Abstract：
:We studied Fos expression in the central nociceptive pathways at different sedative levels in order to clarify the central mechanism of propofol's nociceptive action. Sprague-Dawley rats received propofol (PRO) or pentobarbital (PEN) and were divided into two groups with different doses of drug administration (light and deep sedative levels) based on the electroencephalogram analysis. Rats at each sedative level received heat stimulation to their face and Fos immunohistochemistry was performed at various brain sites. We also infused lidocaine into the jugular vein to test whether PRO directly activated nociceptors distributed in the vein. Fos expression in two major ascending pain pathways (lateral and medial systems) and descending modulatory system were precisely analyzed following intravenous (i.v.) administration of PRO or PEN. Many Fos protein-like immunoreactive (Fos protein-LI) cells were expressed in the trigeminal spinal nucleus caudalis (Vc), parabrachial nucleus, parafascicular nucleus, a wide area of the primary somatosensory cortex, anterior cingulate cortex, amygdala, periaqueductal gray, solitary tract nucleus, and lateral hypothalamus following heating of the face during PRO or PEN infusion. The number of Fos protein-LI cells was significantly greater in many Central nervous system regions during PRO infusion compared with PEN. Fos expression was significantly greater in the Vc and Periaqueductal gray following greater amount of PRO infusions compared, whereas they were significantly smaller in the Vc in the rats with PEN infusion. The Fos expression was significantly depressed following i.v. infusion of lidocaine before PRO administration. The present findings suggest that PRO is involved in the enhancement of Vc activity through direct activation of the primary afferent fibers innervating veins, resulting in pain induction during infusion.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Kubota I,Tsuboi Y,Shoda E,Kondo M,Masuda Y,Kitagawa J,Oi Y,Iwata Kdoi
10.1007/s00221-006-0779-xsubject
Has Abstractpub_date
2007-05-01 00:00:00pages
181-90issue
2eissn
0014-4819issn
1432-1106journal_volume
179pub_type
杂志文章abstract：:The effects of bilateral focal cooling of dorsolateral thoracic spinal cord on segmental reflex pathways to the triceps surae muscles were assessed in decerebrate cats from the reflex forces produced by single shocks or trains of electrical stimuli applied to the ipsilateral caudal cutaneous sural and the contralatera...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00230042
更新日期：1995-01-01 00:00:00
abstract：:Trace eyeblink conditioning was investigated in 31 patients with focal cerebellar lesions and 19 age-matched controls. Twelve patients presented with lesions including the territory of the superior cerebellar artery (SCA). In 19 patients lesions were restricted to the territory of the posterior inferior cerebellar art...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-005-0171-2
更新日期：2006-03-01 00:00:00
abstract：:Olfactory neurones of Xenopus laevis were studied by the patch clamp technique under voltage-clamp conditions. Isolated receptor cells were obtained by dissociating the olfactory mucosa in a Ca(2+)-free solution. Usually some of the resulting isolated olfactory cells lost all of their cilia during the dissociation pro...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231774
更新日期：1991-01-01 00:00:00
abstract：:Efferent and afferent connections of the visually responsive cortex (area anteromedial, AM) located in the anterior portion of area 18b were studied with degeneration and horseradish peroxidase (HRP) methods following small lesions and HRP injections into this area. Degenerating axons, terminals and retrogradely HRP-l...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237996
更新日期：1984-01-01 00:00:00
abstract：:Many previous studies have demonstrated the existence of neurons with tremor-frequency activity ("tremor cells") in the thalamus of Parkinson's disease (PD) patients and these neurons are presumed to play a role in the pathogenesis of tremor. Since a major input to motor thalamus (Voa and Vop) is from the internal seg...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/pl00005606
更新日期：1997-03-01 00:00:00
abstract：:Numerical magnitude is believed to be represented along a mental number line (MNL), and there is evidence to suggest that the activation of the MNL affects the perception and representation of external space. In the present study, we investigated whether a spatial motor task affects numerical processing in the auditor...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-010-2451-8
更新日期：2011-01-01 00:00:00
abstract：:Normal subjects standing on an earth-fixed force platform inside a movable room displaced at velocities comparable to those accompanying spontaneous body sway, exhibit a visually evoked postural response (VEPR) some 600 ms after the start of the room movement. It consists of a displacement of the centre of force of th...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237488
