Abstract：
:In this study, we investigated the neural basis of virtual time to contact (VTC) and the hypothesis that VTC provides predictive information for future postural instability. A novel approach to differentiate stable pre-falling and transition-to-instability stages within a single postural trial while a subject was performing a challenging single leg stance with eyes closed was developed. Specifically, we utilized wavelet transform and stage segmentation algorithms using VTC time series data set as an input. The VTC time series was time-locked with multichannel (n = 64) EEG signals to examine its underlying neural substrates. To identify the focal sources of neural substrates of VTC, a two-step approach was designed combining the independent component analysis (ICA) and low-resolution tomography (LORETA) of multichannel EEG. There were two major findings: (1) a significant increase of VTC minimal values (along with enhanced variability of VTC) was observed during the transition-to-instability stage with progression to ultimate loss of balance and falling; and (2) this VTC dynamics was associated with pronounced modulation of EEG predominantly within theta, alpha and gamma frequency bands. The sources of this EEG modulation were identified at the cingulate cortex (ACC) and the junction of precuneus and parietal lobe, as well as at the occipital cortex. The findings support the hypothesis that the systematic increase of minimal values of VTC concomitant with modulation of EEG signals at the frontal-central and parietal-occipital areas serve collectively to predict the future instability in posture.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Slobounov S,Cao C,Jaiswal N,Newell KMdoi
10.1007/s00221-009-1956-5subject
Has Abstractpub_date
2009-10-01 00:00:00pages
1-16issue
1eissn
0014-4819issn
1432-1106journal_volume
199pub_type
杂志文章abstract：:Hemi-seesaw nystagmus (hemi-SSN) is a jerk-waveform nystagmus with conjugate torsional and disjunctive vertical components. Halmagyi et al. in Brain 117(Pt 4):789-803 (1994), reported hemi-SSN in patients with unilateral lesions in the vicinity of the Interstitial Nucleus of Cajal (INC) and suggested that an imbalance...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-010-2376-2
更新日期：2010-09-01 00:00:00
abstract：:The superior colliculus has long been recognized as an important structure in the generation of saccadic displacements of the visual axis. Neurons with presaccadic activity encoding saccade vectors are topographically organized and form a "motor map." Recently, neurons with fixation-related activity have been recorded...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00243221
更新日期：1994-01-01 00:00:00
abstract：:We examined the characteristic features of galanin (GAL)-containing nerve afferents in the intermediolateral nucleus (IML) of the rat lumbosacral spinal cord (L6, S1), i.e., spinal parasympathetic nucleus, by immunocytochemistry at both light and electron microscopic levels. Firstly, the types of synapses formed by GA...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00229624
更新日期：1996-06-01 00:00:00
abstract：:The position of the center of gravity (CG) is a reference value that is controlled by the nervous system during the performance of movements. In order to maintain equilibrium, leg movement is preceded by a shift of the CG towards the supporting side. This CG shift is initiated by an early displacement of the center of...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050453
更新日期：1998-07-01 00:00:00
abstract：:The sense of agency is a profoundly important human experience and is strongly linked to volitional action. The importance of this experience is underscored by the fact that many neurological and psychiatric disorders are partially characterized by an abnormal sense of agency (e.g., schizophrenia, anxiety disorders, d...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-3372-5
更新日期：2013-09-01 00:00:00
abstract：:The thalamic reticular nucleus (RTN) exerts an inhibitory influence upon the dorsal thalamus. During wakefulness and arousal, RTN neurons fire tonically, whereas during slow-wave sleep they fire rhythmic high frequency bursts. The effects produced by RTN inhibition upon the activity of dorsal thalamic neurons will the...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00227192
更新日期：1994-01-01 00:00:00
abstract：:The purpose of this study was to establish whether visual motion parallax participates in the control of postural sway. Body sway was measured in ten normal subjects by photoelectric recordings of head movements and by force-plate posturography. Subjects viewed a visual display ("background"), which briefly moved (2 s...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF02450322
更新日期：1997-02-01 00:00:00
abstract：:Insulin-like growth factor-1 (IGF-1) is an endogenous peptide transported across the blood brain barrier that is protective in several brain injury models, including an acute animal model of Parkinson's disease (PD). Motor deficits in PD are due largely to the progressive loss of nigrostriatal dopaminergic neurons. Th...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-016-4572-1
更新日期：2016-07-01 00:00:00
