Surgical management around the paratracheal area of hypopharyngeal cancer.

Abstract:

OBJECTIVE:We aimed to clarify the suitable surgical management around the paratracheal area of patients who undergo total pharyngolaryngectomy based on the pathological results of hypopharyngeal cancer. METHODS:The study was conducted under a multicenter, retrospective observational design in Japan. We analyzed histopathological paratracheal lymph node metastasis and thyroid invasion, and recurrence around the paratracheal area for 184 patients who underwent initial surgery among 280 participants. RESULTS:There were significant differences in the frequency of metastasis to paratracheal lymph nodes as cN advances (P = 0.0344) and cT advances (P = 0.00028). By subsite, the paratracheal lymph node metastasis ratio was 22/130 patients (16.9%) in piriform sinus (PS), 8/32 (25.0%) in PW, 5/22 (22.7%) in PC and 10/17 (58.8%) in cervical esophagus (Ce+). The ratio of cases with bilateral paratracheal metastasis tended to be higher in cN2c, posterior wall (PW) and postcricoid (PC). Invasion to the thyroid was histopathologically confirmed in 16/184 patients (8.7%). Invasion from the primary lesion was in 15 patients. CONCLUSION:This study indicates that it is better for patients with advanced hypopharyngeal cancer at minimum undergo ipsilateral paratracheal lymph node dissection. Tumor subsite of PW, PC or cN2c disease or disease extending to the Ce+ should be treated with bilateral paratracheal neck dissection. In order to more reliably perform paratracheal dissection, there is also an option to resect the thyroid lobe in the range of dissection. Preservation of the thyroid gland can be considered if invasion into the thyroid gland has been clearly ruled out.

journal_name

Jpn J Clin Oncol

authors

Tomioka T,Beppu T,Fujii T,Ozawa T,Asakage T,Onitsuka T,Fujimoto Y,Matsuura K,Kawabata K,Hayashi R

doi

10.1093/jjco/hyz019

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

452-457

issue

5

eissn

0368-2811

issn

1465-3621

pii

5366307

journal_volume

49

pub_type

杂志文章,多中心研究
  • Late recurrence and second primary malignancy among 139 patients with germ cell tumors: long-term outcome of the disease in a single-center experience.

    abstract:OBJECTIVE:We retrospectively evaluated long-term oncological outcomes in patients with germ cell tumors (GCTs) primarily treated at our institution and assessed late recurrence and second primary malignancies. METHODS:This study included a total of 139 males with newly diagnosed GCTs of the testis or extragonadal orig...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyp142

    authors: Sato S,Tanaka T,Takahashi A,Sasai M,Kitamura H,Masumori N,Tsukamoto T

    更新日期:2010-02-01 00:00:00

  • A randomized phase II trial of preoperative exercise to reduce operative risk in gastric cancer patients with metabolic syndrome: adjuvant exercise for general elective surgery (AEGES) study group.

    abstract::This study is conducted to evaluate the efficacy and safety of preoperative exercise in patients with T1N0/T1N1/T2N0 gastric cancer and metabolic syndrome, which has emerged as a global health care issue. The primary endpoint is an incidence of perioperative complications and the secondary endpoints are weight change,...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/jjco/hym134

    authors: Cho H,Tsuburaya A,Sakamoto J,Morita S,Oba K,Yoshikawa T,Miyajima N,Adjuvant Exercise for General Elective Surgery (AEGES) Study Group.

