Abstract:
:In the present article a number of comparative lesion studies in two inbred strains of mice (C57BL/6 and DBA/2) with different levels of radial maze performance are reviewed. The effects of lesions in several brain areas on maze learning were investigated, thus revealing strain differences in the neural circuitry subserving spatial cognition. Results showed that the hippocampus and parietal cortex appear to be involved in the control of radial maze learning in both C57 and DBA mice, although in a strain-dependent fashion. Lesions in other structures such as the medial frontal cortex and the amygdala only affected spatial learning in the C57 strain. Lastly, the results showed some improvement in radial maze performance in DBA mice with nucleus accumbens lesions. The data highlight the variability in the neural mechanisms subserving well-differentiated levels of spatial performance. The contribution of inbred mice to our general understanding of the neural basis of spatial cognition is discussed.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Rossi-Arnaud C,Ammassari-Teule Mdoi
10.1007/s002210050542subject
Has Abstractpub_date
1998-11-01 00:00:00pages
36-44issue
1-2eissn
0014-4819issn
1432-1106journal_volume
123pub_type
杂志文章,评审abstract::Human walking dynamics are typically framed in the context of mechanics and energetics rather than in the context of neuromuscular control. Dynamic walking principles describe one helpful theoretical approach to characterize efficient human walking mechanics over many steps. These principles do not, however, address h...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-013-3708-9
更新日期:2013-12-01 00:00:00
abstract::The firing patterns of alpha and gamma efferent fibres and of group I and group II afferent fibres innervating the gastrocnemius muscle were observed during spontaneous locomotor movements in the thalamic cat. Multi-unit discharges of each kind of fibre were obtained by electronic sorting of the action potentials from...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00340493
更新日期:1986-01-01 00:00:00
abstract::This study aimed to examine the effect of explicit cuing on reactive stepping with the paretic limb during slip-like perturbations in stroke survivors and to identify differences in postural stability and fall-risk while stepping with either limb. Eleven chronic hemiparetic stroke survivors received slip-like stance p...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4367-9
更新日期:2015-11-01 00:00:00
abstract::In order to determine the responses of paraventricular nucleus neurones following activation of central serotonergic pathways, single unit activity was recorded and responses following electrical stimulation of the midbrain dorsal raphe nucleus were examined. Excitation was recorded from approximately 50% of the cells...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00228913
更新日期:1989-01-01 00:00:00
abstract::The main input of the lateral part of the cat's lateralis posterior-pulvinar complex (LP-P) comes from the primary visual cortex. We investigated the response properties of cells in area 17 projecting to the striate-recipient zone (LP1) of the cat's LP-P complex. The cells' receptive fields were stimulated with drifti...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00227105
更新日期:1993-01-01 00:00:00
abstract::This investigation was designed to study the effects of post-activation depression in different spinal pathways fed by group I afferents available to investigation in human subjects. It was precipitated by a recent investigation in the cat showing that-contrary to the general assumption-post-activation depression is n...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-005-2360-4
更新日期:2005-10-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-016-4591-y
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-006-0747-5
更新日期:2007-04-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-004-2209-2
更新日期:2005-07-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050685
更新日期:1999-04-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-019-05628-6
更新日期:2019-11-01 00:00:00
abstract::There are important developmental changes occurring during infancy in visual cortical structures that underlie higher-order perceptual abilities. Using high-density electrophysiological recording techniques, the present study aimed to examine the development of visual mechanisms, during the first year of life, associa...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-0854-y
更新日期:2007-06-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00228977
更新日期:1994-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050384
更新日期:1998-05-01 00:00:00
abstract::Supernumerary phantom limb (SPL) designates the experience of an illusory additional limb occurring after brain damage. Functional neuroimaging during SPL movements documented increased response in the ipsilesional supplementary motor area (SMA), premotor cortex (PMC), thalamus and caudate. This suggested that motor c...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-017-5044-y
更新日期:2017-10-01 00:00:00
abstract::As a consequence of the fragility of various neural structures, preterm infants born at a low gestation and/or birthweight are at an increased risk of developing motor abnormalities. The lack of a reliable means of assessing motor integrity prevents early therapeutic intervention. In this paper, we propose a new metho...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002219900227
