Abstract：
:In searching for regulatory mechanisms involved in the cell-specific neuronal and glial transcription a cell-free transcriptional system has been developed using neuronal and glial rat brain chromatin and partially purified neuronal and glial nuclear rat brain RNA polymerases. Both free and chromatin-bound (engaged) neuronal and glial RNA polymerase fractions were separated from isolated neuronal and glial rat brain nuclei to determine their transcriptive efficiency. A double number of RNA initiation sites was measured on the neuronal when compared to the glial chromatin, independently of whether the neuronal or the glial RNA polymerase preparation was used for the determination. Structural modification of the neuronal and glial chromatin template by acetylation with acetyl-coenzyme A leads to an increase of the total number of RNA initiation sites available for exogenously added rat brain RNA polymerase. This indicates that acetylation of chromatin-bound proteins is capable to render primarily restricted gene sequences transcriptable. A positive correlation exists between the extent of acetate uptake by neuronal and glial chromatin-bound histone fractions and the extent of the increase of the number of RNA initiation sites is specifically related to histone acetylation rather than to acetylation of any other chromatin protein. Significant information in this respect could be achieved by dissociation of chromatin into its principal components and selectively reconstituting DNA with specifically acetylated histone and non-histone proteins.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Sarkander HI,Dulce HJdoi
10.1007/BF00237292subject
Has Abstractpub_date
1978-03-15 00:00:00pages
317-27issue
3eissn
0014-4819issn
1432-1106journal_volume
31pub_type
杂志文章abstract：:Experiments were carried out in urethane-anaesthetised rats to investigate whether GABA is involved in mediating inhibition of neuronal activity in the dorsal half of the periaqueductal grey matter (PAG) after stimulation of the serotonin-containing projection to the PAG from nucleus raphe obscurus (NRO). Multibarrell...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210000627
更新日期：2001-03-01 00:00:00
abstract：:Previous investigations have suggested that the dorsolateral pontine tegmentum (DLP) may be part of a system essential for classical conditioning of the nictitating membrane response. The present study examined CR-related firing patterns of extracellularly-recorded single units in the DLP. Differential conditioning, u...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00243830
更新日期：1986-01-01 00:00:00
abstract：:This study explored the directional specificity of fear of falling (FoF) effects on the stabilizing function of anticipatory postural adjustments (APA). Participants (N = 71) performed a series of lateral leg raises from an elevated surface in three conditions: in the "Control condition", participants stood at the mid...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4471-x
更新日期：2016-03-01 00:00:00
abstract：:The purpose of this study was to investigate the temporal relationship between presaccadic neuronal discharges in the frontal eye fields (FEF) and supplementary eye fields (SEF) and the initiation of saccadic eye movements in macaque. We utilized an analytical technique that could reliably identify periods of neuronal...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00241967
更新日期：1995-01-01 00:00:00
abstract：:The presence of discrete events during an interval to be estimated generally causes a dilation of perceived duration (event-filling effect). Here, we investigated this phenomenon in the thermal modality using multi-seconds (19 s) innocuous cool stimuli that were either constant (continuous interval) or fluctuating to ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4537-9
更新日期：2016-04-01 00:00:00
abstract：:The cerebellum is known to participate in visually guided eye movements. The cerebellar uvula receives projections from pontine nuclei that have been implicated in visual motion processing and the generation of smooth pursuit. Single-unit and lesion studies were conducted to determine how the uvula might further proce...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00241368
更新日期：1996-06-01 00:00:00
abstract：:Trajectories of goal-directed movements are less curved for movements over a surface (constrained) than for movements in empty space (unconstrained). To study whether this difference arises from feeling the surface slip across the skin or having to control the movements in a third dimension, we manipulated the availab...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-014-4030-x
更新日期：2014-11-01 00:00:00
