Abstract:
:The present review examines the experimental evidence supporting the existence of central mechanisms able to modulate the synaptic effectiveness of sensory fibers ending in the spinal cord of vertebrates. The first section covers work on the mode of operation and the synaptic mechanisms of presynaptic inhibition, in particular of the presynaptic control involving axo-axonic synapses made by GABAergic interneurons with the terminal arborizations of the afferent fibers. This includes reviewing of the ionic mechanisms involved in the generation of primary afferent depolarization (PAD) by GABAergic synapses, the ultrastructural basis underlying the generation of PAD, the relationship between PAD and presynaptic inhibition, the conduction of action potentials in the terminal arborizations of the afferent fibers, and the modeling of the presynaptic inhibitory synapse. The second section of the review deals with the functional organization of presynaptic inhibition. This includes the segmental and descending presynaptic control of the synaptic effectiveness of group-I and group-II muscle afferents, the evidence dealing with the local character of PAD as well as the differential inhibition of PAD in selected collaterals of individual muscle-spindle afferents by cutaneous and descending inputs. This section also examines observations on the presynaptic modulation of large cutaneous afferents, including the modulation of the synaptic effectiveness of thin myelinated and unmyelinated cutaneous fibers and of visceral afferents, as well as the presynaptic control of the synaptic actions of interneurons and descending tract neurons. The third section deals with the changes in PAD occurring during sleep and fictive locomotion in higher vertebrates and with the changes of presynaptic inhibition in humans during the execution of a variety of voluntary movements. In the final section, we examine the non-synaptic presynaptic modulation of transmitter release, including the possibility that the intraspinal endings of primary afferents also release colocalized peptides in a similar way as in the periphery. The outcome of the studies presently reviewed is that intraspinal terminals of sensory fibers are not hard-wired conductors of the information generated in their peripheral sensory receptors, but dynamic systems that convey information that can be selectively addressed by central mechanisms to specific neuronal targets. This central control of information flow in peripheral afferents appears to play an important role in the generation of integrated movements and processing of sensory information, including nociceptive information.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Rudomin P,Schmidt RFdoi
10.1007/s002210050933keywords:
subject
Has Abstractpub_date
1999-11-01 00:00:00pages
1-37issue
1eissn
0014-4819issn
1432-1106pii
91290001.221journal_volume
129pub_type
杂志文章,评审abstract::Lateral and medial thalamus are traditionally thought to have separate roles in pain processing, with lateral lemniscal regions transmitting discriminative information about location and intensity, while medial nonspecific regions are involved in emotional responses. Contrary to this view, the present study shows that...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00228914
更新日期:1989-01-01 00:00:00
abstract::Human subjects attempted to modify their vestibuloocular reflex (VOR) in the dark by fixating imagined targets while experiencing predictable (SIN) sinusoidal (0.01-2.5 Hz) and unpredictable (SSN) sum of sines rotational stimuli (0.02-1.9 Hz). Modification was attempted under 2 instructional sets: VOR enhancement, ie ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00236931
更新日期:1985-01-01 00:00:00
abstract::A magnetic stimulus applied to the human scalp over the motor cortex causes a short latency contraction of contralateral limb muscles. This is presumed to result from the indirect excitation of corticospinal neurons with monosynaptic connections to motoneurons. The excitability of these cortical neurons can be estimat...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00247369
更新日期:1989-01-01 00:00:00
abstract::It is known that kittens reared in ways that restrict movement while visual stimulation is received exhibit deficits in visually guided behavior. Presumably, the behavioral dysfunction is due to a lack of sensorimotor coordination during visual exposure. The current investigation was undertaken to study this effect bo...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238794
更新日期:1978-09-15 00:00:00
abstract::This study investigated whether the execution of an accurate pointing response depends on a prior saccade orientation towards the target, independent of the vision of the limb. A comparison was made between the accuracy of sequential responses (in which the starting position of the hand is known and the eye centred on...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/BF00228987
更新日期:1994-01-01 00:00:00