更新日期:2000-04-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050499
更新日期:1998-09-01 00:00:00
abstract::Earlier studies have suggested an impairment in the attention and eye movement control of children with ADHD. An important phenomenon in the control of attentional shifts and eye movements is the inhibition of return (IOR), which states that our brain works in a way that prevents our attention from returning to a spat...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-002-1362-8
更新日期:2003-03-01 00:00:00
abstract::This study examined precision-grip force applied to an instrumented test object held aloft while the weight of the object was predictably varied by transporting and placing loads (50, 100, or 200 g) atop the test object. Transport of the loads was performed either by the subject or the experimenter. Grip force was exa...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210000337
更新日期:2000-06-01 00:00:00
abstract::The fate of monoclonal anti-vasopressin antibodies (VP-MAbs) injected in vivo into the paraventricular nucleus (PVN) of the rat brain was studied by immunocytochemistry. Depending on the post survival time, VP-MAbs contained in an ascites fluid were stained at different levels of the VP neurons: the cytoplasm of the P...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235986
更新日期:1987-01-01 00:00:00
abstract::When asked to identify the position of a sound, listeners can report its perceived location as well as their subjective certainty about this spatial judgement. Yet, research to date focused primarily on measures of perceived location (e.g., accuracy and precision of pointing responses), neglecting instead the phenomen...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-020-05748-4
更新日期:2020-03-01 00:00:00
abstract::The evoked expression of the immediate early gene-encoded proteins c-Fos and Krox-24 was used to study activation of hindbrain neurons as a function of the development of cyclophosphamide (CP) cystitis in behaving rats. CP-injected animals received a single dose of 100 mg/kg i.p. under transient volatile anesthesia an...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00227263
更新日期:1996-03-01 00:00:00
abstract::Transcranial direct current stimulation (tDCS) induces cortical excitability changes in animals and humans that can last beyond the duration of stimulation. Preliminary evidence suggests that tDCS may have an analgesic effect; however, the timing of these effects, especially when associated with consecutive sessions o...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-012-3149-x
更新日期:2012-08-01 00:00:00
abstract::The relationship between neuronal calcium binding protein content (calbindin D28K: CaBP and parvalbumin: PV) and vulnerability to ischemia was studied in different regions of the rat brain using the four vessel occlusion model of complete forebrain ischemia. The areas studied, i.e. the hippocampal formation, neocortex...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00232193
更新日期:1990-01-01 00:00:00
abstract::Pineal glands were collected from superior cervical ganglionectomized (SCGX) and sham-treated rats at time intervals following surgical manipulation. Pineal noradrenaline (NA) levels were quantitated by a radioisotopic-enzyme technique, or the pineals were examined by histofluorescence or electron microscopic techniqu...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238713
更新日期:1978-07-14 00:00:00
abstract::Our recent work has revealed that visuospatial working memory (VSWM) relates to the rate of explicit motor sequence learning (Bo and Seidler in J Neurophysiol 101:3116-3125, 2009) and implicit sequence performance (Bo et al. in Exp Brain Res 214:73-81, 2011a) in young adults (YA). Although aging has a detrimental impa...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-012-3189-2
更新日期:2012-09-01 00:00:00
abstract::A total of ten alpha motor axons which innervated the peroneus brevis muscle were isolated in two cynomolgus monkeys. In each experiment, the isolated alpha axons were stimulated collectively to deplete glycogen from their muscle units. The muscle was then frozen quickly , cut serially, and stained for glycogen. Of th...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237175
更新日期:1982-01-01 00:00:00
abstract::In order to clarify the functional role of the supplementary motor area (SMA) and its rostral part (pre-SMA) in relation to the rate of repetitive finger movements, we recorded movement-related cortical potentials (MRCPs) directly from the surface of the mesial frontal lobe by using subdural electrode grids implanted ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210000519
更新日期:2000-11-01 00:00:00
abstract::A gradual increase in iron occurs in the lesioned hippocampus after neuronal injury induced by the excitotoxin kainate, and the present study was carried out to investigate whether this increase in iron might be associated with changes in expression of the iron binding protein, ferritin. An increase in ferritin immuno...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-004-2110-z
更新日期:2005-03-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-004-2033-8
更新日期:2005-01-01 00:00:00