Facilitation of learning after lesions of the tuberomammillary nucleus region in adult and aged rats.

Abstract:

:The tuberomammillary nucleus (TM) located in the posterior part of the hypothalamus is the main source of neuronal histamine in the central nervous system. Recent work from our laboratories has indicated an involvement of the TM region in neuronal plasticity and reinforcement processes. In the present study, we investigated the effects of TM lesions on the performance of adult and aged Wistar rats in a set of learning tasks, which differed in terms of complexity and reward contingencies (habituation learning, inhibitory avoidance, discrimination learning, Morris water maze). An improvement was found in every test applied, indicating that TM lesions seem to generally enhance learning and memory capacities independent of the special demands of a given task. Age-related learning deficits were strongly diminished. Immunohistochemistry revealed that the excitotoxic lesions used to destroy the TM region led to a marked decrease in the number of histamine-positive neurons in the vicinity of the injection site, indicating an involvement of the brain histaminergic system in the observed behavioral changes.

journal_name

Exp Brain Res

authors

Frisch C,Hasenöhrl RU,Haas HL,Weiler HT,Steinbusch HW,Huston JP

doi

10.1007/s002210050301

subject

Has Abstract

pub_date

1998-02-01 00:00:00

pages

447-56

issue

4

eissn

0014-4819

issn

1432-1106

journal_volume

118

pub_type

杂志文章
  • Spatial coding of eye movements relative to perceived earth and head orientations during static roll tilt.

    abstract::This purpose of this study was to examine the spatial coding of eye movements during static roll tilt (up to +/-45 degrees) relative to perceived earth and head orientations. Binocular videographic recordings obtained in darkness from eight subjects allowed us to quantify the mean deviations in gaze trajectories along...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210050436

    authors: Wood SJ,Paloski WH,Reschke MF

    更新日期:1998-07-01 00:00:00

  • Are automatic postural responses in patients with Parkinson's disease abnormal due to their stooped posture?

    abstract::Abnormal automatic postural responses are thought to contribute to balance impairment in Parkinson's disease. However, because postural responses are modifiable by stance, we have speculated that some postural abnormalities in patients with Parkinson's disease are secondary to their stooped stance. We have studied thi...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210050644

    authors: Bloem BR,Beckley DJ,van Dijk JG

    更新日期:1999-02-01 00:00:00

  • Conditional task-related responses in monkey dorsomedial frontal cortex.

    abstract::Dorsomedial frontal cortex (DMFC) was studied in monkeys trained to make visually guided eye or arm movements. Portions of DMFC are involved in the execution of learned, goal-directed behaviors. Many neurons discharge with both eye and hand movements as well as when motor responses are withheld, provided these behavio...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00247300

    authors: Mann SE,Thau R,Schiller PH

    更新日期:1988-01-01 00:00:00

  • Effect of contrast on spatial frequency tuning of neurones in area 17 of cat's visual cortex.

    abstract::Previous investigations have revealed that perceived spatial frequency of gratings rises as contrast is lowered. In order to account for this finding it has been postulated that the spatial frequency which produces the maximum response from cortical neurones decreases with contrast. We have examined this hypothesis by...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00236862

    authors: Skottun BC,Bradley A,Ramoa AS

    更新日期:1986-01-01 00:00:00

  • Changes in motor performance and mental workload during practice of reaching movements: a team dynamics perspective.

    abstract::Few investigations have examined mental workload during motor practice or learning in a context of team dynamics. This study examines the underlying cognitive-motor processes of motor practice by assessing the changes in motor performance and mental workload during practice of reaching movements. Individuals moved a r...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-017-5136-8

    authors: Shuggi IM,Shewokis PA,Herrmann JW,Gentili RJ

    更新日期:2018-02-01 00:00:00

  • Properties of a new vestibulospinal projection, the caudal vestibulospinal tract.

    abstract::Neurons in the caudal portions of the medial and descending vestibular nuclei and in vestibular cell group f that project to the cervical or lumbar spinal cord were located by antidromic spinal stimulation. These caudal vestibulospinal tract (CVST) neurons have a median conduction velocity of 12 m/sec, which is well b...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00239733

    authors: Peterson BW,Maunz RA,Fukushima K

    更新日期:1978-06-19 00:00:00

  • Simultaneous repetitive movements following pallidotomy or subthalamic deep brain stimulation in patients with Parkinson's disease.

