A phase III trial to confirm modified S-1 adjuvant chemotherapy for pathological stage II/III vulnerable elderly gastric cancer patients who underwent gastric resection (JCOG1507, BIRDIE).

Abstract:

:Adjuvant chemotherapy with S-1 is a standard treatment for patients with stage II/III gastric cancer after D2 gastrectomy; however, this is not uniformly applicable in older patients. The Stomach Cancer Study Group of the Japan Clinical Oncology Group conducted a questionnaire survey on older patients aged ≥80 years and revealed wide heterogeneity among older patients of similar chronological age. This randomized trial aims to confirm the superiority of modified S-1 treatment (reduced initial dose of S-1 by ≥ 1 level compared with the standard dose) versus surgery alone in vulnerable older (≥80 years old) patients with pathological stage II/III gastric cancer after curative resection. A total of 370 patients will be enrolled from 62 institutions over 4.5 years. The primary endpoint of this study is overall survival. This trial has been registered in the UMIN Clinical Trials Registry with code UMIN000025742 [http://www.umin.ac.jp/ctr/index.htm].

journal_name

Jpn J Clin Oncol

authors

Mizutani T,Yamaguchi K,Mizusawa J,Ito S,Nishida Y,Yabusaki H,Boku N,Sano T,Yoshida K,Sasako M,Yoshikawa T,Terashima M,Stomach Cancer Study Group\/Japan Clinical Oncology Group.

doi

10.1093/jjco/hyy152

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

1101-1104

issue

12

eissn

0368-2811

issn

1465-3621

pii

5139695

journal_volume

48

pub_type

杂志文章
  • Effectiveness of rapid titration with intravenous administration of oxycodone injection in advanced cancer patients with severe pain.

    abstract::Some cancer patients suddenly develop severe, excruciating pain that requires rapid management using opioid medication. This study aimed to evaluate the effectiveness of rapid titration using oxycodone injection. Study subjects were advanced cancer patients who experienced severe pain (numeric rating scale ≥7) and nee...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyz145

    authors: Nakajima N

    更新日期:2019-12-18 00:00:00

  • The current clinical use of adjuvant analgesics for refractory cancer pain in Japan: a nationwide cross-sectional survey.

    abstract:BACKGROUND:Although adjuvant analgesics are used to treat opioid-refractory cancer pain, there is insufficient evidence to support this practice and limited data to guide the choice depending on cancer pain pathophysiology, dose titration and starting dose. This survey aimed to clarify the current use of adjuvant analg...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyaa147

    authors: Tagami K,Matsuoka H,Ariyoshi K,Oyamada S,Hiratsuka Y,Kizawa Y,Koyama A,Inoue A

    更新日期:2020-12-16 00:00:00

  • Distribution and clinical significance of circulating tumor cells in nasopharyngeal carcinoma.

    abstract:OBJECTIVE:Nasopharyngeal carcinoma is one of the leading malignancies with obscure etiology. Circulating tumor cells have been showed to intimately correlate with characteristics in different kinds of cancer. But links between circulating tumor cells and nasopharyngeal carcinoma were still lacking. Therefore, we explor...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyw046

    authors: Si Y,Lan G,Deng Z,Wang Y,Lu Y,Qin Y,Huang B,Yang Y,Weng J,Han X,Zhang B,Qin Y,Xiong W,Li B,Wu S

    更新日期:2016-07-01 00:00:00

  • Mucin-producing carcinoma of the thyroid gland--a case report and review of the literature.

    abstract::Mucin-producing carcinoma of the thyroid is rare and its histogenesis has been debated. The first case was reported by Diaz-Perez et al. (1976). We herein report the sixth case of mucin-producing carcinoma of the thyroid which was discovered in a 72-year-old Japanese woman. This patient was admitted with a 10-year his...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Harada T,Shimaoka K,Hiratsuka M,Hirokawa M,Tsukayama C