    更新日期:2008-01-01 00:00:00

  • Early results of LH-RH agonist treatment with or without chlormadinone acetate for hormone therapy of naive localized or locally advanced prostate cancer: a prospective and randomized study. The Prostate Cancer Study Group.

    abstract:BACKGROUND:The majority of patients with localized and some cases of locally advanced prostate cancer undergo radical prostatectomy. However, radical prostatectomy cannot always be selected for those patients. In this situation, primary hormone therapy is an alternative treatment option. We have designed a prospective ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1093/jjco/hyd035

    authors: Akaza H,Homma Y,Okada K,Yokoyama M,Moriyama N,Usami M,Hirao Y,Tsushima T,Ohashi Y,Aso Y

    更新日期:2000-03-01 00:00:00

  • Trends and projections of cancer mortality in Osaka, Japan from 1977 to 2032.

    abstract::Projecting cancer mortality is fundamental to the process of planning cancer control. Although the prefecture is one of the main units for the implementation and evaluation of cancer control in Japan, a long-term detailed future projection of cancer mortality has not been conducted by prefecture. The main objective of...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyy204

    authors: Fukui K,Ito Y,Nakayama T

    更新日期:2019-04-01 00:00:00

  • Redevelopment of small cell lung cancer after a long disease-free period: a case report.

    abstract::Although it has been reported that the risk of second malignancies increases in long-term survivors of small cell lung cancer (SCLC) and late recurrence of SCLC is sometimes experienced, it seems uncommon. We recently experienced a case of redevelopment of SCLC after a long disease-free period. The case was considered...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyf008

    authors: Kitamoto Y,Hayakawa K,Mitsuhashi N,Tsuchiya S,Saito R

    更新日期:2002-01-01 00:00:00

  • Should ipsilateral solitary adrenal involvement in renal cell carcinoma be staged as M1?

    abstract:OBJECTIVE:In 2009, the TNM classification of malignant tumors was revised, and the renewal of the T2-4 stage in renal cell carcinoma was adopted. To date, however, the staging of ipsilateral solitary adrenal involvement in renal cell carcinoma has not been sufficiently evaluated. METHODS:We retrospectively reviewed th...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/jjco/hyr031

    authors: Takayama T,Sugiyama T,Kai F,Ito T,Furuse H,Mugiya S,Ozono S

    更新日期:2011-06-01 00:00:00

  • Cancer epidemiology and control in Taiwan: a brief review.

    abstract::Malignant neoplasm has become the leading cause of death in Taiwan since 1982. There has been a decreasing trend for cancers of the stomach and cervix uteri, while an increasing trend has been observed for cancers of the lung, liver, oral cavity, colon and rectum, breast and prostate. International comparison and migr...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/hye138

    authors: Chen CJ,You SL,Lin LH,Hsu WL,Yang YW

    更新日期:2002-03-01 00:00:00

  • Chemoradiotherapy for limited-disease small-cell lung cancer in elderly patients aged 75 years or older.

    abstract:BACKGROUND:As clinical trials for limited-disease small-cell lung cancer often exclude elderly patients due to comorbidities and a decline in organ function, the most suitable treatment for limited-disease small-cell lung cancer patients aged 75 years or older still remains unclear. METHODS:From July 2002 to June 2011...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hys197

    authors: Shukuya T,Takahashi T,Harada H,Ono A,Akamatsu H,Taira T,Kenmotsu H,Naito T,Murakami H,Endo M,Takahashi K,Yamamoto N

    更新日期:2013-02-01 00:00:00

  • Characteristics of lymph node metastases defining the outcome after radical cystectomy of urothelial bladder carcinoma.

    abstract:OBJECTIVE:The aim of this study was to identify clinicopathological variables associated with the clinical outcomes of patients with lymph node metastasis-positive urothelial bladder carcinoma after radical cystectomy. METHODS:Forty-six patients who underwent radical cystectomy without preoperative chemotherapy and ha...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hys136

    authors: Nakagawa T,Kanai Y,Nakanishi H,Komiyama M,Fujimoto H

    更新日期:2012-11-01 00:00:00

  • A competing-risks nomogram for predicting probability of death from CRC in Chinese Han patients with Stage I-III CRC.

