Adequacy evaluation of the annual colonoscopic surveillance and individual difference of disease phenotypes in Lynch syndrome.

Abstract:

BACKGROUND:Regular endoscopic surveillance for Lynch syndrome is reported to reduce colorectal cancer (CRC)-related mortality. However, the appropriate surveillance intervals are still unclear. We evaluated the adequacy of annual colonoscopy and investigated the differences in tumor occurrence rates between individual patients. METHODS:In total, 25 patients with Lynch syndrome who underwent colonoscopic surveillance between 2007 and 2016 at the Iwakuni Clinical Center were included. We retrospectively investigated the surveillance frequency and the clinical features associated with tumor development. RESULTS:Colonoscopic surveillance was performed every 397 days on average. A total of 101 tumors, including 8 intramucosal carcinomas and 15 carcinomas, were observed within the study period. Annual colonoscopy detected six malignancies, including a carcinoma requiring surgery. Tumor incidence was associated with tumor existence in the initial colonoscopies (P = 0.018). Patients with a tumor occurrence rate of 0.4 tumors per year during our observation period were significantly more likely to have malignancies detected during regular surveillance than patients who had a lower occurrence rate (P < 0.001). Malignancy occurrence rate was strongly associated with tumor occurrence rate (P < 0.001, R2 = 0.44). CONCLUSIONS:Annual colonoscopic surveillance for Lynch syndrome patients was effective in reducing the risk of CRC progression, but was insufficient to completely avoid surgery. Because the tumor occurrence rate differed substantially between individuals, more intensive surveillance was required for high-risk patients.

journal_name

Jpn J Clin Oncol

authors

Taniguchi F,Tanakaya K,Sugano K,Akagi K,Ishida H,Nagahisa S,Nishimura S,Une Y,Kimura Y,Watanabe M,Utsumi M,Aoki H

doi

10.1093/jjco/hyaa006

subject

Has Abstract

pub_date

2020-06-10 00:00:00

pages

635-642

issue

6

eissn

0368-2811

issn

1465-3621

pii

5830794

journal_volume

50

pub_type

杂志文章
  • Mass screening for gastric cancer by X-ray examination.

    abstract::The characteristics of early gastric cancer detected by gastric mass survey were examined. The progress of the screening test using the indirect X-ray examination and the tendency toward reduction in mortality from stomach cancer were evaluated. In 1981 the number of examinees in the gastric mass surveys amounted to o...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Hisamichi S,Sugawara N

    更新日期:1984-06-01 00:00:00

  • Results of a qualitative and field study using the WHOQOL instrument for cancer patients.

    abstract::The main purpose of the study was to evaluate quality of life (QOL) among cancer patients using the WHOQOL-100 instrument and to see if any significant differences were seen in cancer stages, treatment status and prognosis. This study consisted of two parts; qualitative and quantitative. For the qualitative study, two...

    journal_title:Japanese journal of clinical oncology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1093/jjco/28.2.134

    authors: Tazaki M,Nakane Y,Endo T,Kakikawa F,Kano K,Kawano H,Kuriyama K,Kuroko K,Miyaoka E,Ohta H,Okamoto N,Shiratori S,Takamiya S,Tanemura K,Tsuchiya R

    更新日期:1998-02-01 00:00:00

  • Phase II trial of UFT activity in pretreated breast cancer patients.

    abstract::Seventy metastatic breast adenocarcinoma patients, pretreated with standard hormonotherapy or chemotherapy, received continuous UFT at 10 mg/kg/day, orally, for at least two months. There were one complete response (1.5%), 12 partial responses (17%), one minor response and 37 disease stabilizations. The median duratio...

    journal_title:Japanese journal of clinical oncology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Daniels M,Díaz-Rubio E,Guillem V,Montero JM,García-Conde J,Estapé J,Martín M,Herranz C,Ordoñez A,Galán A

    更新日期:1993-12-01 00:00:00

  • MicroRNA-338-3p inhibits colorectal carcinoma cell invasion and migration by targeting smoothened.