    更新日期:1984-09-01 00:00:00

  • Phyllodes tumor of the prostate: a case report.

    abstract::A case of prostatic phyllodes tumor which developed in a 78-yr-old man is reported. Histologically, the tumor comprised myxomatous and cellular portions with a proliferation of atypical stromal cells. Multinucleated giant cells were occasionally present, but mitoses were rare. Fibroblastic differentiation of the tumor...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:

    authors: Ito H,Ito M,Mitsuhata N,Tahara E

    更新日期:1989-09-01 00:00:00

  • Sentinel node navigation surgery in cervical and endometrial cancer: a review.

    abstract::Pelvic lymphadenectomy is generally performed to treat early-stage cervical cancer, and pelvic ± para-aortic lymphadenectomy is performed in patients with endometrial cancer confined to the uterus. However, systematic lymphadenectomy is frequently associated with sequelae including lymphocele, lymphedema and celluliti...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/hyz062

    authors: Niikura H,Tsuji K,Tokunaga H,Shimada M,Ishikawa M,Yaegashi N

    更新日期:2019-06-01 00:00:00

  • Clinical features and prognosis of a unilateral fibroadenoma of the breast in a 16-month-old female.

    abstract::Fibroadenoma of the breast is a common benign disease, occurring mainly in females younger than 30 years of age. Infant fibroadenoma is extremely rare. Here, we report on a 16-month-old female with a 6 month history of unilateral progressive breast enlargement. Upon clinical evaluation, a palpable mass was observed in...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyq181

    authors: Shi A,Li S,Xu N,Nie G,Li X,Zhang T,Fan Z

    更新日期:2011-02-01 00:00:00

  • Detecting circulating cancer cells using reverse transcriptase-polymerase chain reaction for cytokeratin mRNA in peripheral blood from patients with gastric cancer.

    abstract:BACKGROUND:Cytokeratins (CKs) 19 and 20 have been used as targets for detecting cancer cells. We attempted to detect circulating cancer cells in patients with gastric cancer using a high-sensitivity reverse transcriptase-polymerase chain reaction (RT-PCR) assay for CK transcripts. METHODS:RT-PCR for CK 19 and CK 20 wa...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyd130

    authors: Majima T,Ichikura T,Takayama E,Chochi K,Mochizuki H

    更新日期:2000-11-01 00:00:00

  • Family environment, hobbies and habits as psychosocial predictors of survival for surgically treated patients with breast cancer.

    abstract::Many psychosocial factors have been reported to influence the duration of survival of breast cancer patients. We have studied how family members, hobbies and habits of the patients may alter their psychosocial status. Female patients with surgically treated breast cancer diagnosed between 1986 and 1995 at the Tochigi ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/28.1.36

    authors: Tominaga K,Andow J,Koyama Y,Numao S,Kurokawa E,Ojima M,Nagai M

    更新日期:1998-01-01 00:00:00

  • Current therapeutic strategy for multiple myeloma.

    abstract::This is a review regarding the current therapeutic strategies in the management of multiple myeloma. Due to the introduction of several new effective therapeutic agents, multiple myeloma is one of the most active and changing fields in clinical oncology. Multiple myeloma is caused by the expansion of monoclonal plasma...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/hys215

    authors: Suzuki K

    更新日期:2013-02-01 00:00:00

  • Epidemiology and survival of hepatocellular carcinoma in Turkey: outcome of multicenter study.

    abstract:OBJECTIVE:Hepatocellular cancer (HCC) is one of the important health problems in Turkey. We aimed to determine the clinical and demographic features of HCC in the Turkish population and to evaluate the prognostic and survival features. METHOD:Two hundred and twenty-one patients with HCC from five hospitals in Turkey a...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/jjco/hyn082

    authors: Alacacioglu A,Somali I,Simsek I,Astarcioglu I,Ozkan M,Camci C,Alkis N,Karaoglu A,Tarhan O,Unek T,Yilmaz U

