Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan.

    更新日期:2012-01-01 00:00:00

  • Concurrent chemoradiotherapy with protracted infusion of 5-FU and cisplatin for postoperative recurrent or residual esophageal cancer.

    abstract:BACKGROUND:We carried out the present study to investigate the feasibility and effectiveness of concurrent chemoradiotherapy (CT-RT) for postoperative recurrent esophageal cancer, which are, at present, unclear. METHODS:Between 1998 and 2002, 16 patients with postoperative loco-regional recurrence of esophageal cancer...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyg065

    authors: Nishimura Y,Koike R,Nakamatsu K,Kanamori S,Suzuki M,Shigeoka H,Shiozaki H

    更新日期:2003-07-01 00:00:00

  • A Phase 1 study evaluating AMG 337 in Asian patients with advanced solid tumors.

    abstract::AMG 337, a selective small-molecule MET inhibitor, was evaluated in Asian patients with advanced solid tumors. Eligible patients orally self-administered AMG 337; the initial dose of 150 mg once daily (QD) was escalated to 300 mg QD (modified 3+3+3 design). Treatment continued until disease progression, intolerability...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyx067

    authors: Yasui H,Go N,Yang H,Amore BM,Jung AS,Doi T

    更新日期:2017-08-01 00:00:00

  • A comparison of HER2/neu gene amplification and its protein overexpression between primary breast cancer and metastatic lymph nodes.

    abstract:OBJECTIVE:Breast cancer is a heterogeneous disease. The aim of this prospective study, in which fluorescence in situ hybridization was used to determine human epidermal growth factor receptor 2 status in primary breast cancers and in the lymph node metastases, was to verify the stability of human epidermal growth facto...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyq019

    authors: Aoyama K,Kamio T,Nishikawa T,Kameoka S

    更新日期:2010-07-01 00:00:00

  • Cancer control in Australia: into the 21(st) Century.

    abstract::Australia ranks highly internationally for cancer control, in part because cancer registries provide comprehensive national incidence and mortality and other cancer data annually. This has facilitated short- and long-term planning over the last quarter of a century. For example, male death rates from lung cancer in Au...

    journal_title:Japanese journal of clinical oncology

    pub_type: 历史文章,杂志文章

    doi:10.1093/jjco/hye121

    authors: Burton RC

    更新日期:2002-03-01 00:00:00

  • Preoperative endocrine therapy in patients with locally advanced prostate cancer.

    abstract::Recently, there has been increased interest in the application of preoperative endocrine therapy prior to radical prostatectomy for locally advanced cancer in order to enhance surgical curability and increase survival. Between 1986 and 1993, 40 patients with prostate cancer were given endocrine therapy before radical ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Maeda O,Meguro N,Saiki S,Kinouchi T,Kuroda M,Usami M,Kotake T

    更新日期:1995-08-01 00:00:00

  • Continuous intravenous administration of 1-(2-tetrahydrofuryl)-5-fluorouracil [FT] by intravenous hyperalimentation (IVH)--stability of FT in IVH solution and tumor levels of 5-fluorouracil (5-FU).

    abstract::The continuous intravenous administration of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT) to colorectal cancer patients was studied in regard to the stability of FT in intravenous hyperalimentation (IVH) solutions and tumor levels of 5-fluorouracil (5-FU). FT was very compatible with IVH solutions, because the decomposit...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Moriya Y,Koyama Y,Hojo K,Tsunematsu R

    更新日期:1983-03-01 00:00:00

  • Cisplatin and etoposide chemotherapy combined with early concurrent twice-daily thoracic radiotherapy for limited-disease small cell lung cancer in elderly patients.

    abstract:OBJECTIVE:The optimal management of elderly patients with limited-disease small cell lung cancer (LD-SCLC) has not been established. METHODS:The records of elderly (>or=70 years of age) patients with LD-SCLC who had been treated with etoposide and cisplatin chemotherapy with early concurrent twice-daily thoracic radio...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyp137

    authors: Okamoto K,Okamoto I,Takezawa K,Tachibana I,Fukuoka M,Nishimura Y,Nakagawa K