    abstract:OBJECTIVE:To investigate the regulative effect of microRNA-338-3p on colorectal carcinoma cell invasion and migration. METHODS:The microRNA-338-3p expression pattern of colorectal carcinoma tissues and cell lines was detected by real-time reverse transcriptase polymerase chain reaction. The protein level of smoothened...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyt181

    authors: Xue Q,Sun K,Deng HJ,Lei ST,Dong JQ,Li GX

    更新日期:2014-01-01 00:00:00

  • Palliative chemotherapy preferences and factors that influence patient choice in incurable advanced cancer.

    abstract:OBJECTIVE:To determine the extent of informed decision-making and treatment preference of Korean patients receiving palliative chemotherapy. METHODS:We assessed 138 patients (median age: 58 years; 73% male) with advanced cancer who had received at least one cycle of chemotherapy. General demographic information, the e...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hym147

    authors: Kim MK,Lee JL,Hyun MS,Do YR,Song HS,Kim JG,Bae SH,Ryoo HM,Park KU,Lee KH

    更新日期:2008-01-01 00:00:00

  • Blue nodes left behind after vital blue dye-guided axillary sentinel node biopsy in breast cancer patients.

    abstract:BACKGROUND:Vital dye-guided sentinel node biopsy is affordable in most hospitals, but may be of limited accuracy in identifying all sentinel nodes. Leaving sentinel nodes in the axilla may result in a false nodal staging of breast carcinomas. METHODS:From a series of 112 successful sentinel lymph node biopsies with Pa...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyd072

    authors: Cserni G,Rajtár M,Boross G

    更新日期:2000-06-01 00:00:00

  • Medical treatment for inoperable insulinoma: clinical usefulness of diphenylhydantoin and diltiazem.

    abstract::This report describes a 78-year-old woman with insulinoma, treated with a combination of diphenylhydantoin and a calcium antagonist. The effectiveness of 200 mg of diphenylhydantoin and 180 mg of diltiazem was evaluated by measuring the levels of plasma glucose, immunoreactive insulin and immunoreactive insulin/plasma...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Imanaka S,Matsuda S,Ito K,Matsuoka T,Okada Y

    更新日期:1986-03-01 00:00:00

  • The variation of cell type distribution in lung cancer: a study of 10,910 cases at a medical center in Taiwan between 1970 and 1993.

    abstract::The rise in the incidence of lung cancer has been associated with shifts in histologic distribution. A study was conducted to investigate changes in the cell type distribution in lung cancer in relation to age, sex, and smoking history, based on a retrospective analysis of 10,910 proven cases of lung cancer at the Vet...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.jjco.a023219

    authors: Perng DW,Perng RP,Kuo BI,Chiang SC

    更新日期:1996-08-01 00:00:00

  • Real-time elastography for the diagnosis of prostate cancer: evaluation of elastographic moving images.

    abstract:OBJECTIVE:Elastography is a technique for detecting the stiffness of tissues. We applied elastography for the diagnosis of prostate cancer and evaluated the usefulness of elastography for prostate biopsy. METHODS:The subjects of this study were 311 patients who underwent elastography during prostate needle biopsy at H...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyp026

    authors: Miyagawa T,Tsutsumi M,Matsumura T,Kawazoe N,Ishikawa S,Shimokama T,Miyanaga N,Akaza H

    更新日期:2009-06-01 00:00:00

  • Efficacy of CDDP and AGM-1470 chemotherapy against lung metastasis in rat osteosarcoma depends on the timing of combined administration.

    abstract::The efficacy of combination therapy with cis-diammine-dichloroplatinum (II) (CDDP) and o-(chloroacetyl-carbamoyl) fumagillol (AGM-1470) was evaluated experimentally using a transplantable rat osteosarcoma line, previously established in our laboratory, with a high potential for metastasis. Tumor-bearing male Fischer 3...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/27.4.236

    authors: Morishita T,Mii Y,Miyauchi Y,Miura S,Honoki K,Aoki M,Kido A,Tamai S,Tsutsumi M,Konishi Y

    更新日期:1997-08-01 00:00:00

  • Helpful parameter for malignant potential of gastrointestinal stromal tumors (GIST).

