Publication of lung cancer clinical trials in the Japanese Clinical Trial Registry.


Introduction:Since June 2005, the University Hospital Medical Information Network-Clinical Trial Registry (UMIN-CTR) has been an International Committee of Medical Journal Editors (ICMJE)-approved clinical trial registry in Japan. The number of clinical trials registered in the UMIN-CTR has increased annually. To date, no report exists regarding the publishing of clinical trials registered in the UMIN-CTR. Therefore, we evaluated the publication frequency of clinical trials registered in the UMIN-CTR in Japan. Methods:We targeted trials that assessed the treatment effect of chemotherapy or molecular targeting drugs for lung cancer. We included trials registered between June 2005 and January 2010, and identified published trials through a computer-based search of MEDLINE and Google Scholar. The cumulative publication rate of the trials was calculated using Kaplan-Meier analysis. Results:In our study, 179 trials met the inclusion criteria. Of these, 46.4% (83/179) trials were published by the end of the cut-off period. With regard to publication, differences existed between the information recorded in the UMIN-CTR database and the actual searched results. The publication rate between groups was insignificantly different; however, whether a clinical study group did or did not conduct a trial differed significantly (53.3% vs. 36.1%; P = 0.024). Phase II studies with positive results were more likely to be published (84.4%); however, the overall publication rate was low (41.8%), which may reflect publication bias. Conclusions:The UMIN-CTR fundamentally functions as the unique ICMJE-approved clinical trial registry in Japan. However, it seems insufficient to require it as the official clinical database.


Jpn J Clin Oncol


Ochi N,Kawahara T,Nagasaki Y,Nakagawa N,Yamagishi T,Umemura S,Honda Y,Nakanishi H,Yamane H,Takigawa N




Has Abstract


2018-11-01 00:00:00














  • Dynamic computed tomography and color Doppler ultrasound of renal parenchymal neoplasms: correlations with histopathological findings.

    abstract:BACKGROUND:We evaluated whether color Doppler ultrasound (US) had diagnostic accuracy equal to dynamic computed tomography (CT) and whether performing dynamic CT and Doppler US together would be more informative in preoperative diagnosis of renal solid tumors. METHODS:A total of 110 renal solid tumors smaller than 7 c...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章


    authors: Kitamura H,Fujimoto H,Tobisu K,Mizuguchi Y,Maeda T,Matsuoka N,Komiyama M,Nakagawa T,Kakizoe T

    更新日期:2004-02-01 00:00:00

  • Expression of pyrimidine nucleoside phosphorylase (PyNPase) in colorectal cancer.

    abstract:BACKGROUND:We investigated the expression of PyNPase both in cancer cells and in stroma cells to clarify the correlation between PyNPase expression and the prognosis of patients with colorectal cancer. METHODS:Using immunohistochemical staining with an anti-PyNPase antibody, the PyNPase expression in tissues from 114 ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章


    authors: Osanai T,Ichikawa W,Takagi Y,Uetake H,Nihei Z,Sugihara K

    更新日期:2001-10-01 00:00:00

  • The first case of primary testicular germ cell tumor containing nephroblastoma as the only one non-germ cell component.

    abstract::Adult extrarenal nephroblastomas (Wilms' tumor) are extremely rare tumors. They show a higher incidence of non-seminomatous elements and these so-called 'teratoid' Wilms' tumors are suggested to be of germ cell origin. To date, however, the number of reported cases with gonadal teratoma containing nephroblastoma is ve...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章


    authors: Keskin S,Ekenel M,Başaran M,Aksu C,Kiliçaslan I,Tunç M,Bavbek S

    更新日期:2011-08-01 00:00:00

  • A Phase III study of oral steroid administration versus local steroid injection therapy for the prevention of esophageal stricture after endoscopic submucosal dissection (JCOG1217, Steroid EESD P3).

    abstract::A randomized Phase III trial commenced in Japan in September 2014. Endoscopic local steroid injection has been commonly used and considered acceptable as the current standard treatment for the prevention of esophageal stricture after endoscopic submucosal dissection for superficial esophageal cancer. The purpose of th...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Mizutani T,Tanaka M,Eba J,Mizusawa J,Fukuda H,Hanaoka N,Takeuchi M,Aoyama I,Kojima T,Takizawa K,Ono H,Muto M,Gastrointestinal Endoscopy Study Group of the Japan Clinical Oncology Group (JCOG).

