Abstract:
:The firing of neurons from layers II and III of medial entorhinal cortex (MEC) was examined in relation to the hippocampal theta rhythm in urethane anesthetized and walking rats. 1) MEC neurons showed a significant phase relation to the hippocampal theta rhythm in both walking and urethane anesthetized rats, suggesting that this region contributes to the generation of both atropine-resistant and atropine-sensitive theta rhythm components. 2) The proportion of phase-locked cells was three times greater in walking rats (22/23 cells) as compared to anesthetized rats (8/23 cells), indicating that MEC cells made a greater contribution during walking theta rhythm. This difference was also manifest in the greater mean vector length for the group of phase-locked MEC cells during walking: 0.39 +/- 0.13 versus 0.21 +/- 0.08. Firing rate differences between walking and urethane conditions were not significant. 3) In walking rats, MEC cells fired on the positive peak of the dentate theta rhythm (group mean phase = 5 degrees; 0 degrees = positive peak at the hippocampal fissure). This is close to the reported phases for dentate granule and hippocampal pyramidal cells. The distribution of MEC cell phases in urethane anesthetized rats was broader (group mean phase = 90 degrees), consistent with the phase data reported for hippocampal projection cells. These findings suggest that medial entorhinal neurons are the principal determinant of theta-related firing of hippocampal neurons and that their robust rhythmicity in walking as compared to urethane anesthesia accounts for EEG differences across the two conditions.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Stewart M,Quirk GJ,Barry M,Fox SEdoi
10.1007/BF00229252keywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
21-8issue
1eissn
0014-4819issn
1432-1106journal_volume
90pub_type
杂志文章abstract::The cerebellum is recognised to bilaterally modulate sensorimotor function and has recently been shown to play a role in swallowing. Unilateral cerebellar repetitive trans-cranial magnetic stimulation (rTMS) excites corticobulbar motor pathways to the pharynx but the effects of bilateral versus unilateral cerebellar r...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-020-05787-x
更新日期:2020-08-01 00:00:00
abstract::While diverging efficacy and inter-individual response variability have repeatedly been reported for paired-associative stimulation (PAS), approaches to overcome these issues are yet lacking. Hence, the aim of the present study was to determine whether response variability could be reduced through the application of a...
journal_title:Experimental brain research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00221-019-05542-x
更新日期:2019-07-01 00:00:00
abstract::The effect of the intermittency of visual information in the bimanual coordination of an isometric force coordination task was investigated as a function of criterion force level. Eight levels of visual information intermittency (.2-25.6 Hz) were used in blocked fashion at each force level. Participants were required ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-016-4606-8
更新日期:2016-07-01 00:00:00
abstract::Percutaneous electrical stimulation of the motor point of the first dorsal interosseous muscle (FDI) was used to produce a non-painful contraction of the FDI muscle that caused index finger abduction movement but no radiating cutaneous paraesthesias or sharp sensations localized to joints. Pairs of stimuli separated b...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-005-2353-3
更新日期:2005-10-01 00:00:00
abstract::1.) Eye movements were recorded in four Java monkeys (M. fascicularis) after unilateral microinjections (1 microliter, concentration 1 micrograms/microliter) of the GABA antagonist, bicuculline, and the GABA agonist, muscimol, into oculomotor related regions of the vestibular nuclei. Eye movements were investigated in...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00228958
更新日期:1991-01-01 00:00:00
abstract::Previous experiments have suggested that the analysis of visual images could be a gravity-dependent process. We investigated this hypothesis using a mental rotation paradigm with pictures of three-dimensional objects during a 26-day orbital flight aboard the Soviet MIR station. The analysis of cosmonauts' response tim...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00230478
更新日期:1993-01-01 00:00:00
abstract::Visual stimulation alone is sufficient to produce visually induced postural reactivity (VIPR). While some studies have shown that VIPR increases with the velocity of a moving visual stimulus, others have shown that it decreases with the temporal frequency of an oscillating visual stimulus. These results seem contradic...