    更新日期:2010-01-01 00:00:00

  • Cyclophosphamide, adriamycin, 5-fluorouracil and high-dose toremifene for patients with advanced/recurrent breast cancer. The Japan Toremifene Cooperative Study Group.

    abstract:BACKGROUND:Multi-combination chemotherapy consisting of anthracyclines has been effective but has not invariably prolonged the survival period in advanced/recurrent breast cancer. The possibility has been discussed that chemoendocrine therapy combined with endocrine agents is more effective. METHODS:In order to evalua...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/28.4.250

    authors: Tominaga T,Nomura Y,Uchino J,Hirata K,Kimura M,Yoshida M,Aoyama H,Kinoshita H,Koyama H,Monden Y,Takashima S,Ogawa M

    更新日期:1998-04-01 00:00:00

  • Phase II clinical trial of pegylated liposomal doxorubicin (JNS002) in Japanese patients with mullerian carcinoma (epithelial ovarian carcinoma, primary carcinoma of fallopian tube, peritoneal carcinoma) having a therapeutic history of platinum-based chem

    abstract:OBJECTIVE:This study was conducted to evaluate the efficacy and safety of pegylated liposomal doxorubicin (PLD) in Japanese patients with Müllerian carcinoma having a therapeutic history of platinum-based chemotherapy. METHODS:Patients who were diagnosed with Müllerian carcinoma (epithelial ovarian carcinoma, primary ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/jjco/hyn101

    authors: Katsumata N,Fujiwara Y,Kamura T,Nakanishi T,Hatae M,Aoki D,Tanaka K,Tsuda H,Kamiura S,Takehara K,Sugiyama T,Kigawa J,Fujiwara K,Ochiai K,Ishida R,Inagaki M,Noda K

    更新日期:2008-11-01 00:00:00

  • Completion and toxicity of induction chemotherapy for metastatic testicular cancer: an updated evaluation of Japanese patients.

    abstract:BACKGROUND:Combination of bleomycin, etoposide and cisplatin (BEP) remains the standard chemotherapy for testicular cancer. Since the development of BEP in the 1980s, there has been a considerable advance in supportive therapies, such as granulocyte colony-stimulating-factor and 5-HT3 antagonists. Therefore, we re-eval...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyl053

    authors: Kawai K,Ando S,Hinotsu S,Oikawa T,Sekido N,Miyanaga N,Shimazui T,Akaza H

    更新日期:2006-07-01 00:00:00

  • Paroxysmal nocturnal hemoglobinuria: termination in acute monocytic leukemia and reappearance after chemotherapy with N4-palmitoyl-1-beta-D-arabinofuranosylcytosine (PL-AC) and vincristine.

    abstract::Acute monocytic leukemia developed in a 77-year-old woman about 18 months after a diagnosis of paroxysmal nocturnal hemoglobinuria (PNH) had been made. The classical features of PNH disappeared with the onset of the leukemia. Chemotherapy with N4-palmitoyl-1-beta-D-arabinosylcytosine and vincristine resulted in the di...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Kawano F,Chosa M,Matsuoka M,Oyamada N,Takatsuki K

    更新日期:1987-06-01 00:00:00

  • Detection of microsatellite alterations in bronchial washings in squamous cell lung cancer: the first study from India.

    abstract:BACKGROUND:In recent times, the possibility of detecting lung cancer using microsatellite alterations (microsatellite instability and loss of heterozygosity) in DNA of bronchial washings has been explored. However, no data regarding the presence of microsatellite alterations in lung cancer are available from India, a c...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyh079

    authors: Malhotra P,Behera D,Srinivasan R,Majumdar S,Wali A,Mir S,Kaur R

    更新日期:2004-08-01 00:00:00

  • Bradycardia induced by irinotecan: a case report.

    abstract::Irinotecan chloride (CPT-11) is a new semi-synthetic camptothecin analogue which has encouraging antitumor activity against various malignancies. The major and unique toxicity of CPT-11 is diarrhea. Cardiovascular toxicity is rare and has not been found in clinical trials performed in Japan except for a very few cases...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/28.11.709

    authors: Miya T,Fujikawa R,Fukushima J,Nogami H,Koshiishi Y,Goya T

    更新日期:1998-11-01 00:00:00

  • Comparison of the accuracy and characteristics of the prognostic prediction of survival of identical terminally ill cancer patients by oncologists and palliative care physicians.

