Abstract：
:Several non-physiological stimuli (i.e. pharmacological or electrical stimuli) have been shown to induce Fos expression in striatal neurons. In this work, striatal Fos (i.e. Fos-like) expression was studied after physiological stimulation, i.e. motor activity (treadmill running at 36 m/min for 20 min). In rats killed 2 h after the treadmill session, Fos expression was observed in the medial region of the rostral and central striatum, and in the dorsal region of the caudal striatum. Fos expression was prevented by pretreatment with the non-competitive N-methyl-D-aspartate (NMDA) glutamate receptor antagonist MK-801 (0.1 mg/kg) or the D1 dopamine receptor antagonist SCH-23390 (0.1 mg/kg), but not by pretreatment with the D2 receptor antagonist eticlopride (0.5 mg/kg). Thirty-six hours after 6-hydroxydopamine lesion, a considerable reduction in treadmill-induced Fos expression was observed in both sides; however, Fos expression in the lesioned striatum was higher than in the contralateral intact striatum. Several weeks after unilateral 6-hydroxydopamine lesion of the nigrostriatal system, treadmill-induced Fos expression was significantly, but not totally, reduced in the lesioned striatum. Corticostriatal deafferentation also led to considerable reduction in treadmill-induced Fos expression. The present results indicate that exercise induces striatal Fos expression and that, under physiological stimulation, concurrent activation of D1 and NMDA receptors is necessary for such expression to occur. Reduction of Fos expression is practically absolute after acute blockage of these receptors, but not after lesions, possibly due partially to compensatory changes.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Liste I,Guerra MJ,Caruncho HJ,Labandeira-Garcia JLdoi
10.1007/pl00005715subject
Has Abstractpub_date
1997-07-01 00:00:00pages
458-68issue
3eissn
0014-4819issn
1432-1106journal_volume
115pub_type
杂志文章abstract：:Explant cultures of rat spinal cord, brain stem and cerebellum were used to visualize GABAA-receptors by means of immunohistochemistry. For these studies we have incubated the cultures with the monoclonal antibody bd 17 against the beta-subunit of the GABAA/benzodiazepine/chloride channel complex. In spinal cord cultu...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228810
更新日期：1990-01-01 00:00:00
abstract：:The distributions of the kainate/DL-alpha-amino-3-hydroxy-5-methylisoxazolepropionic acid (KA/ AMPA) receptors GluR1 and calcium-activated neutral protease II (calpain II) in the hippocampus of normal and kainate-lesioned rats were studied by immunocytochemistry. There was a reduction in GluR1 immunoreactivity and a s...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF02454147
更新日期：1997-01-01 00:00:00
abstract：:In this study we examined the performance of human subjects in three oculomotor tasks: a visually guided saccade task (VST), a simple antisaccade task (SAT) and a mirror antisaccade task (MAT). The stimulus presentation was identical for all three tasks, and the differentiation of the tasks was based on the instructio...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0462-2
更新日期：2006-09-01 00:00:00
abstract：:Quick detection of changes in the sensory environment is very important for survival, resulting in automatic shifts of attention to the event and the facilitation of subsequent processes to execute appropriate behaviors. The abrupt onset or offset of a sensory stimulus should also activate the neural network detecting...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1468-8
更新日期：2008-09-01 00:00:00
abstract：:Previous work has suggested that conscious error awareness may fluctuate with levels of attention. Here, we explore this relationship by showing that error awareness can be impaired when exogenous support to attentional systems is reduced by decreasing task demands. Twenty participants performed a manual Go/No-Go resp...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-007-1054-5
更新日期：2007-09-01 00:00:00
abstract：:The modification of the normal locomotor pattern of humans was investigated using a split-belt locomotion protocol (treadmill belt speeds of 4.5 km/h and 1.5 km/h for the right and left legs, respectively) and also by changing afferent input from the legs (30% reduction or increase in body weight by suspending subject...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/s002210050262
更新日期：1998-01-01 00:00:00
abstract：:The experiments were designed to test two hypotheses and their corollaries: 1. That adaptation of EMG responses to support surface rotations is due to a decrease in the gain of proprioceptively triggered long-loop stretch reflexes (Nashner 1976), and that the adaptation is dependent on a normally functioning vestibula...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00247031
更新日期：1987-01-01 00:00:00
abstract：:The survival of grafts of dissociated allogeneic fetal neural dopamine (DA) rich tissue in the striatum has been studied after transplantation between inbred strains of mice differing at defined immunogenetical loci between donor and recipient. Six to 7 weeks and 15 weeks after grafting, surviving grafted DA neurons w...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00253636
更新日期：1989-01-01 00:00:00
abstract：:As a consequence of the fragility of various neural structures, preterm infants born at a low gestation and/or birthweight are at an increased risk of developing motor abnormalities. The lack of a reliable means of assessing motor integrity prevents early therapeutic intervention. In this paper, we propose a new metho...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002219900227
更新日期：2000-04-01 00:00:00
abstract：:Recent studies have demonstrated that dyslexia is associated with deficits in the temporal encoding of sensory information. While most previous studies have focused on information processing within a single sensory modality, it is clear that the deficits seen in dyslexia span multiple sensory systems. Surprisingly, al...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/s00221-005-2387-6
更新日期：2005-10-01 00:00:00
abstract：:Normal development of motor function was compared to that of cats with spinal transections at birth (newborn operates) or at approximately two weeks after birth (two week operates). Newborn operates expressed motor behavior not seen until sometime later in normal newborn cats, suggesting that this behavior is normally...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00238857
更新日期：1986-01-01 00:00:00
abstract：:While mechanisms of orienting attention in unilateral spatial neglect (USN) have frequently been studied in the visual domain, these mechanisms remain relatively unexplored in the auditory domain. Our first goal was to replicate Spence and Driver's (J Exp Psychol Hum 22:1005-1030, 1994) results with a virtual reality ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-016-4691-8