    abstract:Background:Many patients with colorectal cancer are elderly with competing comorbidities. When constructing nomogram for assessing survival, we should consider the influence of competing risk. A competing-risks nomogram was developed to estimate the probability of death due to colorectal cancer for patients after curat...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyy136

    authors: Li J,Li X,Gu J,Ma X,Xue F

    更新日期:2018-12-01 00:00:00

  • The variation of cell type distribution in lung cancer: a study of 10,910 cases at a medical center in Taiwan between 1970 and 1993.

    abstract::The rise in the incidence of lung cancer has been associated with shifts in histologic distribution. A study was conducted to investigate changes in the cell type distribution in lung cancer in relation to age, sex, and smoking history, based on a retrospective analysis of 10,910 proven cases of lung cancer at the Vet...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.jjco.a023219

    authors: Perng DW,Perng RP,Kuo BI,Chiang SC

    更新日期:1996-08-01 00:00:00

  • Mucin-producing carcinoma of the thyroid gland--a case report and review of the literature.

    abstract::Mucin-producing carcinoma of the thyroid is rare and its histogenesis has been debated. The first case was reported by Diaz-Perez et al. (1976). We herein report the sixth case of mucin-producing carcinoma of the thyroid which was discovered in a 72-year-old Japanese woman. This patient was admitted with a 10-year his...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Harada T,Shimaoka K,Hiratsuka M,Hirokawa M,Tsukayama C

    更新日期:1984-09-01 00:00:00

  • Skull base malignant lymphoma: a case report and review of the literature.

    abstract::A case of primary malignant lymphoma of the skull base is reported. A 62-year-old man was admitted with headache and diplopia. Computed tomography and magnetic resonance imaging showed an abnormal mass in the right parasellar region. The final diagnosis after surgery was primary malignant lymphoma of the skull base. P...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:

    authors: Oyama H,Nagane M,Shibui S,Nomura K,Mukai K

    更新日期:1992-04-01 00:00:00

  • Latent prostatic carcinoma: pathological and epidemiological aspects.

    abstract::In conclusion, a review of the epidemiology and pathology of latent prostatic cancer suggests this tumor to be the probable initial phase of a biological continuum that ends with metastatic cancer. Histological grade and tumor volume are highly correlated, as are histological grade and mitotic index. It has also been ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:

    authors: Yatani R,Kusano I,Shiraishi T,Hayashi T,Stemmermann GN

    更新日期:1989-12-01 00:00:00

  • Morphometry of bladder cancer cells in tissue sections according to histological grade of malignancy.

    abstract::Morphometrical analysis was performed on cells of bladder carcinomas taken from patients who had undergone surgery at the National Cancer Center Hospital. Ten cases each of the following groups were compared as to the nuclear area, standard deviation of nuclear areas, cytoplasmic area, and nuclear/cytoplasmic ratio: n...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Hanai S,Kishi K,Watanabe S,Shimosato Y

    更新日期:1985-12-01 00:00:00

  • Comparison of radiotherapy infrastructure between Korea and Japan.

    abstract:BACKGROUND:Patterns of cancer incidence and radiotherapy use are similar in Korea and Japan, with differences in radiotherapy infrastructure. METHODS:The authors surveyed the megavoltage machines in 91 radiotherapy centers in Korea and published data in Japan. The number of megavoltage machines per center was used as ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyz124

    authors: Huh SJ,Nishimura T,Park W,Nakamura K

    更新日期:2019-12-18 00:00:00

  • Combination chemotherapy for a senile patient with adenoid cystic carcinoma of the esophagus: a case report.

    abstract::Adenoid cystic carcinoma of the esophagus with multiple liver metastases was found in a 77-year-old Japanese female in October, 1991. Combination chemotherapy, including etoposide (VP-16) and tegafur (FT) allowed the patient to survive for approximately a year after the onset of the initial symptoms. During her course...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Matsumoto M,Nomiyama T,Nakae J,Nishikawa H

    更新日期:1993-08-01 00:00:00

  • Re-analysis of the outcomes of post-remission therapy for acute myeloid leukemia with core binding factor according to years of patient enrollment.

