Abstract:
OBJECTIVE:To identify predictors of biochemical recurrence (BCR) after radical prostatectomy with or without standard pelvic lymphadenectomy in Korean men with high-risk prostate cancer. METHODS:The clinical and pathologic data of 199 patients with high-risk features were reviewed retrospectively. High-risk features were prostate-specific antigen level >20 ng/ml, biopsy Gleason score ≥8 or clinical tumor category ≥2c. All patients were followed up by measuring their prostate-specific antigen levels every 3 months. The median follow-up period was 37.0 months (range: 1.0-143.0). RESULTS:During the follow-up period, biochemical recurrence was observed in 68 patients (34.2%). The 1-, 3- and 5-year biochemical recurrence-free survival rates were 79.6, 61.9 and 49.2%, respectively. Surgical Gleason score ≥8, positive surgical margin, extracapsular extension, and seminal vesicle invasion correlated significantly with biochemical recurrence-free survival (all P < 0.05), but pelvic lymphadenectomy did not. Multivariate Cox's proportional hazard analysis revealed that the only significant independent prognostic factor of biochemical recurrence-free survival was seminal vesicle invasion (P = 0.035, relative risk = 1.81). CONCLUSIONS:Men with seminal vesicle invasion appear to have a significantly higher biochemical recurrence risk in patients with high-risk prostate cancer. However, since the natural history of prostate cancer is variable and accurate means of identifying those who will progress are currently available, it will be necessary to conduct further studies to find prognostic parameters that will allow the early identification of high-risk patients who could benefit from early salvage or adjuvant therapy.
journal_name
Jpn J Clin Oncoljournal_title
Japanese journal of clinical oncologyauthors
Ku JH,Jeong CW,Park YH,Cho MC,Kwak C,Kim HHdoi
10.1093/jjco/hyr030subject
Has Abstractpub_date
2011-05-01 00:00:00pages
656-62issue
5eissn
0368-2811issn
1465-3621pii
hyr030journal_volume
41pub_type
杂志文章abstract:OBJECTIVE:The aim of this study is to evaluate the liver metastasis risk among colorectal cancer patients with liver cirrhosis. METHODS:This was a nationwide population-based cohort study of 2973 newly diagnosed colorectal cancer patients with liver cirrhosis and 11 892 age-sex matched controls enrolled in Taiwan betw...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyu178
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Although radiotherapy in combination with endocrinal manipulation has been identified as an effective treatment for patients with high-risk prostate cancer, the optimal dose for locoregional control of prostate cancer in combination with hormonal therapy has not yet been determined. METHODS:The efficacy of ...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyh059
更新日期:2004-07-01 00:00:00
abstract::Interleukin-12 (IL-12), known to be a strong inducer of interferon-gamma (IFN-gamma), plays a vital role in activating the immune surveillance system against intracellular pathogens and malignant tumors. The authors have found that cancer patients showing marked IFN-gamma induction after inoculation with BCG-CWS (the ...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.jjco.a023194
更新日期:1996-06-01 00:00:00
abstract::Over the past 10 years, immunotherapy with immune checkpoint inhibitors has revolutionized the management of various cancers. However, immunotherapy in breast cancer has not been successful. Breast cancer has long been recognized as an immunologically 'cold' tumor, although a higher frequency of tumor-infiltrating lym...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyaa230
更新日期:2020-12-15 00:00:00
abstract:BACKGROUND:In Japan, concurrent chemoradiotherapy is the standard treatment for unresectable esophageal cancer. The optimal combination of chemotherapeutic agents and radiotherapy dose remains controversial. The present study consists of a phase II trial of a cisplatin (CDDP)/5-fluorouracil (5-FU) infusion with concurr...
