Concurrent chemoradiotherapy with protracted infusion of 5-FU and cisplatin for postoperative recurrent or residual esophageal cancer.

abstract：:Comprehensive genomic profiling using next-generation sequencing technologies provides insights into understanding the genomic architecture of human cancer. This new understanding of the cancer genome allows us to identify many more genomic alterations occurring within tumors than before, some of which could be potent...

journal_title：Japanese journal of clinical oncology

authors： Kou T,Kanai M,Matsumoto S,Okuno Y,Muto M

更新日期：2016-05-01 00:00:00

abstract：INTRODUCTION:Thymic epithelial tumors are a rare type of neoplasm. Accordingly, it is difficult to perform phase III trials in patients with thymic epithelial tumors, and thus, no standard treatment has been established for these tumors. In this study, we aimed to investigate the current status of thymic epithelial tum...

journal_title：Japanese journal of clinical oncology

authors： Kanemura H,Tamura T,Nishimura N,Kobayashi D,Higashi T

更新日期：2020-03-09 00:00:00

abstract：:A case of prostatic phyllodes tumor which developed in a 78-yr-old man is reported. Histologically, the tumor comprised myxomatous and cellular portions with a proliferation of atypical stromal cells. Multinucleated giant cells were occasionally present, but mitoses were rare. Fibroblastic differentiation of the tumor...

journal_title：Japanese journal of clinical oncology

authors： Ito H,Ito M,Mitsuhata N,Tahara E

更新日期：1989-09-01 00:00:00

abstract：OBJECTIVE:To clarify the association between pre-treatment total bilirubin (PTB) level and severe toxicity in patients receiving cisplatin and irinotecan. METHODS:We analyzed retrospectively the relationships of grade 4 neutropenia or grade 3-4 diarrhea and clinical variables including PTB and pre-treatment neutrophil...

journal_title：Japanese journal of clinical oncology

authors： Fujiwara Y,Sekine I,Ohe Y,Kunitoh H,Yamamoto N,Nokihara H,Simmyo Y,Fukui T,Yamada K,Tamura T

更新日期：2007-05-01 00:00:00

abstract：:A 56-year-old housewife was incidentally discovered to have an abnormal shadow in the right B6 area upon a chest X-ray film being taken. A transcutaneous lung biopsy of the mass revealed adenocarcinoma of the lung (WHO classification). A brain computed tomography (CT) scan demonstrated multiple brain metastasis. Follo...

journal_title：Japanese journal of clinical oncology

authors： Akiba T,Saijo N,Miyamoto K,Taguchi J,Taito H,Sakurai M,Tamura T,Sasaki Y,Eguchi K,Shinkai T

更新日期：1987-06-01 00:00:00

abstract：OBJECTIVE:We aimed to clarify the suitable surgical management around the paratracheal area of patients who undergo total pharyngolaryngectomy based on the pathological results of hypopharyngeal cancer. METHODS:The study was conducted under a multicenter, retrospective observational design in Japan. We analyzed histop...

journal_title：Japanese journal of clinical oncology

authors： Tomioka T,Beppu T,Fujii T,Ozawa T,Asakage T,Onitsuka T,Fujimoto Y,Matsuura K,Kawabata K,Hayashi R

更新日期：2019-05-01 00:00:00

abstract：Background:Shorter duration of infusion of monoclonal antibody treatments may reduce treatment burden and improve healthcare resource utilization. Methods:This phase II study recruited Japanese patients with previously untreated CD20+ B-cell non-Hodgkin lymphoma. Patients received intravenous obinutuzumab 1000 mg by r...

journal_title：Japanese journal of clinical oncology

authors： Ohmachi K,Ando K,Kinoshita T,Kumagai K,Hatake K,Ishikawa T,Teshima T,Kato K,Izutsu K,Ueda E,Nakai K,Kuriki H,Tobinai K

更新日期：2018-08-01 00:00:00

abstract：:New drug delivery systems for cis-diamminedichloroplatinum (CDDP) incorporated into vehicles, such as polymethylmethacrylate (PMMA), fibrin glue (F.G.), alpha-tricalciumphosphate (TCP) and ethylenevinyleacetate copolymer (Polymer) were examined using a rat osteosarcoma model. The materials containing CDDP were directl...

journal_title：Japanese journal of clinical oncology

authors： Miura S,Mii Y,Miyauchi Y,Ohgushi H,Morishita T,Hohnoki K,Aoki M,Tamai S,Konishi Y

更新日期：1995-06-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to specifically investigate the clinicopathological role of expression of vascular endothelial growth factor-C (VEGF-C) as well as the correlation with clinical outcomes in esophageal squamous cell carcinomas (ESCCs). METHODS:Seventy-three patients with ESCC resected in our inst...

journal_title：Japanese journal of clinical oncology

authors： Liu P,Chen W,Zhu H,Liu B,Song S,Shen W,Wang F,Tucker S,Zhong B,Wang D

更新日期：2009-10-01 00:00:00

abstract：Backgrounds:With the aim to validate the applicability of the eighth T classifications of AJCC/UICC staging system for nasopharyngeal carcinoma patients. Materials and methods:We compare the seventh and eighth T classifications of the UICC/AJCC staging system in 382 newly diagnosed nasopharyngeal carcinoma patients wi...

