Abstract：
:The distributions of the kainate/DL-alpha-amino-3-hydroxy-5-methylisoxazolepropionic acid (KA/ AMPA) receptors GluR1 and calcium-activated neutral protease II (calpain II) in the hippocampus of normal and kainate-lesioned rats were studied by immunocytochemistry. There was a reduction in GluR1 immunoreactivity and a slight increase in calpain II immunoreactivity on the dendrites of pyramidal neurons in CA fields affected by the kainate at 18 h postinjection. Calpain II immunore-activity was associated with amyloid fibrils at electron microscopy. These fibrils were most often intracellular, in membrane-bound profiles, some of which were contacted by axon terminals and were identified as degenerating dendrites. There was extensive destruction of mitochondrial membranes in degenerating profiles, and accumulations of amyloid fibrils were often localised in mitochondria in a calpain-positive profile. This was unlike other, calpain-negative degenerating profiles, that contained tubulovesicular profiles or multilamellar bodies, where mitochondrial membranes were preserved. Many more calpain-positive profiles were observed at electron microscopy 6 days after kainate injection. The enzyme was present in macrophages and astrocytes in lesioned areas.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Ong WY,Garey LJ,Tan KKdoi
10.1007/BF02454147subject
Has Abstractpub_date
1997-01-01 00:00:00pages
117-29issue
1eissn
0014-4819issn
1432-1106journal_volume
113pub_type
杂志文章abstract：:This study investigated the modulation of somatosensory evoked potentials (SEPs) during precisely controlled force generation and force relaxation in a visuomotor tracking task. Subjects were instructed to track a target line with a line that represented their own force generated by grip movement with the right hand a...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-3082-z
更新日期：2012-06-01 00:00:00
abstract：:Postsynaptic potentials (PSPs) evoked in motoneurons innervating the back and abdominal muscles in the lumbar part of the body by stimulating hindlimb cutaneous afferents were investigated in unanesthetized decerebate and spinal cats. Various types of PSP: pure excitatory postsynaptic potential (EPSP), pure inhibitory...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050879
更新日期：1999-10-01 00:00:00
abstract：:The muscle activation patterns in anterior and posterior leg muscles were investigated with two types of perturbations to standing balance. Subjects stood with each foot on adjacent force platforms and performed arm flexion movements to shoulder height. Nine subjects performed ten repetitions unilaterally and bilatera...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-003-1732-x
更新日期：2004-04-01 00:00:00
abstract：:Primates can gradually increase or decrease H-reflex amplitude in one leg when reward depends on that amplitude. The magnitude of change varies greatly from animal to animal. This study sought to define the factors that control this magnitude. It evaluated the influence of animal age, muscle size (absolute and relativ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228815
更新日期：1993-01-01 00:00:00
abstract：:Previous investigations have revealed that perceived spatial frequency of gratings rises as contrast is lowered. In order to account for this finding it has been postulated that the spatial frequency which produces the maximum response from cortical neurones decreases with contrast. We have examined this hypothesis by...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236862
更新日期：1986-01-01 00:00:00
abstract：:Immunoreactivities for tyrosine hydroxylase (TH), gamma-aminobutyric acid (GABA) and, in some cases, glutamic acid decarboxylase (GAD) were detected by light and electron microscopy in axons projecting into the median eminence and pituitary gland of various mammals (rats, mice, guinea pigs, cats, rabbits and hares). L...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00229836
更新日期：1991-01-01 00:00:00
abstract：:The ability to make accurate reaching movements toward proprioceptively defined target locations was studied in seven normal subjects who were trained to reach to five different targets in a horizontal plane, with no vision of hand or target. The task consisted of moving a handle from a fixed origin to each target loc...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00229793
更新日期：1993-01-01 00:00:00
abstract：:We assessed the influence of vestibular stimulation by whole-body oscillation in the yaw plane on the cardiorespiratory responses after a change of posture from sitting to standing. Eighteen healthy subjects (21-70 years old) and six patients with bilateral vestibular loss (46-59 years old) were tested. For comparison...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-003-1422-8
更新日期：2003-06-01 00:00:00
abstract：:Empathy, i.e., the ability to perceive and share another person's affective state, is associated with activity in a complex neural network, including the anterior insula, the anterior and mid-cingulate cortex, and the lateral prefrontal cortex. Here, we were interested in the question how facial emotions influence the...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-016-4731-4
更新日期：2016-11-01 00:00:00
abstract：:The brain needs information about the size of the body to control our interactions with the environment. No receptor signals this information directly; the brain must determine body size from multiple sensory inputs and then store this information. This process is poorly understood, but somatosensory information is th...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4249-1
更新日期：2015-06-01 00:00:00
abstract：:When two hands require different information in bimanual asymmetric movements, interference can occur via callosal connections and ipsilateral corticospinal pathways. This interference could potentially work as a cost-effective measure in symmetric movements, allowing the same information to be commonly available to b...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-010-2244-0
更新日期：2010-06-01 00:00:00
abstract：:Two components of long-term potentiation (LTP) are distinguished with extracellular recording electrodes: a synaptic and an EPSP-Spike (E-S) component. The latter consists of the enhancement produced in the population spike amplitude in excess of that predicted by EPSP potentiation alone. The experiments carried out i...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00229331
更新日期：1990-01-01 00:00:00
abstract：:We explored whether the synergic control of the hand during multi-finger force production tasks depends on the hand muscles involved. Healthy subjects performed accurate force production tasks and targeted force pulses while pressing against loops positioned at the level of fingertips, middle phalanges, and proximal p...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-018-5231-5
更新日期：2018-05-01 00:00:00
abstract：:In earlier studies the tetrahydroisoquinoline derivative N-methyl-norsalsolinol (2-MDTIQ) was discovered in lumbar cerebrospinal fluid and brain of patients with Parkinson's disease. To establish whether 2-MDTIQ is toxic to the dopaminergic system, 2-MDTIQ or 6-hydroxydopamine (6-OHDA) were stereotactically injected i...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00227181
更新日期：1996-11-01 00:00:00
abstract：:Cellular relationships between serotonin (5-HT) axons and tyrosine hydroxylase (TH)-containing neurons were examined by combined (3H)5-HT uptake radioautography and TH immunocytochemistry in the medial zona incerta (ZI) of adult rats, 7 and 50 days after an intracerebral injection of 5,7-Dihydroxytryptamine (5,7-DHT)....
