A preliminary experimental study of boron neutron capture therapy for malignant tumors spreading in thoracic cavity.

Abstract:

BACKGROUND:The purpose of the present study is to verify the treatment effects of boron neutron capture therapy (BNCT) in ectopic tumors implanted in the thoracic cavity mimicking malignant pleural mesothelioma (MPM). METHODS:The tumor model was created by implanting murine squamous cell carcinoma cells into the thoracic cavity. Mice were sorted into four groups: group I for non-treatment; group II for neutron irradiation; group III for gamma-ray irradiation; and group IV for BNCT irradiation. The antitumor effect was evaluated on the basis of the change in survival time. To assess the effects of BNCT on normal lung, non-tumor bearing mice were treated using the same method as done to the tumor-burdened mice. RESULTS:The BNCT group had a longer survival time of 31 days (range 5 - 60), which was significantly longer than that of the non-treated control group (P = 0.011), but not significantly different from that of the neutron and gamma-ray groups (P = 0.067 and 0.094, respectively). In the BNCT and neutron groups, incidence of minimal lung fibrosis was significantly higher compared with the non-treated control group (P = 0.003 and 0.04, respectively). CONCLUSIONS:BNCT is a potentially promising treatment for malignant tumors spreading in the thoracic cavity such as MPM.

journal_name

Jpn J Clin Oncol

authors

Suzuki M,Sakurai Y,Masunaga S,Kinashi Y,Nagata K,Maruhashi A,Ono K

doi

10.1093/jjco/hym022

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

245-9

issue

4

eissn

0368-2811

issn

1465-3621

pii

hym022

journal_volume

37

pub_type

杂志文章
  • Multicenter questionnaire survey on patterns of care for elderly patients with esophageal squamous cell carcinoma by the Japan Esophageal Oncology Group.

    abstract:OBJECTIVE:There is little information about the patterns of care for elderly esophageal squamous cell carcinoma patients, and a standardized strategy has not been established. Therefore, we conducted a questionnaire survey about the patterns of care for these patients. METHODS:On September 2014, the questionnaires wer...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/jjco/hyv183

    authors: Hamamoto Y,Akutsu Y,Nagashima F,Hironaka S,Ito Y,Kato K,Hara H,Tsubosa Y,Nakagawa S,Daiko H,Ozawa S,Kitagawa Y

    更新日期:2016-02-01 00:00:00

  • Weekly hepatic arterial infusion of 5-fluorouracil and subsequent systemic chemotherapy for liver metastases from colorectal cancer.

    abstract:OBJECTIVE:To determine the antitumor activity and toxicity of weekly hepatic arterial infusion (HAI) of 5-fluorouracil (5-FU) for liver metastases from colorectal cancer. In addition, the present study also evaluated the efficacy of second-line chemotherapy after termination of HAI. METHODS:A retrospective study was d...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyg021

    authors: Hosokawa A,Yamada Y,Shimada Y,Muro K,Matsumura Y,Fujita S,Akasu T,Moriya Y,Shirao K

    更新日期:2003-03-01 00:00:00

  • Triple carcinomas in Cronkhite-Canada syndrome.

    abstract::The present report describes a 69-year-old man displaying the clinical features of the Cronkhite-Canada syndrome. After taking medicine for the common cold, he suffered hypogeusia and watery diarrhea, eruptions on the lower extremities and an 8 kg loss in body weight. All his finger and toenails began to fall out. He ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:

    authors: Kaneko Y,Kato H,Tachimori Y,Watanabe H,Ushio K,Yamaguchi H,Itabashi M,Noguchi M

    更新日期:1991-06-01 00:00:00

  • Clinicopathological outcomes of clinical T1a renal cell carcinoma by tumor size.

    abstract:OBJECTIVE:We performed a retrospective review of clinical T1a renal cell carcinoma patients treated in our institution. The clinicopathological findings and patients' prognoses were analyzed according to tumor size, and risk factors for tumor recurrence were elucidated. METHODS:A total of 140 cases of sporadic renal c...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyr007

    authors: Kitagawa Y,Nakashima K,Shima T,Izumi K,Narimoto K,Miwa S,Miyagi T,Maeda Y,Kadono Y,Konaka H,Mizokami A,Namiki M

