Abstract：
:In frogs, each lobe of the midbrain optic tectum receives two spatially aligned maps of binocular visual space, one through each eye. The map from the contralateral eye is the product of direct retinal input to the tectum, while that from the ipsilateral eye is mediated by a commissural system of connections that relays binocular visual information from one tectal lobe to the other. In Xenopus laevis, dark-reared from early life, the visuotectal map through the ipsilateral eye exhibits significant signs of disorder indicating that the normal development of the underlying "intertectal" system involves experience-dependent processes. Here we investigate the potential of this system for recovery from such deprivation-induced disruption. Three groups of animals were first dark-reared from embryonic stages until 3 months, 12 months or 2 years after metamorphosis. These short-, medium- and long-term periods of visual deprivation are associated with a progressive disturbance of the intertectal system (Grant and Keating 1989b). The animals then experienced 12-18 months in a normal visual environment, before an electrophysiological mapping experiment was carried out to reveal the status of their intertectal system. Quantitative analyses of the visuotopic order in the ipsilateral visuotectal map and of its spatial alignment with the map derived from the contralateral eye revealed that these features were completely normal in all 3 experimental groups. It is concluded that defects present in the intertectal system of dark-reared Xenopus can be repaired by subsequent visual experience, and that the reparative capacity is not limited either by the animal's age or by the existing degree of prior disruption.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Keating MJ,Dawes EA,Grant Sdoi
10.1007/BF00229263keywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
121-8issue
1eissn
0014-4819issn
1432-1106journal_volume
90pub_type
杂志文章abstract：:1. Unit spikes of burst neurons were extracellularly recorded in the pontomedullary reticular formation of the cat. These neurons were identified by their burst activity coincident with the quick inhibitory phase of the contralateral abducens nerve during vestibular nystagmus and their antidromic activation from the c...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235558
更新日期：1978-11-15 00:00:00
abstract：:The aim of the study was to investigate grip-load force regulation in Huntington's disease (HD) patients as compared to control subjects during the performance of a manipulative task that required rhythmical unimanual or bimanual isodirectional/non-isodirectional actions in the sagittal plane. Results showed that the ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-001-0992-6
更新日期：2002-04-01 00:00:00
abstract：:The purpose of the study was to determine the contributions of endpoint variance and trajectory variability to the endpoint accuracy of goal-directed isometric contractions when the target force and contraction speed were varied. Thirteen young adults (25 +/- 6 years) performed blocks of 15 trials at each of 2 contrac...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-2126-5
更新日期：2010-04-01 00:00:00
abstract：:To investigate whether the sensory perception could be a more direct assessment of sensory deficit as oppose to the postural performance, we examined the effect of reduced cutaneous cues on motion perception and motion control. The subject was translated in a mediolateral direction with a single sinusoidal acceleratio...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-1796-3
更新日期：2009-05-01 00:00:00
abstract：:Transparency is perceived when two or more objects or surfaces can be separated by the visual system whilst they are presented in the same region of the visual field at the same time. This segmentation of distinct entities on the basis of overlapping local visual cues poses an interesting challenge for the understandi...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3631-0
更新日期：2013-09-01 00:00:00
abstract：:Adrenocortical responses, as expressed by changes in plasma corticosterone levels, following ether stress and dorsal hippocampal stimulation, were studied in intact rats and in rats with complete, anterior of posterior hypothalamic deafferentations. Ether stress produced normal responses in all experimental groups. In...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237345
更新日期：1981-01-01 00:00:00
abstract：:In the frog's isolated head preparations, spontaneous activity was recorded from the whole nerve of the left horizontal semicircular canal (HC) for 6 min before and 16 min after destruction of the right labyrinth by heating or administration of d-tubocurarine (0.5 microliter, 5.10(-6)M) into the perilymph of the right...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235790
