Abstract:
:Explant cultures of rat spinal cord, brain stem and cerebellum were used to visualize GABAA-receptors by means of immunohistochemistry. For these studies we have incubated the cultures with the monoclonal antibody bd 17 against the beta-subunit of the GABAA/benzodiazepine/chloride channel complex. In spinal cord cultures, many interneurones were immunoreactive whereas only a small number of large neurones, probably motoneurones was specifically stained. In brain stem cultures, groups of large and medium-sized neurones showed immunoreactivity. In cultures of cerebellum, a great number of neurones was specifically stained. Granule cells showed the strongest immunoreactivity whereas other neurones, presumably Purkinje cells and interneurones, were only moderately stained. The immunoreactivity was mainly confined to the cell bodies of the neurones while their processes were only weakly or not stained. In contrast to neurones, no immunoreactivity could be detected on astrocytes.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Hösli E,Hösli Ldoi
10.1007/BF00228810subject
Has Abstractpub_date
1990-01-01 00:00:00pages
667-71issue
3eissn
0014-4819issn
1432-1106journal_volume
82pub_type
杂志文章abstract::Hand muscle reflexes following muscle stretch and electrical nerve stimulation show a typical pattern consisting of short- and long-latency reflexes. The present investigation was designed to test reflexes following pure cutaneous stimulation. Air puffs were delivered to the palmar tip and the nail bed of the first, s...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00242189
更新日期:1995-01-01 00:00:00
abstract::It has been hypothesized that the steady-state response to a periodic sequence of clicks can be modeled as the superposition of responses to single clicks. Here, this hypothesis is challenged by presenting an extra click halfway between two consecutive clicks of a regular series, while measuring the auditory evoked fi...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4260-6
更新日期:2015-06-01 00:00:00
abstract::When a target moves to a new location during a rapid aiming movement, the hand follows it, even when the participant intends not to. Pisella et al. (Nat Neurosci 3:729-736, 2000) claim that the posterior parietal cortex, in the dorsal visual stream, is responsible for this 'automatic pilot'. Here we study the limits o...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-0935-y
更新日期:2007-08-01 00:00:00
abstract::Changes in the direction of the line of sight (gaze) allow successive sampling of the visual environment. Saccadic eye movements accomplish this goal when the head does not move. Medium-lead burst neurons (MLBs) in the paramedian pontine reticular formation (PPRF) discharge a high frequency burst of action potentials ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-011-2823-8
更新日期:2011-10-01 00:00:00
abstract::In pigmented rabbits anesthetized with N2O (70%) and halothane (2-4%), Purkinje cells were extracellularly recorded in the flocculus. A large central visual field (60 degrees x 60 degrees) was used to optokinetically stimulate either the ipsi- or contralateral eye, and the direction and velocity selectivities of compl...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00228151
更新日期:1990-01-01 00:00:00
abstract::In order to see whether septal neurones are connected to the hypothalamic neurones secreting vasopressin or oxytocin, neurones in different regions of the septum were recorded during electrical stimulation of the supraoptic nucleus. The position of the stimulating electrode within the latter was verified using lactati...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237493
更新日期:1981-01-01 00:00:00
abstract::Postsynaptic potentials (PSPs) evoked in motoneurons innervating the back and abdominal muscles in the lumbar part of the body by stimulating hindlimb cutaneous afferents were investigated in unanesthetized decerebate and spinal cats. Various types of PSP: pure excitatory postsynaptic potential (EPSP), pure inhibitory...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050879
更新日期:1999-10-01 00:00:00
abstract::The aim of this study was to evaluate the hypothesis that an individual's preferred or usual walking speed, step length and cadence optimize the stability of head and pelvic accelerations in vertical (V), anterior-posterior (AP) and medio-lateral (ML) planes when walking. Acceleration patterns of the head and pelvis w...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-1094-x
更新日期:2008-01-01 00:00:00
abstract::A lesion limited to the dorsal columns, at the level of L3-L4, was carried out in chronic cats. This operation produced a "partial axotomy" type of lesion on the ascending branches of Ia hind limb afferents. Two to six months after this operation, intracellular studies on L7-S1 motoneurons were carried out. Similar st...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00340482
更新日期:1986-01-01 00:00:00
abstract::Ganglioside and DNA levels were estimated in the striatum of rats 10 days and 6 weeks after lesioning by intrastriatal injection of kainic acid. There was a moderate, 21-24% decrease of the ganglioside concentration per unit protein on the side of the lesion, which can be ascribed to the loss of the intrinsic striatal...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238752
更新日期:1981-01-01 00:00:00
abstract::A recent study from this laboratory has shown that brief transient ischemia (2 min 30 s) in normo- and hyperglycemic rats leads to moderate neuronal necrosis in CA1 cells of the hippocampus, of equal density in the two groups. However, hyperglycemic animals failed to depolarize during the ischemia, nor did they show a...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/pl00005622
更新日期:1997-03-01 00:00:00
abstract::The projection from the nucleus prepositus hypoglossi (PH) to the superior colliculus (SC) has been proposed to provide a feedback control of collicular saccadic activities. The present study aimed to identify the functional properties of PH neurones projecting to the SC relative to eye movement parameters. Preposito-...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00229141
更新日期:1996-08-01 00:00:00
abstract::The European Resuscitation Guidelines recommend that survivors of cardiac arrest (CA) be resuscitated with 100% O2 and undergo subsequent-post-return of spontaneous circulation (ROSC)-reduction of O2 supply to prevent hyperoxia. Hyperoxia produces a "second neurotoxic hit," which, together with the initial ischemic in...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-020-05746-6
更新日期:2020-04-01 00:00:00
abstract::During fast, saccadic eye movements visual perception is suppressed. This saccadic suppression prevents erroneous and distracting motion percepts resulting from saccade induced retinal slip. Although saccadic suppression occurs over a substantial time interval around the saccade, there is no "perceptual gap" during sa...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-0876-5
