Abstract：
:Sudden limb displacement evokes a complex sequence of compensatory muscle activity. Following the short-latency reflex and preceding voluntary reactions is an epoch termed the medium-latency reflex (MLR) that could reflect spinal processing of group II muscle afferents. One way to test this possibility is oral ingestion of tizanidine, an alpha-2 adrenergic agonist that inhibits the interneurons transmitting group II signals onto spinal motor neurons. We examined whether group II afferents contribute to MLR activity throughout the major muscles that span the elbow and shoulder. MLRs of ankle muscles were also tested during walking on the same day, in the same participants as well as during sitting in a different group of subjects. In contrast to previous reports, the ingestion of tizanidine had minimal impact on MLRs of arm or leg muscles during motor actions. A significant decrease in magnitude was observed for 2/16 contrasts in arm muscles and 0/4 contrasts in leg muscles. This discrepancy with previous studies could indicate that tizanidine's efficacy is altered by subtle changes in protocol or that group II afferents do not substantially contribute to MLRs.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Kurtzer I,Bouyer LJ,Bouffard J,Jin A,Christiansen L,Nielsen JB,Scott SHdoi
10.1007/s00221-017-5162-6subject
Has Abstractpub_date
2018-03-01 00:00:00pages
665-677issue
3eissn
0014-4819issn
1432-1106pii
10.1007/s00221-017-5162-6journal_volume
236pub_type
杂志文章abstract：:We studied intermanual motor transfer for right-to-left or left-to-right direction of transfer between either proximal or distal upper extremity muscle groups. The influence of previously acquired motor engrams (original learning, OL) on learning efficiency of the contralateral side (transfer learning, TL) was examine...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/BF00228105
更新日期：1996-03-01 00:00:00
abstract：:It has been hypothesized that the steady-state response to a periodic sequence of clicks can be modeled as the superposition of responses to single clicks. Here, this hypothesis is challenged by presenting an extra click halfway between two consecutive clicks of a regular series, while measuring the auditory evoked fi...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4260-6
更新日期：2015-06-01 00:00:00
abstract：:Fast goal-directed voluntary movements of the human upper extremity are known to be associated with three distinct bursts of EMG activity in antagonistic muscles. The role of each burst (AG1, ANT, AG2) in controlling motion is not fully understood, largely because overall limb response is a complex function of the ent...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236850
更新日期：1986-01-01 00:00:00
abstract：:The stronger anatomo-functional connections of the supplementary motor area (SMA), as compared with premotor area (PM), with regions of the limbic system, suggest that SMA could play a role in the control of movements triggered by visual stimuli with emotional content. We addressed this issue by analysing the modifica...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-002-1346-8
更新日期：2003-03-01 00:00:00
abstract：:We tested the hypothesis that geniculate X cells are the neural substrate of psychophysically identified pattern channels and that geniculate Y cells are the neural substrate of psychophysically identified flicker channels. The hypothesis was tested by measuring the relative sensitivity of isolated X and Y cells in th...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00240505
更新日期：1984-01-01 00:00:00
abstract：:Fast cyclic movements and discrete motor acts are controlled differently, presumably because fast cyclic tasks are more automated, thereby depending on different circuits. If fast cyclic movements are made less predictable (e.g., by mixing frequencies), one would predict that their control will be less automated, requ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3686-y
更新日期：2013-11-01 00:00:00
abstract：:We conducted a series of experiments to determine whether negative priming is used in the process of target selection for a saccadic eye movement. The key questions addressed the circumstances in which the negative priming of an object takes place, and the distinction between spatial and object-based effects. Experime...
journal_title：Experimental brain research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00221-012-3234-1
更新日期：2012-10-01 00:00:00
abstract：:Changing direction during walking is a common task humans encounter every day. This destabilizing event requires the central nervous system (CNS) to quickly produce an appropriate response, maintain stability, and propel the body in the intended direction. Previous research has demonstrated that 'individuals with mult...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-014-3873-5
更新日期：2014-06-01 00:00:00
abstract：:Ball-racket interactions were investigated in a task where participants propelled a ball rhythmically into the air. The study contrasted two ball-racket conditions: (1) an elastic impact where the ball was able to rebound due to the elasticity of the colliding objects and participants bounced the ball, and (2) a non-e...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-002-1331-2
更新日期：2003-03-01 00:00:00
abstract：:Middle cerebral artery occlusion (MCAO) models have become well established as the most suitable way to simulate stroke in experimental studies. The high variability in the size of the resulting infarct due to filament composition, rodent strain and vessel anatomy makes the setup of such models very complex. Beside co...
