Preoperative endocrine therapy in patients with locally advanced prostate cancer.

Abstract:

:Recently, there has been increased interest in the application of preoperative endocrine therapy prior to radical prostatectomy for locally advanced cancer in order to enhance surgical curability and increase survival. Between 1986 and 1993, 40 patients with prostate cancer were given endocrine therapy before radical prostatectomy. Fifteen patients had stage B2 disease and 25 stage C. The median duration of preoperative endocrine therapy was 3.8 months, and all the patients subsequently underwent radical prostatectomy, pelvic lymphadenectomy and castration. There was an average 25.5% (0-71.8%) decreases in the maximal cross-sectional area of the prostate gland as determined by transrectal ultrasonography. Twenty-four of 25 patients with elevated levels of serum prostate-specific antigen (PSA) showed normal values after preoperative endocrine therapy. Evaluation of treatment-related histological effects, divided into three grades, revealed that 17 patients had pronounced, 11 moderate and 12 poor or no regression. Thirteen of the 40 patients (33%) demonstrated pathological downstaging of disease status from the diagnosis made at the initial clinical examination. After a median follow-up period of 36 months (3-100 months), 36 of the 40 patients are disease-free; two died of cancer 43 and 50 months after surgery, respectively. These results suggest that preoperative endocrine therapy may play an important role in the management of locally advanced prostatic cancer.

journal_name

Jpn J Clin Oncol

authors

Maeda O,Meguro N,Saiki S,Kinouchi T,Kuroda M,Usami M,Kotake T

subject

Has Abstract

pub_date

1995-08-01 00:00:00

pages

135-9

issue

4

eissn

0368-2811

issn

1465-3621

journal_volume

25

pub_type

临床试验,杂志文章
  • A phase I study of split-dose cisplatin and etoposide with concurrent accelerated hyperfractionated thoracic radiotherapy in elderly patients with limited-disease small cell lung cancer.

    abstract:OBJECTIVE:The optimal treatment for elderly patients with limited-disease small cell lung cancer has not been defined. We therefore performed a Phase I study for split-dose cisplatin plus etoposide combined with early concurrent accelerated hyperfractionated thoracic radiotherapy in elderly (70 years of age or older) p...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyu071

    authors: Okamoto K,Okamoto I,Takeda M,Kobayashi S,Takeda K,Nakamatsu K,Nishimura Y,Nakagawa K

    更新日期:2014-08-01 00:00:00

  • Multiple resections for hepatic and pulmonary metastases of colorectal carcinoma.

    abstract:BACKGROUND:Resections are effective for some patients with both hepatic and pulmonary metastases of colorectal cancer, but the best selection criteria for the resections and effective treatment for recurrence after the resections have not been determined. METHODS:A retrospective analysis was performed for 30 consecuti...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hym006

    authors: Takahashi S,Nagai K,Saito N,Konishi M,Nakagohri T,Gotohda N,Nishimura M,Yoshida J,Kinoshita T

    更新日期:2007-03-01 00:00:00

  • A phase III randomized controlled trial comparing surgery plus adjuvant chemotherapy with preoperative chemoradiotherapy followed by surgery plus adjuvant chemotherapy for locally recurrent rectal cancer: Japan Clinical Oncology Group study JCOG1801 (RC-S

    abstract::A randomized phase III trial was initiated in Japan in August 2019 to confirm the superiority of preoperative chemoradiotherapy followed by surgery plus adjuvant chemotherapy compared to the standard treatment, i.e. surgery plus adjuvant chemotherapy, for locally recurrent rectal cancer in local relapse-free survival....