    abstract:BACKGROUND:Although a series of histopathological criteria have been suggested, the prediction of the malignant potential of gastrointestinal stromal tumors (GIST) is still difficult. The older literature called all gastrointestinal stromal tumors smooth muscle tumors or mixed GIST with true smooth muscle tumors. Repor...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyf074

    authors: Wang X,Mori I,Tang W,Utsunomiya H,Nakamura M,Nakamura Y,Zhou G,Kennichi K

    更新日期:2002-09-01 00:00:00

  • Cancer control in Australia: into the 21(st) Century.

    abstract::Australia ranks highly internationally for cancer control, in part because cancer registries provide comprehensive national incidence and mortality and other cancer data annually. This has facilitated short- and long-term planning over the last quarter of a century. For example, male death rates from lung cancer in Au...

    journal_title:Japanese journal of clinical oncology

    pub_type: 历史文章,杂志文章

    doi:10.1093/jjco/hye121

    authors: Burton RC

    更新日期:2002-03-01 00:00:00

  • A phase I/II study of cisplatin and vinorelbine chemotherapy in patients with advanced non-small cell lung cancer.

    abstract:BACKGROUND:A combination of cisplatin and vinorelbine chemotherapy is effective in cases of advanced non-small cell lung cancer, but the optimum administration schedule for both drugs has not yet been defined. The aim of this study was to determine the maximum dose of vinorelbine that can be tolerated while receiving a...

    journal_title:Japanese journal of clinical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1093/jjco/hye129

    authors: Hotta K,Sekine I,Tamura T,Sawada M,Watanabe H,Kusaba H,Akiyama Y,Inoue A,Shimoyama T,Nokihara H,Ueda Y,Yamamoto N,Kunitoh H,Ohe Y,Kodama T,Saijo N

    更新日期:2001-12-01 00:00:00

  • Hepatic arterial infusion of oxaliplatin for a patient with hepatic metastases from colon cancer undergoing hemodialysis.

    abstract::There has been no previous report of oxaliplatin administration in patients undergoing hemodialysis. A 65-year-old female with end-stage renal disease who was undergoing hemodialysis presented with anemia in August 2005. She was diagnosed with colon cancer with multiple liver metastases. After colectomy, hepatic arter...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hym044

    authors: Shitara K,Munakata M,Muto O,Okada R,Mitobe S,Mino M,Ikami I,Sakata Y

    更新日期:2007-07-01 00:00:00

  • Risk factors for sentinel lymph node metastasis and validation study of the MSKCC nomogram in breast cancer patients.

    abstract:OBJECTIVE:To evaluate the risk factors for sentinel lymph node metastasis and validate the value of the Memorial Sloan-Kettering Cancer Center nomogram for the prediction of sentinel lymph node metastasis in breast cancer patients. METHODS:A sentinel lymph node biopsy database containing 1227 consecutive breast cancer...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hys150

    authors: Qiu PF,Liu JJ,Wang YS,Yang GR,Liu YB,Sun X,Wang CJ,Zhang ZP

    更新日期:2012-11-01 00:00:00

  • Cytoplasmic Trop-1/Ep-CAM overexpression is associated with a favorable outcome in node-positive breast cancer.

    abstract:OBJECTIVE:Trop-1/Ep-CAM modulates growth and survival of transformed cells, and it is highly expressed in most carcinomas including breast cancer. Only membranous staining is typically considered in evaluating Trop-1/epithelial cell adhesion molecule (Ep-CAM) expression in tumor cells. However, there is evidence of ret...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hys159

    authors: Alberti S,Ambrogi F,Boracchi P,Fornili M,Querzoli P,Pedriali M,La Sorda R,Lattanzio R,Tripaldi R,Piantelli M,Biganzoli E,Coradini D

    更新日期:2012-12-01 00:00:00

  • Completion and toxicity of induction chemotherapy for metastatic testicular cancer: an updated evaluation of Japanese patients.