journal_title:Japanese journal of clinical oncology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1093/jjco/hyh107
更新日期:2004-10-01 00:00:00
abstract::Recurrence or metastasis of cancer has been considered to occur in the last stage of the patient's life. However, the new notions of oligometastases and oligo-recurrence have been proposed and the paradigm shift in the conceptualization of cancer metastasis or cancer recurrence. Oligometastases is the state in which t...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1093/jjco/hyp167
更新日期:2010-02-01 00:00:00
abstract::Recently total body irradiation has been used as a method of preparation for the bone marrow transplantation. However, it has become apparent that total body irradiation is one of the causes of interstitial pneumonia. There are several factors in total body irradiation that may induce interstitial pneumonia. 1) Total ...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:The purpose of the present study is to verify the treatment effects of boron neutron capture therapy (BNCT) in ectopic tumors implanted in the thoracic cavity mimicking malignant pleural mesothelioma (MPM). METHODS:The tumor model was created by implanting murine squamous cell carcinoma cells into the thora...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hym022
更新日期:2007-04-01 00:00:00
abstract:Objective:This study aims to reveal the present situation of changes in physical appearance induced by treatment, the effects of these changes on social activities, and support from medical staff in male cancer patients. Methods:A questionnaire survey was administered to 949 male patients (response rate: 90.1%) visiti...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyx069
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:The prognosis of breast cancer-derived brain metastasis is poor, but new drugs and recent therapeutic strategies have helped extend survival in patients. Prediction of therapeutic responses and outcomes is not yet possible, however. In a retrospective study, we examined prognostic factors in patients with bre...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyv067
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVE:The CpG island methylator phenotype is strongly associated with poor survival in neuroblastomas. Neuroblastomas with the CpG island methylator phenotype include almost all neuroblastomas with MYCN amplification, and, even among neuroblastomas without MYCN amplification, have worse prognosis. At the same time,...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyt058
更新日期:2013-06-01 00:00:00
abstract::A thyroid ultrasound examination programme has been conducted in Fukushima Prefecture, Japan, after the nuclear disaster in 2011. Although remarkably high prevalence of thyroid cancer was observed, no relevant quantitative evaluation was conducted. We calculated the observed/expected (O/E) ratio of thyroid cancer prev...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyv191
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:The objective of this study was to evaluate the relationship of HIF-1alpha expression and tumor angiogenesis, recurrence/distant metastasis, and its value in the prediction of aggressive behavior of gastrointestinal stromal tumor (GIST). METHODS:Paraffin-embedded specimens from 62 patients with GIST were di...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyi067
更新日期:2005-04-01 00:00:00
abstract:UNLABELLED:Kidney cancer accounts for approximately 2% of all cancers worldwide, with renal cell carcinoma being the most common form and this report is focused on renal cell carcinoma. Globally, the incidence and mortality rates are increasing by 2-3% per decade. Kidney cancer is less common in Asia compared with the ...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyq127
更新日期:2010-09-01 00:00:00
abstract::An in vitro monolayer model for cancer invasion was developed, comprising cultured layers of human pleura-derived mesothelial cells (PM cells). The cells were isolated from normal human pleura at autopsy and cultured in RPMI-1640 supplemented with 10% fetal calf serum; they were polygonal in shape, forming a pavement-...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract::A combined ischiopubic rami resection is extremely rare in the field of gastroenterologic surgery. We report a case of a locally recurrent rectal cancer that was successfully treated by total pelvic exenteration with combined ischiopubic rami resection. A 58-year-old male with locally recurrent rectal cancer and liver...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyr169
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:Study aims include determination of nationwide structural characteristics of radiation oncology facilities, types of radiation therapy equipment, availability of human resources and trends and comparisons with previous surveys. METHODS:An annual nationwide survey was conducted to collect the statistics of in...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyq001
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:To determine the antitumor activity and toxicity of weekly hepatic arterial infusion (HAI) of 5-fluorouracil (5-FU) for liver metastases from colorectal cancer. In addition, the present study also evaluated the efficacy of second-line chemotherapy after termination of HAI. METHODS:A retrospective study was d...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyg021
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVE:Oral fluoropyrimidine plus cisplatin is a standard treatment for advanced gastric cancer, but patients with severe peritoneal metastasis often cannot tolerate this regimen. The aim of this study was to assess the feasibility of fluorouracil, l-leucovorin and paclitaxel therapy in such patients. METHODS:In th...