更新日期：1986-01-01 00:00:00
abstract：:How the CNS deals with the issue of motor redundancy remains a central question for motor control research. Here we investigate the means by which neuromuscular and biomechanical factors interact to resolve motor redundancy in rhythmic multijoint arm movements. We used a two-df motorized robot arm to manipulate the dy...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1437-2
更新日期：2008-08-01 00:00:00
abstract：:In the present study, we report the sensitivity of utricular afferents to sinusoidal translational motion in the horizontal plane. The head orientation was altered relative to the direction of translational travel in 30 degrees increments to allow determination of the head orientation that elicited the maximal and min...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-003-1530-5
更新日期：2003-10-01 00:00:00
abstract：:Sleep disturbances impair cognitive functioning in typically developing populations. Children with attention-deficit/hyperactivity disorder (ADHD), a disorder characterized by impaired inhibitory control and attention, commonly experience sleep disturbances. Whether inhibitory impairments are related to sleep deficits...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-017-4906-7
更新日期：2017-05-01 00:00:00
abstract：:The fast-twitch flexor digitorum longus (FDL) muscle was partially denervated by a unilateral section of the L7 ventral root. After approximately 100 days the isometric, force-velocity and histochemical properties of single motor units from the partially denervated muscle were determined. The diameter of the nerve axo...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236946
更新日期：1985-01-01 00:00:00
abstract：:The desire to increase rewards and minimize punishing events is a powerful driver in behaviour. Here, we assess how the value of a location affects subsequent deployment of goal-directed attention as well as involuntary capture of attention on a trial-to-trial basis. By tracking eye position, we investigated whether t...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3654-6
更新日期：2013-10-01 00:00:00
abstract：:In the present study pineal glands of rats aged 69-71 days were studied in vivo and in vitro with respect to day/night changes of "synaptic" ribbons and spherules. It was found that ribbons outnumber spherules by a factor of 3. In vivo, both ribbons and spherules show a roughly 3-fold increase in number at 1 a.m. when...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237178
更新日期：1982-01-01 00:00:00
abstract：:Visual stimulation alone is sufficient to produce visually induced postural reactivity (VIPR). While some studies have shown that VIPR increases with the velocity of a moving visual stimulus, others have shown that it decreases with the temporal frequency of an oscillating visual stimulus. These results seem contradic...
journal_title：Experimental brain research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00221-013-3592-3
更新日期：2013-08-01 00:00:00
abstract：:The parietal lobes contribute to body-space representation. The present work aims at characterizing the functional role of the inferior parietal lobe in body-space representation and at studying the different roles of the angular gyrus in the right and left hemisphere. We conducted three separate transcranial direct c...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3538-9
更新日期：2013-07-01 00:00:00
abstract：:Parkinson's disease (PD) adversely affects information processing and motor performance. The impact of aerobic exercise on modifying the deleterious effects of PD underlying information and motor control processes is not well established. The primary aim of this project was to determine the effects of an 8-week high i...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-020-06009-0
更新日期：2021-01-04 00:00:00
abstract：:Electrical stimulation with repetitive pulses (6/sec) was applied to the internal medullary lamina and produced tonic contraversive turning movements of eyes and head which were associated with recruiting responses in the visual cortex. Optical gratings of a spatial frequency of 0.5 c/deg which alternated with diffuse...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00234015
更新日期：1976-06-18 00:00:00
abstract：:Aerobic exercise can enhance neuroplasticity although presently the neural mechanisms underpinning these benefits remain unclear. One possible mechanism is through effects on primary motor cortex (M1) function via down-regulation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). The aim of the present...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-016-4767-5
更新日期：2016-12-01 00:00:00