abstract：:Insulin-like growth factor-1 (IGF-1) is an endogenous peptide transported across the blood brain barrier that is protective in several brain injury models, including an acute animal model of Parkinson's disease (PD). Motor deficits in PD are due largely to the progressive loss of nigrostriatal dopaminergic neurons. Th...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-016-4572-1
更新日期：2016-07-01 00:00:00
abstract：:When two target elements are presented in close proximity, the endpoint of a saccade is generally positioned at an intermediate location ('global effect'). Here, we investigated whether the global effect also occurs for eye movements executed to distracting elements. To this end, we adapted the oculomotor capture para...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-011-2602-6
更新日期：2011-04-01 00:00:00
abstract：:Human subjects attempted to modify their vestibuloocular reflex (VOR) in the dark by fixating imagined targets while experiencing predictable (SIN) sinusoidal (0.01-2.5 Hz) and unpredictable (SSN) sum of sines rotational stimuli (0.02-1.9 Hz). Modification was attempted under 2 instructional sets: VOR enhancement, ie ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236931
更新日期：1985-01-01 00:00:00
abstract：:After minimizing proprioceptive input from the legs by ischemia without degradation of muscle force and excluding visual stabilization by eye closure, a characteristic anterior-posterior postural sway around 1 Hz was observed in three normal subjects. This is similar to the instability seen in two tabes dorsalis patie...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237939
更新日期：1980-01-01 00:00:00
abstract：:1. The somatic location and axonal projections of inhibitory vestibular nucleus neurons activated by the horizontal semicircular canal nerve (HCN) were studied in anesthetized cats. Cats were anesthetized with ketamine hydrochloride and pentobarbital sodium. 2. Intracellular recordings were obtained from 11 neck exten...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231035
更新日期：1991-01-01 00:00:00
abstract：:Adrenocortical responses, as expressed by changes in plasma corticosterone levels, following ether stress and dorsal hippocampal stimulation, were studied in intact rats and in rats with complete, anterior of posterior hypothalamic deafferentations. Ether stress produced normal responses in all experimental groups. In...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237345
更新日期：1981-01-01 00:00:00
abstract：:The main belly of the macaque's flexor digitorum profundus (FDP) is divided by a dissectible plane into radial and ulnar regions. The present report describes three findings which suggest that the radial and ulnar regions represent separate functional subdivisions of the FDP. First, electromyographic (EMG) recordings ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00229783
更新日期：1993-01-01 00:00:00
abstract：:Tone bursts produced bands of selective 2-[14C]-deoxyglucose labelling in the inferior colliculus (IC) of the awake monkey. Low tone frequencies produced labelling in dorsal regions and high tone frequencies produced labelling in ventral regions. The position of the bands coincided with the position of a single unit w...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237983
更新日期：1984-01-01 00:00:00
abstract：:We investigated the capacities of human subjects to intercept moving targets in a two-dimensional (2D) space. Subjects were instructed to intercept moving targets on a computer screen using a cursor controlled by an articulated 2D manipulandum. A target was presented in 1 of 18 combinations of three acceleration types...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/pl00005769
更新日期：1997-10-01 00:00:00
abstract：:Selective lesions of the noradrenergic locus coeruleus (LC) system have recently been shown to aggravate both ischemic and epileptic brain damage. This study explores the possibility that the LC system also influences hypoglycemic brain injury. Bilateral 6-hydroxydopamine lesions of the LC projection to the forebrain ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00279676
更新日期：1988-01-01 00:00:00
abstract：:Intracellular recordings from thalamic neurons receiving cerebellar inputs were performed under urethane anesthesia in the rat. A total of 64 neurons were recorded intracellularly with micropipettes filled with 4% biocytin solution (dissolved in 0.5 M K-acetate), and cerebellar-induced EPSPs (CN-EPSPs), the membrane r...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231841
更新日期：1991-01-01 00:00:00
abstract：:This review summarizes anatomical and electrophysiological observations related to corticovestibular interactions as a step toward understanding their possible functions. Vestibular information is represented in at least three distinct regions of the cerebral cortex in cats and monkeys: the parietal and somatosensory ...