journal_title：Experimental brain research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00221-012-3296-0
更新日期：2013-01-01 00:00:00
abstract：:Pontine omnipause neurons (OPNs) have so far been considered as forming a homogeneous group of neurons whose tonic firing stops during the duration of saccades, when the head is immobilized. In cats, they pause for the total duration of gaze shifts, when the head is free to move. In the present study, carried out on a...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050685
更新日期：1999-04-01 00:00:00
abstract：:Synaptic depression was assessed from intracellular recordings in cortical tissue slices. Evoked postsynaptic potentials exhibited synaptic depression with an exponential or double exponential decrease (time constants: < 1-30 s) in amplitude during repetitive afferent stimulation by short trains of suprathreshold stim...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00241364
更新日期：1995-01-01 00:00:00
abstract：:This study investigates coordination between hand transport and grasp movement components by examining a hypothesis that the hand location, relative to the object, in which aperture closure is initiated remains relatively constant under a wide range of transport speed. Subjects made reach-to-grasp movements to a dowel...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0423-9
更新日期：2006-09-01 00:00:00
abstract：:The purpose of this study was to investigate the temporal relationship between presaccadic neuronal discharges in the frontal eye fields (FEF) and supplementary eye fields (SEF) and the initiation of saccadic eye movements in macaque. We utilized an analytical technique that could reliably identify periods of neuronal...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00241967
更新日期：1995-01-01 00:00:00
abstract：:Previous work in our laboratory has demonstrated that binocular vision makes an important contribution to skilled reaching and grasping movements directed at static targets. In the present study we examine the contribution of binocular vision to interceptive reaching movements. We monitored such movements using a high...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/s002210050323
更新日期：1998-03-01 00:00:00
abstract：:The purpose of this study was to determine if recovery of neurologically impaired hand function following isolated motor cortex injury would occur without constraint of the non-impaired limb, and without daily forced use of the impaired limb. Nine monkeys (Macaca mulatta) received neurosurgical lesions of various exte...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-010-2157-y
更新日期：2010-05-01 00:00:00
abstract：:The activity of voltage-gated K(+) channels (Kv) can be dynamically modulated by several events, including neurotransmitter stimulated biochemical cascades mediated by G protein-coupled receptors such as 5-HT2 receptors (5-HT2Rs). Activation of 5-HT2A/CR inhibits the Shaker-like K(+) channels Kv1.1 and Kv1.2, and this...
journal_title：Experimental brain research
pub_type： 杂志文章,评审
doi：10.1007/s00221-013-3555-8
更新日期：2013-10-01 00:00:00
abstract：:Previous research has demonstrated that viewing one's hand can induce tactile response compatibility effects at the hands. Here, we investigated the question of whether vision of one's own hand is actually necessary. The Eriksen flanker task was combined with the rubber hand illusion in order to determine whether tact...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-014-4129-0
更新日期：2015-02-01 00:00:00
abstract：:Humans show a gravitational advantage in perception: we are more precise at judging the speed of downwards-moving than upwards-moving objects, indicating that gravitational acceleration is an internalised prior. However, it is unclear whether this gravity prior is based on purely perceptual cues or whether it can inco...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-020-05852-5
更新日期：2020-09-01 00:00:00
abstract：:1. The responses are described of cochlear nucleus neurons of anaesthetized cats as a function of time in dependence on intensity and frequency of tonal stimuli. Depending on spectral properties three types are distinguished in the group of spontaneously active units: A type (activation only) AS type (activation and s...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00238021
更新日期：1975-10-24 00:00:00
abstract：:In 15 musicians, cortical DC-potentials were recorded from the scalp before and during the execution of bimanual motor sequences. Subjects (Ss) either tapped with their two index fingers in synchrony (quavers against quavers; "2 against 2") or they tapped quavers against triplets ("2 against 3"). Either the right or t...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00229320
更新日期：1990-01-01 00:00:00
abstract：:Receptive field (RF) characteristics of cells in primary visual cortex of the mouse (C57B16 strain) were studied by single unit recording. We have studied the functional organization of area 17 along both the radial and tangential dimensions of the cortex. Eighty seven percent of the visual neurons could be classified...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00247312
更新日期：1988-01-01 00:00:00
abstract：:X-ray photography was employed to analyse the postural syndromes following unilateral global and selective lesions of the vestibular apparatus in guinea pigs. Following hemilabyrinthectomy, head rotation in the horizontal plane resulted mainly from rotation of the cervical vertebrae whereas lateral head tilt was due t...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00250579
更新日期：1989-01-01 00:00:00
abstract：:Pax genes are important modulators of CNS development. Pax7 and Pax6 polarise the neural tube and regionalise the brain. Pax7 is pivotal in specifying the superior colliculus/tectum, an important centre for integration of visuomotor responses and a target for Pax6+ retinal ganglion cell axons during retinocollicular m...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0735-9
更新日期：2007-04-01 00:00:00
abstract：:The purpose of this study was to examine the effect of prior experience concerning direction of a postural perturbation on the balance response of cats to translations of their support surface. Previous work has shown that, when cats are translated in many directions in the horizontal plane, they respond by exerting a...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00227333
更新日期：1994-01-01 00:00:00
abstract：:Emotional memory consolidation has been associated with rapid eye movement (REM) sleep, and recent evidence suggests that increased electroencephalogram spectral power in the theta (4-8 Hz) frequency range indexes this activity. REM sleep has been implicated in posttraumatic stress disorder (PTSD) as well as in emotio...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-014-3857-5
更新日期：2014-05-01 00:00:00
abstract：:Observing an action activates action representations in the motor system. Moreover, the representations of manipulable objects are closely linked to the motor systems at a functional and neuroanatomical level. Here, we investigated whether action observation can facilitate object recognition using an action priming pa...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-1953-8
更新日期：2010-01-01 00:00:00
abstract：:Adrenocortical responses, as expressed by changes in plasma corticosterone levels, following ether stress and dorsal hippocampal stimulation, were studied in intact rats and in rats with complete, anterior of posterior hypothalamic deafferentations. Ether stress produced normal responses in all experimental groups. In...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237345
更新日期：1981-01-01 00:00:00
abstract：:The firing of neurons from layers II and III of medial entorhinal cortex (MEC) was examined in relation to the hippocampal theta rhythm in urethane anesthetized and walking rats. 1) MEC neurons showed a significant phase relation to the hippocampal theta rhythm in both walking and urethane anesthetized rats, suggestin...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00229252
更新日期：1992-01-01 00:00:00
abstract：:The aim of this study was to examine coherence between surface electromyographic (EMG) signals from two index finger flexor muscles, the first dorsal interosseous (FDI) and flexor digitorum superficialis (FDS), during and immediately following sustained, fatiguing isometric contraction. Coherence was observed between ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-2110-0
更新日期：2010-04-01 00:00:00