journal_title:Experimental brain research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00221-013-3592-3
更新日期:2013-08-01 00:00:00
abstract::The experiments were designed to test two hypotheses and their corollaries: 1. That adaptation of EMG responses to support surface rotations is due to a decrease in the gain of proprioceptively triggered long-loop stretch reflexes (Nashner 1976), and that the adaptation is dependent on a normally functioning vestibula...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00247031
更新日期:1987-01-01 00:00:00
abstract::The projections of the medial terminal nucleus (MTN) of the accessory optic system (AOS) upon pretectal nuclei have been studied in pigmented rats by means of (i) the anterograde transport of 3H-leucine with the use of light autoradiography and (ii) the retrograde transport of horseradish peroxidase (HRP). Injections ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237218
更新日期:1982-01-01 00:00:00
abstract::While mechanisms of orienting attention in unilateral spatial neglect (USN) have frequently been studied in the visual domain, these mechanisms remain relatively unexplored in the auditory domain. Our first goal was to replicate Spence and Driver's (J Exp Psychol Hum 22:1005-1030, 1994) results with a virtual reality ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-016-4691-8
更新日期:2016-10-01 00:00:00
abstract::The anatomical pathway from the prepyriform cortex to the hippocampus in the cat was traced autoradiographically by means of anterograde transport of [3H] leucine. A direct projection from the prepyriform cortex to the lateral entorhinal area was confirmed in the cat: the termination of these fibers was largely confin...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00236644
更新日期:1980-02-01 00:00:00
abstract::The startle reaction (SR) is usually understood as an involuntary reaction to an unexpected sensory input. However, there is evidence that the mechanisms involved in the SR contribute also to the execution of actions that we consider voluntary. We need to exert a fine control of the motor output, which usually involve...
journal_title:Experimental brain research
pub_type: 杂志文章,评审
doi:10.1007/s00221-008-1402-0
更新日期:2008-06-01 00:00:00
abstract::Interneurons of rat motor cortex in vivo and of rat hippocampal slices were studied during penicillin-induced epileptic discharges. Synchronous with pyramidal cells, they showed transient depolarizations similar to paroxysmal depolarization shifts in pyramidal cells. The transient depolarizations were followed by hype...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00229848
更新日期:1991-01-01 00:00:00
abstract::Following the theoretical notion that tools often extend one's body, in the present study, we investigated whether imitation of hand or tool actions is modulated by effector-specific information. Subjects performed grasping actions toward an object with either a handheld tool or their right hand. Actions were initiate...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-011-2852-3
更新日期:2011-10-01 00:00:00
abstract::Using a declarative memory paradigm, the anatomical correlates of spatial location encoding and retrieval in the healthy human brain as reflected by BOLD fMRI were investigated. During encoding, subjects were instructed to view and keep in mind different locations of an object on a platform seen from different viewpoi...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-006-0408-8
更新日期:2006-09-01 00:00:00
abstract::This study exploited the alterations in pedal speed and joints kinematics elicited by changing crank length (CL) to test how altered task mechanics during cycling will modulate the muscle activation characteristics in human rectus femoris (RF), biceps femoris long head (BF), soleus (SOL) and tibialis anterior (TA). Ki...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-003-1561-y
更新日期:2003-10-01 00:00:00
abstract::The tendency to generate head movements during saccades varies from person to person. Head movement tendencies can be measured as subjects fixate sequences of illuminated targets, but the extent to which such measures reflect eye-head coupling during more natural behaviors is unknown. We quantified head movement tende...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-008-1534-2
更新日期:2008-12-01 00:00:00
abstract::Extracellularly recorded action potentials from 49 Bötzinger-complex, bulbospinal expiratory neurones were used as triggers to compute 162 spike-triggered averages (STAs) of intracellular potentials recorded from 167 respiratory neurones in the ventral respiratory group (VRG) near the obex in 15 vagotomized, paralysed...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050612
更新日期:1999-01-01 00:00:00