    更新日期:2011-05-01 00:00:00

  • Repression of the expression of PPP3CC by ZEB1 confers activation of NF-κB and contributes to invasion and growth in glioma cells.

    abstract:Background:Gliomas are highly malignant brain tumors. Aberrant activation of NF-κB plays a crucial role in tumor progression. Method:ELISA assay was used to detect NF-κB activity in glimoas cells with different treatments. PPP3CC expression was evaluated by qRT-PCR and western blot assay. Kaplan-Meier analysis estimat...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyx182

    authors: Wang H,Zhao S,Chen B,Fu C,Dang Y,Fang P,Wang J,Wang N,Liu L

    更新日期:2018-02-01 00:00:00

  • Results of a qualitative and field study using the WHOQOL instrument for cancer patients.

    abstract::The main purpose of the study was to evaluate quality of life (QOL) among cancer patients using the WHOQOL-100 instrument and to see if any significant differences were seen in cancer stages, treatment status and prognosis. This study consisted of two parts; qualitative and quantitative. For the qualitative study, two...

    journal_title:Japanese journal of clinical oncology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1093/jjco/28.2.134

    authors: Tazaki M,Nakane Y,Endo T,Kakikawa F,Kano K,Kawano H,Kuriyama K,Kuroko K,Miyaoka E,Ohta H,Okamoto N,Shiratori S,Takamiya S,Tanemura K,Tsuchiya R

    更新日期:1998-02-01 00:00:00

  • Characteristics of genomic alterations in Chinese cholangiocarcinoma patients.

    abstract:OBJECTIVE:Cholangiocarcinoma (CCA) is a primary malignancy, which is often diagnosed as advanced and inoperable due to the lack of effective biomarkers and poor sensitivity of clinical diagnosis. Here, we aimed to identify the genomic profile of CCA and provided molecular evidence for further biomarker development. ME...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyaa088

    authors: Jiang G,Zhang W,Wang T,Ding S,Shi X,Zhang S,Shi W,Liu A,Zheng S

    更新日期:2020-09-28 00:00:00

  • Psychiatric disorders in patients who lost family members to cancer and asked for medical help: descriptive analysis of outpatient services for bereaved families at Japanese cancer center hospital.

    abstract:OBJECTIVE:There have been no previous studies about consultation of the bereaved who have lost a loved one to cancer and ask for medical help. The aim of this study was to investigate their basic characteristics and their psychiatric disorders. METHODS:A retrospective study using clinical and background data obtained ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyq213

    authors: Ishida M,Onishi H,Wada M,Tada Y,Ito H,Narabayashi M,Sasaki Y,Nomura S,Uchitomi Y

    更新日期:2011-03-01 00:00:00

  • A randomized phase III study comparing continuation and discontinuation of PD-1 pathway inhibitors for patients with advanced non-small-cell lung cancer (JCOG1701, SAVE study).

    abstract::The development of PD-1 pathway inhibitors has dramatically altered the treatment of advanced/recurrent non-small-cell lung cancer patients. However, the prognostic significance of their ongoing usage is controversial, especially for patients who have not progressed for a period of time. If discontinuation has no nega...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/jjco/hyaa054

    authors: Nomura S,Goto Y,Mizutani T,Kataoka T,Kawai S,Okuma Y,Murakami H,Tanaka K,Ohe Y

    更新日期:2020-07-09 00:00:00

  • A phase 2 study of abiraterone acetate in Japanese men with metastatic castration-resistant prostate cancer who had received docetaxel-based chemotherapy.

    abstract:OBJECTIVE:In this Phase 2 multicenter study the efficacy and safety of oral abiraterone acetate (1000 mg/once daily) plus prednisolone (5 mg/twice daily) was evaluated in metastatic castration-resistant prostate cancer patients from Japan who had previously received docetaxel-based chemotherapy. METHODS:Men (aged ≥20 ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/jjco/hyu148

    authors: Satoh T,Uemura H,Tanabe K,Nishiyama T,Terai A,Yokomizo A,Nakatani T,Imanaka K,Ozono S,Akaza H

    更新日期:2014-12-01 00:00:00

  • A case of lateral pelvic lymph node recurrence after TME for submucosal rectal carcinoma successfully treated by lymph node dissection with en bloc resection of the internal iliac vessels.