    abstract:OBJECTIVE:The purpose of this study was to re-evaluate post-remission therapy outcomes after first remission according to years of patient enrollment in patients with core binding factor acute myeloid leukaemia. METHODS:We conducted a retrospective study on 138 patients aged less than 60 years diagnosed with core bind...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyq007

    authors: Shin HJ,Kim HJ,Sohn SK,Min YH,Won JH,Kim I,Yoon HJ,Lee JH,Jo DY,Joo YD,Jung CW,Lee KH,Korean Society of Hematology, AML\/MDS Working Party.,Chung JS,Ahn JS,Kim SJ,Lee JH,Choi SJ,Lee JH,Bae SH,Hong DS,Zang DY,K

    更新日期:2010-06-01 00:00:00

  • Cisplatin and etoposide chemotherapy combined with early concurrent twice-daily thoracic radiotherapy for limited-disease small cell lung cancer in elderly patients.

    abstract:OBJECTIVE:The optimal management of elderly patients with limited-disease small cell lung cancer (LD-SCLC) has not been established. METHODS:The records of elderly (>or=70 years of age) patients with LD-SCLC who had been treated with etoposide and cisplatin chemotherapy with early concurrent twice-daily thoracic radio...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyp137

    authors: Okamoto K,Okamoto I,Takezawa K,Tachibana I,Fukuoka M,Nishimura Y,Nakagawa K

    更新日期:2010-01-01 00:00:00

  • Primary osteogenic sarcoma with pulmonary metastasis: clinical results and prognostic factors in 91 patients.

    abstract:OBJECTIVE:Osteosarcoma is the most common primary malignant bone tumor. The long-term outcome is poor for patients with metastatic disease. METHODS:From June 1989 to January 2008, 202 patients (128 males and 74 females) with high-grade osteosarcoma of the extremities were treated at our institution. Patients were divi...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyp057

    authors: Wu PK,Chen WM,Chen CF,Lee OK,Haung CK,Chen TH

    更新日期:2009-08-01 00:00:00

  • Inflammatory pseudotumor of the spleen: a case report.

    abstract::We report on an inflammatory pseudotumor of the spleen. A 72-year-old woman visited our hospital complaining of nausea. Physical examination and laboratory investigations were unremarkable. Ultrasonography, computed tomography, magnetic resonance imaging and angiography showed a hypovascular splenic mass measuring abo...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyd048

    authors: Noguchi H,Kondo H,Kondo M,Shiraiwa M,Monobe Y

    更新日期:2000-04-01 00:00:00

  • Validation and suggestion of eighth T classifications of the UICC/AJCC staging system for nasopharyngeal carcinoma patients: a retrospective analysis.

    abstract:Backgrounds:With the aim to validate the applicability of the eighth T classifications of AJCC/UICC staging system for nasopharyngeal carcinoma patients. Materials and methods:We compare the seventh and eighth T classifications of the UICC/AJCC staging system in 382 newly diagnosed nasopharyngeal carcinoma patients wi...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyy109

    authors: Li Y,Ou X,Hu C

    更新日期:2018-10-01 00:00:00

  • Antitumor effect and survival benefit of chemotherapy for unresectable advanced gastric cancer.

    abstract::The "Criteria for Evaluating the Efficacy of Chemotherapy/Radiation Therapy in the Treatment of Gastric Cancer" are now widely used in Japan. To assess the validity of the criteria, the relation between the antitumor effect evaluated by the criteria and the survival of patients with gastric cancer was analyzed. The su...

    journal_title:Japanese journal of clinical oncology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Kiyohashi A,Kurihara M,Yoshida S,Ohkubo T,Suga S

    更新日期:1993-02-01 00:00:00

  • Immunohistochemical localization of acidic and basic fibroblast growth factors in human benign and malignant thyroid lesions.

