Cisplatin and etoposide chemotherapy combined with early concurrent twice-daily thoracic radiotherapy for limited-disease small cell lung cancer in elderly patients.

Abstract:

OBJECTIVE:The optimal management of elderly patients with limited-disease small cell lung cancer (LD-SCLC) has not been established. METHODS:The records of elderly (>or=70 years of age) patients with LD-SCLC who had been treated with etoposide and cisplatin chemotherapy with early concurrent twice-daily thoracic radiotherapy (TRT) were reviewed retrospectively. RESULTS:Of the 25 elderly patients with LD-SCLC identified, 12 (48%) individuals received etoposide-cisplatin chemotherapy with early concurrent twice-daily TRT. The main toxicities of this treatment regimen were hematologic, with neutropenia of Grade 4 being observed in all patients and febrile neutropenia of Grade 3 in eight patients during the first cycle of chemoradiotherapy. The toxicity of TRT was acceptable, with all patients completing the planned radiotherapy within a median of 29 days (range, 19-33). No treatment-related deaths were observed. The median progression-free survival and overall survival times were 14.2 months (95% confidence interval, 4.3-18.2) and 24.1 months (95% confidence interval, 11.3-27.2), respectively. CONCLUSIONS:Etoposide-cisplatin chemotherapy with early concurrent twice-daily TRT was highly myelotoxic in elderly patients with LD-SCLC, although no treatment-related deaths were observed in our cohort. Prospective studies are required to establish the optimal schedule and dose of chemotherapy and TRT in such patients.

journal_name

Jpn J Clin Oncol

authors

Okamoto K,Okamoto I,Takezawa K,Tachibana I,Fukuoka M,Nishimura Y,Nakagawa K

doi

10.1093/jjco/hyp137

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

54-9

issue

1

eissn

0368-2811

issn

1465-3621

pii

hyp137

journal_volume

40

pub_type

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