    更新日期:2015-11-01 00:00:00

  • A case of adenocarcinoma of the lung which was successfully treated by chemotherapy with patient survival without recurrence for more than three years.

    abstract::A 63-year-old man was admitted to the National Cancer Center Hospital on December 20, 1983 for a close examination of the abnormal shadows found in chest roentgenograms. Chest radiographs showed a massive right pleural effusion, a large tumor in the right hilar region and swelling of the left hilar nodes. Transcutaneo...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章


    authors: Akiba T,Saijo N,Miyamoto K,Sakurai M,Tamura T,Sasaki Y,Eguchi K,Shinkai T,Uei Y,Fujiwara Y

    更新日期:1987-06-01 00:00:00

  • Giant cell tumor of bone: oncological and functional results of long-term follow-up.

    abstract:BACKGROUND:Giant cell tumor (GCT) of bone is a rare and unpredictable lesion. Its standard treatment has ranged from surgical curettage to wide resection and varying oncological and functional results have been reported. METHODS:A retrospective review of 47 patients (17 males and 30 females) with GCT of bone was perfo...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章


    authors: Oda Y,Miura H,Tsuneyoshi M,Iwamoto Y

    更新日期:1998-05-01 00:00:00

  • Head and neck cancer in Hong Kong.

    abstract::Head and neck cancer is a major cause of morbidity and mortality in Hong Kong. HNC is well-known for its heterogeneity in epidemiology, clinical behavior, clinic-pathological features and patient characteristics. Treatment strategies for this heterogeneous disease vary greatly in different parts of the world, dependin...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审


    authors: Ng WT,Wong ECY,Lee VHF,Chan JYW,Lee AWM

    更新日期:2018-01-01 00:00:00

  • Long-term follow-up of a randomized Phase II study of cisplatin/5-FU concurrent chemoradiotherapy for esophageal cancer (KROSG0101/JROSG021).

    abstract:OBJECTIVE:Long-term survival and late toxicities of a randomized Phase II study of chemoradiotherapy for esophageal cancer were analyzed. METHODS:Eligible patients were <75 years old and performance status 0-2, and had Stages II-IVA esophageal cancer. For arm A (short-term infusion), cisplatin 70 mg/m(2) Days 1 and 29...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,随机对照试验


    authors: Nishimura Y,Hiraoka M,Koike R,Nakamatsu K,Itasaka S,Kawamura M,Negoro Y,Araki N,Ishikawa H,Fujii T,Mitsuhashi N

    更新日期:2012-09-01 00:00:00

  • Recent innovations in the USA National Cancer Institute-sponsored investigator initiated Phase I and II anticancer drug development.

    abstract::Exciting recent advancements in deep-sequencing technology have enabled a rapid and cost-effective molecular characterization of patient-derived tumor samples. Incorporating these innovative diagnostic technologies into early clinical trials could significantly propel implementation of precision medicine by identifyin...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审


    authors: Bando H,Takebe N

    更新日期:2015-11-01 00:00:00

  • Sentinel node navigation surgery in cervical and endometrial cancer: a review.

    abstract::Pelvic lymphadenectomy is generally performed to treat early-stage cervical cancer, and pelvic ± para-aortic lymphadenectomy is performed in patients with endometrial cancer confined to the uterus. However, systematic lymphadenectomy is frequently associated with sequelae including lymphocele, lymphedema and celluliti...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审


    authors: Niikura H,Tsuji K,Tokunaga H,Shimada M,Ishikawa M,Yaegashi N

    更新日期:2019-06-01 00:00:00

  • Analysis of myelodysplastic syndrome clones arising after multiple myeloma: a case study by correlative interphase cytogenetic analysis.