journal_title：Experimental brain research
pub_type： 杂志文章,评审
doi：10.1007/pl00005786
更新日期：1997-10-01 00:00:00
abstract：:The present study used the redundant target paradigm on healthy subjects to investigate functional hemispheric asymmetries and interhemispheric cooperation in the perception of emotions from faces. In Experiment 1 participants responded to checkerboards presented either unilaterally to the left (LVF) or right visual h...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-005-0279-4
更新日期：2006-05-01 00:00:00
abstract：:The present review examines the experimental evidence supporting the existence of central mechanisms able to modulate the synaptic effectiveness of sensory fibers ending in the spinal cord of vertebrates. The first section covers work on the mode of operation and the synaptic mechanisms of presynaptic inhibition, in p...
journal_title：Experimental brain research
pub_type： 杂志文章,评审
doi：10.1007/s002210050933
更新日期：1999-11-01 00:00:00
abstract：:This study was undertaken to elucidate neural control of the arterial blood pressure (ABP) in head-down postural change which causes both stimulation to the vestibular system and head-ward fluid shift. Experiments were carried out with urethane-anesthetized rabbits. The animal was mounted on a tilting table, tilted to...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-1732-6
更新日期：2009-04-01 00:00:00
abstract：:Clear vision of objects moving in three-dimensional space near an observer is attained by a combination of smooth-pursuit and vergence eye movements. The two systems must interact with the vestibular system to maintain the image of the object on the fovea. Previous studies showed that training with smooth-pursuit vest...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-003-1777-x
更新日期：2004-05-01 00:00:00
abstract：:Nociceptive suppression of tonic voluntary electromyographic (EMG) activity in human hand muscles (cutaneous silent period, CSP) is in its functional organization consistent with a spinal protective reflex. Motoneuronal excitability and its modulation may also be investigated by conditioned motor evoked potentials (ME...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1372-2
更新日期：2008-07-01 00:00:00
abstract：:Nine participants performed a reciprocal precision aiming task under different experimental conditions. Due to the anisotropy of the work space, varying the direction of motion (from 0 degrees to 315 degrees in steps of 45 degrees ) allowed exploration of the effects of biomechanical constraints that were found to aff...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00221-004-1964-4
更新日期：2004-12-01 00:00:00
abstract：:There is ample evidence that motor learning changes the function of perceptual systems. Previous studies examining the interactions between speech production and perception have shown that the discrimination of phonetic contrasts characterized by the difference in articulatory place features is altered following their...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-019-05584-1
更新日期：2019-09-01 00:00:00
abstract：:Single unit activity was recorded from tuberoinfundibular neurones in urethane-anaesthetized pro-oestrous rats. Responses following single shock (0.2 Hz) stimulation of the preoptic area/anterior hypothalamus (PO/AH) or nucleus accumbens (ACB) were recorded and computed for 137 single units. More cells were shown, by ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236546
更新日期：1985-01-01 00:00:00
abstract：:The hand, one of the most versatile but mechanically redundant parts of the human body, suffers more and longer than other body parts after stroke. One of the rehabilitation paradigms, task-oriented rehabilitation, encourages motor repeatability, the ability to produce similar motor performance over repetitions throug...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-017-5074-5
更新日期：2017-12-01 00:00:00
abstract：:We studied the potential contribution of postsynaptic mechanisms to the depression of reflex excitability which occurs immediately after a voluntary release from tonic muscle contraction. The excitability of the Soleus (Sol) motor pool was tested at rest and after voluntary muscle relaxation. In both cases the Sol H-r...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00230904
更新日期：1985-01-01 00:00:00
abstract：:It has been proposed that visually guided reaching movements performed in the lower visual field (LVF) of peripersonal space are more effective and efficient than their upper visual field (UVF) counterparts (Danckert and Goodale 2001). In the present investigation we sought to determine whether this purported visual f...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0386-x
更新日期：2006-03-01 00:00:00
