Abstract:
OBJECTIVE:We aimed to clarify the suitable surgical management around the paratracheal area of patients who undergo total pharyngolaryngectomy based on the pathological results of hypopharyngeal cancer. METHODS:The study was conducted under a multicenter, retrospective observational design in Japan. We analyzed histopathological paratracheal lymph node metastasis and thyroid invasion, and recurrence around the paratracheal area for 184 patients who underwent initial surgery among 280 participants. RESULTS:There were significant differences in the frequency of metastasis to paratracheal lymph nodes as cN advances (P = 0.0344) and cT advances (P = 0.00028). By subsite, the paratracheal lymph node metastasis ratio was 22/130 patients (16.9%) in piriform sinus (PS), 8/32 (25.0%) in PW, 5/22 (22.7%) in PC and 10/17 (58.8%) in cervical esophagus (Ce+). The ratio of cases with bilateral paratracheal metastasis tended to be higher in cN2c, posterior wall (PW) and postcricoid (PC). Invasion to the thyroid was histopathologically confirmed in 16/184 patients (8.7%). Invasion from the primary lesion was in 15 patients. CONCLUSION:This study indicates that it is better for patients with advanced hypopharyngeal cancer at minimum undergo ipsilateral paratracheal lymph node dissection. Tumor subsite of PW, PC or cN2c disease or disease extending to the Ce+ should be treated with bilateral paratracheal neck dissection. In order to more reliably perform paratracheal dissection, there is also an option to resect the thyroid lobe in the range of dissection. Preservation of the thyroid gland can be considered if invasion into the thyroid gland has been clearly ruled out.
journal_name
Jpn J Clin Oncoljournal_title
Japanese journal of clinical oncologyauthors
Tomioka T,Beppu T,Fujii T,Ozawa T,Asakage T,Onitsuka T,Fujimoto Y,Matsuura K,Kawabata K,Hayashi Rdoi
10.1093/jjco/hyz019subject
Has Abstractpub_date
2019-05-01 00:00:00pages
452-457issue
5eissn
0368-2811issn
1465-3621pii
5366307journal_volume
49pub_type
杂志文章,多中心研究abstract:OBJECTIVE:We retrospectively evaluated long-term oncological outcomes in patients with germ cell tumors (GCTs) primarily treated at our institution and assessed late recurrence and second primary malignancies. METHODS:This study included a total of 139 males with newly diagnosed GCTs of the testis or extragonadal orig...
journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:10.1093/jjco/hyp142
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abstract::This study is conducted to evaluate the efficacy and safety of preoperative exercise in patients with T1N0/T1N1/T2N0 gastric cancer and metabolic syndrome, which has emerged as a global health care issue. The primary endpoint is an incidence of perioperative complications and the secondary endpoints are weight change,...
journal_title:Japanese journal of clinical oncology
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abstract:BACKGROUND:The majority of patients with localized and some cases of locally advanced prostate cancer undergo radical prostatectomy. However, radical prostatectomy cannot always be selected for those patients. In this situation, primary hormone therapy is an alternative treatment option. We have designed a prospective ...
journal_title:Japanese journal of clinical oncology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1093/jjco/hyd035
更新日期:2000-03-01 00:00:00
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章
doi:
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
doi:
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
doi:
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abstract::Morphometrical analysis was performed on cells of bladder carcinomas taken from patients who had undergone surgery at the National Cancer Center Hospital. Ten cases each of the following groups were compared as to the nuclear area, standard deviation of nuclear areas, cytoplasmic area, and nuclear/cytoplasmic ratio: n...
journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
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pub_type: 杂志文章
doi:
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更新日期:2013-03-01 00:00:00
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更新日期:2011-04-01 00:00:00
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journal_title:Japanese journal of clinical oncology
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journal_title:Japanese journal of clinical oncology
pub_type: 杂志文章,评审
doi:
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更新日期:2007-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-08-01 00:00:00