abstract：:Several recent studies have provided support for the view that tactile stimuli/events are remapped into an abstract spatial frame of reference beyond the initial somatotopic representation present in the primary somatosensory cortex. Here, we demonstrate for the first time that the extent to which this remapping of ta...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1510-x
更新日期：2008-11-01 00:00:00
abstract：:We explored the effects of sensory information upon procedural learning using three versions of the serial reaction-time task (SRTT): a standard task where the position of the stimulus cued the response; a non-standard task where the color of the stimulus was related to the correct response; and a combined task where ...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002210000673
更新日期：2001-04-01 00:00:00
abstract：:Erythropoietin (Epo) has neuroprotective and neurotrophic effects and improves cognitive function in animal models of neurodegenerative and neuropsychiatric illness. In humans, weekly Epo administration over 3 months improves cognitive function in schizophrenia. The neural underpinnings and time-course of this effect ...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/s00221-007-1102-1
更新日期：2008-01-01 00:00:00
abstract：:Integration of tactile afferent signals with motor commands is crucial for the performance of purposeful movements such as during manipulation of an object in the hand. To study the somatotopic organization of sensorimotor integration we applied electrical peripheral conditioning stimuli to a digit located near (homot...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050005
更新日期：2000-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236782
更新日期：1979-03-09 00:00:00
abstract：:The main input of the lateral part of the cat's lateralis posterior-pulvinar complex (LP-P) comes from the primary visual cortex. We investigated the response properties of cells in area 17 projecting to the striate-recipient zone (LP1) of the cat's LP-P complex. The cells' receptive fields were stimulated with drifti...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00227105
更新日期：1993-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228547
更新日期：1996-07-01 00:00:00
abstract：:The reduction in saccade latency when the fixation point is removed (fixation offset effect-FOE) reflects the degree to which fixation neurons are under influence by a stimulus at fixation. Strategic manipulations of oculomotor readiness that bring these neurons under endogenous control reduce the magnitude of the FOE...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1655-7
更新日期：2009-02-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237573
更新日期：1986-01-01 00:00:00
abstract：:The firing of tuberoinfundibular neurones antidromically identified as projecting to the median eminence was recorded during electrical stimulation of the preoptic and/or anterior hypothalamic areas (PO/AH) of the rostral hypothalamus. Parameters of stimulation were chosen which are known to cause increased secretion ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237074
更新日期：1980-01-01 00:00:00
abstract：:Prior studies identify two cortical areas, posterior parahippocampal cortex and retrosplenial cortex, that preferentially activate to images of real-world scenes compared to images of other meaningful visual stimuli such as objects and faces. Behavioral and computational studies suggest that sub-categories of real-wor...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0766-2
更新日期：2007-05-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050788
更新日期：1999-07-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00227964
更新日期：1992-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00242013
更新日期：1995-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-3257-7
更新日期：2012-11-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-2030-z
更新日期：2010-03-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00239743
更新日期：1975-09-29 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210000450
更新日期：2000-09-01 00:00:00
abstract：:The time course of local changes of the extracellular space (ES) was investigated by measuring concentration changes of repeatedly injected tetramethylammonium (TMA+) and choline (Ch+) ions for which cell membranes are largely impermeable. After stimulus-induced extracellular [K+] elevations the delta [TMA+] and delta...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236151
更新日期：1980-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4526-z
更新日期：2016-04-01 00:00:00
abstract：:The tuberomammillary nucleus (TM) located in the posterior part of the hypothalamus is the main source of neuronal histamine in the central nervous system. Recent work from our laboratories has indicated an involvement of the TM region in neuronal plasticity and reinforcement processes. In the present study, we invest...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050301
更新日期：1998-02-01 00:00:00
abstract：:A wealth of evidence implicates the crossed descending projection from the superior colliculus (SC) in orientation and approach behaviours directed towards novel, non-noxious stimuli. In our preceding paper, we identified a population of nociceptive neurones in the rat SC that have axons that project to the contralate...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231781
更新日期：1996-05-01 00:00:00