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/jjco/hyaa058

    authors: Kadota T,Tsukada Y,Ito M,Katayama H,Mizusawa J,Nakamura N,Ito Y,Bando H,Ando M,Onaya H,Fukuda H,Kanemitsu Y

    更新日期:2020-08-04 00:00:00

  • A phase 2 trial of abiraterone acetate in Japanese men with metastatic castration-resistant prostate cancer and without prior chemotherapy (JPN-201 study).

    abstract:OBJECTIVE:Abiraterone acetate has been approved in >70 countries for chemotherapy-naïve metastatic castration-resistant prostate cancer patients. Efficacy and safety of abiraterone acetate (1000 mg/once daily) with prednisolone (5 mg/twice daily) in chemotherapy-naïve Japanese patients with metastatic castration-resist...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyu149

    authors: Matsubara N,Uemura H,Satoh T,Suzuki H,Nishiyama T,Uemura H,Hashine K,Imanaka K,Ozono S,Akaza H

    更新日期:2014-12-01 00:00:00

  • Burden on oncologists when communicating the discontinuation of anticancer treatment.

    abstract:OBJECTIVE:Communicating the discontinuation of anticancer treatment to patients is a difficult task. The primary aim of this study was to clarify the level of oncologist-reported burden when communicating about discontinuation of an anticancer treatment. The secondary aims were (i) to identify the sources of burden con...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyr092

    authors: Otani H,Morita T,Esaki T,Ariyama H,Tsukasa K,Oshima A,Shiraisi K

    更新日期:2011-08-01 00:00:00

  • Late recurrence and second primary malignancy among 139 patients with germ cell tumors: long-term outcome of the disease in a single-center experience.

    abstract:OBJECTIVE:We retrospectively evaluated long-term oncological outcomes in patients with germ cell tumors (GCTs) primarily treated at our institution and assessed late recurrence and second primary malignancies. METHODS:This study included a total of 139 males with newly diagnosed GCTs of the testis or extragonadal orig...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyp142

    authors: Sato S,Tanaka T,Takahashi A,Sasai M,Kitamura H,Masumori N,Tsukamoto T

    更新日期:2010-02-01 00:00:00

  • Superior vena cava syndrome revisited.

    abstract::A clinical review with analysis of prognostic factors, including the impact of the initial management modality, was conducted on 137 patients with superior vena cava syndrome (SVCS) seen at the Veterans General Hospital-Taipei between 1989 and 1993. Malignant diseases account for most of the SVCS in our Chinese patien...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Chen YM,Yang S,Perng RP,Tsai CM

    更新日期:1995-04-01 00:00:00

  • Geriatric Research Policy: Japan Clinical Oncology Group (JCOG) policy.

    abstract::Due to the rapid aging of Japan's population, clinical research focusing on older patients with cancer is urgently needed. The Japan Clinical Oncology Group (JCOG) has conducted several such clinical trials, but there has been no formal policy for geriatric research. We have therefore established a JCOG policy for ger...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyz093

    authors: Mizutani T,Nakamura K,Fukuda H,Ogawa A,Hamaguchi T,Nagashima F,Geriatric Study Committee\/Japan Clinical Oncology Group.

    更新日期:2019-10-01 00:00:00

  • Adenoid basal carcinoma of the uterine cervix: immunohistochemical study and literature review.

    abstract::Adenoid basal carcinoma of the uterine cervix is rare and its cell origin is still obscure. We report a case of adenoid basal carcinoma of the uterine cervix discovered incidentally in a 69-year-old woman who had been hysterectomized due to endometrial adenocarcinoma of the uterine corpus. Histologically, small round-...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/27.6.437

    authors: Senzaki H,Osaki T,Uemura Y,Kiyozuka Y,Ogura E,Okamura A,Tsubura A

    更新日期:1997-12-01 00:00:00

  • A case of subglottic carcinoma effectively treated with intraluminal irradiation using low dose rate iridium-192 thin wires combined with external beam irradiation.

    abstract::Subglottic carcinoma is rare and has a poor prognosis. It is usually treated with surgical resection, external beam irradiation (EBR) and/or a combination of both. Intraluminal irradiation (IR) as a curative treatment for subglottic carcinoma has never been reported. We report a case of subglottic carcinoma in a 66-ye...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyg016

    authors: Wakisaka M,Fuwa N,Matsumoto A,Tachibana H,Kodaira T,Furutani K,Kamata M,Mori H

    更新日期:2003-02-01 00:00:00

  • A phase II clinical study of mFOLFOX6 plus bevacizumab as first-line therapy for Japanese advanced/recurrent colorectal cancer patients.

