当前位置： SCI文献检索 > EXPERIMENTAL BRAIN RESEARCH期刊下所有文献 > The influence of insulin-induced hypoglycemia on the calcium transients accompanying reversible forebrain ischemia in the rat.

The influence of insulin-induced hypoglycemia on the calcium transients accompanying reversible forebrain ischemia in the rat.

Abstract：

:The primary objective of this study was to explore why preischemic hypoglycemia, which restricts tissue acidosis during the ischemic insult, does not ameliorate cell damage incurred as a result of transient ischemia. The question arose whether hypoglycemia (plasma glucose concentration 2-3 mM) delays resumption of extrusion of Ca2+ from cells during recirculation. Measurements of extracellular Ca2+ concentration during forebrain ischemia of 15 min duration proved that this was the case. Thus, normoglycemic animals resumed Ca2+ extrusion upon recirculation after a delay of 1.5-2.0 min, and hypoglycemic ones after an additional delay which could amount to 3-4 min. We attempted to explore the cause of this delay. At first sight, the results suggested that resumption of oxidative phosphorylation upon recirculation was substrate limited. However, glucose infusion during ischemia or just after recirculation failed to accelerate Ca2+ extrusion from the cells. A comparison between non-injected and insulin-injected animals at equal plasma glucose concentrations suggested that insulin was responsible for the delay. On analysis, the delay proved to be related to a sluggish recovery of cerebral blood flow. The results suggest that when cell damage is evaluated after transient ischemia in hypo- and normoglycemic subjects, attention should be directed to the period of cell calcium 'overload'. Unobserved differences in the duration of the calcium transient may also confound interpretation of data on the effects of insulin.

journal_name

Exp Brain Res

journal_title

Experimental brain research

authors

Li PA,Kristián T,Katsura K,Shamloo M,Siesjö BK

doi

10.1007/BF00233036

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

363-9

issue

3

eissn

0014-4819

issn

1432-1106

journal_volume

105

pub_type

杂志文章

相关文献

EXPERIMENTAL BRAIN RESEARCH文献大全
  • Control of oculomotor reflexes: independent effects of strategic and automatic preparation.

    abstract：:The reduction in saccade latency when the fixation point is removed (fixation offset effect-FOE) reflects the degree to which fixation neurons are under influence by a stimulus at fixation. Strategic manipulations of oculomotor readiness that bring these neurons under endogenous control reduce the magnitude of the FOE...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/s00221-008-1655-7

    authors： Van Koningsbruggen MG,Rafal RD

    更新日期：2009-02-01 00:00:00

  • Visuomotor memory is independent of conscious awareness of target features.

    abstract：:A recent study by our group showed that the scaling of reach trajectories to target size is independent of conscious visual awareness of that intrinsic target property (Binsted et al. in Proc Natl Acad Sci USA 104:12669-12672, 2007). The present investigation sought to extend previous work and determine whether uncons...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/s00221-008-1385-x

    authors： Heath M,Neely KA,Yakimishyn J,Binsted G

    更新日期：2008-07-01 00:00:00

  • Organization of the upper limb movement for piano key-depression differs between expert pianists and novice players.

    abstract：:The present study investigated the expert-novice difference in the organization of upper-limb movement for the key-depression on the piano. Kinematic and electromyographic recordings were made while experts (N = 7) and novices (N = 7) of classical-piano players performed a right hand octave keystroke to produce four d...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/s00221-007-1184-9

    authors： Furuya S,Kinoshita H

    更新日期：2008-03-01 00:00:00

  • Substituting auditory for visual feedback to adapt to altered dynamic and kinematic environments during reaching.

    abstract：:The arm movement control system often relies on visual feedback to drive motor adaptation and to help specify desired trajectories. Here we studied whether kinematic errors that were indicated with auditory feedback could be used to control reaching in a way comparable with when vision was available. We randomized twe...

    journal_title：Experimental brain research

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00221-012-3144-2

    authors： Oscari F,Secoli R,Avanzini F,Rosati G,Reinkensmeyer DJ

    更新日期：2012-08-01 00:00:00

  • Effects of lingual nerve afferents on swallowing in sheep.

    abstract：:We investigated in sheep the effects of stimulation of the thick afferent fibers running through the lingual nerve (LN) upon the activity of some of the muscles and medullary interneurons or motoneurons which are active during swallowing. Using electromyography (EMG), and extra- and intracellular neuronal recording, w...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/s002210000361

    authors： Zoungrana OR,Lamkadem M,Amri M,Car A,Roman C

    更新日期：2000-06-01 00:00:00

  • Cognitive spatial-motor processes. 4. Specification of the direction of visually guided isometric forces in two-dimensional space: information transmitted and effects of visual force-feedback.