更新日期：1982-01-01 00:00:00
abstract：:We investigated the contributions of lateral intracortical connections to the orientation tuning of area 17 cells using micro-iontophoresis of the inhibitory transmitter gamma-aminobutyric acid (GABA) to inactivate small cortical sites in the vicinity of a recorded cell. GABA was ejected from an array of micropipettes...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228003
更新日期：1990-01-01 00:00:00
abstract：:We investigated the effect of musical expertise on sensitivity to asynchrony for drumming point-light displays, which varied in their physical characteristics (Experiment 1) or in their degree of audiovisual congruency (Experiment 2). In Experiment 1, 21 repetitions of three tempos x three accents x nine audiovisual d...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-1817-2
更新日期：2009-09-01 00:00:00
abstract：:Here, we demonstrate a systematic shift in the perceived location of a tactile stimulus on the arm toward where the eye is looking. Participants reported the perceived position of touches presented between the elbow and the wrist while maintaining eye positions at various eccentricities. The perceived location of the ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-1884-4
更新日期：2009-09-01 00:00:00
abstract：:Responses of motoneurons supplying muscles of the forelimbs, hindlimbs, back, and neck to stimulation of the medial pontomedullary reticular formation were studied with intracellular recording in cerebellectomized cats under chloralose anesthesia. Stimulation of the midline or of a reticular region consisting of nucle...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00238464
更新日期：1979-06-01 00:00:00
abstract：:Past studies of the kinematics of human prehension have shown that varying object size affects the maximum opening of the hand, while varying object distance affects the kinematic profile of the reaching limb. These data contributed to the formulation of a theory that the reaching and grasping components of human preh...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231054
更新日期：1991-01-01 00:00:00
abstract：:In the present study the neurotoxic effects of a low dosage (0.5 mg/kg per day) of methylmercury (MeHg) on the developing nervous system were investigated. Pregnant rats were treated with MeHg from day 7 of pregnancy to day 7 of lactation. Locomotor activity (locomotion, rearing, and motility) and spatial learning abi...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050237
更新日期：1997-12-01 00:00:00
abstract：:Bradykinin is an endogenous nonapeptide known to induce pain and hyperalgesia to heat and mechanical stimulation. Correspondingly, it excites nociceptors in various tissues and sensitizes them to heat, whereas sensitizing effect on the mechanical response of nociceptors is not well established. Protein kinase C and TR...
journal_title：Experimental brain research
pub_type： 杂志文章,评审
doi：10.1007/s00221-009-1814-5
更新日期：2009-06-01 00:00:00
abstract：:The foot is a critical interface between the body and supporting surface during walking, but there is no coherent framework on which to model the dynamics of the stance and swing phases. To establish this framework, we studied the rotational and translational dynamics of foot movement in three dimensions with a motion...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0633-1
更新日期：2007-01-01 00:00:00
abstract：:Reflexive attentional shift in response to another individual's gaze direction has been reported, but it remains unknown whether this process can occur subliminally. We investigated this issue using facial stimuli consisting of drawings (Experiment 1) and photographs (Experiment 2). The gaze direction was expressed by...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-007-1025-x
更新日期：2007-10-01 00:00:00
abstract：:We had recumbent subjects (n = 7) indicate the amplitude of imposed, passive yaw-axis body rotations in the 0, 1, and 1.8 g background force levels generated during parabolic flight maneuvers. The blindfolded subject, restrained in a cradle, aligned a gravity-neutral pointer with the subjective vertical while in an in...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-1785-6
更新日期：2009-05-01 00:00:00
abstract：:It is known that kittens reared in ways that restrict movement while visual stimulation is received exhibit deficits in visually guided behavior. Presumably, the behavioral dysfunction is due to a lack of sensorimotor coordination during visual exposure. The current investigation was undertaken to study this effect bo...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00238794
更新日期：1978-09-15 00:00:00
abstract：:The primary objective of this study was to explore why preischemic hypoglycemia, which restricts tissue acidosis during the ischemic insult, does not ameliorate cell damage incurred as a result of transient ischemia. The question arose whether hypoglycemia (plasma glucose concentration 2-3 mM) delays resumption of ext...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00233036