abstract::The tectofugal pathway in birds has been reported to process primarily information from the contralateral eye. Although this pathway has access to the contralateral hemisphere by various connections, electrophysiological recordings up to now have failed to demonstrate any excitatory influence of visual stimulation in ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00271850
更新日期:1988-01-01 00:00:00
abstract::The time course of development of visual acuity for square wave gratings was measured behaviourally in a number of cats that were reared in total darkness until they were either 4 (5 cats) or 6 (1 cat) months of age. Less extensive measurements were also made on animals reared in a similar manner until they were eithe...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00239811
更新日期:1978-04-14 00:00:00
abstract::The effects on striatal high affinity glutamate uptake (HAGU) of an apomorphine injection administered either alone or along with an electrical stimulation of the frontal cortex were compared between intact control rats and animals with 6-hydroxydopamine (6-OHDA) induced lesions of the nigrostriatal dopaminergic neuro...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00247588
更新日期:1988-01-01 00:00:00
abstract::Both human and animal research indicate that rapid eye movement sleep (REM) plays an important role in the processing of emotional information. REM is altered after fear conditioning in rats, but this alteration can be mitigated by exposure to a naïve conspecific. In addition, both the housing condition (isolated vs p...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-014-3828-x
更新日期:2014-05-01 00:00:00
abstract::The memory for the final position of a moving object which suddenly disappears has been found to be displaced forward, in the direction of motion, and downwards, in the direction of gravity. These phenomena were coined, respectively, Representational Momentum and Representational Gravity. Although both these and simil...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-016-4654-0
更新日期:2016-09-01 00:00:00
abstract::Transcranial magnetic stimulation (TMS) has been first described 30 years ago, and since then has gained enormous attention by neurologists, psychiatrists, neurosurgeons, clinical neurophysiologists, psychologists, and neuroscientist alike. In the early days, it was primarily used to test integrity of the corticospina...
journal_title:Experimental brain research
pub_type: 历史文章,杂志文章,评审
doi:10.1007/s00221-016-4865-4
更新日期:2017-04-01 00:00:00
abstract::Dorsomedial frontal cortex (DMFC) was studied in monkeys trained to make visually guided eye or arm movements. Portions of DMFC are involved in the execution of learned, goal-directed behaviors. Many neurons discharge with both eye and hand movements as well as when motor responses are withheld, provided these behavio...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00247300
更新日期:1988-01-01 00:00:00
abstract::The synapsins are presynaptic membrane-associated proteins involved in neurotransmitter release. They are differentially expressed in tissues and cells of the central and peripheral nervous system. In vestibular end organs of mammals, synapsin I-like immunoreactivity has been reported in efferent and afferent terminal...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-004-2194-5
更新日期:2005-04-01 00:00:00
abstract::Reports of spatial interactions between current and upcoming elements in a movement sequence could be due to intentional planning of a "global" action sequence (i.e., strategic effects), or to unintentional motor planning arising from merely paying attention to upcoming target objects (i.e., interference effects). The...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4511-6
更新日期:2016-04-01 00:00:00
abstract::Neutral buoyancy facilities are used to prepare astronauts and cosmonauts for extra vehicular activities e.g. on-board of the International Space Station. While previous studies indicated a decrease in cognitive performance in an under water setting, they have only provided behavioural data. This study aimed to review...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-014-4019-5
更新日期:2014-10-01 00:00:00
abstract::Recently, it has been reported that grasping with the left hand is more vulnerable to visual size illusions than grasping with the right hand. The present study investigated whether this increased sensitivity of the left hand for visual context extends to reaching. Left- and right-handed participants reached for targe...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-010-2214-6
更新日期:2010-05-01 00:00:00
abstract::Two experiments were conducted to determine the effects of conditioned circling on the concentrations of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) within discrete regions of the striatum (STR). The first study assessed the inherent regional distributions of these compounds with ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00247949
更新日期:1989-01-01 00:00:00
abstract::The results of this study show that the different receptive fields of multisensory neurons in the cortex of the cat anterior ectosylvian sulcus (AES) were in spatial register, and it is this register that determined the manner in which these neurons integrated multiple sensory stimuli. The functional properties of mul...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00227844
