Abstract：
:Two components of long-term potentiation (LTP) are distinguished with extracellular recording electrodes: a synaptic and an EPSP-Spike (E-S) component. The latter consists of the enhancement produced in the population spike amplitude in excess of that predicted by EPSP potentiation alone. The experiments carried out in this study were designed to investigate intracellular correlates of E-S potentiation and to examine the hypothesis that an increased postsynaptic excitability underlies E-S potentiation. CA1 pyramidal neurons were synaptically activated from stratum radiatum. LTP, defined as a stable increase in the probability of firing to afferent stimulation, was found to be related to a decrease in the intracellular PSP peak amplitude and slope required to fire the cells at a probability of 0.5. These changes were accompanied by a decrease in threshold to direct activation. No significant changes in input resistance or resting potential were recorded. These excitability changes were only observed in cells displaying LTP; they were not related to the potentiation of the synaptic component (PSP amplitude). Our results support the hypothesis that different mechanisms underlie the two components of LTP, and that a reduction in threshold for neuronal discharge accompanies tetanus-induced E-S potentiation. It is suggested that an increase in the ratio of synaptically evoked excitation/inhibition and a reduction in tonic synaptic inhibition through GABAA channels contribute to E-S potentiation.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Chavez-Noriega LE,Halliwell JV,Bliss TVdoi
10.1007/BF00229331subject
Has Abstractpub_date
1990-01-01 00:00:00pages
633-41issue
3eissn
0014-4819issn
1432-1106journal_volume
79pub_type
杂志文章abstract：:Several non-physiological stimuli (i.e. pharmacological or electrical stimuli) have been shown to induce Fos expression in striatal neurons. In this work, striatal Fos (i.e. Fos-like) expression was studied after physiological stimulation, i.e. motor activity (treadmill running at 36 m/min for 20 min). In rats killed ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/pl00005715
更新日期：1997-07-01 00:00:00
abstract：:This study exploited the alterations in pedal speed and joints kinematics elicited by changing crank length (CL) to test how altered task mechanics during cycling will modulate the muscle activation characteristics in human rectus femoris (RF), biceps femoris long head (BF), soleus (SOL) and tibialis anterior (TA). Ki...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-003-1561-y
更新日期：2003-10-01 00:00:00
abstract：:It is an important issue to address the mode of information processing in the somatic motor circuit linking the frontal cortex and the basal ganglia. In the present study, we investigated the extent to which corticostriatal input zones from the primary motor cortex (MI), the supplementary motor area (SMA), and the pre...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050384
更新日期：1998-05-01 00:00:00
abstract：:We examined the control of postural stability in preparation to a discrete, quick whole-body sway toward a target and back to the initial position. Several predictions were tested based on the theory of control with referent body orientation and the notion of multi-muscle synergies stabilizing center of pressure (COP)...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-019-05510-5
更新日期：2019-05-01 00:00:00
abstract：:Pyramidal cell structure varies systematically in occipitotemporal visual areas in monkeys. The dendritic trees of pyramidal cells, on average, become larger, more branched and more spinous with progression from the primary visual area (V1) to the second visual area (V2), the fourth (V4, or dorsolateral DL visual area...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-005-0057-3
更新日期：2005-12-01 00:00:00
abstract：:It has recently been shown that spatially uninformative sounds can cause a visual stimulus to pop out from an array of similar distractor stimuli when that sound is presented in temporal proximity to a feature change in the visual stimulus. Until now, this effect has predominantly been demonstrated by using stationary...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-011-2797-6
更新日期：2011-09-01 00:00:00
abstract：:In rat barrel cortex, evoked potentials (EPs) to vibrissa stimulation can be divided into two distinct classes according to the relative contribution of their principal components. Our experiments support the notion that these components can be attributed to activation of two pyramidal cell populations: supra- and inf...