    abstract：:The information transmitted (Ti) by the direction of two-dimensional (2-D) isometric forces at different stereoscopic depths was studied in 50 naive human subjects using an isometric manipulandum and random dot stereograms generated in a color display (Massey et al. 1988). Subjects viewed the display through appropria...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/BF00231170

    authors： Massey JT,Drake RA,Lurito JT,Georgopoulos AP

    更新日期：1991-01-01 00:00:00

  • Excitability of reciprocal and recurrent inhibitory pathways after voluntary muscle relaxation in man.

    abstract：:We studied the potential contribution of postsynaptic mechanisms to the depression of reflex excitability which occurs immediately after a voluntary release from tonic muscle contraction. The excitability of the Soleus (Sol) motor pool was tested at rest and after voluntary muscle relaxation. In both cases the Sol H-r...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/BF00230904

    authors： Schieppati M,Crenna P

    更新日期：1985-01-01 00:00:00

  • Reinnervation of dopamine neurons by regenerating serotonin axons in the rat medial zona incerta. A combined radioautographic and immunocytochemical ultrastructural study.

    abstract：:Cellular relationships between serotonin (5-HT) axons and tyrosine hydroxylase (TH)-containing neurons were examined by combined (3H)5-HT uptake radioautography and TH immunocytochemistry in the medial zona incerta (ZI) of adult rats, 7 and 50 days after an intracerebral injection of 5,7-Dihydroxytryptamine (5,7-DHT)....

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/BF00250592

    authors： Frankfurt M,Beaudet A

    更新日期：1988-01-01 00:00:00

  • Perception of finger forces within the hand after index finger fatiguing exercise.

    abstract：:The effect of fatigue on finger force perception within a hand during ipsilateral finger force matching was examined. Thirteen subjects were instructed to match a reference force of an instructed finger using the same or different finger within the hand before and after index finger fatigue. Absolute reference force t...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/s00221-007-0978-0

    authors： Park WH,Leonard CT,Li S

    更新日期：2007-09-01 00:00:00

  • An object-centred reference frame for control of grasping: effects of grasping a distractor object on visuomotor control.

    abstract：:Previous evidence based on perceptual integration and arbitrary responses suggests extensive cross-modal links in attention across the various modalities. Attention typically shifts to a common location across the modalities, despite the vast differences in their initial coding of space. An issue that remains unclear ...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/s00221-005-0240-6

    authors： Patchay S,Haggard P,Castiello U

    更新日期：2006-04-01 00:00:00

  • Supervised learning of postural tasks in patients with poststroke hemiparesis, Parkinson's disease or cerebellar ataxia.

    abstract：:Supervised learning of different postural tasks in patients with lesions of the motor cortex or pyramidal system (poststroke hemiparesis: 20 patients), nigro-striatal system (Parkinson's disease: 33 patients) and cerebellum (spinocerebellar ataxia: 37 patients) was studied. A control group consisted of 13 healthy subj...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/s00221-005-0096-9

    authors： Ioffe ME,Ustinova KI,Chernikova LA,Kulikov MA

    更新日期：2006-01-01 00:00:00

  • Visual responses of thalamic neurons depending on the direction of gaze and the position of targets in space.

    abstract：:Visual receptive field properties of neurons in the region of the thalamic internal medullary lamina were studied in alert cats while they fixated in various directions. In slightly more than 50% of the cells, the responsiveness of the cells was found to depend on the location of the stimulus with respect to the head-...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/BF00237535

    authors： Schlag J,Schlag-Rey M,Peck CK,Joseph JP

    更新日期：1980-01-01 00:00:00

  • Perception of horizontal head and trunk rotation: modification of neck input following loss of vestibular function.

    abstract：:Chronic loss of vestibular function modifies the role of neck afferents in human perception of self-motion. We characterized this change by comparing the self-motion perception of patients with chronic vestibular loss (Ps) to that of normal subjects (Ns). Stimuli consisted of sinusoidal horizontal rotations (0.025-0.4...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/BF00227147

    authors： Schweigart G,Heimbrand S,Mergner T,Becker W

    更新日期：1993-01-01 00:00:00

  • Periodontal anaesthesia reduces common 8 Hz input to masseters during isometric biting.