journal_title：Japanese journal of clinical oncology

authors： Li Y,Ou X,Hu C

更新日期：2018-10-01 00:00:00

abstract：:Inguinal lymph node metastasis from adenocarcinoma arising at a colostomy site is extremely rare, and the significance of surgical resection for metastatic inguinal lymph nodes has not been established. An 82-year-old woman who had undergone abdominoperineal resection 27 years earlier was admitted to our hospital comp...

journal_title：Japanese journal of clinical oncology

authors： Iwamoto M,Kawada K,Hida K,Hasegawa S,Sakai Y

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:Triplet antiemetic therapy with neurokinin 1 receptor blocker, 5-hydroxytryptamine receptor blocker and steroids is commonly used in patients who are highly emetic after chemotherapy. However, an alternative antiemetic therapy for patients who are resistant to triplet antiemetic therapy is not established. Ol...

journal_title：Japanese journal of clinical oncology

authors： Sato J,Kashiwaba M,Komatsu H,Ishida K,Nihei S,Kudo K

更新日期：2016-05-01 00:00:00

abstract：:The hematogenous metastases of colon cancer have primarily been explained by the cascade hypothesis based on the cadaveric study. However, we experienced several cases with isolated lung metastasis. The metastatic patterns of a total of 982 patients with colon cancer who underwent surgery were reviewed. The incidence ...

journal_title：Japanese journal of clinical oncology

authors： Sadahiro S,Suzuki T,Tanaka A,Okada K,Kamata H

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:A Phase I/II study of S-1 combined radiation therapy was conducted in patients with Stage II (T2N0) glottic cancer. The purpose of the Phase I study was to identify the maximum tolerated dose, the recommended dose and the dose limiting toxicity. The objectives in the phase II study were to estimate the local ...

journal_title：Japanese journal of clinical oncology

authors： Nakayama M,Hayakawa K,Okamoto M,Niibe Y,Ishiyama H,Kotani S

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:We investigated the expression of PyNPase both in cancer cells and in stroma cells to clarify the correlation between PyNPase expression and the prognosis of patients with colorectal cancer. METHODS:Using immunohistochemical staining with an anti-PyNPase antibody, the PyNPase expression in tissues from 114 ...

journal_title：Japanese journal of clinical oncology

authors： Osanai T,Ichikawa W,Takagi Y,Uetake H,Nihei Z,Sugihara K

更新日期：2001-10-01 00:00:00

abstract：:A case of advanced parotid cancer in which long-term control was achieved by superselective intra-arterial cisplatin infusion with concomitant radiotherapy is reported. A 63-year-old woman with parotid squamous cell carcinoma was referred to our hospital. Magnetic resonance images revealed extraparotid extension of th...

journal_title：Japanese journal of clinical oncology

authors： Kashiwagi N,Fujii T,Nishiyama K,Nakanishi K,Tomiyama N,Yagyu Y,Tsurusaki M,Kitano M,Murakami T

更新日期：2015-04-01 00:00:00

abstract：:The flexible bronchofiberscope developed by Ikeda et al. has brought about revolutionary changes in the diagnosis and treatment of lung cancer. Advances in this device are continuing to emerge and lesions even smaller than those visible to the naked eye can now be visualized. In addition, the use of ultrasound now ena...

journal_title：Japanese journal of clinical oncology

authors： Kaneko M

更新日期：2010-09-01 00:00:00

abstract：UNLABELLED:Kidney cancer accounts for approximately 2% of all cancers worldwide, with renal cell carcinoma being the most common form and this report is focused on renal cell carcinoma. Globally, the incidence and mortality rates are increasing by 2-3% per decade. Kidney cancer is less common in Asia compared with the ...

journal_title：Japanese journal of clinical oncology

authors： Naito S,Tomita Y,Rha SY,Uemura H,Oya M,Song HZ,Zhong LH,Wahid MI

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:Human papillomavirus vaccines are being introduced worldwide and are expected to reduce the incidence of cervical cancer. Here we report a cross-sectional study using a validated human papillomavirus genotyping method to reveal the human papillomavirus prevalence and genotype distribution in Japanese women wi...

journal_title：Japanese journal of clinical oncology

authors： Azuma Y,Kusumoto-Matsuo R,Takeuchi F,Uenoyama A,Kondo K,Tsunoda H,Nagasaka K,Kawana K,Morisada T,Iwata T,Aoki D,Kukimoto I

更新日期：2014-10-01 00:00:00

abstract：:We report a case of gefitinib-induced bilateral upper urinary tract bleeding in an 82-year-old woman administered the drug daily for advanced non-small cell adenocarcinoma of the lung (T4N3M0). Hematuria is an uncommon adverse effect of gefitinib, and in most cases, the bleeding site is unknown. On the 44th day of ora...