    abstract:OBJECTIVE:In Japan, there had been no prospective clinical studies conducted in terms of modified FOLFOX6 + bevacizumab therapy. We performed a post-marketing Phase II multicenter clinical study to examine the efficacy and safety of this regimen as first-line therapy for Japanese patients with advanced/recurrent colore...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/jjco/hyt127

    authors: Nishina T,Takano Y,Denda T,Yasui H,Takeda K,Ura T,Esaki T,Okuyama Y,Kondo K,Takahashi Y,Sugiyama Y,Muro K

    更新日期:2013-11-01 00:00:00

  • Long-term outcomes of 60 Gy conventional radiotherapy combined with androgen deprivation for localized or locally advanced prostate cancer.

    abstract:BACKGROUND:Until 1998 in Japan, very few institutions were treating prostate cancer solely with radiotherapy (RT) >70 Gy and most were using < or =65 Gy in combination with hormone therapy. The present study reports the long-term results of RT combined with hormone therapy for localized and locally advanced prostate ca...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyi174

    authors: Hashine K,Numata K,Azuma K,Sumiyoshi Y,Kataoka M

    更新日期:2005-11-01 00:00:00

  • A case of thymic cyst with elevated sialylated Lewis X-i, carbohydrate antigen 19-9 and tissue polypeptide antigen in the cystic fluid with no elevation of serum tumor markers.

    abstract::A 56-year-old man, tentatively diagnosed as having cardiomegaly, was found to have a large cyst in the left anterior mediastinum. At thoracotomy a multilocular cystic mass containing a colorless serous fluid was found and resected. Histologically, the cyst was lined with flattened epithelial cells, and thymic tissue w...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Sano T,Kuramochi S,Takahashi M,Asanuma F,Yamada Y,Uesato K,Toyoda H,Miyagawa T,Kurokawa T,Kawamura E

    更新日期:1991-10-01 00:00:00

  • Phase I studies of cisplatin and docetaxel administered by three consecutive weekly infusions for advanced non-small cell lung cancer in elderly and non-elderly patients.

    abstract:BACKGROUND:To determine the maximum tolerated dose and recommended dose of cisplatin and docetaxel administered by three consecutive weekly infusions in both non-elderly (< or =74 years) and elderly (> or =75 years) patients, we conducted two independent phase I studies for nonelderly and elderly patients with non-smal...

    journal_title:Japanese journal of clinical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1093/jjco/hye019

    authors: Ohe Y,Niho S,Kakinuma R,Kubota K,Matsumoto T,Ohmatsu H,Goto K,Kunitoh H,Saijo N,Nishiwaki Y

    更新日期:2001-03-01 00:00:00

  • Techniques and clinical effect of aseptic procedures on patients with acute leukemia in laminar airflow rooms.

    abstract::The techniques of aseptic procedures in the laminar airflow room (LAF) were evaluated in 110 adult patients undergoing antileukemic chemotherapy for remission induction. The patients were divided into three groups according to the regimens: Group A, consisting of 20 patients who stayed in the LAF and received the gown...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Takeo H,Sakurai T,Amaki I

    更新日期:1983-01-01 00:00:00

  • A phase II study of paclitaxel and nedaplatin as first-line chemotherapy in patients with advanced esophageal cancer.

    abstract:OBJECTIVE:The aim of this study was to assess the efficacy and toxicity of the combination of paclitaxel and nedaplatin as a first-line chemotherapy for patients with advanced esophageal cancer. METHODS:Patients with advanced esophageal cancer received 175 mg/m(2) of paclitaxel over a 3 h infusion, followed by nedapla...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyp058

    authors: Cao W,Xu C,Lou G,Jiang J,Zhao S,Geng M,Xi W,Li H,Jin Y

    更新日期:2009-09-01 00:00:00

  • The national database of hospital-based cancer registries: a nationwide infrastructure to support evidence-based cancer care and cancer control policy in Japan.