    更新日期:2008-10-01 00:00:00

  • Interleukin-11 receptor predicts post-operative clinical outcome in patients with early-stage clear-cell renal cell carcinoma.

    abstract:OBJECTIVE:To investigate the prognostic value of interleukin-11 receptor α chain in patients with early-stage clear-cell renal cell carcinoma. Interleukin-11 receptor α chain, a member of the gp130-dependent receptors, exerts pleiotropic oncogenic activities by promoting proliferation, angiogenesis and metastasis in ma...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyu194

    authors: Pan D,Xu L,Liu H,Zhang W,Zhu Y,Xu J,Gu J

    更新日期:2015-02-01 00:00:00

  • Leiomyosarcoma of the pancreas: report of a case diagnosed by fine needle aspiration biopsy.

    abstract::We present a case of pancreatic leiomyosarcoma with liver metastasis diagnosed by liver tumor biopsy. A 66-year-old man had a pancreatic tumor and hepatic tumors, which were hypoechoic and mixed echoic on ultrasonography, respectively. They were stained in enhanced computed tomography and angiography. A fine needle as...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Ishii H,Okada S,Okazaki N,Nose H,Yoshimori M,Aoki K,Tsuda H,Hirohashi S

    更新日期:1994-02-01 00:00:00

  • Patient with extensive small cell lung cancer given moderately dose-intensified chemotherapy and peripheral blood stem cell support.

    abstract::Although recent progress in multi-drug chemotherapy has increased the median survival of patients with extensive Small cell lung cancer (SCLC) to 7 months, 2-year survivors are still exceptional. We describe a 40-year-old man with extensive SCLC involving the lungs and systemic nodes who was initially treated with 6 c...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Shimizu E,Takaue Y,Yamamoto A,Ogura T,Sone S

    更新日期:1995-10-01 00:00:00

  • Prevalence and molecular characteristics of defective mismatch repair epithelial ovarian cancer in a Japanese hospital-based population.

    abstract:Background:The prevalence and molecular characteristics of defective mismatch repair epithelial ovarian cancers in the Japanese population have scarcely been investigated. Methods:Immunohistochemistry for mismatch repair proteins (MLH1, MSH2, MSH6 and PMS2) was performed in formalin-fixed paraffin-embedded sections pr...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyy081

    authors: Tajima Y,Eguchi H,Chika N,Nagai T,Dechamethakun S,Kumamoto K,Tachikawa T,Akagi K,Tamaru JI,Seki H,Okazaki Y,Ishida H

    更新日期:2018-08-01 00:00:00

  • An individual patient data meta-analysis of adjuvant therapy with carmofur in patients with curatively resected colon cancer.

    abstract:BACKGROUND:Oral carmofur, either as a single or in combination with other chemotherapeutic agents, has been used as adjuvant chemotherapy for curatively resected colon cancer patients. Past trials and meta-analyses indicate that it is somewhat effective in extending survival of patients with this cancer. The objective ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,meta分析

    doi:10.1093/jjco/hyi147

    authors: Sakamoto J,Hamada C,Rahman M,Kodaira S,Ito K,Nakazato H,Ohashi Y,Yasutomi M

    更新日期:2005-09-01 00:00:00

  • The variation of cell type distribution in lung cancer: a study of 10,910 cases at a medical center in Taiwan between 1970 and 1993.

    abstract::The rise in the incidence of lung cancer has been associated with shifts in histologic distribution. A study was conducted to investigate changes in the cell type distribution in lung cancer in relation to age, sex, and smoking history, based on a retrospective analysis of 10,910 proven cases of lung cancer at the Vet...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.jjco.a023219

    authors: Perng DW,Perng RP,Kuo BI,Chiang SC

    更新日期:1996-08-01 00:00:00

  • Cytoplasmic Trop-1/Ep-CAM overexpression is associated with a favorable outcome in node-positive breast cancer.