更新日期：2016-10-01 00:00:00
abstract：:The purposes of this pilot study were to create a model of focal cortical ischemia in Macaca fascicularis and to explore contributions of the reticulospinal system in recovery of reaching. Endothelin-1 was used to create a focal lesion in the shoulder/elbow representation of left primary motor cortex (M1) of two adult...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4390-x
更新日期：2015-11-01 00:00:00
abstract：:Many studies have demonstrated attenuated verbal working memory (WM) under articulatory suppression. However, performance is not completely abolished, suggesting a less efficient, non-articulatory mechanism for the maintenance of verbal information. The neural causes for the reduced efficiency of such a putative compl...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3770-3
更新日期：2014-02-01 00:00:00
abstract：:The total number of granule cells in the dentate gyrus was estimated in 17 male rats, four each aged 30, 120, and 200 days, and five aged 365 days. There is a substantial 35-43% linear increase between 1 month and 1 year. Two parameters of the granular layer are involved in the numerical change. First, total granular ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00238626
更新日期：1982-01-01 00:00:00
abstract：:Smooth eye pursuit is believed to involve the integration of an extraretinal signal formed by an internal representation of the moving target and a retinal signal using the visual feedback to evaluate performance. A variation of the smooth eye pursuit paradigm (in which the moving target is occluded for a short period...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-011-2887-5
更新日期：2011-12-01 00:00:00
abstract：PURPOSE:To examine the accuracy and latency of reflexive saccades to vibratory stimulation of the fingertips made by normal human subjects and to compare the findings to those of visually guided saccades. METHODS:Eye movements were recorded using infrared oculography. Stimuli were presented via an array of audiometric...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-003-1749-1
更新日期：2004-02-01 00:00:00
abstract：:The blood-brain barrier (BBB) arises from epithelial-like tight junctions that virtually cement adjoining capillary endothelium together in the brain microvasculature. Several experimental manipulations have been shown able to increase the permeability of brain capillaries, by altering endothelial cell membrane integr...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/pl00005725
更新日期：1997-07-01 00:00:00
abstract：:Although several features of brain motor function appear to be preserved even in chronic complete SCI, previous functional MRI (fMRI) studies have also identified significant derangements such as a strongly reduced volume of activation, a poor modulation of function and abnormal activation patterns. It might be specul...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1465-y
更新日期：2008-09-01 00:00:00
abstract：:The time course of development of visual acuity for square wave gratings was measured behaviourally in a number of cats that were reared in total darkness until they were either 4 (5 cats) or 6 (1 cat) months of age. Less extensive measurements were also made on animals reared in a similar manner until they were eithe...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00239811
更新日期：1978-04-14 00:00:00
abstract：:The effects of short-term, constant practice on the kinematics of a multi-joint pointing movement were studied in the hemiparetic arm of 20 chronic patients with unilateral left cerebro-vascular accident (CVA) and in 10 age- and sex-matched healthy individuals. Practice consisted of a single session of 70 pointing mov...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-003-1568-4
更新日期：2003-10-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-007-0910-7
更新日期：2007-07-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237270
更新日期：1984-01-01 00:00:00
abstract：:The Ca++ -dependence of the repetitive firing of neostriatal neurons was studied in an in vitro slice preparation of the rat neostriatum. Neuronal firing was evoked by injecting depolarizing currents of 100-200 ms duration. In normal conditions, the mode of firing was tonic and showed very little adaptation. The frequ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00248539
更新日期：1989-01-01 00:00:00
abstract：:Repetitive finger tapping is a well-established clinical test for the evaluation of parkinsonian bradykinesia, but few studies have investigated other finger movement modalities. We compared the kinematic changes (movement rate and amplitude) and response to levodopa during a conventional index finger-thumb-tapping ta...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3491-7
更新日期：2013-06-01 00:00:00
abstract：:Besides luminance change, the pupil responds to changes in spatial pattern, color content and target motion. Our experimental results show that transient pupillary constriction can also be elicited by dichoptically viewing a change in stereoscopic stimuli composed of dynamic random-dot stereograms from an initially fl...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-004-2161-1
更新日期：2005-01-01 00:00:00
abstract：:Single unit activity was recorded from tuberoinfundibular neurones in urethane-anaesthetized pro-oestrous rats. Responses following single shock (0.2 Hz) stimulation of the preoptic area/anterior hypothalamus (PO/AH) or nucleus accumbens (ACB) were recorded and computed for 137 single units. More cells were shown, by ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236546
更新日期：1985-01-01 00:00:00
abstract：:We examined how cerebellar deficits in isolated reaching or grasping movements contribute to abnormalities in a combined reach and grasp movement, and whether people with cerebellar damage show abnormalities in the spatiotemporal relationships of reach and grasp movements. We studied subjects with cerebellar damage an...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-002-1191-9
更新日期：2002-10-01 00:00:00
abstract：:Seizure susceptibility waxes and wanes in an apparently circadian manner in many epileptic patients. Fluctuations of melatonin concentration with highest levels during the night and lowest levels in the early morning could be involved in this phenomenon. Therefore, the action of melatonin on epileptic activity was tes...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00230052
更新日期：1995-01-01 00:00:00
abstract：:This paper presents ILGM (the Infant Learning to Grasp Model), the first computational model of infant grasp learning that is constrained by the infant motor development literature. By grasp learning we mean learning how to make motor plans in response to sensory stimuli such that open-loop execution of the plan leads...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-004-1914-1
更新日期：2004-10-01 00:00:00