    abstract::Most terminally ill cancer patients in our hospice ward are referred from hospitals for anticancer treatment. For identical terminally ill cancer patients referred from other hospitals, differences in the accuracy and characteristics of the prognostic prediction of survival by oncologists and palliative care physician...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyy080

    authors: Urahama N,Sono J,Yoshinaga K

    更新日期:2018-07-01 00:00:00

  • BUBR1 overexpression predicts disease-specific survival after nephroureterectomy in patients with upper tract urothelial carcinoma.

    abstract:OBJECTIVE:To date, there are few reliable markers to distinguish tumors with aggressive characteristics in upper tract urothelial carcinoma. The purpose of this study was to identify a biomarker related to genetic instability (chromosomal instability or microsatellite instability) with prognostic value, in patients wit...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyw060

    authors: Yamamoto Y,Oga A,Akao J,Misumi T,Fuji N,Kobayashi K,Kawai Y,Inoue R,Hirata H,Matsumoto H,Nagao K,Sakano S,Matsuyama H

    更新日期:2016-08-01 00:00:00

  • Massive hematuria from the bilateral upper urinary tract in a patient treated for advanced lung cancer with gefitinib.

    abstract::We report a case of gefitinib-induced bilateral upper urinary tract bleeding in an 82-year-old woman administered the drug daily for advanced non-small cell adenocarcinoma of the lung (T4N3M0). Hematuria is an uncommon adverse effect of gefitinib, and in most cases, the bleeding site is unknown. On the 44th day of ora...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyp141

    authors: Mori H,Ohno Y,Ito F,Funaguchi N,Yanase K,Endo J,Nakano M,Bai La BL,Minatoguchi S

    更新日期:2010-03-01 00:00:00

  • p53 status identifies two subgroups of triple-negative breast cancers with distinct biological features.

    abstract:OBJECTIVE:Despite the clinical similarities triple-negative and basal-like breast cancer are not synonymous. Indeed, not all basal-like cancers are negative for estrogen receptor, progesterone receptor and HER2 expression while triple-negative also encompasses other cancer types. P53 protein appears heterogeneously exp...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyq227

    authors: Biganzoli E,Coradini D,Ambrogi F,Garibaldi JM,Lisboa P,Soria D,Green AR,Pedriali M,Piantelli M,Querzoli P,Demicheli R,Boracchi P,Nenci I,Ellis IO,Alberti S

    更新日期:2011-02-01 00:00:00

  • Vessel-contouring-based pelvic radiotherapy in patients with uterine cervical cancer.

    abstract:OBJECTIVE:The aim of this study was to assess clinically the adequacy of vessel-contouring-based pelvic radiotherapy with regard to nodal coverage for uterine cervical cancer. METHODS:Fifty patients with Stages I-III cervical cancer, treated with vessel-contouring-based three-dimensional radiotherapy since August 2002...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyp029

    authors: Uno T,Isobe K,Ueno N,Kobayashi H,Sanayama Y,Mitsuhashi A,Shozu M,Ito H

    更新日期:2009-06-01 00:00:00

  • A phase 2 trial of abiraterone acetate in Japanese men with metastatic castration-resistant prostate cancer and without prior chemotherapy (JPN-201 study).

    abstract:OBJECTIVE:Abiraterone acetate has been approved in >70 countries for chemotherapy-naïve metastatic castration-resistant prostate cancer patients. Efficacy and safety of abiraterone acetate (1000 mg/once daily) with prednisolone (5 mg/twice daily) in chemotherapy-naïve Japanese patients with metastatic castration-resist...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyu149

    authors: Matsubara N,Uemura H,Satoh T,Suzuki H,Nishiyama T,Uemura H,Hashine K,Imanaka K,Ozono S,Akaza H

    更新日期:2014-12-01 00:00:00