Abstract：
:Ganglioside and DNA levels were estimated in the striatum of rats 10 days and 6 weeks after lesioning by intrastriatal injection of kainic acid. There was a moderate, 21-24% decrease of the ganglioside concentration per unit protein on the side of the lesion, which can be ascribed to the loss of the intrinsic striatal neurons following the injection of kainic acid. On the other hand, there was a 131 and 60% increase of DNA per unit protein in the kainate injected side 10 days and 6 weeks after the lesions, respectively; these changes apparently reflected the gliotic reaction brought about by the neurotoxin. Qualitatively similar findings--a decrease of ganglioside and an increase of DNA levels per unit protein--were also found in the brain of patients with Huntington's disease; however, as compared with the corresponding control material, the decrease of the ganglioside concentration was more pronounced in the striatum of Huntington's disease (by 38% in the caudate nucleus and by 46% in the putamen) than in the kainate lesioned rat striatum. This difference could be due to the different proportions of the intrinsic and extrinsic neuronal plasma membranes in the striatum of the two species; however, the possibility of a more generalized affection of neuronal plasma membranes in Huntington's disease may also be envisaged.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Higatsberger MR,Sperk G,Bernheimer H,Shannak KS,Hornykiewicz Odoi
10.1007/BF00238752subject
Has Abstractpub_date
1981-01-01 00:00:00pages
93-6issue
1eissn
0014-4819issn
1432-1106journal_volume
44pub_type
杂志文章abstract：:Research in the vestibular field has revealed the existence of a central process, called 'velocity storage', that is activated by both visual and vestibular rotation cues and is modified by gravity, but whose functional relevance during natural motion has often been questioned. In this review, we explore spatial orien...
journal_title：Experimental brain research
pub_type： 杂志文章,评审
doi：10.1007/s00221-011-2568-4
更新日期：2011-05-01 00:00:00
abstract：:The spatial properties of human binocular mechanisms were investigated using the technique of subthreshold summation. Isolation of binocular mechanisms was achieved by means of interocular stimulus presentation. The contrast detection threshold for a sinusoidal test grating viewed by one eye was found to be reduced by...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237700
更新日期：1977-02-16 00:00:00
abstract：:In the present study pineal glands of rats aged 69-71 days were studied in vivo and in vitro with respect to day/night changes of "synaptic" ribbons and spherules. It was found that ribbons outnumber spherules by a factor of 3. In vivo, both ribbons and spherules show a roughly 3-fold increase in number at 1 a.m. when...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237178
更新日期：1982-01-01 00:00:00
abstract：:Previous studies have shown that the "synaptic" bodies of mammalian pinealocytes are a heterogeneous group of organelles. Whereas "synaptic" ribbons (SR) exhibit a day/night rhythm with small numbers during daytime and high numbers at night, the so-called "synaptic" spherules (SS) show species-specific differences in ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236214
更新日期：1987-01-01 00:00:00
abstract：:The dorsal and ventral streams model of action and perception suggests that reaching to grasp a tool for use involves integrated operation of the two streams. Few attempts have been made to test the limits of this integration in normal subjects. Twenty normal subjects reached for tools or geometric objects which were ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3501-9
更新日期：2013-06-01 00:00:00
abstract：:In order to further our understanding of action-blindsight, four hemianopic patients suffering from visual field loss contralateral to a unilateral occipital lesion were compared to six healthy controls during a double task of verbally reported target detection and saccadic responses toward the target. Three oculomoto...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3803-y
更新日期：2014-03-01 00:00:00
abstract：:This study examined hippocampal theta power during configural and non-configural tasks in rats. Experiment 1 compared hippocampal theta power during a negative patterning task (A+, B+, AB-) to a configural task and a simple discrimination task (A+, B-) as a non-configural task. The results showed that hippocampal thet...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-3359-2
更新日期：2013-03-01 00:00:00
