5-HT2 receptors-mediated modulation of voltage-gated K+ channels and neurophysiopathological correlates.

Abstract:

:The activity of voltage-gated K(+) channels (Kv) can be dynamically modulated by several events, including neurotransmitter stimulated biochemical cascades mediated by G protein-coupled receptors such as 5-HT2 receptors (5-HT2Rs). Activation of 5-HT2A/CR inhibits the Shaker-like K(+) channels Kv1.1 and Kv1.2, and this modulation involves the dual coordination of both RPTPα and distinct tyrosine kinases coupled to this receptor; 5-HT2Rs-mediated modulation of Kv channels controls glutamate release onto prefrontal cortex neurons that might play critical roles in neurophysiological, neurological, and psychiatric conditions. Noticeably, hallucinogens modulate Kv channel activity, acting at 5-HT2R. Hence, comprehensive knowledge of 5-HT2R signaling through modulation of distinct K(+) channels is a pivotal step in the direction that will enable scientists to discover novel 5-HT functions and dysfunctions in the brain and to identify original therapeutic targets.

journal_name

Exp Brain Res

authors

D'Adamo MC,Servettini I,Guglielmi L,Di Matteo V,Di Maio R,Di Giovanni G,Pessia M

doi

10.1007/s00221-013-3555-8

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

453-62

issue

4

eissn

0014-4819

issn

1432-1106

journal_volume

230

pub_type

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