    abstract:BACKGROUND:A patient with multiple myeloma developed myelodysplastic syndrome (MDS). Chromosomal analysis performed after the development of MDS revealed monosomy of chromosome 9 in all the meta-phases. We wished to identify the extent of the clone with the chromosomal abnormality originating from MDS clone. METHODS:A...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章


    authors: Kobayashi Y,Nakayama M,Uemura N,Takeyama K,Tobinai K,Takenaka T,Choi SH,Satoh H,Mori S,Asano S

    更新日期:1999-08-01 00:00:00

  • Cancer trends and incidences in Singapore.

    abstract::Cancer is the leading cause of mortality in Singapore. The age-standardized incidence rates continue to increase as the population grows and ages, and the influence of environmental and lifestyle choices bear their consequences. The increase is most marked in colorectal, breast and prostate cancers, mirroring the most...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章


    authors: Teo MC,Soo KC

    更新日期:2013-03-01 00:00:00

  • Leiomyosarcoma of the pancreas: report of a case diagnosed by fine needle aspiration biopsy.

    abstract::We present a case of pancreatic leiomyosarcoma with liver metastasis diagnosed by liver tumor biopsy. A 66-year-old man had a pancreatic tumor and hepatic tumors, which were hypoechoic and mixed echoic on ultrasonography, respectively. They were stained in enhanced computed tomography and angiography. A fine needle as...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章


    authors: Ishii H,Okada S,Okazaki N,Nose H,Yoshimori M,Aoki K,Tsuda H,Hirohashi S

    更新日期:1994-02-01 00:00:00

  • An individual patient data meta-analysis of adjuvant therapy with carmofur in patients with curatively resected colon cancer.

    abstract:BACKGROUND:Oral carmofur, either as a single or in combination with other chemotherapeutic agents, has been used as adjuvant chemotherapy for curatively resected colon cancer patients. Past trials and meta-analyses indicate that it is somewhat effective in extending survival of patients with this cancer. The objective ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,meta分析


    authors: Sakamoto J,Hamada C,Rahman M,Kodaira S,Ito K,Nakazato H,Ohashi Y,Yasutomi M

    更新日期:2005-09-01 00:00:00

  • Attitudes toward participating in Phase I clinical trials: an investigation with patient-family-physician triads.

    abstract:OBJECTIVE:Phase I oncology trials have raised concerns that patients' 'unrealistic' optimism could compromise the validity of informed consent, and that patients often participate in trials to conform to physicians' or family members' recommendations. We aimed to determine whether patients or families-given the same in...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章


    authors: Shin DW,Cho J,Kim SY,Yang HK,Cho B,Shin DB,Chun MS,Min YJ,Kim YW,Park JH

    更新日期:2016-12-01 00:00:00

  • Chemoradiotherapy for limited-disease small-cell lung cancer in elderly patients aged 75 years or older.

    abstract:BACKGROUND:As clinical trials for limited-disease small-cell lung cancer often exclude elderly patients due to comorbidities and a decline in organ function, the most suitable treatment for limited-disease small-cell lung cancer patients aged 75 years or older still remains unclear. METHODS:From July 2002 to June 2011...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章


    authors: Shukuya T,Takahashi T,Harada H,Ono A,Akamatsu H,Taira T,Kenmotsu H,Naito T,Murakami H,Endo M,Takahashi K,Yamamoto N

    更新日期:2013-02-01 00:00:00

  • Human papillomavirus genotype distribution in cervical intraepithelial neoplasia grade 2/3 and invasive cervical cancer in Japanese women.

    abstract:OBJECTIVE:Human papillomavirus vaccines are being introduced worldwide and are expected to reduce the incidence of cervical cancer. Here we report a cross-sectional study using a validated human papillomavirus genotyping method to reveal the human papillomavirus prevalence and genotype distribution in Japanese women wi...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章


    authors: Azuma Y,Kusumoto-Matsuo R,Takeuchi F,Uenoyama A,Kondo K,Tsunoda H,Nagasaka K,Kawana K,Morisada T,Iwata T,Aoki D,Kukimoto I