    abstract:OBJECTIVE:Trop-1/Ep-CAM modulates growth and survival of transformed cells, and it is highly expressed in most carcinomas including breast cancer. Only membranous staining is typically considered in evaluating Trop-1/epithelial cell adhesion molecule (Ep-CAM) expression in tumor cells. However, there is evidence of ret...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hys159

    authors: Alberti S,Ambrogi F,Boracchi P,Fornili M,Querzoli P,Pedriali M,La Sorda R,Lattanzio R,Tripaldi R,Piantelli M,Biganzoli E,Coradini D

    更新日期:2012-12-01 00:00:00

  • A computer-assisted model for predicting probability of dying within 7 days of hospice admission in patients with terminal cancer.

    abstract:OBJECTIVE:The aim of the present study is to compare the accuracy in using laboratory data or clinical factors, or both, in predicting probability of dying within 7 days of hospice admission in terminal cancer patients. METHODS:We conducted a prospective cohort study of 727 patients with terminal cancer. Three models ...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyp188

    authors: Chiang JK,Cheng YH,Koo M,Kao YH,Chen CY

    更新日期:2010-05-01 00:00:00

  • Giant cell tumor of bone: oncological and functional results of long-term follow-up.

    abstract:BACKGROUND:Giant cell tumor (GCT) of bone is a rare and unpredictable lesion. Its standard treatment has ranged from surgical curettage to wide resection and varying oncological and functional results have been reported. METHODS:A retrospective review of 47 patients (17 males and 30 females) with GCT of bone was perfo...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/28.5.323

    authors: Oda Y,Miura H,Tsuneyoshi M,Iwamoto Y

    更新日期:1998-05-01 00:00:00

  • Multicenter questionnaire survey on patterns of care for elderly patients with esophageal squamous cell carcinoma by the Japan Esophageal Oncology Group.

    abstract:OBJECTIVE:There is little information about the patterns of care for elderly esophageal squamous cell carcinoma patients, and a standardized strategy has not been established. Therefore, we conducted a questionnaire survey about the patterns of care for these patients. METHODS:On September 2014, the questionnaires wer...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/jjco/hyv183

    authors: Hamamoto Y,Akutsu Y,Nagashima F,Hironaka S,Ito Y,Kato K,Hara H,Tsubosa Y,Nakagawa S,Daiko H,Ozawa S,Kitagawa Y

    更新日期:2016-02-01 00:00:00

  • Retrospective cohort study on the safety and efficacy of bevacizumab with chemotherapy for metastatic colorectal cancer patients: the HGCSG0801 study.

    abstract:OBJECTIVE:After approval of bevacizumab in Japan, post-marketing surveillance studies reported on safety. However, few reports have shown the efficacy of bevacizumab as used in daily practice. We evaluated the efficacy and safety of bevacizumab for metastatic colorectal cancer patients in daily practice. METHODS:All u...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyr008

    authors: Sogabe S,Komatsu Y,Yuki S,Kusumi T,Hatanaka K,Nakamura M,Kato T,Miyagishima T,Hosokawa A,Iwanaga I,Sakata Y,Asaka M

    更新日期:2011-04-01 00:00:00

  • Psychotherapy for depression among patients with advanced cancer.

    abstract::Cancer causes profound suffering for patients, and previous reports have demonstrated that psychological distress, particularly depression, is frequently observed in advanced and/or terminally ill cancer patients. Such depression can lead to serious and far-reaching negative consequences in patients with advanced canc...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/hys152

    authors: Akechi T

    更新日期:2012-12-01 00:00:00

  • Alemtuzumab, fludarabine and melphalan as a conditioning therapy in severe aplastic anemia and hypoplastic myelodysplastic syndrome--single center experience.