abstract：:The motor cortex contains a distributed map of muscles, with a single muscle represented over a wide cortical area. We have searched for inter-connections between distant sites projecting to common muscles by delivering pairs of 20-microA single-pulse intracortical microstimuli (ICMS) to sites separated by 1.5-2 mm in...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050585
更新日期：1998-12-01 00:00:00
abstract：:Electron microscopic examination of the monkey lateral geniculate nucleus, pars dorsalis (LGNd) reveals the occurrence of synaptic contacts between profiles belonging to interneurons (I-cells). Almost all combinations are observed, namely, axodendritic, dendrodendritic, dendrosomatic and somatodendritic, the most freq...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237322
更新日期：1976-05-10 00:00:00
abstract：:In the base of each temporal lobe in 4 monkeys (Macaca fascicularis) we sectioned the pia mater in an antero-posterior line along the most medial part of the inferior temporal visual association cortex (area TE), lateral to the parahippocampal cortex. This pial section interrupts the blood flow in branches of the post...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228525
更新日期：1991-01-01 00:00:00
abstract：:Human observers are experts at visual face recognition due to specialized visual mechanisms for face processing that evolve with perceptual expertize. Such expertize has long been attributed to the use of configural processing, enabled by fast, parallel information encoding of the visual information in the face. Here ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3463-y
更新日期：2013-05-01 00:00:00
abstract：:Adrenocortical responses, as expressed by changes in plasma corticosterone levels, following ether stress and dorsal hippocampal stimulation, were studied in intact rats and in rats with complete, anterior of posterior hypothalamic deafferentations. Ether stress produced normal responses in all experimental groups. In...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237345
更新日期：1981-01-01 00:00:00
abstract：:This study examined the hypothesis that the mirror reflection of one hand's movement directly influences motor output of the other (hidden) hand, during performance of bimanual drawing. A mirror was placed between the two hands during bimanual circle drawing, with one hand and its reflection visible and the other hand...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-004-1831-3
更新日期：2004-07-01 00:00:00
abstract：:In the present article a number of comparative lesion studies in two inbred strains of mice (C57BL/6 and DBA/2) with different levels of radial maze performance are reviewed. The effects of lesions in several brain areas on maze learning were investigated, thus revealing strain differences in the neural circuitry subs...
journal_title：Experimental brain research
pub_type： 杂志文章,评审
doi：10.1007/s002210050542
更新日期：1998-11-01 00:00:00
abstract：:Trace eyeblink conditioning was investigated in 31 patients with focal cerebellar lesions and 19 age-matched controls. Twelve patients presented with lesions including the territory of the superior cerebellar artery (SCA). In 19 patients lesions were restricted to the territory of the posterior inferior cerebellar art...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-005-0171-2
更新日期：2006-03-01 00:00:00
abstract：:The principal goal of our study is to gain an insight into the representation of peripersonal space. Two different experiments were conducted in this study. In the first experiment, subjects were asked to represent principal anatomical reference planes by drawing ellipses in the sagittal, frontal and horizontal planes...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-005-0121-z
更新日期：2006-02-01 00:00:00
abstract：:The purpose of this study was to establish whether visual motion parallax participates in the control of postural sway. Body sway was measured in ten normal subjects by photoelectric recordings of head movements and by force-plate posturography. Subjects viewed a visual display ("background"), which briefly moved (2 s...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF02450322
更新日期：1997-02-01 00:00:00
abstract：:Little is known about mechanisms used by the nervous system to encode time. In light of recent evidence, cerebellar cortex involvement in the learned timing of conditioned eyelid responses shows promise as an area of investigation into neural timing mechanisms. Lesion studies indicate that the cerebellar cortex is nec...