    abstract::Monitoring the current status of cancer care is essential for effective cancer control and high-quality cancer care. To address the information needs of patients and physicians in Japan, hospital-based cancer registries are operated in 397 hospitals designated as cancer care hospitals by the national government. These...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/hyt013

    authors: Higashi T,Nakamura F,Shibata A,Emori Y,Nishimoto H

    更新日期:2014-01-01 00:00:00

  • Dynamic computed tomography and color Doppler ultrasound of renal parenchymal neoplasms: correlations with histopathological findings.

    abstract:BACKGROUND:We evaluated whether color Doppler ultrasound (US) had diagnostic accuracy equal to dynamic computed tomography (CT) and whether performing dynamic CT and Doppler US together would be more informative in preoperative diagnosis of renal solid tumors. METHODS:A total of 110 renal solid tumors smaller than 7 c...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyh013

    authors: Kitamura H,Fujimoto H,Tobisu K,Mizuguchi Y,Maeda T,Matsuoka N,Komiyama M,Nakagawa T,Kakizoe T

    更新日期:2004-02-01 00:00:00

  • Rectum dose analysis employing a multi-purpose brachytherapy phantom.

    abstract:PURPOSE:It is difficult to reproduce a brachytherapy measurement because of changes in the rectal shape during inter-fraction. We constructed a multi-purpose brachytherapy phantom (MPBP) and reproduced the same conditions found in actual therapy. We further attempted to apply the measured optimal dose to reduce rectal ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hym032

    authors: Huh H,Kim W,Loh JJ,Lee S,Kim CY,Lee S,Shin D,Shin D,Cho S,Jang J,Lim S,Cho KH,Kwon S,Kim S

    更新日期:2007-05-01 00:00:00

  • Risk factors for sentinel lymph node metastasis and validation study of the MSKCC nomogram in breast cancer patients.

    abstract:OBJECTIVE:To evaluate the risk factors for sentinel lymph node metastasis and validate the value of the Memorial Sloan-Kettering Cancer Center nomogram for the prediction of sentinel lymph node metastasis in breast cancer patients. METHODS:A sentinel lymph node biopsy database containing 1227 consecutive breast cancer...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hys150

    authors: Qiu PF,Liu JJ,Wang YS,Yang GR,Liu YB,Sun X,Wang CJ,Zhang ZP

    更新日期:2012-11-01 00:00:00

  • Trousseau's syndrome: cancer-associated thrombosis.

    abstract::Trousseau's syndrome (cancer-associated thrombosis) is the second leading cause of death in cancer patients, after death from cancer itself. The risk of a venous thromboembolism is 4- to 7-fold higher in patients with cancer than in those without cancer. The causes of this impaired coagulation are associated with gene...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/hyv165

    authors: Ikushima S,Ono R,Fukuda K,Sakayori M,Awano N,Kondo K

    更新日期:2016-03-01 00:00:00

  • A phase I/II study of cisplatin and vinorelbine chemotherapy in patients with advanced non-small cell lung cancer.

    abstract:BACKGROUND:A combination of cisplatin and vinorelbine chemotherapy is effective in cases of advanced non-small cell lung cancer, but the optimum administration schedule for both drugs has not yet been defined. The aim of this study was to determine the maximum dose of vinorelbine that can be tolerated while receiving a...

    journal_title:Japanese journal of clinical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1093/jjco/hye129

    authors: Hotta K,Sekine I,Tamura T,Sawada M,Watanabe H,Kusaba H,Akiyama Y,Inoue A,Shimoyama T,Nokihara H,Ueda Y,Yamamoto N,Kunitoh H,Ohe Y,Kodama T,Saijo N

    更新日期:2001-12-01 00:00:00

  • The relationship between technical parameters of external beam radiation therapy and complications for localized prostate cancer.

    abstract:BACKGROUND:This study was performed to review retrospectively the clinical course of chronic rectal bleeding as a complication of external beam radiation therapy for localized prostate cancer and to analyze the relationship between technical parameters of radiation therapy and the complications. METHODS:Seventy-one pa...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyd058

    authors: Kitamura K,Shirato H,Suzuki K,Shinohara N,Demura T,Harabayashi T,Nishioka T,Kagei K,Takayama N,Shinno Y,Kawakura K,Koyanagi T,Miyasaka K