更新日期:1992-01-01 00:00:00
abstract::The adaptation and habituation characteristics produced by the repeated presentation of a moving visual stimulus were studied in single cells in the pigeon's optic tectum. Units located near the surface in the stratum opticum showed little adaptation. However, cells located in deeper layers exhibited varying rates and...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235509
更新日期:1977-03-30 00:00:00
abstract::The projections of the medial terminal nucleus (MTN) of the accessory optic system (AOS) upon pretectal nuclei have been studied in pigmented rats by means of (i) the anterograde transport of 3H-leucine with the use of light autoradiography and (ii) the retrograde transport of horseradish peroxidase (HRP). Injections ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237218
更新日期:1982-01-01 00:00:00
abstract:PURPOSE:To examine the accuracy and latency of reflexive saccades to vibratory stimulation of the fingertips made by normal human subjects and to compare the findings to those of visually guided saccades. METHODS:Eye movements were recorded using infrared oculography. Stimuli were presented via an array of audiometric...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-003-1749-1
更新日期:2004-02-01 00:00:00
abstract::We investigated the association between the degree of lesion overlap with the corticospinal tract and walking performance before and after 4-weeks of partial body weight support (PBWS) treadmill training in 18 individuals (ten male, eight female) with a mean age 59 +/- 13 years (mean +/- SD), range 32-74 years, who we...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-1237-0
更新日期:2008-03-01 00:00:00
abstract::In this study, we investigated the neural basis of virtual time to contact (VTC) and the hypothesis that VTC provides predictive information for future postural instability. A novel approach to differentiate stable pre-falling and transition-to-instability stages within a single postural trial while a subject was perf...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-009-1956-5
更新日期:2009-10-01 00:00:00
abstract::Anticipatory synergy adjustment (ASA) is a feed-forward control mechanism that describes a continuous decrease in the stability of the current motor state beginning about 150 ms prior to a state transition. Recently, we described an associated phenomenon in which the system stability was reduced solely in response to ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-018-5333-0
更新日期:2018-10-01 00:00:00
abstract::In a series of experiments in which the known projections of the septal complex to the hippocampal formation have been transected, we have used both anterograde and retrograde tracing techniques in an attempt to demonstrate a ventral septo-hippocampal pathway. In cases where transections of the fimbria, dorsal fornix ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235290
更新日期:1984-01-01 00:00:00
abstract::In one of the most-widely used species in pineal gland research, the strongly photoperiodic golden hamster, Mesocricetus auratus, no electrophysiological data on pinealocytes are currently available. To fill this gap, in the present study 185 spontaneously active pinealocytes from male golden hamsters were recorded ex...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00269449
更新日期:1987-01-01 00:00:00
abstract::Research on joint attention has addressed both the effects of gaze following and the ability to share representations. It is largely unknown, however, whether sharing attention also affects the perceptual processing of jointly attended objects. This study tested whether attending to stimuli with another person from op...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-011-2625-z
更新日期:2011-06-01 00:00:00
abstract::We studied in humans the effects of transcranial stimulation of cortical motor areas on the execution of single and sequential rapid arm movements. In a reaction time paradigm with an auditory "go" signal, stimulation given after an auditory tone and before the start of movements delayed the onset but did not affect t...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00233987
更新日期:1994-01-01 00:00:00
abstract::The properties of adaptation within the locomotor and balance control systems directed towards improving one's recovery strategy for fall prevention are not well understood. The purpose of this study was to examine adaptive control of gait stability to repeated slip exposure leading to a reduction in backward loss of ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-005-0189-5
更新日期:2006-03-01 00:00:00
abstract::The effects of L-DOPA, naloxone, and the opioids (D-Ala2,N-Me-Phe4,Gly5-ol)-enkephalin (DAGO) and D-Ser2-Leu-enkephalin-Thr6 (DSLET) on spinal motor rhythm generation were compared in anemically decapitated high spinal cats. After premedication with nialamide, DOPA caused the well-known, slow rhythmic motor activity w...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00241493
更新日期:1995-01-01 00:00:00