    abstract::Patients with Parkinson's disease (PD) commonly exhibit difficulties performing simultaneous tasks and levodopa has been shown to improve the performance of these movements to a greater extent than movements performed in isolation. The aim of this study was to compare the effects of acute unilateral pallidal lesions (...

    journal_title:Experimental brain research

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00221-002-1257-8

    authors: Levy R,Lang AE,Hutchison WD,Lozano AM,Dostrovsky JO

    更新日期:2002-12-01 00:00:00

  • Sight-reading of violinists: eye movements anticipate the musical flow.

    abstract::When sight-reading a piece of music the eyes constantly scan the score slightly ahead of music execution. This separation between reading and acting is commonly termed eye-hand span and can be expressed in two ways: as anticipation in notes or in time. Previous research, predominantly in piano players, found skill-dep...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-009-1719-3

    authors: Wurtz P,Mueri RM,Wiesendanger M

    更新日期:2009-04-01 00:00:00

  • Fooling the brain into thinking it sees both hands moving enhances bimanual spatial coupling.

    abstract::This study examined the hypothesis that the mirror reflection of one hand's movement directly influences motor output of the other (hidden) hand, during performance of bimanual drawing. A mirror was placed between the two hands during bimanual circle drawing, with one hand and its reflection visible and the other hand...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-004-1831-3

    authors: Franz EA,Packman T

    更新日期:2004-07-01 00:00:00

  • The cognitive and neural mechanisms underlying norm-enforcement behaviors under social observation.

    abstract::Abundant evidence has revealed that social observation could enhance people's norm-enforcement behaviors to norm violators. However, whether such enhancement is strategically reputation-based without changes on awareness of social norms or it is accompanied with strengthened perception of norm violations remains uncle...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-020-05762-6

    authors: Ouyang H,Sun F,Che L,Zhang W,Cheng X,Zheng L

    更新日期:2020-05-01 00:00:00

  • Cerebello-cortical linkage in the monkey as revealed by transcellular labeling with the lectin wheat germ agglutinin conjugated to the marker horseradish peroxidase.

    abstract::The possibility of a cerebellar linkage, via the thalamus with medial area 6 of the cerebral cortex was further explored in the present experiments (cf. preceding companion paper). It was found that HRP conjugated to the lectin wheat germ agglutinin injected into motor cortical areas was transported beyond the thalamu...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00237671

    authors: Wiesendanger R,Wiesendanger M

    更新日期:1985-01-01 00:00:00

  • Time processing reflected by EEG surface Laplacians.

    abstract::We previously described significant relationships between amplitude variations in slow brain potentials and timed between-press intervals (2.5 s). We suggested that these variations are neural traces of timing mechanisms. To determine which time processing stage is concerned, the current study examines whether these v...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-002-1103-z

    authors: Macar F,Vidal F

    更新日期:2002-08-01 00:00:00

  • Neuroplasticity of imagined wrist actions after spinal cord injury: a pilot study.

    abstract::Motor imagery (MI - i.e., the mental representation of an action without physically executing it) stimulates brain motor networks and promotes motor learning after spinal cord injury (SCI). An interesting issue is whether the brain networks controlling MI are being reorganized with reference to spared motor functions....

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-014-4114-7

    authors: Di Rienzo F,Guillot A,Mateo S,Daligault S,Delpuech C,Rode G,Collet C

    更新日期:2015-01-01 00:00:00

  • The COGs (context, object, and goals) in multisensory processing.

    abstract::Our understanding of how perception operates in real-world environments has been substantially advanced by studying both multisensory processes and "top-down" control processes influencing sensory processing via activity from higher-order brain areas, such as attention, memory, and expectations. As the two topics have...