    更新日期:2014-10-01 00:00:00

  • A case of subglottic carcinoma effectively treated with intraluminal irradiation using low dose rate iridium-192 thin wires combined with external beam irradiation.

    abstract::Subglottic carcinoma is rare and has a poor prognosis. It is usually treated with surgical resection, external beam irradiation (EBR) and/or a combination of both. Intraluminal irradiation (IR) as a curative treatment for subglottic carcinoma has never been reported. We report a case of subglottic carcinoma in a 66-ye...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章


    authors: Wakisaka M,Fuwa N,Matsumoto A,Tachibana H,Kodaira T,Furutani K,Kamata M,Mori H

    更新日期:2003-02-01 00:00:00

  • Adequacy evaluation of the annual colonoscopic surveillance and individual difference of disease phenotypes in Lynch syndrome.

    abstract:BACKGROUND:Regular endoscopic surveillance for Lynch syndrome is reported to reduce colorectal cancer (CRC)-related mortality. However, the appropriate surveillance intervals are still unclear. We evaluated the adequacy of annual colonoscopy and investigated the differences in tumor occurrence rates between individual ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章


    authors: Taniguchi F,Tanakaya K,Sugano K,Akagi K,Ishida H,Nagahisa S,Nishimura S,Une Y,Kimura Y,Watanabe M,Utsumi M,Aoki H

    更新日期:2020-06-10 00:00:00

  • Successful unrelated cord blood transplantation in Philadelphia chromosome positive acute lymphoblastic leukemia during pulmonary aspergillosis treated by anti-fungal therapy, granulocyte colony-stimulating factor-mobilized granulocytes and surgical resec

    abstract::A 3-year-old girl with Philadelphia chromosome positive acute lymphoblastic leukemia developed pulmonary aspergillosis during severe neutropenia by re-induction therapy. She was treated by intravenous fluconazole, oral itraconazole with plasma level monitoring and surgical resection of the focus for 3 months after cli...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章


    authors: Kudoh T,Suzuki N,Hatakeyama N,Mizue N,Hori T,Oda T,Watanabe J,Imamura M,Chiba S

    更新日期:2001-06-01 00:00:00

  • Vessel-contouring-based pelvic radiotherapy in patients with uterine cervical cancer.

    abstract:OBJECTIVE:The aim of this study was to assess clinically the adequacy of vessel-contouring-based pelvic radiotherapy with regard to nodal coverage for uterine cervical cancer. METHODS:Fifty patients with Stages I-III cervical cancer, treated with vessel-contouring-based three-dimensional radiotherapy since August 2002...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章


    authors: Uno T,Isobe K,Ueno N,Kobayashi H,Sanayama Y,Mitsuhashi A,Shozu M,Ito H

    更新日期:2009-06-01 00:00:00

  • Troubles and hardships faced by psychologists in cancer care.

    abstract:OBJECTIVE:The aim of this study was to identify problems experienced by psychologists involved in cancer and palliative care and consider an education system for psychologists. METHODS:We conducted a questionnaire survey of psychologists involved in cancer care and palliative care. At the 403 facilities, 419 psycholog...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章


    authors: Iwamitsu Y,Oba A,Hirai K,Asai M,Murakami N,Matsubara M,Kizawa Y

    更新日期:2013-03-01 00:00:00

  • Successful use of dydrogesterone as maintenance therapy in recurrent endometrial stromal sarcoma: a case report.

    abstract::Endometrial stromal sarcoma is known to be a hormone-dependent tumor. Efficacy of hormonal therapy including high-dose progestins, aromatase inhibitors or gonadotropin-releasing hormone analogs has been reported. We report a case of recurrent endometrial stromal sarcoma, the tumor cells of which were strongly positive...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章


    authors: Akashi D,Todo Y,Shimada C,Okamoto K,Minobe S,Kato H

    更新日期:2013-11-01 00:00:00

  • Pure red cell aplasia associated with non-Hodgkin's lymphoma and hemolytic anemia.

