Abstract：
:The purposes of this pilot study were to create a model of focal cortical ischemia in Macaca fascicularis and to explore contributions of the reticulospinal system in recovery of reaching. Endothelin-1 was used to create a focal lesion in the shoulder/elbow representation of left primary motor cortex (M1) of two adult female macaques. Repetitive microstimulation was used to map upper limb motor outputs from right and left cortical motor areas and from the pontomedullary reticular formation (PMRF). In subject 1 with a small lesion and spontaneous recovery, reaching was mildly impaired. Changes were evident in the shoulder/elbow representations of both the lesioned and contralesional M1, and there appeared to be fewer than expected upper limb responses from the left (ipsilesional) PMRF. In subject 2 with a substantial lesion, reaching was severely impaired immediately after the lesion. After 12 weeks of intensive rehabilitative training, reach performance recovered to near-baseline levels, but movement times remained about 50% slower. Surprisingly, the shoulder/elbow representation in the lesioned M1 remained completely absent after recovery, and there was a little change in the contralesional M1. There was a definite difference in motor output patterns for left versus right PMRF for this subject, with an increase in right arm responses from right PMRF and a paucity of left arm responses from left PMRF. The results are consistent with increased reliance on PMRF motor outputs for recovery of voluntary upper limb motor control after significant cortical ischemic injury.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Herbert WJ,Powell K,Buford JAdoi
10.1007/s00221-015-4390-xsubject
Has Abstractpub_date
2015-11-01 00:00:00pages
3231-51issue
11eissn
0014-4819issn
1432-1106pii
10.1007/s00221-015-4390-xjournal_volume
233pub_type
杂志文章abstract：:Limb proprioception is an awareness by the central nervous system (CNS) of the location of a limb in three-dimensional space and is essential for movement and postural control. The CNS uses the position of the head and neck when interpreting the position of the upper limb, and altered input from neck muscles may affec...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4240-x
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00239581
更新日期：1982-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1319-7
更新日期：2008-05-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210100738
更新日期：2001-06-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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journal_title：Experimental brain research
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0502-y
更新日期：2006-10-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：2019-05-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237269
更新日期：1977-11-24 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00608257
更新日期：1990-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：2010-05-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-3292-4
更新日期：2013-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-001-0971-y
更新日期：2002-03-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00229624
更新日期：1996-06-01 00:00:00
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journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/s002210050489
更新日期：1998-09-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-1840-3
更新日期：2009-06-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00269449
更新日期：1987-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4382-x
更新日期：2015-11-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00243214
更新日期：1994-01-01 00:00:00
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doi：10.1007/s00221-015-4473-8
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更新日期：2016-08-01 00:00:00
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更新日期：2009-01-01 00:00:00
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更新日期：2018-01-01 00:00:00
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更新日期：1984-01-01 00:00:00
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更新日期：2008-03-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：2002-08-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：2012-11-01 00:00:00
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更新日期：2008-08-01 00:00:00
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journal_title：Experimental brain research
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更新日期：1980-01-01 00:00:00
abstract：:The effects of alteration of thyroid state on neurochemical maturation have been studied in rats made hypothyroid by daily injections of methimazole or hyperthyroid by daily supplementation with thyroid hormone (T3) from postnatal days 1 to 27. Biochemical assays on seven brain regions plus the spinal cord were carrie...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00229834
更新日期：1991-01-01 00:00:00