更新日期：1995-01-01 00:00:00
abstract：:When two hands require different information in bimanual asymmetric movements, interference can occur via callosal connections and ipsilateral corticospinal pathways. This interference could potentially work as a cost-effective measure in symmetric movements, allowing the same information to be commonly available to b...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-010-2244-0
更新日期：2010-06-01 00:00:00
abstract：:In two monkeys, we measured the initial vergence eye movements elicited by sudden forward motion on a linear sled. Animals faced a tangent screen and experienced the translation while in darkness, fixating a small, centered spot, or viewing a large-field pattern. Forward movements elicited convergent responses that we...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-002-1351-y
更新日期：2003-02-01 00:00:00
abstract：:Postsynaptic potentials (PSPs) evoked in motoneurons innervating the back and abdominal muscles in the lumbar part of the body by stimulating hindlimb cutaneous afferents were investigated in unanesthetized decerebate and spinal cats. Various types of PSP: pure excitatory postsynaptic potential (EPSP), pure inhibitory...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050879
更新日期：1999-10-01 00:00:00
abstract：:Single neurons were recorded from the superficial layers of the superior colliculus of immobilized monkeys (Macaca mulatta and Macaca irus). Two main functional types of neurons were found. The neurons of the first type (Type I neurons) responded well to simple stationary and moving stimuli such as spots, bars or slit...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237928
更新日期：1980-01-01 00:00:00
abstract：:Humans are known to show anticipatory adjustments in the grip force prior to a self-generated or predictable action or perturbation applied to a hand-held object. We investigated whether humans can also adjust covariation of individual finger forces (multi-finger synergies) prior to self-triggered perturbations. To ad...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0583-7
更新日期：2006-11-01 00:00:00
abstract：:The extent to which attending to one stimulus while ignoring another influences the integration of visual and inertial (vestibular, somatosensory, proprioceptive) stimuli is currently unknown. It is also unclear how cue integration is affected by an awareness of cue conflicts. We investigated these questions using a t...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-1767-8
更新日期：2009-09-01 00:00:00
abstract：:Explant cultures of rat spinal cord, brain stem and cerebellum were used to visualize GABAA-receptors by means of immunohistochemistry. For these studies we have incubated the cultures with the monoclonal antibody bd 17 against the beta-subunit of the GABAA/benzodiazepine/chloride channel complex. In spinal cord cultu...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228810
更新日期：1990-01-01 00:00:00
abstract：:Motoneurones innervating the retractor bulbi muscle in the cat have been identified by retrograde labelling with horseradish peroxidase, by intracellular recording and by intracellular staining with horseradish peroxidase. Their somata are found in an accessory abducens nucleus, analogous to that described in some oth...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00239148
更新日期：1979-02-15 00:00:00
abstract：:Prism adaptation (PA) is a promising rehabilitation technique for visuo-spatial neglect, an attention disorder that is characterized by spatial attention deficits (i.e., deficits in orienting). PA involves visuo-motor adaptation to rightward shifting prism goggles. Following goggle removal, this adaptation results in ...
journal_title：Experimental brain research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00221-015-4218-8
更新日期：2015-05-01 00:00:00
abstract：:Transcranial magnetic stimulation (TMS) applied over the occipital lobe approximately 100 ms after the onset of a stimulus decreases its visibility if it appears in the location of the phosphene. Because phosphenes can also be elicited by stimulation of the parietal regions, we asked if the same procedure that is used...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-014-3888-y
更新日期：2014-06-01 00:00:00
abstract：:The distribution of the calcium-binding proteins calbindin D-28K and parvalbumin was examined in newborn and adult superior colliculus of cat and rhesus monkey using immunohistochemical techniques. In adult animals of both species, calbindin-immunoreactive neurons had a three-tiered arrangement: one band was present i...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-001-0908-5
更新日期：2001-12-01 00:00:00