    abstract:BACKGROUND:Combination of bleomycin, etoposide and cisplatin (BEP) remains the standard chemotherapy for testicular cancer. Since the development of BEP in the 1980s, there has been a considerable advance in supportive therapies, such as granulocyte colony-stimulating-factor and 5-HT3 antagonists. Therefore, we re-eval...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyl053

    authors: Kawai K,Ando S,Hinotsu S,Oikawa T,Sekido N,Miyanaga N,Shimazui T,Akaza H

    更新日期:2006-07-01 00:00:00

  • Successful use of dydrogesterone as maintenance therapy in recurrent endometrial stromal sarcoma: a case report.

    abstract::Endometrial stromal sarcoma is known to be a hormone-dependent tumor. Efficacy of hormonal therapy including high-dose progestins, aromatase inhibitors or gonadotropin-releasing hormone analogs has been reported. We report a case of recurrent endometrial stromal sarcoma, the tumor cells of which were strongly positive...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyt142

    authors: Akashi D,Todo Y,Shimada C,Okamoto K,Minobe S,Kato H

    更新日期:2013-11-01 00:00:00

  • Two cases of stereotactic radiosurgical boost as an initial treatment for young nasopharyngeal cancer patients.

    abstract::Case 1: A 14-year-old boy with nasopharyngeal cancer (T4N0M0) was treated with stereotactic radiosurgery (SRS) as a boost therapy after conventional radiotherapy. Persistent residual tumor visible with MR remained after conventional radiotherapy comprising 59.6 Gy in total. We therefore performed SRS to add a further ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyh126

    authors: Yokouchi J,Satani K,Kanesaka N,Abe K,Hasegawa T

    更新日期:2004-11-01 00:00:00

  • Hematogenous metastatic patterns of curatively resected colon cancer were different from those of stage IV and autopsy cases.

    abstract::The hematogenous metastases of colon cancer have primarily been explained by the cascade hypothesis based on the cadaveric study. However, we experienced several cases with isolated lung metastasis. The metastatic patterns of a total of 982 patients with colon cancer who underwent surgery were reviewed. The incidence ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyt002

    authors: Sadahiro S,Suzuki T,Tanaka A,Okada K,Kamata H

    更新日期:2013-04-01 00:00:00

  • A preliminary study of preoperative chemotherapy combining irinotecan and cisplatin in patients with gastric cancer with unresectable para-aortic lymph node metastases.

    abstract:BACKGROUND:A high response rate has been reported for chemotherapy combining irinotecan (CPT-11) and cisplatin (CDDP) against advanced gastric cancer. The strong anti-tumor activity of this regimen makes it very attractive as a preoperative chemotherapy. We conducted a preliminary study on preoperative chemotherapy wit...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyh046

    authors: Yamao T,Ohta K,Ohyama S,Ishihara S,Chin K,Maruyama M,Takahashi T,Nakajima T

    更新日期:2004-05-01 00:00:00

  • BUBR1 overexpression predicts disease-specific survival after nephroureterectomy in patients with upper tract urothelial carcinoma.

    abstract:OBJECTIVE:To date, there are few reliable markers to distinguish tumors with aggressive characteristics in upper tract urothelial carcinoma. The purpose of this study was to identify a biomarker related to genetic instability (chromosomal instability or microsatellite instability) with prognostic value, in patients wit...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyw060

    authors: Yamamoto Y,Oga A,Akao J,Misumi T,Fuji N,Kobayashi K,Kawai Y,Inoue R,Hirata H,Matsumoto H,Nagao K,Sakano S,Matsuyama H

    更新日期:2016-08-01 00:00:00

  • Epidemiology, tumor characteristics and survival in patients with angiosarcoma in the United States: a population-based study of 4537 cases.

    abstract:OBJECTIVE:Limited by sample size, angiosarcoma was rarely studied. We aimed to investigate the characteristics and prognosis of angiosarcoma in the National Cancer Institute's Surveillance, Epidemiology and End Results database. METHODS:Patients who were diagnosed with primary angiosarcoma from 1973 to 2014 were extra...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyz113

    authors: Zhang C,Xu G,Liu Z,Xu Y,Lin F,Baklaushev VP,Chekhonin VP,Peltzer K,Mao M,Wang X,Wang G,Zhang C