    abstract::In Japan, lateral lymph node dissection (LLND) is generally performed for the treatment of T3-4 lower rectal carcinoma, and not for T1 lower rectal carcinoma, because of a low positive rate in patients with T1 lesion. We experienced a rare case of lateral pelvic lymph node recurrence after total mesorectal resection f...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyn011

    authors: Hara J,Yamamoto S,Fujita S,Akasu T,Moriya Y

    更新日期:2008-04-01 00:00:00

  • A 12-mm carcinoid tumor of the minor duodenal papilla with lymph node metastases.

    abstract::Carcinoid tumors located in the minor duodenal papilla are extremely rare, with only a few cases reported in the literature. Herein, we report the case of a 71-year-old man with a 12-mm carcinoid tumor at the minor duodenal papilla with lymph node metastases. Multidetector-row computed tomography with contrast enhance...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hys185

    authors: Fukami Y,Kurumiya Y,Mizuno K,Sekoguchi E,Kobayashi S,Ito A,Tomida A,Onishi S,Shirotsuki R,Okubo K,Narita M

    更新日期:2013-01-01 00:00:00

  • Prediction of renal function after nephroureterectomy in patients with upper tract urothelial carcinoma.

    abstract:OBJECTIVE:The estimated glomerular filtration rate is significantly decreased after nephroureterectomy. Deteriorating renal function likely affects the eligibility for cisplatin-based chemotherapy in patients with upper tract urothelial carcinoma. The present study was undertaken to identify preoperative factors for th...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyv136

    authors: Hashimoto T,Ohno Y,Nakashima J,Gondo T,Nakagami Y,Namiki K,Horiguchi Y,Yoshioka K,Ohori M,Tachibana M

    更新日期:2015-11-01 00:00:00

  • Pure red cell aplasia associated with non-Hodgkin's lymphoma and hemolytic anemia.

    abstract::Pure red cell aplasia (PRCA) rarely occurs in non-thymic lymphoproliferative disorders. The present article describes a patient with non-Hodgkin's lymphoma (follicular, mixed type), who concurrently developed PRCA and warm type autoimmune hemolytic anemia during the clinical course. The PRCA and hemolytic anemia were ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Suzuki A,Takahashi T,Taniguchi A,Kotake C,Seo T,Toda T,Kobayashi K,Tsukamoto N,Fukumoto M

    更新日期:1991-10-01 00:00:00

  • Goserelin acetate with or without antiandrogen or estrogen in the treatment of patients with advanced prostate cancer: a multicenter, randomized, controlled trial in Japan. Zoladex Study Group.

    abstract:OBJECTIVE:The aims of this randomized, controlled study were to investigate the efficacy and safety of long-term monotherapy with the luteinizing hormone-releasing hormone agonist goserelin acetate compared with both short- and long-term combined androgen blockade. METHODS:Patients with advanced prostate cancer (n = 3...

    journal_title:Japanese journal of clinical oncology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1093/jjco/29.11.562

    authors: Kotake T,Usami M,Akaza H,Koiso K,Homma Y,Kawabe K,Aso Y,Orikasa S,Shimazaki J,Isaka S,Yoshida O,Hirao Y,Okajima E,Naito S,Kumazawa J,Kanetake H,Saito Y,Ohi Y,Ohashi Y

    更新日期:1999-11-01 00:00:00

  • A review of changes to and clinical implications of the eighth TNM classification of hepatobiliary and pancreatic cancers.

    abstract::Hepatobiliary and pancreatic cancers have poor outcomes. Clinical staging is useful for predicting survival and selecting treatment options. The 8th edition of tumor-node metastasis (TNM) was published in 2016 and came into effect from 2018. Regarding liver cancer (hepatocellular carcinoma), tumour size and vascular i...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/hyz150

    authors: Ueno M,Morizane C,Ikeda M,Okusaka T,Ishii H,Furuse J

    更新日期:2019-12-27 00:00:00

  • Regimen selection for first-line FOLFIRI and FOLFOX based on UGT1A1 genotype and physical background is feasible in Japanese patients with advanced colorectal cancer.