    abstract::The localization of acidic fibroblast growth factor (aFGF) and basic fibroblast growth factor (bFGF) was investigated immunohistochemically in human benign and malignant thyroid lesions. Immunostaining for aFGF and bFGF displayed diffuse or granular deposits of the reaction products in the cytoplasm of neoplastic cell...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Kodama M,Daa T,Kashima K,Yokoyama S,Nakayama I,Noguchi S

    更新日期:1994-04-01 00:00:00

  • Cancer trends and incidences in Singapore.

    abstract::Cancer is the leading cause of mortality in Singapore. The age-standardized incidence rates continue to increase as the population grows and ages, and the influence of environmental and lifestyle choices bear their consequences. The increase is most marked in colorectal, breast and prostate cancers, mirroring the most...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hys230

    authors: Teo MC,Soo KC

    更新日期:2013-03-01 00:00:00

  • Retrospective cohort study on the safety and efficacy of bevacizumab with chemotherapy for metastatic colorectal cancer patients: the HGCSG0801 study.

    abstract:OBJECTIVE:After approval of bevacizumab in Japan, post-marketing surveillance studies reported on safety. However, few reports have shown the efficacy of bevacizumab as used in daily practice. We evaluated the efficacy and safety of bevacizumab for metastatic colorectal cancer patients in daily practice. METHODS:All u...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyr008

    authors: Sogabe S,Komatsu Y,Yuki S,Kusumi T,Hatanaka K,Nakamura M,Kato T,Miyagishima T,Hosokawa A,Iwanaga I,Sakata Y,Asaka M

    更新日期:2011-04-01 00:00:00

  • Serum total bilirubin as a predictive factor for severe neutropenia in lung cancer patients treated with cisplatin and irinotecan.

    abstract:OBJECTIVE:To clarify the association between pre-treatment total bilirubin (PTB) level and severe toxicity in patients receiving cisplatin and irinotecan. METHODS:We analyzed retrospectively the relationships of grade 4 neutropenia or grade 3-4 diarrhea and clinical variables including PTB and pre-treatment neutrophil...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hym033

    authors: Fujiwara Y,Sekine I,Ohe Y,Kunitoh H,Yamamoto N,Nokihara H,Simmyo Y,Fukui T,Yamada K,Tamura T

    更新日期:2007-05-01 00:00:00

  • Triple carcinomas in Cronkhite-Canada syndrome.

    abstract::The present report describes a 69-year-old man displaying the clinical features of the Cronkhite-Canada syndrome. After taking medicine for the common cold, he suffered hypogeusia and watery diarrhea, eruptions on the lower extremities and an 8 kg loss in body weight. All his finger and toenails began to fall out. He ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:

    authors: Kaneko Y,Kato H,Tachimori Y,Watanabe H,Ushio K,Yamaguchi H,Itabashi M,Noguchi M

    更新日期:1991-06-01 00:00:00

  • A preliminary experimental study of boron neutron capture therapy for malignant tumors spreading in thoracic cavity.

    abstract:BACKGROUND:The purpose of the present study is to verify the treatment effects of boron neutron capture therapy (BNCT) in ectopic tumors implanted in the thoracic cavity mimicking malignant pleural mesothelioma (MPM). METHODS:The tumor model was created by implanting murine squamous cell carcinoma cells into the thora...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hym022

    authors: Suzuki M,Sakurai Y,Masunaga S,Kinashi Y,Nagata K,Maruhashi A,Ono K

    更新日期:2007-04-01 00:00:00

  • Detection of microsatellite alterations in bronchial washings in squamous cell lung cancer: the first study from India.

    abstract:BACKGROUND:In recent times, the possibility of detecting lung cancer using microsatellite alterations (microsatellite instability and loss of heterozygosity) in DNA of bronchial washings has been explored. However, no data regarding the presence of microsatellite alterations in lung cancer are available from India, a c...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyh079

    authors: Malhotra P,Behera D,Srinivasan R,Majumdar S,Wali A,Mir S,Kaur R

    更新日期:2004-08-01 00:00:00