    journal_title:Experimental brain research

    pub_type: 杂志文章,评审

    doi:10.1007/s00221-016-4590-z

    authors: ten Oever S,Romei V,van Atteveldt N,Soto-Faraco S,Murray MM,Matusz PJ

    更新日期:2016-05-01 00:00:00

  • Electrophysiological and anatomical observations concerning the pallidostriatal pathway in the rat.

    abstract::Anatomical studies in several species have demonstrated a pallidostriatal pathway. We employed electrophysiological and anatomical methods to distinguish the neurones of this pathway from the two pallidocortical groups reported in the rat. Injection of fluorescent retrograde tracers, combined with immunohistochemistry...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00248863

    authors: Walker RH,Arbuthnott GW,Wright AK

    更新日期:1989-01-01 00:00:00

  • Paired-pulse facilitation and inhibition in the dentate gyrus is dependent on behavioral state.

    abstract::It is well established that neuronal transmission from the entorhinal cortex through the dentate gyrus via the perforant path is dependent on behavioral state. To further study the modulation of neuronal transmission by behavioral state we employed the paired-pulse technique to study interneuronally-mediated inhibitio...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00249612

    authors: Austin KB,Bronzino JD,Morgane PJ

    更新日期:1989-01-01 00:00:00

  • Neural compensation for mechanical loading of the hand during coupled oscillations of the hand and foot.

    abstract::The role of kinaesthetic afferences in controlling coupling of voluntary oscillation of the hand and foot, both in-phase and anti-phase, was investigated by modifying the mechanical properties of one of the two segments (the hand) with applied inertial or elastic loads. Loads consisted of a lead disk, rotating coaxial...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210100762

    authors: Baldissera F,Cavallari P

    更新日期:2001-07-01 00:00:00

  • Ocular dominance in kitten cortex: induced changes of single cells while they are recorded.

    abstract::We have monitored extracellularly individual neurons in the striate cortex of 4-week-old unparalyzed kittens with the aim of changing the ocular dominance of these cells during recording. To do this, we elicited conjugate eye movements using a bipolar stimulating electrode positioned in the internal medullary lamina (...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00236575

    authors: Tsumoto T,Freeman RD

    更新日期:1981-01-01 00:00:00

  • Head movement propensity.

    abstract::In studies of human eye-head coordinated saccadic gaze shifts, different laboratories have found greatly different magnitudes of head movements for a given amplitude of gaze shift (head movement gain). The present study was conducted to examine why, and to quantify volitional head movements. Fixation/target lights wer...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00230391

    authors: Fuller JH

    更新日期:1992-01-01 00:00:00

  • Prism adaptation magnitude has differential influences on perceptual versus manual responses.

    abstract::Previous research has indicated that rightward prism adaptation can reduce symptoms of spatial neglect following right brain damage. In addition, leftward prism adaptation can create "neglect-like" patterns of performance in healthy adults on tasks that measure attention and spatial biases. Although a great deal of re...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-016-4678-5

    authors: Striemer CL,Russell K,Nath P

    更新日期:2016-10-01 00:00:00

  • Evidence for a role of the reticulospinal system in recovery of skilled reaching after cortical stroke: initial results from a model of ischemic cortical injury.

    abstract::The purposes of this pilot study were to create a model of focal cortical ischemia in Macaca fascicularis and to explore contributions of the reticulospinal system in recovery of reaching. Endothelin-1 was used to create a focal lesion in the shoulder/elbow representation of left primary motor cortex (M1) of two adult...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-015-4390-x

    authors: Herbert WJ,Powell K,Buford JA

    更新日期:2015-11-01 00:00:00

  • Static and dynamic discharge properties of vestibular-nerve afferents in the mouse are affected by core body temperature.

    abstract::The goal of this study was to determine the effect of changes in core body temperature on the resting discharge rate and sensitivity of vestibular-nerve afferents. Extracellular recordings were made from vestibular-nerve afferents innervating the semicircular canals in anesthetized C57BL/6 mice maintained at a core bo...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-009-2015-y

    authors: Park HJ,Lasker DM,Minor LB

    更新日期:2010-01-01 00:00:00

  • Abnormal morphology and subcortical projections to the medial geniculate in an animal model of autism.