abstract::Performing joint actions often requires precise temporal coordination of individual actions. The present study investigated how people coordinate their actions at discrete points in time when continuous or rhythmic information about others' actions is not available. In particular, we tested the hypothesis that making ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-011-2706-z
更新日期:2011-06-01 00:00:00
abstract::The firing of tuberoinfundibular neurones antidromically identified as projecting to the median eminence was recorded during electrical stimulation of the preoptic and/or anterior hypothalamic areas (PO/AH) of the rostral hypothalamus. Parameters of stimulation were chosen which are known to cause increased secretion ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237074
更新日期:1980-01-01 00:00:00
abstract::Several recent studies have provided support for the view that tactile stimuli/events are remapped into an abstract spatial frame of reference beyond the initial somatotopic representation present in the primary somatosensory cortex. Here, we demonstrate for the first time that the extent to which this remapping of ta...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-008-1510-x
更新日期:2008-11-01 00:00:00
abstract::In the cat it is known that the distribution and modulation of the so-called P2 responses are similar, irrespective of whether they are obtained with electrodes implanted in the different skin areas or in the various leg muscles. In man it is known that the specific stimulation of cutaneous afferents from different pa...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-002-1366-4
更新日期:2003-04-01 00:00:00
abstract::The tuberomammillary nucleus (TM) located in the posterior part of the hypothalamus is the main source of neuronal histamine in the central nervous system. Recent work from our laboratories has indicated an involvement of the TM region in neuronal plasticity and reinforcement processes. In the present study, we invest...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050301
更新日期:1998-02-01 00:00:00
abstract::Gaze in real-world scenarios is controlled by a huge variety of parameters, such as stimulus features, instructions or context, all of which have been studied systematically in laboratory studies. It is, however, unclear how these results transfer to real-world situations, when participants are largely unconstrained i...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-012-3254-x
更新日期:2012-11-01 00:00:00
abstract::We investigated the effect of foot position and foot orientation on asymmetrical body weight loading and the inter- and intra-foot coordination dynamics of standing postures. The participants were instructed to stand with the feet side-by-side and in staggered and tandem positions with the right foot oriented at diffe...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-013-3627-9
更新日期:2013-09-01 00:00:00
abstract::We examined the characteristics of postsynaptic potentials (PSPs) produced in antidromically-identified medical gastrocnemius (MG) alpha-motoneurons by electrical stimulation of low threshold (less than 3 x T) distal limb cutaneous afferents in the sural (SUR) nerve in adult cats anesthetized with alpha-chloralose, to...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235772
更新日期:1982-01-01 00:00:00
abstract::Dynamic changes of deficits in canal and otolith vestibulo-ocular reflexes (VORs) to high acceleration, eccentric yaw rotations were investigated in five subjects aged 25-65 years before and at frequent intervals 3-451 days following unilateral vestibular deafferentation (UVD) due to labyrinthectomy or vestibular neur...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-006-0761-7
更新日期:2007-04-01 00:00:00
abstract::The latencies of visually-evoked responses from X- and Y-type neurons of the cat's dorsal lateral geniculate nucleus were measured in a manner that takes account of the inherent variability of discharge in these cells. Latencies measured in this way vary from trial to trial in one cell (and also between cells) by tens...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235998
更新日期:1987-01-01 00:00:00
abstract::Motor control tasks like stance or object handling require sensory feedback from proprioception, vision and touch. The distinction between tactile and proprioceptive sensors is not frequently made in dynamic motor control tasks, and if so, mostly based on signal latency. We previously found that force control tasks en...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-012-3341-z
更新日期:2013-02-01 00:00:00
abstract::Depending on individual lesion location and extent, reorganization of the human motor system has been observed with a high interindividual variability. In addition, variability of forces exerted, of motor effort, and of movement strategies complicates the interpretation of functional imaging studies. We hypothesize th...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-001-0981-9
更新日期:2002-03-01 00:00:00