abstract：:Encoding of visual target location in extrapersonal space requires convergence of at least three types of information: retinal signals, information about orbital eye positions, and the position of the head on the body. Since the position of gaze is the sum of the head position and the eye position, inaccuracy of spati...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00241543
更新日期：1994-01-01 00:00:00
abstract：:The hypothesis that anticipatory postural adjustments (APAs) may concur in generating the directional preference experienced during limb coupled movements was tested by measuring the electromyographic and mechanic postural actions elicited when moving: (1) one single arm/hand and, (2) both limbs, iso- or antidirection...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1470-1
更新日期：2008-09-01 00:00:00
abstract：:A photographic technique was used to study the evolution of lateral head-tilt following hemilabyrinthectomy in adult cats. Animals were maintained post-operatively in normally lit conditions (LM cats), in total darkness (DM cats), or in stroboscopic light. In LM casts, the head tilt peaked at 45 degrees (with the lesi...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235707
更新日期：1977-06-27 00:00:00
abstract：:The effects of learning on strategy selection in the context of action imitation have been investigated in two experiments conducted with healthy individuals. It was predicted that, once learnt, meaningless actions are processed by the cognitive system as meaningful and this new representational status might influence...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/s00221-006-0395-9
更新日期：2006-08-01 00:00:00
abstract：:In anesthetized cats 251 cells within the cortical vestibular projection area, adjacent to the post-cruciate dimple, were analyzed as to their input characteristics employing extracellular recording techniques. The post cruciate dimple vestibular field, which is located in area 3a, has a high degree of convergence bet...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237688
更新日期：1975-01-01 00:00:00
abstract：:The responses of 80 amygdaloid neurons to the four basic taste (sucrose, NaCl, HCl and quinine hydrochloride), thermal (5 degrees C, 20 degrees C and 40 degrees C) and tactile (brushing) stimuli applied to the anterior part of the tongue were recorded in anesthetized rats. About 90% of the taste-sensitive amygdaloid n...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237437
更新日期：1984-01-01 00:00:00
abstract：:People are more sensitive to detecting asynchrony between a self-generated movement of the hand and delayed visual feedback when what they see matches the expected "self" perspective rather than an "other" perspective (Hoover and Harris in Exp Brain Res 222:389-397, 2012). We take this as corresponding to the ability ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-014-4181-9
更新日期：2015-04-01 00:00:00
abstract：:The proportions and some of the properties of X and Y cells in lateral geniculate nucleus (LGN) of adult cats were measured 14-16 days after monocular paralysis. The paralysis was produced by sectioning cranial nerves III, IV and VI. No difference from normal was observed in the proportions of X and Y cells either in ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236898
更新日期：1981-01-01 00:00:00
abstract：:Pax genes are important modulators of CNS development. Pax7 and Pax6 polarise the neural tube and regionalise the brain. Pax7 is pivotal in specifying the superior colliculus/tectum, an important centre for integration of visuomotor responses and a target for Pax6+ retinal ganglion cell axons during retinocollicular m...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0735-9
更新日期：2007-04-01 00:00:00
abstract：:Two superimposed gratings, which differ in orientation and move independently, combine into a coherently moving plaid if the component gratings are similar. The effect on the plaid motion percept of the addition of texture to each grating was investigated. The texture disambiguates the motion of each component grating...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228400
更新日期：1993-01-01 00:00:00
abstract：:We investigated the influence of gaze elevation on judging the possibility of passing under high obstacles during pitch body tilts, while stationary, in absence of allocentric cues. Specifically, we aimed at studying the influence of egocentric references upon geocentric judgements. Seated subjects, orientated at vari...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1589-0
更新日期：2009-02-01 00:00:00
abstract：:The authors determined the effects of changes in task demands on interpersonal and intrapersonal coordination. Participants performed a joint task in which one participant held a stick to which a circle was attached at the top (holding role), while the other held a pointer through the circle without touching its borde...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-011-2653-8
更新日期：2011-06-01 00:00:00