    abstract：:During isometric contractions of the jaw muscles, oscillations in the rectified masseteric EMG record that are coherent with the mandibular force output are evident at ~8 Hz. We have investigated the load dependence of these oscillations under both force and EMG feedback conditions and the extent to which these oscill...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/s00221-005-0144-5

    authors： Sowman PF,Brinkworth RS,Türker KS

    更新日期：2006-03-01 00:00:00

  • Studies on the regulation of RNA synthesis in neuronal and glial nuclei isolated from rat brain.

    abstract：:In searching for regulatory mechanisms involved in the cell-specific neuronal and glial transcription a cell-free transcriptional system has been developed using neuronal and glial rat brain chromatin and partially purified neuronal and glial nuclear rat brain RNA polymerases. Both free and chromatin-bound (engaged) n...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/BF00237292

    authors： Sarkander HI,Dulce HJ

    更新日期：1978-03-15 00:00:00

  • Further studies on the fiber connections of the central cervical nucleus in the cat.

    abstract：:The course and cerebellar termination of the axons of the cells in the central cervical nucleus (CCN) was studied in five cats after injections of wheat germ agglutinin-horseradish peroxidase conjugate (WGA-HRP) into the C1-4 segments involving the CCN. In two cats a hemisection was performed ipsilateral to and above ...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/BF00248549

    authors： Wiksten B

    更新日期：1987-01-01 00:00:00

  • Is it better to sit down, stand up or walk when performing memory and arithmetic activities?

    abstract：:It is now accepted that performing a cognitive task impacts postural control (Polskaia and Lajoie 2016; Vuillerme et al. Neurosci Lett 291: 77-80, 2000). However, the reverse impact of posture on cognitive performance is less documented. The present study investigated performance in two cognitive activities (memory an...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/s00221-020-05858-z

    authors： Abou Khalil G,Doré-Mazars K,Senot P,Wang DP,Legrand A

    更新日期：2020-11-01 00:00:00

  • Human vestibular perceptual thresholds for pitch tilt are slightly worse than for roll tilt across a range of frequencies.

    abstract：:Vestibular perceptual thresholds measure vestibular sensory and perceptual noise by quantifying how small of a passive self-motion an individual is able to reliably perceive. Vestibular thresholds have clinical and operational relevance, as they are elevated in vestibular migraine patients, and even healthy individual...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/s00221-020-05830-x

    authors： Suri K,Clark TK

    更新日期：2020-06-01 00:00:00

  • Hand digit control in children: age-related changes in hand digit force interactions during maximum flexion and extension force production tasks.

    abstract：:We studied the finger interactions during maximum voluntary force (MVF) production in flexion and extension in children and adults. The goal of this study was to investigate the age-related changes and flexion-extension differences of MVF and finger interaction indices, such as finger inter-dependency (force enslaving...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/s00221-006-0629-x

    authors： Shim JK,Oliveira MA,Hsu J,Huang J,Park J,Clark JE

    更新日期：2007-01-01 00:00:00

  • Intended rather than actual movement velocity determines the latency of anticipatory postural adjustments.

    abstract：:The literature reports that anticipatory postural adjustments (APAs) are programmed according to movement velocity. However, the linkage between APAs and velocity has been highlighted within single subjects who were asked to voluntarily change movement velocity; therefore, till now, it has been impossible to discern w...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/s00221-014-4122-7

    authors： Esposti R,Bruttini C,Bolzoni F,Cavallari P

    更新日期：2015-02-01 00:00:00

  • Anticipatory postural adjustments stabilise the whole upper-limb prior to a gentle index finger tap.

    abstract：:Little is known about anticipatory postural adjustments (APAs) developing when body segments of tiny mass are moved. Thus, APAs in the human upper-limb were investigated during a gentle and small index finger tap (35 mm stroke in 50 ms). This task was fulfilled by ten subjects either with prone or supine hand. EMG was...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/s00221-008-1668-2

    authors： Caronni A,Cavallari P

    更新日期：2009-03-01 00:00:00

  • Involvement of GABA in medullary raphe-evoked modulation of neuronal activity in the periaqueductal grey matter in the rat.

