Abstract:
:The tuberomammillary nucleus (TM) located in the posterior part of the hypothalamus is the main source of neuronal histamine in the central nervous system. Recent work from our laboratories has indicated an involvement of the TM region in neuronal plasticity and reinforcement processes. In the present study, we investigated the effects of TM lesions on the performance of adult and aged Wistar rats in a set of learning tasks, which differed in terms of complexity and reward contingencies (habituation learning, inhibitory avoidance, discrimination learning, Morris water maze). An improvement was found in every test applied, indicating that TM lesions seem to generally enhance learning and memory capacities independent of the special demands of a given task. Age-related learning deficits were strongly diminished. Immunohistochemistry revealed that the excitotoxic lesions used to destroy the TM region led to a marked decrease in the number of histamine-positive neurons in the vicinity of the injection site, indicating an involvement of the brain histaminergic system in the observed behavioral changes.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Frisch C,Hasenöhrl RU,Haas HL,Weiler HT,Steinbusch HW,Huston JPdoi
10.1007/s002210050301subject
Has Abstractpub_date
1998-02-01 00:00:00pages
447-56issue
4eissn
0014-4819issn
1432-1106journal_volume
118pub_type
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