    abstract:BACKGROUND:Allogeneic hematopoietic stem cell transplantation is the treatment of choice in young patients with severe aplastic anemia. The main causes of failure after this procedure are graft versus host disease, infections and graft failure, often exacerbated by large numbers of transfusions and prolonged disease du...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyi211

    authors: Rzepecki P,Sarosiek T,Szczylik C

    更新日期:2006-01-01 00:00:00

  • Reduced-intensity hematopoietic stem cell transplantation (RIST) for solid malignancies.

    abstract::Reduced intensity stem cell transplantation (RIST) is a new approach of stem cell transplantation, which has shown promising features as reported in multiple phase I and II studies. Elderly patients, who are not eligible for conventional myeloablative hematopoietic stem cell transplantation (HSCT), are now treatable w...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/hyh139

    authors: Kami M,Makimoto A,Heike Y,Takaue Y

    更新日期:2004-12-01 00:00:00

  • Pulmonary reaction to an aspirated balanced liquid diet in a cancer patient.

    abstract::A 60-year-old man with pharyngeal carcinoma developed spontaneous pneumothorax. A biopsied lung tissue revealed an extensive granulomatous reaction to some yellow material. Because of the patient's frequent aspirations of the liquid diet which was mixed with an artificial lemon flavor, it is considered that the aspira...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors: Yamashina M,Moatamed F

    更新日期:1987-12-01 00:00:00

  • Adenoid basal carcinoma of the uterine cervix: immunohistochemical study and literature review.

    abstract::Adenoid basal carcinoma of the uterine cervix is rare and its cell origin is still obscure. We report a case of adenoid basal carcinoma of the uterine cervix discovered incidentally in a 69-year-old woman who had been hysterectomized due to endometrial adenocarcinoma of the uterine corpus. Histologically, small round-...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1093/jjco/27.6.437

    authors: Senzaki H,Osaki T,Uemura Y,Kiyozuka Y,Ogura E,Okamura A,Tsubura A

    更新日期:1997-12-01 00:00:00

  • Statistical analyses of clinico-pathological, virological and epidemiological data on lymphoid malignancies with special reference to adult T-cell leukemia/lymphoma: a report of the second nationwide study of Japan. The T- and B-Cell Malignancy Study Grou

    abstract::In the present nationwide survey, 1,040 new cases of lymphoid malignancy, in most of which expression of cell surface markers had been determined, and 243 controls for a case-control study on adult T-cell leukemia/lymphoma (ATL) and other types of lymphoid malignancies were enrolled during the two years (1982-84) from...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:

    authors:

    更新日期:1985-09-01 00:00:00

  • Risk factors for para-aortic lymph node metastasis of gastric cancer from a randomized controlled trial of JCOG9501.

    abstract:BACKGROUND:No risk factor has been confirmed for para-aortic lymph node (PAN) metastasis from gastric cancer. To identify the risk factors and the most frequent route of metastasis to PAN, we analyzed the prospective data from a phase III trial. METHODS:In JCOG9501 comparing D2 and D2 + PAN dissection, 260 patients wi...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/jjco/hym067

    authors: Nomura E,Sasako M,Yamamoto S,Sano T,Tsujinaka T,Kinoshita T,Furukawa H,Shimizu T,Hiratsuka M,Kobayashi O,Kurokawa Y,Tanigawa N,Gastric Cancer Surgical Study Group of the Japan Clinical Oncology Group.

    更新日期:2007-06-01 00:00:00

  • Successful management by provocative angiography and endovascular stent of Ureteroarterial fistula in a patient with a long-term indwelling ureteral stent.

    abstract::We present the clinical course of a ureteroiliac arterial fistula in a patient who had been managed by ureteral stenting for 8 years for severe ureteral stricture after abdominoperineal resection with pelvic irradiation for advanced rectal cancer. A multidisciplinary team approach including provocative angiography and...

    journal_title:Japanese journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1093/jjco/hyp154

    authors: Yamasaki K,Omori K,Takaoka E,Sekido N,Shigai M,Mori K,Minami M,Watanabe Y,Shimazui T,Akaza H

    更新日期:2010-03-01 00:00:00