Abstract:
BACKGROUND:Although a series of histopathological criteria have been suggested, the prediction of the malignant potential of gastrointestinal stromal tumors (GIST) is still difficult. The older literature called all gastrointestinal stromal tumors smooth muscle tumors or mixed GIST with true smooth muscle tumors. Reports on GIST including homogeneous cases were rare. METHODS:We examined 73 cases of GIST, which were immunohistochemically positive for c-kit and/or CD34, and mainly focused on the correlation between mitotic count and the other clinicopathological features to establish any helpful and reproducible parameters to indicate the malignant potential and to be used practically and objectively in the routine histopathological diagnosis of GIST. RESULTS:The results showed that there was a statistically significant difference in mitotic count between benign and malignant groups. Other proposed parameters, such as high cellularity, tumor size > or =5 cm, stomach and intestinal location, hemorrhage, necrosis, p53 expression and Ki-67 labeling index >10%, were frequently observed in tumors with mitotic figure. Three patients with one mitotic figure in 50HPF died from metastasis or recurrence of the tumors. CONCLUSIONS:Ki-67 index and cellularity should be used as predictors for the malignant potential of GIST. When other morphological features appear benign, mitotic count might also be a helpful practical factor in the prediction of the malignant potential of GIST.
journal_name
Jpn J Clin Oncoljournal_title
Japanese journal of clinical oncologyauthors
Wang X,Mori I,Tang W,Utsunomiya H,Nakamura M,Nakamura Y,Zhou G,Kennichi Kdoi
10.1093/jjco/hyf074keywords:
subject
Has Abstractpub_date
2002-09-01 00:00:00pages
347-51issue
9eissn
0368-2811issn
1465-3621journal_volume
32pub_type
杂志文章abstract::We report a 41-year-old woman with a retroperitoneal schwannoma mimicking hepatic tumor in the caudate lobe. Dynamic computed tomography in the early phase showed an enhanced tumor (2.7 cm in diameter) in the Spiegel lobe of the liver, which compressed the inferior vena cava (IVC). We also performed left hepatic angio...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/27.4.282
更新日期:1997-08-01 00:00:00
abstract:OBJECTIVE:To identify predictors of biochemical recurrence (BCR) after radical prostatectomy with or without standard pelvic lymphadenectomy in Korean men with high-risk prostate cancer. METHODS:The clinical and pathologic data of 199 patients with high-risk features were reviewed retrospectively. High-risk features w...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
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更新日期:2013-06-01 00:00:00
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journal_title:Japanese journal of clinical oncology
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doi:10.1093/jjco/hyd072
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doi:10.1093/jjco/hyi092
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journal_title:Japanese journal of clinical oncology
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doi:
更新日期:1984-03-01 00:00:00
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更新日期:1985-04-01 00:00:00
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
pub_type: 临床试验,杂志文章
doi:
更新日期:1995-08-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyn100
更新日期:2008-11-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyu149
更新日期:2014-12-01 00:00:00
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journal_title:Japanese journal of clinical oncology
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更新日期:2015-02-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,meta分析
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更新日期:2014-09-01 00:00:00
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journal_title:Japanese journal of clinical oncology
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更新日期:2001-05-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,多中心研究
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更新日期:2004-01-01 00:00:00
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journal_title:Japanese journal of clinical oncology
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更新日期:2010-05-01 00:00:00
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
doi:
更新日期:1995-02-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyaa006
更新日期:2020-06-10 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1995-10-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1983-03-01 00:00:00
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journal_title:Japanese journal of clinical oncology
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doi:10.1093/jjco/hyz054
更新日期:2019-08-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2012-09-01 00:00:00
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doi:10.1093/jjco/hyp026
更新日期:2009-06-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 临床试验,杂志文章
doi:
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pub_type: 杂志文章
doi:10.1093/jjco/28.4.250
更新日期:1998-04-01 00:00:00