更新日期:2007-07-01 00:00:00
abstract::3,4-Methylene-dioxy-N-methylamphetamine (MDMA, 'ecstasy') has a broad spectrum of molecular targets in the brain, among them receptors and transporters of the serotonergic (5-hydroxytryptamine, 5-HT) and noradrenergic systems. Its action on the serotonergic system modulates motor systems in rodents and humans. Althoug...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-014-4095-6
更新日期:2015-01-01 00:00:00
abstract::A series of step-tracking experiments was conducted before, during, and after a 3-week space mission to assess the effects of prolonged microgravity on a non-postural motor-control task. In- and post-flight accuracy was affected only marginally. However, kinematic analyses revealed a considerable change in the underly...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050906
更新日期:1999-12-01 00:00:00
abstract::Eye and head rotations are normally correlated with changes in walking direction; however, it is unknown whether they play a causal role in the control of steering. The objective of the present study was to answer two questions about the role of head rotations in steering control when walking to a goal. First, are hea...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-012-3077-9
更新日期:2012-06-01 00:00:00
abstract::In the present study, we examined the effects of explicit knowledge, obtained through instruction or spontaneous detection, on the transfer of visuomotor sequence learning. In the learning session, participants learned a visuomotor sequence, via trial and error. In the transfer session, the order of the sequence was r...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-017-4933-4
更新日期:2017-06-01 00:00:00
abstract::Size constancy is the ability to perceive objects as remaining constant in size regardless of their distance from the observer. Emmert's law demonstrates that viewing distance determines the perceived size of afterimages according to the amount of depth cues that are available. Using an afterimage paradigm, we examine...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-020-05747-5
更新日期:2020-04-01 00:00:00
abstract::Saccade kinematics are altered by ongoing head movements. The hypothesis that a head movement command signal, proportional to head velocity, transiently reduces the gain of the saccadic burst generator (Freedman 2001, Biol Cybern 84:453-462) can account for this observation. Using electrical stimulation of the rhesus ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-004-1840-2
更新日期:2004-06-01 00:00:00
abstract::According to the size principle for motoneurons one would expect that an excitatory stimulus given to a motoneuronal pool should evoke small excitatory postsynaptic potentials (EPSPs) in large and large EPSPs in small motoneurons of the pool. In this study this expectation was tested for the motoneuron pool of the fir...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00229117
更新日期:1994-01-01 00:00:00
abstract::The hypoglossal nucleus (Mo12) contains motoneurons that innervate the tongue, while the motor trigeminal nucleus (Mo5) contains motoneurons that elevate or depress the mandible. Previous studies have revealed lateral and medial tegmental field neuronal afferents to the Mo12 adjacent to, but not within, the motor trig...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00227237
更新日期:1992-01-01 00:00:00
abstract::Previous evidence based on perceptual integration and arbitrary responses suggests extensive cross-modal links in attention across the various modalities. Attention typically shifts to a common location across the modalities, despite the vast differences in their initial coding of space. An issue that remains unclear ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-005-0240-6
更新日期:2006-04-01 00:00:00
abstract::In the present work, we characterize electrophysiologically a commissural subcortical pathway which is related to binocular interactions in the nucleus of the optic tract (NOT) of the opossum. The main role played by the circuit comprising this pathway seems to be in relaying information coming from the ipsilateral ey...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00227519
更新日期:1994-01-01 00:00:00
abstract::During cerebral neocortical development, excitatory neurons are generated from radial glial cells in the ventricular zone (VZ) or from secondary progenitor cells in the subventricular zone (SVZ); these neurons then migrate toward the pial surface. We have observed that post-mitotic neurons generated directly in the VZ...
journal_title:Experimental brain research
pub_type: 杂志文章,评审
doi:10.1007/s00221-011-2933-3
更新日期:2012-01-01 00:00:00
abstract::Previous studies have demonstrated changes in motor memories with the passage of time on the order of hours. We sought to further this work by determining the influence that time on the order of seconds has on motor learning by changing the duration between successive reaches (inter-reach-interval (IRI)). Human subjec...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-005-0062-6
更新日期:2005-11-01 00:00:00
abstract::When humans pursue motion stimuli composed of alternating constant velocity segments of randomised duration (RD), they nevertheless initiate anticipatory eye deceleration before stimulus direction changes at a pre-programmed time based on averaging prior stimulus timing. We investigated, in both the time and frequency...
journal_title:Experimental brain research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00221-011-2725-9
更新日期:2011-07-01 00:00:00
abstract::The time course of the microglial cell reaction in central nervous system primary sensory projection territories has been examined following peripheral nerve injury in the adult rat using qualitative and quantitative analysis of immunoreactivity with the monoclonal antibody OX-42, which recognises the complement recep...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00230435
更新日期:1993-01-01 00:00:00
abstract::Fourteen healthy adults were tested to assess the potential influence on stance maintenance of two parts of the visual feedback technique (display scale and time delay). The task consisted in their keeping a spot on the screen representing their center of pressure, CoP (i.e. successive points of application of the gro...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-005-2288-8
更新日期:2005-08-01 00:00:00
abstract::Olfaction is unique among the senses in that signals from the peripheral sensory receptors bypass the thalamus on their way to the cortex. The fact that olfactory stimuli are not gated by the thalamus has led some researchers to suggest that people may be unable to selectively direct their attention toward the olfacto...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210100713
更新日期:2001-06-01 00:00:00