Participation of interneurons in penicillin-induced epileptic discharges.

Abstract:

:Interneurons of rat motor cortex in vivo and of rat hippocampal slices were studied during penicillin-induced epileptic discharges. Synchronous with pyramidal cells, they showed transient depolarizations similar to paroxysmal depolarization shifts in pyramidal cells. The transient depolarizations were followed by hyperpolarizing or depolarizing afterpotentials lasting 600 to 1200 ms. During the transient depolarizations and the afterdepolarizations the interneurons discharged with increased frequency. This may contribute to the enlarged and prolonged synaptic inhibitions following interictal discharges in pyramidal cells.

journal_name

Exp Brain Res

authors

Domann R,Uhlig S,Dorn T,Witte OW

doi

10.1007/BF00229848

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

683-6

issue

3

eissn

0014-4819

issn

1432-1106

journal_volume

83

pub_type

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