Abstract:
BACKGROUND:Combination of bleomycin, etoposide and cisplatin (BEP) remains the standard chemotherapy for testicular cancer. Since the development of BEP in the 1980s, there has been a considerable advance in supportive therapies, such as granulocyte colony-stimulating-factor and 5-HT3 antagonists. Therefore, we re-evaluated the completion and toxicity of BEP combined with modern supportive care. METHODS:The medical records of all 42 testicular cancer patients who received induction chemotherapy at Tsukuba University Hospital were reviewed. Toxicities during the induction chemotherapy were graded according to the Japanese CTCAE v3.0. RESULTS:Dose reduction was needed in only three patients. The subsequent chemotherapy was started at the planned 3 week interval or within 3 days of postponement in 89% of the treatment cycles. The average relative dose intensity (RDI) of bleomycin was 0.95, while that for etoposide and cisplatin was 0.97. There was no death due to toxicity. The most frequent toxicity was leukopenia (grade 3 in 44% and grade 4 in 55%). Post-chemotherapy diffusion capacity was significantly decreased in 30% of patients. Two patients developed bleomycin-induced pneumonitis, but recovered successfully. Sixteen patients received second line or salvage chemotherapy after BEP, subsequently. The overall 5 year cause-specific survival rate was 85%. CONCLUSION:BEP with high RDIs is acceptable if combined with modern supportive care, with acceptable toxicity profile in most patients.
journal_name
Jpn J Clin Oncoljournal_title
Japanese journal of clinical oncologyauthors
Kawai K,Ando S,Hinotsu S,Oikawa T,Sekido N,Miyanaga N,Shimazui T,Akaza Hdoi
10.1093/jjco/hyl053subject
Has Abstractpub_date
2006-07-01 00:00:00pages
425-31issue
7eissn
0368-2811issn
1465-3621pii
hyl053journal_volume
36pub_type
杂志文章abstract:BACKGROUND:Duodenal carcinoma is very rare and its culture cell lines have rarely been established. METHODS:Tumor cells separated from a surgically resected primary tumor of duodenal carcinoma were put into culture. The patient was an 81-year-old female and had metastatic lymph nodes. We investigated the biological ch...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/29.12.596
更新日期:1999-12-01 00:00:00
abstract::The rise in the incidence of lung cancer has been associated with shifts in histologic distribution. A study was conducted to investigate changes in the cell type distribution in lung cancer in relation to age, sex, and smoking history, based on a retrospective analysis of 10,910 proven cases of lung cancer at the Vet...
journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
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更新日期:2017-09-01 00:00:00
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
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abstract::A 63-year-old man was admitted to the National Cancer Center Hospital on December 20, 1983 for a close examination of the abnormal shadows found in chest roentgenograms. Chest radiographs showed a massive right pleural effusion, a large tumor in the right hilar region and swelling of the left hilar nodes. Transcutaneo...
journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,多中心研究
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1992-02-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
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更新日期:1998-01-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
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doi:
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
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doi:
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