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00250592
更新日期：1988-01-01 00:00:00
abstract：:Muscle sympathetic nerve activity (MSNA) is modulated on a beat-to-beat basis by the baroreflex. Vestibular input from the otolith organs also modulates MSNA, but characteristics of the vestibulo-sympathetic reflex (VSR) are largely unknown. The purpose of this study was to elicit the VSR with electrical stimulation t...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-005-0266-9
更新日期：2006-05-01 00:00:00
abstract：:The phase of the angular vestibulo-ocular reflex (VOR) is subject to adaptive control. We had previously found that adapting the phase of the VOR also produced changes in drift on eccentric gaze-holding, implying a change in the time constant of the velocity-to-position neural integrator. Here we attempted to dissocia...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/s002210050392
更新日期：1998-05-01 00:00:00
abstract：:In goal-oriented locomotion, healthy adults generate highly stereotyped trajectories and a consistent anticipatory head orienting behaviour, both evidence of top-down, open-loop control. The aim of this study is to describe the typical development of anticipatory orienting strategies and trajectory formation. Our hypo...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3495-3
更新日期：2013-05-01 00:00:00
abstract：:This study employed neurophysiological methods to relate the condition of the corticospinal system with the voluntary control of lower-limb muscles in persons with motor-incomplete spinal cord injury. It consisted of two phases. In a group of ten healthy subjects, single and paired transcranial magnetic stimulation (T...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-004-2190-9
更新日期：2005-06-01 00:00:00
abstract：:Light touch of the index finger with a stationary surface at non-mechanically supportive force levels (<100 g) greatly attenuates the body sway of standing subjects. In three experiments, we evaluated the properties of finger contact and of the contacted object necessary to produce postural stabilization in subjects s...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/s002210100775
更新日期：2001-08-01 00:00:00
abstract：:Sensitivity to many visual stimuli, and, in particular, image displacement, is reduced during a change in fixation (saccade) compared to when the eye is still. In these experiments, we studied the sensitivity of observers to ecologically relevant image translations of large, complex, real world scenes either during ho...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-2120-y
更新日期：2010-04-01 00:00:00
abstract：:A force-matching task was used to study the influence of constraining tactile information from the hand on the perception of forces generated with the index finger flexors, the palmar prehensile grasp and with the elbow flexors. Subjects generated the same reference forces (2-10 N) with each muscle group and matched t...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-005-0259-8
更新日期：2006-01-01 00:00:00
abstract：:During voluntary movement, muscle spindles of both the agonist and antagonist muscles potentially can supply information about position of the limb. Muscle vibration is known to increase muscle spindle discharge and cause systematic distortions of limb position sense in humans. The following two experiments attempted ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF02423506
更新日期：1990-01-01 00:00:00
abstract：:Many neurons in the deeper layers of the superior colliculus (SC) respond to multiple sensory inputs--visual, auditory, and somatic--as well as provide signals essential for saccadic eye movements to targets in different modalities. When the eyes and pinnae are in primary position, the neural map of auditory space is ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231709
更新日期：1995-01-01 00:00:00
abstract：:The tectofugal pathway in birds has been reported to process primarily information from the contralateral eye. Although this pathway has access to the contralateral hemisphere by various connections, electrophysiological recordings up to now have failed to demonstrate any excitatory influence of visual stimulation in ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00271850
更新日期：1988-01-01 00:00:00
abstract：:Emotional memory consolidation has been associated with rapid eye movement (REM) sleep, and recent evidence suggests that increased electroencephalogram spectral power in the theta (4-8 Hz) frequency range indexes this activity. REM sleep has been implicated in posttraumatic stress disorder (PTSD) as well as in emotio...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-014-3857-5
更新日期：2014-05-01 00:00:00
abstract：:In order to see whether septal neurones are connected to the hypothalamic neurones secreting vasopressin or oxytocin, neurones in different regions of the septum were recorded during electrical stimulation of the supraoptic nucleus. The position of the stimulating electrode within the latter was verified using lactati...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237493
更新日期：1981-01-01 00:00:00
abstract：:Local alpha-band synchronization has been associated with both cortical idling and active inhibition. Recent evidence, however, suggests that long-range alpha synchronization increases functional coupling between cortical regions. We demonstrate increased long-range alpha and beta band phase synchronization during sho...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-2086-9
更新日期：2010-04-01 00:00:00
abstract：:Extracellular recordings were made from single on-center optic tract fibres in cats. Light spots of 10sec duration were focussed on the center of the receptive field under 1cd/m2 adaptation luminance by diffuse light. In the maintained discharges at 1 cd/m2, the shape of inter-spike interval histograms (IH) tended to ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235016
更新日期：1976-01-26 00:00:00
abstract：:The present study assessed changes in perceived heaviness of weights lifted by the thumb, index, ring and little fingers during anaesthesia of the "lifting" digit. Subjects (n = 19) lifted weights solely by flexion of the distal joint of the digit, using a bilateral weight-matching paradigm. Changes in perceived heavi...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050247
更新日期：1997-12-01 00:00:00