    abstract:OBJECTIVE:We examined the feasibility of regimen selection for first-line irinotecan, 5-fluorouracil and leucovorin or oxaliplatin, 5-fluorouracil and leucovorin in Japanese patients with advanced colorectal cancer based on UDP-glucuronosyltransferase 1A1 genotype as well as physical status of patients related to diarr...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyr010

    authors: Ishida H,Fujita K,Akiyama Y,Sunakawa Y,Yamashita K,Mizuno K,Miwa K,Kawara K,Ichikawa W,Ando Y,Saji S,Sasaki Y

    更新日期:2011-05-01 00:00:00

  • A case of thymic cyst with elevated sialylated Lewis X-i, carbohydrate antigen 19-9 and tissue polypeptide antigen in the cystic fluid with no elevation of serum tumor markers.

    abstract::A 56-year-old man, tentatively diagnosed as having cardiomegaly, was found to have a large cyst in the left anterior mediastinum. At thoracotomy a multilocular cystic mass containing a colorless serous fluid was found and resected. Histologically, the cyst was lined with flattened epithelial cells, and thymic tissue w...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Sano T,Kuramochi S,Takahashi M,Asanuma F,Yamada Y,Uesato K,Toyoda H,Miyagawa T,Kurokawa T,Kawamura E

    更新日期:1991-10-01 00:00:00

  • Antitumor effect and survival benefit of chemotherapy for unresectable advanced gastric cancer.

    abstract::The "Criteria for Evaluating the Efficacy of Chemotherapy/Radiation Therapy in the Treatment of Gastric Cancer" are now widely used in Japan. To assess the validity of the criteria, the relation between the antitumor effect evaluated by the criteria and the survival of patients with gastric cancer was analyzed. The su...

    journal_title:Japanese journal of clinical oncology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Kiyohashi A,Kurihara M,Yoshida S,Ohkubo T,Suga S

    更新日期:1993-02-01 00:00:00

  • Induced oxidative stress and decreased expression of inducible heat shock protein 70 (ihsp 70) in patients with colorectal adenocarcinomas.

    abstract:BACKGROUND:Colorectal cancer is one of the most common carcinomas observed in humans. Recently we have reported that increased oxidative stress is associated with human colorectal cancer. There are few and controversial studies on the clinical relevance of the expression of heat shock protein 70 (HSP 70), a member of t...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyi022

    authors: Ozdemirler Erata G,Kanbağli O,Durlanik O,Bulut T,Toker G,Uysal M

    更新日期:2005-02-01 00:00:00

  • Stereotactic body radiotherapy for bone metastases in patients with colorectal cancer.

    abstract:OBJECTIVE:To clarify the clinical outcomes of stereotactic body radiotherapy for colorectal cancer-derived bone metastases and identify factors predicting treatment failure. METHODS:Patients treated with stereotactic body radiotherapy for bone metastases from colorectal cancer between September 2013 and June 2019 were...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyaa128

    authors: Ito K,Yamaguchi T,Ogawa H,Nakajima Y,Karasawa K

    更新日期:2020-12-16 00:00:00

  • Disconnection of a venous Port-A-Cath followed by embolization after saline flush: rare case report.

    abstract::A 77-year-old man presented with painful swelling of his Port-A-Cath insertion site soon after flushing with normal saline. No discomfort or abnormality was found during the saline flush. A chest roentgenogram showed that the disconnected catheter had separated from the disc and was absent from its original location. ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/29.12.643

    authors: Lam AW,Chen YM,Yang KY,Tsai CM,Perng RP

    更新日期:1999-12-01 00:00:00

  • Successful unrelated cord blood transplantation in Philadelphia chromosome positive acute lymphoblastic leukemia during pulmonary aspergillosis treated by anti-fungal therapy, granulocyte colony-stimulating factor-mobilized granulocytes and surgical resec

    abstract::A 3-year-old girl with Philadelphia chromosome positive acute lymphoblastic leukemia developed pulmonary aspergillosis during severe neutropenia by re-induction therapy. She was treated by intravenous fluconazole, oral itraconazole with plasma level monitoring and surgical resection of the focus for 3 months after cli...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hye058

    authors: Kudoh T,Suzuki N,Hatakeyama N,Mizue N,Hori T,Oda T,Watanabe J,Imamura M,Chiba S

    更新日期:2001-06-01 00:00:00

  • Relationship between tumor-infiltrating T lymphocytes and clinical response after reduced-intensity allogeneic hematopoietic stem cell transplantation for advanced renal cell carcinoma: a single center prospective study.