    abstract::Pure red cell aplasia (PRCA) rarely occurs in non-thymic lymphoproliferative disorders. The present article describes a patient with non-Hodgkin's lymphoma (follicular, mixed type), who concurrently developed PRCA and warm type autoimmune hemolytic anemia during the clinical course. The PRCA and hemolytic anemia were ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章


    authors: Suzuki A,Takahashi T,Taniguchi A,Kotake C,Seo T,Toda T,Kobayashi K,Tsukamoto N,Fukumoto M

    更新日期:1991-10-01 00:00:00

  • Modified and bilateral retroperitoneal lymph node dissection for testicular cancer: peri- and postoperative complications and therapeutic outcome.

    abstract:OBJECTIVE:To characterize surgical invasiveness and morbidity and to verify therapeutic efficacy, we reviewed perioperative and postoperative courses and therapeutic outcomes of patients who underwent retroperitoneal lymph node dissection (RPLND) for testicular germ cell cancers. METHODS:The study included 31 patients...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章


    authors: Tanaka T,Kitamura H,Kunishima Y,Takahashi S,Takahashi A,Masumori N,Itoh N,Tsukamoto T

    更新日期:2006-06-01 00:00:00

  • A case of thymic cyst with elevated sialylated Lewis X-i, carbohydrate antigen 19-9 and tissue polypeptide antigen in the cystic fluid with no elevation of serum tumor markers.

    abstract::A 56-year-old man, tentatively diagnosed as having cardiomegaly, was found to have a large cyst in the left anterior mediastinum. At thoracotomy a multilocular cystic mass containing a colorless serous fluid was found and resected. Histologically, the cyst was lined with flattened epithelial cells, and thymic tissue w...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章


    authors: Sano T,Kuramochi S,Takahashi M,Asanuma F,Yamada Y,Uesato K,Toyoda H,Miyagawa T,Kurokawa T,Kawamura E

    更新日期:1991-10-01 00:00:00

  • Construction and validation of a simple scoring system for stage III colorectal cancer recurrence (SiS-SCORE). A case control study.

    abstract:BACKGROUND:Stage III colorectal cancer is an indication for adjuvant chemotherapy; however, there is no definite view on the selection of regimen. If the recurrence can be predicted, it can serve as the indicator of regimen selection. The present study aimed to predict the recurrence of stage III colorectal cancer by c...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章


    authors: Ishikawa S,Sawayama H,Matsuo A,Uchino R,Honda S,Hirota M,Baba H

    更新日期:2019-03-01 00:00:00

  • Brachytherapy for oral tongue cancer: an analysis of treatment results with various biological markers.

    abstract:OBJECTIVE:Low-dose-rate (LDR) brachytherapy is an effective treatment for tongue cancer. However, little is known about the biological mechanism underlying this therapy, characterized by delivery of continuous exposures of LDR irradiation. It is reported that lower microvessel density (MVD), lower Ki-67 index or higher...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章


    authors: Sakata K,Someya M,Nagakura H,Nakata K,Oouchi A,Takagi M,Hareyama M

    更新日期:2008-06-01 00:00:00

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    abstract::A histopathologic study was made on 1,095 thyroid specimens which had been removed surgically under various diagnoses at Seoul National University Hospital during the six-year period, 1976-1981. Among the 1,095 surgically removed thyroids, adenomatous goiter was the most common single disease, accounting for 43% of al...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章


    authors: Park SH,Suh EH,Chi JG

    更新日期:1988-12-01 00:00:00

  • Alcohol consumption and cancers of hormone-related organs in females.

    abstract::The relations between alcohol consumption and cancers of the breast, corpus uteri and ovary were investigated in a case-control study involving 1,740 cases of breast cancer, 239 cases of cancer of the corpus uteri, 417 cases of ovarian cancer and 8,920 controls with other cancer sites identified from the Aichi Cancer ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章


    authors: Kato I,Tominaga S,Terao C

    更新日期:1989-09-01 00:00:00