journal_title：Experimental brain research
pub_type： 杂志文章,评审
doi：10.1007/s002210050552
更新日期：1998-11-01 00:00:00
abstract：:Touches on one hand or forearm can affect tactile sensitivity at contralateral locations on the opposite side of the body. These interactions suggest an intimate connection between the two sides of the body. Here, we explore the effect of masking not across the body but through the body by measuring the effect of a ma...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-014-3955-4
更新日期：2014-09-01 00:00:00
abstract：:The present experiment was designed to test the hypothesis that fatigue-induced impairment in movement accuracy is caused by a decrease in muscle cocontraction rather than a reduced ability to produce muscular force. Seven participants performed fast and accurate elbow extensions aimed at a target, before and after a ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-007-1264-x
更新日期：2008-02-01 00:00:00
abstract：:The purpose of this study is to analyze the coordination patterns of the elevation angles of lower limb segments following the onset of unsupported walking in children and to look for the existence of a planar covariation rule as previously described in adult human locomotion. The kinematic patterns of locomotion were...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/s002210000663
更新日期：2001-04-01 00:00:00
abstract：:If horizontal saccades or smooth-pursuit eye movements are made with the line-of-sight at different elevations, the three-dimensional (3D) angular rotation axis of the globe tilts by half the vertical eye eccentricity. This phenomenon is named "half-angle rule" and is a consequence of Listing's law. It was recently fo...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050943
更新日期：1999-11-01 00:00:00
abstract：:Saslow and others have shown that the latency of foveating saccades can be altered by changing the offset time of the current fixation point relative to the onset of the peripheral target. Whether anticipatory saccades contributed to these results was not known. By the criteria of direction error and amplitude error t...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00255238
更新日期：1987-01-01 00:00:00
abstract：:Although several features of brain motor function appear to be preserved even in chronic complete SCI, previous functional MRI (fMRI) studies have also identified significant derangements such as a strongly reduced volume of activation, a poor modulation of function and abnormal activation patterns. It might be specul...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1465-y
更新日期：2008-09-01 00:00:00
abstract：:It has previously been shown that light contact with the finger tip on a fixed surface reduces centre of pressure (CoP) fluctuations in the frontal plane when standing in an unstable posture with the feet in line (tandem Romberg stance). Positive cross-correlations between horizontal finger forces and CoP fluctuations...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050711
更新日期：1999-04-01 00:00:00
abstract：:We investigated whether perception of affordances for standing on an inclined surface depended on the height of center of mass of the perceiver-actor. Participants adjusted the angle of inclination of a surface until they felt that it was just barely possible for them to stand on that surface. They performed this task...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1492-8
更新日期：2008-10-01 00:00:00
abstract：:The goal of this study was to identify the control mechanism used for locomotion pointing regulation under different external temporal constraints. Subjects ( n=8) had to walk on a treadmill through a number of virtual hallways and cross a pair of gliding doors that opened and closed at a constant preset frequency (0....
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-001-0990-8
更新日期：2002-03-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-1817-2
更新日期：2009-09-01 00:00:00
abstract：:Earlier studies have reported temporal rotation of Listing's plane with convergence of the eyes causing torsion, which is dependent on eye elevation. The amount by which the planes rotate differs from study to study. To gain insight into the functional significance of the temporal tilt of Listing's plane for vision, w...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050727
更新日期：1999-05-01 00:00:00
abstract：:There is extensive evidence that emotional information is better remembered than neutral information across long delays, especially if the delay interval contains an opportunity for sleep. However, as prior studies have focused on memory for negative stimuli, it is unclear whether positive memories benefit from time a...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3779-7
更新日期：2014-05-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00230025
更新日期：1992-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0779-x
更新日期：2007-05-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1621-4
更新日期：2009-02-01 00:00:00
abstract：:Intradermal injection of capsaicin results in sensitization of spinothalamic tract cells to brushing and pressure applied to the cutaneous receptive field in anesthetized monkeys. A significant increase in background activity also occurs immediately after capsaicin injection that lasts for at least 2 h. A 40-50% decre...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/pl00005675
更新日期：1997-06-01 00:00:00
abstract：:In the present study pineal glands of rats aged 69-71 days were studied in vivo and in vitro with respect to day/night changes of "synaptic" ribbons and spherules. It was found that ribbons outnumber spherules by a factor of 3. In vivo, both ribbons and spherules show a roughly 3-fold increase in number at 1 a.m. when...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237178
更新日期：1982-01-01 00:00:00
abstract：:It is a common experience, immediately after the removal of a cast or a splint, to feel motor awkwardness, which is usually attributed to muscular and joint immobilization. However, the same feeling may also be perceived after a brief period of immobilization. We provide evidence that this last effect stems from chang...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-3115-7
更新日期：2012-07-01 00:00:00
abstract：:Neuromagnetic fields from the left cerebral hemisphere of five healthy, right-handed subjects were investigated under three different experimental conditions: (1) electrical stimulation of the right index finger (task S); (2) voluntary movement of the same finger (M); (3) M+S condition, consisting of voluntary movemen...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00230430
更新日期：1996-01-01 00:00:00
abstract：:Using laminar field potential analysis, we examined responses elicited by both photic and optic nerve stimulations in 30 kittens of 0--65 days of age and in three adult cats. In adult cats, the response in the visual cortex on optic nerve stimulations is a wave complex which consists mainly of surface positive depth n...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236803
更新日期：1983-01-01 00:00:00
abstract：:Transcranial direct current stimulation (tDCS) using intensities ≤ 2 mA on physical and cognitive outcomes has been extensively investigated. Studies comparing the effects of different intensities of tDCS have yielded mixed results and little is known about how higher intensities (> 2 mA) affect outcomes. This study e...
journal_title：Experimental brain research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00221-019-05721-w
更新日期：2020-02-01 00:00:00
abstract：:Three patients with cerebellar limb ataxia and three age-matched controls performed arm-pointing movements towards a visual stimulus during an experimental procedure using a double-step paradigm in a three-dimensional space. Four types of trajectories were defined: P1, single-step pointing movement towards the visual ...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/s002210050361
更新日期：1998-04-01 00:00:00
abstract：:The phase of the angular vestibulo-ocular reflex (VOR) is subject to adaptive control. We had previously found that adapting the phase of the VOR also produced changes in drift on eccentric gaze-holding, implying a change in the time constant of the velocity-to-position neural integrator. Here we attempted to dissocia...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/s002210050392
更新日期：1998-05-01 00:00:00