    abstract::Auditory dysfunction, including hypersensitivity and tinnitus, is a common symptom of autism spectrum disorder (ASD). Prenatal exposure to the antiseizure medication valproic acid (VPA) significantly increases the risk of ASD in humans and similar exposure is utilized as an animal model of ASD in rodents. Animals expo...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-020-05982-w

    authors: Mansour Y,Ahmed SN,Kulesza R

    更新日期:2020-11-16 00:00:00

  • Embodied and disembodied allocentric simulation in high schizotypal subjects.

    abstract::It is known that non-clinical subjects with high levels of schizotypal personality traits (High-S), as well as schizophrenic patients, have difficulties to judge how a scene would appear (so-called Appearance questions) from a point of view other than their own after having performed a disembodied perspective taking (...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-014-3991-0

    authors: Vastano R,Sulpizio V,Steinisch M,Comani S,Committeri G

    更新日期:2014-10-01 00:00:00

  • Impaired anticipatory control of force sharing patterns during whole-hand grasping in Parkinson's disease.

    abstract::We examined the coordination of multi-digit grasping forces as they developed during object grasping and lifting. Ten subjects with Parkinson's disease (PD; OFF and ON medication) and ten healthy age-matched control subjects lifted a manipulandum that measured normal forces at each digit and the manipulandum's positio...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-007-1129-3

    authors: Muratori LM,McIsaac TL,Gordon AM,Santello M

    更新日期:2008-02-01 00:00:00

  • Neurogenesis of cuneothalamic neurons and NO-containing neurons in the cuneate nucleus of the rat.

    abstract::The genesis of the cuneothalamic neurons (CTNs) in the rat cuneate nucleus was determined by a double-labeling method using 5'-bromodeoxyuridine (BrdU), the thymidine analogue, and Fluoro-Gold (FG), a retrograde fluorescent tracer. BrdU-positive cells were observed in the cuneate nucleus in all rats receiving BrdU inj...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-001-0950-3

    authors: Wang TJ,Lue JH,Wu CH,Shieh JY,Wen CY

    更新日期:2002-02-01 00:00:00

  • Ipsilesional functional recruitment within lower mu band in children with unilateral cerebral palsy, an event-related desynchronization study.

    abstract::Cerebral palsy (CP) is a group of non-progressive developmental movement disorders inducing a strong brain reorganization in primary and secondary motor areas. Nevertheless, few studies have been dedicated to quantify brain pattern changes and correlate them with motor characteristics in CP children. In this context, ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-017-5149-3

    authors: Inuggi A,Bassolino M,Tacchino C,Pippo V,Bergamaschi V,Campus C,De Franchis V,Pozzo T,Moretti P

    更新日期:2018-02-01 00:00:00

  • Increased attentiveness is associated with hemispheric asymmetry measured with lateral tympanic membrane temperature in humans and dogs.

    abstract::In this study, we examined the relationship between a measure of cerebral lateralization--differences in tympanic temperature (T(Ty))--and questionnaire measures of inattentiveness and hyperactivity in both people and dogs. Theories of cerebral lateralization indicate that cerebral asymmetry may improve attentive beha...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-012-3093-9

    authors: Helton WS,Maginnity M

    更新日期:2012-06-01 00:00:00

  • Sex differences in the acquisition of complex skilled movements.

    abstract::The praxis system comprises a network of brain regions dedicated to complex skilled movements. Following suggestions of a female advantage on learned movements (Chipman and Hampson in Neuropsychologia 44(12):2315-2329, 2006), we investigated how males and females acquire skilled movements. Subjects viewed and imitated...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-010-2351-y

    authors: Cohen NR,Pomplun M,Gold BJ,Sekuler R

    更新日期:2010-08-01 00:00:00

  • The primary visual cortex in the mouse: receptive field properties and functional organization.

    abstract::Receptive field (RF) characteristics of cells in primary visual cortex of the mouse (C57B16 strain) were studied by single unit recording. We have studied the functional organization of area 17 along both the radial and tangential dimensions of the cortex. Eighty seven percent of the visual neurons could be classified...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00247312

    authors: Métin C,Godement P,Imbert M

    更新日期:1988-01-01 00:00:00