Abstract：
:We investigated the association between the degree of lesion overlap with the corticospinal tract and walking performance before and after 4-weeks of partial body weight support (PBWS) treadmill training in 18 individuals (ten male, eight female) with a mean age 59 +/- 13 years (mean +/- SD), range 32-74 years, who were ambulant and 6 months from a subcortical ischaemic stroke. Lesion volumes were manually defined on high resolution T1-weighted 3T-MRI scans and a probabilistic map of the corticospinal tract created using diffusion tensor imaging data collected previously in healthy subjects. The percentage overlap between the lesion and the corticospinal tract was calculated for each patient. Walking performance was determined by measures of 10 m speed, spatiotemporal parameters, percentage recovery of centre of mass (CoM), walking symmetry and 2-min endurance walk prior to and following 4 weeks of treadmill training with PBWS that emphasised normal fast walking. Lesion overlap measures weakly correlated with walking performance measures. Spatiotemporal and performance measures changed in response to training, but spatial symmetry and mechanical energy recovery did not. Walking speed at entry to the study predicted change in response to training of 10 m walk time and swing time asymmetry. Age and lesion overlap did not add to prediction of outcome models. The extent of lesion overlap with the corticospinal tract was not strongly associated with either walking performance or response to gait retraining, despite the correlation of these parameters with upper limb recovery.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Dawes H,Enzinger C,Johansen-Berg H,Bogdanovic M,Guy C,Collett J,Izadi H,Stagg C,Wade D,Matthews PMdoi
10.1007/s00221-007-1237-0subject
Has Abstractpub_date
2008-03-01 00:00:00pages
325-33issue
2eissn
0014-4819issn
1432-1106journal_volume
186pub_type
杂志文章abstract：:Intracellular recording techniques were used to test for cross-modality and topographic convergence among inputs to area 3a of cerebral cortex. Recordings were made within the projection area of group I afferent fibers of the deep radial nerve in barbiturate-anesthetized cats. Epsps were evoked in 90% of neurons (81/9...
journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：1985-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Experimental brain research
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pub_type： 杂志文章
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更新日期：2011-01-01 00:00:00
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journal_title：Experimental brain research
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：2009-12-01 00:00:00
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更新日期：2002-09-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237983
更新日期：1984-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/pl00005729
更新日期：1997-08-01 00:00:00
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更新日期：2009-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s002210050672
更新日期：1999-03-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00229666
更新日期：1993-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：2005-12-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050453
更新日期：1998-07-01 00:00:00
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journal_title：Experimental brain research
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更新日期：2007-02-01 00:00:00
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更新日期：2006-11-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章,随机对照试验
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更新日期：2014-09-01 00:00:00
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journal_title：Experimental brain research
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更新日期：1997-06-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：1998-06-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235318
更新日期：1985-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
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更新日期：2003-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-05-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00250567
更新日期：1989-01-01 00:00:00