    更新日期:2019-12-27 00:00:00

  • Minute squamous cell carcinoma of the gallbladder: a case report.

    abstract::Following a simple cholecystectomy, a 63-year-old woman with gallstones was histologically diagnosed as having minute squamous cell carcinoma of the gallbladder. A laparotomy revealed a small, firm nodule that appeared to be an adenoma, which was palpated in the fundus of the gallbladder. The resected gallbladder cont...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyd010

    authors: Roppongi T,Takeyoshi I,Ohwada S,Sato Y,Fujii T,Honma M,Morishita Y

    更新日期:2000-01-01 00:00:00

  • The first case of primary testicular germ cell tumor containing nephroblastoma as the only one non-germ cell component.

    abstract::Adult extrarenal nephroblastomas (Wilms' tumor) are extremely rare tumors. They show a higher incidence of non-seminomatous elements and these so-called 'teratoid' Wilms' tumors are suggested to be of germ cell origin. To date, however, the number of reported cases with gonadal teratoma containing nephroblastoma is ve...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyr080

    authors: Keskin S,Ekenel M,Başaran M,Aksu C,Kiliçaslan I,Tunç M,Bavbek S

    更新日期:2011-08-01 00:00:00

  • Initial experience with the quality assurance program of radiation therapy on behalf of Japan Radiation Oncology Group (JAROG).

    abstract:BACKGROUND:We evaluated the efficacy of our quality assurance (QA) program of radiation therapy (RT) in a prospective phase II study. This is the first description of the experience of the Japan Radiation Oncology Group (JAROG) with this program. METHODS:Clinical records, all diagnostic radiological films or color pho...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyl129

    authors: Isobe K,Kagami Y,Higuchi K,Kodaira T,Hasegawa M,Shikama N,Nakazawa M,Fukuda I,Nihei K,Ito K,Teshima T,Oguchi M,Japan Radiation Oncology Group (JAROG).

    更新日期:2007-02-01 00:00:00

  • A 12-mm carcinoid tumor of the minor duodenal papilla with lymph node metastases.

    abstract::Carcinoid tumors located in the minor duodenal papilla are extremely rare, with only a few cases reported in the literature. Herein, we report the case of a 71-year-old man with a 12-mm carcinoid tumor at the minor duodenal papilla with lymph node metastases. Multidetector-row computed tomography with contrast enhance...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hys185

    authors: Fukami Y,Kurumiya Y,Mizuno K,Sekoguchi E,Kobayashi S,Ito A,Tomida A,Onishi S,Shirotsuki R,Okubo K,Narita M

    更新日期:2013-01-01 00:00:00

  • Prediction model of critical weight loss in cancer patients during particle therapy.

    abstract:Background and purpose:The objective of this study is to investigate the predictors of critical weight loss in cancer patients receiving particle therapy, and build a prediction model based on its predictive factors. Materials and methods:Patients receiving particle therapy were enroled between June 2015 and June 2016...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyx145

    authors: Zhang Z,Zhu Y,Zhang L,Wang Z,Wan H

    更新日期:2018-01-01 00:00:00

  • A competing-risks nomogram for predicting probability of death from CRC in Chinese Han patients with Stage I-III CRC.

    abstract:Background:Many patients with colorectal cancer are elderly with competing comorbidities. When constructing nomogram for assessing survival, we should consider the influence of competing risk. A competing-risks nomogram was developed to estimate the probability of death due to colorectal cancer for patients after curat...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyy136

    authors: Li J,Li X,Gu J,Ma X,Xue F

    更新日期:2018-12-01 00:00:00

  • Prognosis for resected lung cancer patients with tumors greater than ten centimeters in diameter.

    abstract::During the period 1962-1986, 43 lung cancer patients, 2.3% of the 1,832 patients who underwent pulmonary resections at the National Cancer Center Hospital, Tokyo, had tumors greater than 10 cm in diameter. These 43 cancers were classified postsurgically according to the 1987 guidelines for TNM classification of malign...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Sano T,Naruke T,Kondo H,Goya T,Tsuchiya R,Suemasu K

    更新日期:1990-12-01 00:00:00