    abstract:OBJECTIVE:Renal cell carcinoma (RCC) is refractory to conventional therapy, including chemotherapy and radiation. However, because RCC is sensitive to cytokine therapy, an immunotherapeutic approach such as hematopoietic stem cell transplantation (HSCT) might lead to a cure. We performed an institutional clinical study...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyp104

    authors: Ishiyama K,Takami A,Suzuki S,Konaka H,Namiki M,Ooi A,Nakao S

    更新日期:2009-12-01 00:00:00

  • Paroxysmal nocturnal hemoglobinuria: termination in acute monocytic leukemia and reappearance after chemotherapy with N4-palmitoyl-1-beta-D-arabinofuranosylcytosine (PL-AC) and vincristine.

    abstract::Acute monocytic leukemia developed in a 77-year-old woman about 18 months after a diagnosis of paroxysmal nocturnal hemoglobinuria (PNH) had been made. The classical features of PNH disappeared with the onset of the leukemia. Chemotherapy with N4-palmitoyl-1-beta-D-arabinosylcytosine and vincristine resulted in the di...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Kawano F,Chosa M,Matsuoka M,Oyamada N,Takatsuki K

    更新日期:1987-06-01 00:00:00

  • Cytoplasmic Trop-1/Ep-CAM overexpression is associated with a favorable outcome in node-positive breast cancer.

    abstract:OBJECTIVE:Trop-1/Ep-CAM modulates growth and survival of transformed cells, and it is highly expressed in most carcinomas including breast cancer. Only membranous staining is typically considered in evaluating Trop-1/epithelial cell adhesion molecule (Ep-CAM) expression in tumor cells. However, there is evidence of ret...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hys159

    authors: Alberti S,Ambrogi F,Boracchi P,Fornili M,Querzoli P,Pedriali M,La Sorda R,Lattanzio R,Tripaldi R,Piantelli M,Biganzoli E,Coradini D

    更新日期:2012-12-01 00:00:00

  • Adjuvant chemotherapy for gastric cancer in Japan: present status and suggestions for rational clinical trials.

    abstract::A review of the present status of adjuvant chemotherapy for gastric cancer in Japan has been made. The single use of mitomycin C (MMC) after curative gastrectomy, a multidrug combination of MMC, 5-fluorouracil (5FU) and cytosine arabinoside (CA) (MFC therapy), and a combination of inductive MFC followed by maintenance...

    journal_title:Japanese journal of clinical oncology

    pub_type: 临床试验,杂志文章,评审

    doi:

    authors: Nakajima T

    更新日期:1990-03-01 00:00:00

  • Concurrent chemoradiotherapy for squamous cell carcinoma of thoracic esophagus: feasibility and outcome of large regional field and high-dose external beam boost irradiation.

    abstract:OBJECTIVE:To assess the feasibility and outcome of concurrent chemoradiotherapy (CT-RT) with large regional field and high-dose external beam boost irradiation in thoracic esophageal cancer. METHODS:Patients with clinical stage T1 (submucosal)-4N0-1M0 (UICC 1997) squamous cell carcinoma of the thoracic esophagus were ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hye084

    authors: Toita T,Ogawa K,Adachi G,Kakinohana Y,Nishikuramori Y,Iraha S,Utsunomiya T,Murayama S

    更新日期:2001-08-01 00:00:00

  • Microsatellite instability associated with primary head and neck cancers and secondary esophageal cancers.

    abstract:BACKGROUND:It is common that patients with head and neck cancers have secondary malignant neoplasm of esophageal cancer. METHODS:To know the genetic background of the development of these secondary cancers, we performed microsatellite assay at six loci and immunohistochemical analysis on head and neck cancers of eight...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/28.12.733

    authors: Kiriu H,Yokozaki H,Yasui W,Ito K,Tahara E

    更新日期:1998-12-01 00:00:00

  • A histopathologic study on 1,095 surgically resected thyroid specimens.

    abstract::A histopathologic study was made on 1,095 thyroid specimens which had been removed surgically under various diagnoses at Seoul National University Hospital during the six-year period, 1976-1981. Among the 1,095 surgically removed thyroids, adenomatous goiter was the most common single disease, accounting for 43% of al...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Park SH,Suh EH,Chi JG

    更新日期:1988-12-01 00:00:00