journal_title:Japanese journal of clinical oncology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1093/jjco/hys111
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:The purpose of the present study was to obtain preliminary findings regarding psychiatric disorders and background characteristics among Japanese family members of cancer patients. METHODS:We investigated the psychiatric diagnosis and background factors of family members of cancer patients by analyzing the c...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyl029
更新日期:2006-05-01 00:00:00
abstract::Expression of carcinoembryonic antigen (CEA) and nonspecific cross-reacting antigen (NCA) mRNAs were observed in malignant and nonmalignant colon tissues by Northern blot analysis. CEA mRNA was detected together with NCA mRNA in nine cultured cell lines, with the exception of the lung carcinoma A549 cell line, and in ...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.jjco.a039449
更新日期:1991-04-01 00:00:00
abstract:BACKGROUND:In recent times, the possibility of detecting lung cancer using microsatellite alterations (microsatellite instability and loss of heterozygosity) in DNA of bronchial washings has been explored. However, no data regarding the presence of microsatellite alterations in lung cancer are available from India, a c...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyh079
更新日期:2004-08-01 00:00:00
abstract:Background:Stathmin has been found to be involved in malignant tumors; the aim of this study was to investigate the relationship between serum stathmin and clinico-pathological features of lung cancer. Methods:In three lung cancer cell lines, stathmin expression and its secretion level in the supernatant were examined...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyx005
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:This study aimed to describe the health behaviors of cancer survivors in the Republic of Korea and to compare them with the health behaviors of two control groups: (i) individuals with no history of cancer but with other chronic diseases and (ii) individuals with no history of cancer or other chronic diseases...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyt118
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the association of molecular markers and conventional clinicopathological factors with bladder tumour recurrence in patients with primary upper tract urothelial carcinoma after radical nephroureterectomy. METHODS:The expressions of Ki-67 and P53 were measured by immunohistochemical staining prosp...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyv139
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:A retrospective analysis was made to clarify the relationship between prognosis, radiation dose and survival of brain stem gliomas. METHODS:From 1983 to 1995, 22 children with brain stem tumors were treated by radiotherapy in the Veterans General Hospital-Taipei. Twelve patients had pathology proof and the ...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/28.8.474
更新日期:1998-08-01 00:00:00
abstract::This study was conducted to assess, by continuous exposure, the inhibitory effects of rH-TNF and rH-IFN-alpha, -beta and -gamma, either alone or in combination, on the colony formations of human lung cancer cell lines. The cell lines tested were PC-7 and PC-9 (adenocarcinoma), PC-10 (squamous cell carcinoma) and PC-13...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1987-03-01 00:00:00
abstract::Carcinoid tumors located in the minor duodenal papilla are extremely rare, with only a few cases reported in the literature. Herein, we report the case of a 71-year-old man with a 12-mm carcinoid tumor at the minor duodenal papilla with lymph node metastases. Multidetector-row computed tomography with contrast enhance...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hys185
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To clarify the association between pre-treatment total bilirubin (PTB) level and severe toxicity in patients receiving cisplatin and irinotecan. METHODS:We analyzed retrospectively the relationships of grade 4 neutropenia or grade 3-4 diarrhea and clinical variables including PTB and pre-treatment neutrophil...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hym033
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:The detection of prostate-specific antigen (PSA) molecular forms such as free PSA and PSA-ACT and the use of PSA molecular ratios, especially the percentage of free to total PSA, have been reported to improve the diagnostic accuracy of prostate cancer in the patients with slightly elevated serum PSA values. ...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/29.6.303
更新日期:1999-06-01 00:00:00