journal_title：Japanese journal of clinical oncology

authors： Mori H,Ohno Y,Ito F,Funaguchi N,Yanase K,Endo J,Nakano M,Bai La BL,Minatoguchi S

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:A patient with multiple myeloma developed myelodysplastic syndrome (MDS). Chromosomal analysis performed after the development of MDS revealed monosomy of chromosome 9 in all the meta-phases. We wished to identify the extent of the clone with the chromosomal abnormality originating from MDS clone. METHODS:A...

journal_title：Japanese journal of clinical oncology

authors： Kobayashi Y,Nakayama M,Uemura N,Takeyama K,Tobinai K,Takenaka T,Choi SH,Satoh H,Mori S,Asano S

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:The disease status of axillary lymph nodes at diagnosis is the most powerful predictor of prognosis for patients with breast cancer. Axillary lymph node dissection (ALND) has been the standard treatment. Recently, lymphatic mapping and sentinel lymph node biopsy (SNB) have been suggested as alternatives to A...

journal_title：Japanese journal of clinical oncology

authors： Koizumi M,Makita M,Yoshimoto M,Kasumi F,Sakamoto G,Ogata E

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVE:To describe changes in Japanese clinical trial regulations after the implementation of the Clinical Trials Act in April 2018. METHODS:First, how to apply multiple regulations after the enforcement of Clinical Trials Act was described. Second, the changes in the number of clinical trials in the National Cance...

journal_title：Japanese journal of clinical oncology

authors： Nakamura K,Shibata T

更新日期：2020-04-07 00:00:00

abstract：:Projecting cancer mortality is fundamental to the process of planning cancer control. Although the prefecture is one of the main units for the implementation and evaluation of cancer control in Japan, a long-term detailed future projection of cancer mortality has not been conducted by prefecture. The main objective of...

journal_title：Japanese journal of clinical oncology

authors： Fukui K,Ito Y,Nakayama T

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:The optimal treatment for elderly patients with limited-disease small cell lung cancer has not been defined. We therefore performed a Phase I study for split-dose cisplatin plus etoposide combined with early concurrent accelerated hyperfractionated thoracic radiotherapy in elderly (70 years of age or older) p...

journal_title：Japanese journal of clinical oncology

authors： Okamoto K,Okamoto I,Takeda M,Kobayashi S,Takeda K,Nakamatsu K,Nishimura Y,Nakagawa K

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Cytokeratins (CKs) 19 and 20 have been used as targets for detecting cancer cells. We attempted to detect circulating cancer cells in patients with gastric cancer using a high-sensitivity reverse transcriptase-polymerase chain reaction (RT-PCR) assay for CK transcripts. METHODS:RT-PCR for CK 19 and CK 20 wa...

journal_title：Japanese journal of clinical oncology

authors： Majima T,Ichikura T,Takayama E,Chochi K,Mochizuki H

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVES:Immune checkpoint inhibitors offer longer survival than chemotherapy in several clinical trials for advanced non-small cell lung cancer. In subset analyses of clinical trials, immune checkpoint inhibitors extended survival in patients aged ≥65 years, but the effects in patients aged ≥75 years are controversi...

journal_title：Japanese journal of clinical oncology

authors： Kubo T,Watanabe H,Ninomiya K,Kudo K,Minami D,Murakami E,Ochi N,Ninomiya T,Harada D,Yasugi M,Ichihara E,Ohashi K,Rai K,Fujiwara K,Hotta K,Tabata M,Maeda Y,Kiura K

更新日期：2020-12-16 00:00:00

abstract：BACKGROUND:Second primary head and neck cancers after endoscopic resection of esophageal squamous cell carcinoma adversely affect patients' outcomes and the quality of life; however, an adequate surveillance schedule remains unclear. METHODS:We analyzed 330 patients with early esophageal squamous cell carcinoma who un...

journal_title：Japanese journal of clinical oncology

authors： Shinozaki T,Katada C,Shiga K,Asakage T,Yokoyama T,Yano T,Oda I,Shimizu Y,Takemura K,Ishikawa H,Yokoyama A,Muto M

更新日期：2020-09-28 00:00:00

abstract：:Recent studies have suggested that glutathione S-transferase pi (GST-pi) may play a role in determining tumor sensitivities to cytotoxic drugs. In order to better understand the role of this enzyme in chemo- and/or radioresistance of lung cancer cells, we examined whether introduction of GST-pi cDNA into a chemo- and ...

journal_title：Japanese journal of clinical oncology

authors： Miyara H,Hida T,Nishida K,Takahashi T,Sugiura T,Ariyoshi Y,Morishita M,Takahashi T,Ueda R

更新日期：1996-02-01 00:00:00

abstract：:Castleman's disease is a rare disorder characterized by benign proliferation of lymphoid tissue. Most cases occur as a mediastinal mass, although extrathoracic involvement including nodal and extranodal locations has been reported. The left suprarenal location of this localized disease may be mistaken for an adrenal t...

journal_title：Japanese journal of clinical oncology

authors： Chen JH,Yu CY,Pai CY,Chan DC,Chen CJ,Yu JC,Liu YC

更新日期：2005-06-01 00:00:00