    更新日期:2000-05-01 00:00:00

  • Treatment of hepatocellular carcinoma using arterial chemoembolization with degradable starch microspheres and continuous arterial infusion of 5-fluorouracil.

    abstract:OBJECTIVE:Transcatheter arterial embolization (TAE) with gelatin sponge particles and iodized oil often yields poor results when used to treat unresectable multifocal hepatocellular carcinoma (HCC). The present study retrospectively investigated the utility of a novel combination chemotherapy regimen for treating multi...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyn076

    authors: Ishida K,Hirooka M,Hiraoka A,Kumagi T,Uehara T,Hiasa Y,Horiike N,Onji M

    更新日期:2008-09-01 00:00:00

  • Epithelioid hemangioendothelioma of the lung: CT findings and clinical course of 35 cases.

    abstract:OBJECTIVES:To evaluate computed tomography findings and assess the clinical course of patients with pulmonary epithelioid hemangioendothelioma. METHODS:Patients diagnosed with pulmonary epithelioid hemangioendothelioma at our institution between 2000 and 2019 were retrospectively analyzed. Patients with pleural involv...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyaa106

    authors: Onishi Y,Kusumoto M,Goto Y,Kaku S,Motoi N

    更新日期:2020-09-28 00:00:00

  • Treatment outcomes of the patients with early glottic cancer treated with initial radiotherapy and salvaged by conservative surgery.

    abstract:OBJECTIVE:This retrospective study analyzed the oncological and treatment outcomes of the patients with T1-T2N0 glottic cancer, who were treated with radiotherapy as initial treatment and salvaged by conservative surgery for radiation failure. METHODS:Between May 1999 and December 2010, 115 patients with glottic laryn...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyu203

    authors: Harada A,Sasaki R,Miyawaki D,Yoshida K,Nishimura H,Ejima Y,Kitajima K,Saito M,Otsuki N,Nibu K

    更新日期:2015-03-01 00:00:00

  • A computer-assisted model for predicting probability of dying within 7 days of hospice admission in patients with terminal cancer.

    abstract:OBJECTIVE:The aim of the present study is to compare the accuracy in using laboratory data or clinical factors, or both, in predicting probability of dying within 7 days of hospice admission in terminal cancer patients. METHODS:We conducted a prospective cohort study of 727 patients with terminal cancer. Three models ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyp188

    authors: Chiang JK,Cheng YH,Koo M,Kao YH,Chen CY

    更新日期:2010-05-01 00:00:00

  • Prediction model of critical weight loss in cancer patients during particle therapy.

    abstract:Background and purpose:The objective of this study is to investigate the predictors of critical weight loss in cancer patients receiving particle therapy, and build a prediction model based on its predictive factors. Materials and methods:Patients receiving particle therapy were enroled between June 2015 and June 2016...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyx145

    authors: Zhang Z,Zhu Y,Zhang L,Wang Z,Wan H

    更新日期:2018-01-01 00:00:00

  • Hematogenous metastatic patterns of curatively resected colon cancer were different from those of stage IV and autopsy cases.

    abstract::The hematogenous metastases of colon cancer have primarily been explained by the cascade hypothesis based on the cadaveric study. However, we experienced several cases with isolated lung metastasis. The metastatic patterns of a total of 982 patients with colon cancer who underwent surgery were reviewed. The incidence ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyt002

    authors: Sadahiro S,Suzuki T,Tanaka A,Okada K,Kamata H

    更新日期:2013-04-01 00:00:00

  • Oligometastases and oligo-recurrence: the new era of cancer therapy.

    abstract::Recurrence or metastasis of cancer has been considered to occur in the last stage of the patient's life. However, the new notions of oligometastases and oligo-recurrence have been proposed and the paradigm shift in the conceptualization of cancer metastasis or cancer recurrence. Oligometastases is the state in which t...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/hyp167

    authors: Niibe Y,Hayakawa K

    更新日期:2010-02-01 00:00:00