Abstract：
:A afferent fibers have been reported to participate in the development of the central sensitization induced by inflammation and injuries. Current evidence suggests that myofascial trigger points (MTrPs) induce central sensitization in the related spinal dorsal horn, and clinical studies indicate that A fibers are associated with pain behavior. Because most of these clinical studies applied behavioral indexes, objective evidence is needed. Additionally, MTrP-related neurons in dorsal root ganglia and the spinal ventral horn have been reported to be smaller than normal, and these neurons were considered to be related to A fibers. To confirm the role of A fibers in MTrP-related central changes in the spinal dorsal horn, we studied central sensitization as well as the size of neurons associated with myofascial trigger spots (MTrSs, equivalent to MTrPs in humans) in the biceps femoris muscle of rats and provided some objective morphological evidence. Cholera toxin B subunit-conjugated horseradish peroxidase was applied to label the MTrS-related neurons, and tetrodotoxin was used to block A fibers specifically. The results showed that in the spinal dorsal horn associated with MTrS, the expression of glutamate receptor (mGluR1α/mGluR5/NMDAR1) increased, while the mean size of MTrS-related neurons was smaller than normal. After blocking A fibers, these changes reversed to some extent. Therefore, we concluded that A fibers participated in the development and maintenance of the central sensitization induced by MTrPs and were related to the mean size of neurons associated with MTrPs in the spinal dorsal horn.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Meng F,Ge HY,Wang YH,Yue SWdoi
10.1007/s00221-015-4382-xsubject
Has Abstractpub_date
2015-11-01 00:00:00pages
3133-43issue
11eissn
0014-4819issn
1432-1106pii
10.1007/s00221-015-4382-xjournal_volume
233pub_type
杂志文章abstract：:Organotypic slice cultures of striatum and neocortex were prepared from newborn to seven day old rats and cultured for three to 60 days. When processed for tyrosine hydroxylase (TH) immunocytochemistry medium-sized, aspiny TH immunoreactive (TH-i) neurons with a similar morphology were revealed in the striatum and the...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231159
更新日期：1991-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00406608
更新日期：1988-01-01 00:00:00
abstract：:According to the peak and decline model divergent thinking declines at a specific age (in or after middle age). However, if divergent thinking declines steadily in aging still has to be clarified. In order to explore the age-related changes in verbal and visual divergent thinking, in the present study a sample of 159 ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-016-4857-4
更新日期：2017-04-01 00:00:00
abstract：:Pain catastrophizing has been associated with phantom limb pain, but so far the cortical processes and the brain regions involved in this relationship have not been investigated. It was therefore tested whether catastrophizing was related to (1) spontaneous pain, (2) somatosensory activity and (3) cortical responses i...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-3027-6
更新日期：2012-05-01 00:00:00
abstract：:An object held in precision grip creates predictable load forces on the hand during voluntary hand movement and these are associated with anticipatory modulation of grip force. Conflicting results have been obtained over whether predictable external load perturbations result in anticipatory grip force responses (e.g. ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0537-0
更新日期：2006-10-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228869
更新日期：1990-01-01 00:00:00
abstract：:We studied the development of information-movement couplings in a ball-bouncing task with a special interest in how space- and time-related information is used by people of different ages. Participants from four age groups (children aged 7-8, 9-10 and 11-12 years, and adults) performed a virtual ball-bouncing task in ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4443-1
更新日期：2016-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237996
更新日期：1984-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-011-2653-8
更新日期：2011-06-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/pl00005715
更新日期：1997-07-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-007-1097-7
更新日期：2008-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00230530
更新日期：1991-01-01 00:00:00
abstract：:Several studies have shown that people can catch a ball even if it is visible only during part of its flight. Here, we examine how well they can do so. We measured the movements of a ball and of the hands of both the thrower and the catcher during one-handed underarm throwing and catching. The catcher's sight was occl...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-010-2421-1
更新日期：2010-10-01 00:00:00
abstract：:Sudden limb displacement evokes a complex sequence of compensatory muscle activity. Following the short-latency reflex and preceding voluntary reactions is an epoch termed the medium-latency reflex (MLR) that could reflect spinal processing of group II muscle afferents. One way to test this possibility is oral ingesti...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-017-5162-6
更新日期：2018-03-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237328
更新日期：1976-05-10 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237473
更新日期：1986-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00248862
更新日期：1989-01-01 00:00:00
abstract：:This study investigated whether the execution of an accurate pointing response depends on a prior saccade orientation towards the target, independent of the vision of the limb. A comparison was made between the accuracy of sequential responses (in which the starting position of the hand is known and the eye centred on...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/BF00228987
更新日期：1994-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002210100777
更新日期：2001-08-01 00:00:00
abstract：:The retinal projections of the "non-image forming" system to the hypothalamus, anterodorsal thalamus and basal telencephalon were visualized in adult mink using the anterograde transport of cholera toxin conjugated to horseradish peroxidase injected intraocularly. A major and nearly symmetrical bilateral input of labe...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228253
更新日期：1992-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00230932
更新日期：1992-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00250579
更新日期：1989-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00238808
更新日期：1981-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-2999-6
更新日期：2012-04-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0779-x
更新日期：2007-05-01 00:00:00
abstract：:Inhibitory control plays an important role in goal-directed behavior. Although substantial inter-individual variability exists in the behavioral performance of response inhibition, the corresponding modulating neurochemical and neurophysiological mechanisms remain unclear. Thus, the present study aimed to explore the ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-017-5101-6
更新日期：2017-12-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-3074-z
更新日期：2012-05-01 00:00:00
abstract：:The Attention Network Test (ANT) is a frequently used computer-based tool for measuring the three attention networks (alerting, orienting, and executive control). We examined the psychometric properties of performance on a variant of the ANT, the Attention Network Test-Interaction (ANT-I) in healthy older adults (N = ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4493-4
更新日期：2016-03-01 00:00:00
abstract：:The present experiments were designed to investigate the neuronal mechanisms, at the level of the primary somatosensory cortex, which underlie the observation that somatosensory cortical potentials evoked by air puff stimuli directed at the forearm are decreased, in a nonspecific and widespread manner, during voluntar...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231455
更新日期：1991-01-01 00:00:00
abstract：:Descending vestibular pathways have been shown to influence recruitment thresholds of alpha motoneurones in both human and cat. However, whereas parallel connections to the fusimotor system have been shown in the cat, such connections have not yet been demonstrated in humans. In the present study we investigated wheth...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0836-5
更新日期：2007-06-01 00:00:00