    abstract：:Experiments were carried out in urethane-anaesthetised rats to investigate whether GABA is involved in mediating inhibition of neuronal activity in the dorsal half of the periaqueductal grey matter (PAG) after stimulation of the serotonin-containing projection to the PAG from nucleus raphe obscurus (NRO). Multibarrell...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/s002210000627

    authors： Lovick TA

    更新日期：2001-03-01 00:00:00

  • Spatio-temporal and kinematic analysis of pointing movements performed by cerebellar patients with limb ataxia.

    abstract：:Three patients with cerebellar limb ataxia and three age-matched controls performed arm-pointing movements towards a visual stimulus during an experimental procedure using a double-step paradigm in a three-dimensional space. Four types of trajectories were defined: P1, single-step pointing movement towards the visual ...

    journal_title：Experimental brain research

    pub_type： 临床试验,杂志文章

    doi：10.1007/s002210050361

    authors： Bonnefoi-Kyriacou B,Legallet E,Lee RG,Trouche E

    更新日期：1998-04-01 00:00:00

  • An immunocytochemical study of calpain II in the hippocampus of rats injected with kainate.

    abstract：:The distributions of the kainate/DL-alpha-amino-3-hydroxy-5-methylisoxazolepropionic acid (KA/ AMPA) receptors GluR1 and calcium-activated neutral protease II (calpain II) in the hippocampus of normal and kainate-lesioned rats were studied by immunocytochemistry. There was a reduction in GluR1 immunoreactivity and a s...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/BF02454147

    authors： Ong WY,Garey LJ,Tan KK

    更新日期：1997-01-01 00:00:00

  • Identification and characterization of neurons with tremor-frequency activity in human globus pallidus.

    abstract：:Many previous studies have demonstrated the existence of neurons with tremor-frequency activity ("tremor cells") in the thalamus of Parkinson's disease (PD) patients and these neurons are presumed to play a role in the pathogenesis of tremor. Since a major input to motor thalamus (Voa and Vop) is from the internal seg...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/pl00005606

    authors： Hutchison WD,Lozano AM,Tasker RR,Lang AE,Dostrovsky JO

    更新日期：1997-03-01 00:00:00

  • Motor learning with fading and growing haptic guidance.

    abstract：:Haptic guidance has been shown to have both facilitatory and interfering effects on motor learning. Interfering effects have been hypothesized to result from the particular dynamic environment, which supports a passive role of the learner, and they should be attenuated by fading guidance. Facilitatory effects, in part...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/s00221-014-3914-0

    authors： Heuer H,Lüttgen J

    更新日期：2014-07-01 00:00:00

  • Efferent and afferent activity in a gastrocnemius nerve branch during locomotion in the thalamic cat.

    abstract：:The firing patterns of alpha and gamma efferent fibres and of group I and group II afferent fibres innervating the gastrocnemius muscle were observed during spontaneous locomotor movements in the thalamic cat. Multi-unit discharges of each kind of fibre were obtained by electronic sorting of the action potentials from...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/BF00340493

    authors： Bessou P,Cabelguen JM,Joffroy M,Montoya R,Pagès B

    更新日期：1986-01-01 00:00:00

  • What the hand can't tell the eye: illusion of space constancy during accurate pointing.

    abstract：:When we press an elevator button or pick up a coffee cup, different visual information is used to guide our reach and to form our conscious experience of these objects. But can the information guiding our hand be brought into awareness? The fact that we can see and feel our own hand in action suggests that it might be...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/s00221-004-2116-6

    authors： Chua R,Enns JT

    更新日期：2005-03-01 00:00:00

  • Effects of auditory feedback on movements with two-segment sequence and eye-hand coordination.

    abstract：:The present study investigated the effect of auditory feedback on planning and control of two-segment reaching movements and eye-hand coordination. In particular, it was examined whether additional auditory information indicating the progression of the initial reach (i.e., passing the midway and contacting the target)...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/s00221-018-5366-4

    authors： Rand MK

    更新日期：2018-12-01 00:00:00

  • Synapsin-like immunoreactivity is present in hair cells and efferent terminals of the toadfish crista ampullaris.

    abstract：:The synapsins are presynaptic membrane-associated proteins involved in neurotransmitter release. They are differentially expressed in tissues and cells of the central and peripheral nervous system. In vestibular end organs of mammals, synapsin I-like immunoreactivity has been reported in efferent and afferent terminal...

    journal_title：Experimental brain research

    pub_type： 杂志文章

    doi：10.1007/s00221-004-2194-5

    authors： Holstein GR,Martinelli GP,Nicolae RA,Rosenthal TM,Friedrich VL Jr

    更新日期：2005-04-01 00:00:00