Abstract:
Introduction:Since June 2005, the University Hospital Medical Information Network-Clinical Trial Registry (UMIN-CTR) has been an International Committee of Medical Journal Editors (ICMJE)-approved clinical trial registry in Japan. The number of clinical trials registered in the UMIN-CTR has increased annually. To date, no report exists regarding the publishing of clinical trials registered in the UMIN-CTR. Therefore, we evaluated the publication frequency of clinical trials registered in the UMIN-CTR in Japan. Methods:We targeted trials that assessed the treatment effect of chemotherapy or molecular targeting drugs for lung cancer. We included trials registered between June 2005 and January 2010, and identified published trials through a computer-based search of MEDLINE and Google Scholar. The cumulative publication rate of the trials was calculated using Kaplan-Meier analysis. Results:In our study, 179 trials met the inclusion criteria. Of these, 46.4% (83/179) trials were published by the end of the cut-off period. With regard to publication, differences existed between the information recorded in the UMIN-CTR database and the actual searched results. The publication rate between groups was insignificantly different; however, whether a clinical study group did or did not conduct a trial differed significantly (53.3% vs. 36.1%; P = 0.024). Phase II studies with positive results were more likely to be published (84.4%); however, the overall publication rate was low (41.8%), which may reflect publication bias. Conclusions:The UMIN-CTR fundamentally functions as the unique ICMJE-approved clinical trial registry in Japan. However, it seems insufficient to require it as the official clinical database.
journal_name
Jpn J Clin Oncoljournal_title
Japanese journal of clinical oncologyauthors
Ochi N,Kawahara T,Nagasaki Y,Nakagawa N,Yamagishi T,Umemura S,Honda Y,Nakanishi H,Yamane H,Takigawa Ndoi
10.1093/jjco/hyy131subject
Has Abstractpub_date
2018-11-01 00:00:00pages
995-1000issue
11eissn
0368-2811issn
1465-3621pii
5102209journal_volume
48pub_type
杂志文章abstract:BACKGROUND:We evaluated whether color Doppler ultrasound (US) had diagnostic accuracy equal to dynamic computed tomography (CT) and whether performing dynamic CT and Doppler US together would be more informative in preoperative diagnosis of renal solid tumors. METHODS:A total of 110 renal solid tumors smaller than 7 c...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyh013
更新日期:2004-02-01 00:00:00
abstract:BACKGROUND:We investigated the expression of PyNPase both in cancer cells and in stroma cells to clarify the correlation between PyNPase expression and the prognosis of patients with colorectal cancer. METHODS:Using immunohistochemical staining with an anti-PyNPase antibody, the PyNPase expression in tissues from 114 ...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hye108
更新日期:2001-10-01 00:00:00
abstract::Adult extrarenal nephroblastomas (Wilms' tumor) are extremely rare tumors. They show a higher incidence of non-seminomatous elements and these so-called 'teratoid' Wilms' tumors are suggested to be of germ cell origin. To date, however, the number of reported cases with gonadal teratoma containing nephroblastoma is ve...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyr080
更新日期:2011-08-01 00:00:00
abstract::A randomized Phase III trial commenced in Japan in September 2014. Endoscopic local steroid injection has been commonly used and considered acceptable as the current standard treatment for the prevention of esophageal stricture after endoscopic submucosal dissection for superficial esophageal cancer. The purpose of th...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/jjco/hyv120
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abstract::A 63-year-old man was admitted to the National Cancer Center Hospital on December 20, 1983 for a close examination of the abnormal shadows found in chest roentgenograms. Chest radiographs showed a massive right pleural effusion, a large tumor in the right hilar region and swelling of the left hilar nodes. Transcutaneo...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1987-06-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/28.5.323
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abstract::Head and neck cancer is a major cause of morbidity and mortality in Hong Kong. HNC is well-known for its heterogeneity in epidemiology, clinical behavior, clinic-pathological features and patient characteristics. Treatment strategies for this heterogeneous disease vary greatly in different parts of the world, dependin...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
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abstract:OBJECTIVE:Long-term survival and late toxicities of a randomized Phase II study of chemoradiotherapy for esophageal cancer were analyzed. METHODS:Eligible patients were <75 years old and performance status 0-2, and had Stages II-IVA esophageal cancer. For arm A (short-term infusion), cisplatin 70 mg/m(2) Days 1 and 29...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,随机对照试验
doi:10.1093/jjco/hys112
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abstract::Exciting recent advancements in deep-sequencing technology have enabled a rapid and cost-effective molecular characterization of patient-derived tumor samples. Incorporating these innovative diagnostic technologies into early clinical trials could significantly propel implementation of precision medicine by identifyin...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
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abstract::Pelvic lymphadenectomy is generally performed to treat early-stage cervical cancer, and pelvic ± para-aortic lymphadenectomy is performed in patients with endometrial cancer confined to the uterus. However, systematic lymphadenectomy is frequently associated with sequelae including lymphocele, lymphedema and celluliti...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
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更新日期:2019-06-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/29.8.374
更新日期:1999-08-01 00:00:00
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
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doi:
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,meta分析
doi:10.1093/jjco/hyi147
更新日期:2005-09-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyw135
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journal_title:Japanese journal of clinical oncology
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doi:10.1093/jjco/hys197
更新日期:2013-02-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyu112
更新日期:2014-10-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
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更新日期:2003-02-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyaa006
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
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更新日期:2013-11-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
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journal_title:Japanese journal of clinical oncology
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更新日期:2019-03-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
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更新日期:2008-06-01 00:00:00
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
更新日期:1989-09-01 00:00:00