journal_title：Experimental brain research
pub_type： 杂志文章,评审
doi：10.1007/s002210050443
更新日期：1998-07-01 00:00:00
abstract：:Single unit activity was recorded from tuberoinfundibular neurones in urethane-anaesthetized pro-oestrous rats. Responses following single shock (0.2 Hz) stimulation of the preoptic area/anterior hypothalamus (PO/AH) or nucleus accumbens (ACB) were recorded and computed for 137 single units. More cells were shown, by ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236546
更新日期：1985-01-01 00:00:00
abstract：:The authors inadvertently submitted a wrong figure part for publication. Figure 8b should be as follows. ...
journal_title：Experimental brain research
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00221-018-5429-6
更新日期：2019-01-01 00:00:00
abstract：:We determined whether uncertainty about the location of one's hand in virtual environments limits the efficacy of online control processes. In the Non-aligned and Aligned conditions, the participant's hand was represented by a cursor on a vertical or horizontal display, respectively. In the Natural condition, particip...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-010-2487-9
更新日期：2011-02-01 00:00:00
abstract：:Normal subjects standing on an earth-fixed force platform inside a movable room displaced at velocities comparable to those accompanying spontaneous body sway, exhibit a visually evoked postural response (VEPR) some 600 ms after the start of the room movement. It consists of a displacement of the centre of force of th...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237488
更新日期：1986-01-01 00:00:00
abstract：:This study compared the morphological characteristics and the behavioural effects of intrahippocampal septal cell suspension grafts injected either just above the pyramidal cell layer of the hippocampal region CA1 or within the dorsal leaf of the dentate gyrus (DG) in rats subjected to electrolytic fimbria-fornix lesi...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00227297
更新日期：1996-09-01 00:00:00
abstract：:Our aim was to describe the differences in the presence of trigger points (TrPs) in the shoulder muscles and to investigate the presence of mechanical hypersensitivity in patients with unilateral shoulder impingement and healthy controls. Twelve patients with strictly unilateral shoulder impingement and 10 matched con...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-010-2196-4
更新日期：2010-05-01 00:00:00
abstract：:Previous studies reported that the activity of trigeminal motoneurons innervating masseter muscles is modulated by vestibular inputs. We performed the present study to provide an anatomical substrate for these physiological observations. The transynaptic retrograde tracer pseudorabies virus-Bartha was injected into mu...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-005-0275-8
更新日期：2006-05-01 00:00:00
abstract：:Threshold elevation in the periphery of the visual field as a consequence of repetitive stimulation can be abolished by stimulating a mirror-symmetric position in the contralateral visual half-field. A patient suffering from a congenital malformation of the right superior colliculus did not exhibit threshold elevation...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236761
更新日期：1979-05-02 00:00:00
abstract：:Filial imprinting was originally proposed to be an irreversible process by which a young animal forms a preference for an object experienced early in life. The present study examined the effects of experience after imprinting on the stability of preferences of domestic chicks (Gallus gallus domesticus) for an imprinti...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-011-2769-x
更新日期：2011-08-01 00:00:00
abstract：:Using laminar field potential analysis, we examined responses elicited by both photic and optic nerve stimulations in 30 kittens of 0--65 days of age and in three adult cats. In adult cats, the response in the visual cortex on optic nerve stimulations is a wave complex which consists mainly of surface positive depth n...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236803
更新日期：1983-01-01 00:00:00
abstract：:We investigated the effects of intracerebroventricular (i.c.v.) pertussis toxin upon the sensitivity of supraoptic oxytocin neurones to intravenous morphine (1-5000 micrograms/kg) in urethane-anaesthetized rats. The maximal inhibitory capacity of morphine was diminished by prior administration of pertussis toxin. Some...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00230292
更新日期：1993-01-01 00:00:00
abstract：:Proprioceptive input arising from torsional body movements elicits small reflexive eye movements. The functional relevance of these eye movements is still unknown so far. We evaluated their slow components as a function of stimulus frequency and velocity. The horizontal eye movements of seven adult subjects were recor...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050418
更新日期：1998-06-01 00:00:00
