Abstract:
:Supernumerary phantom limb (SPL) designates the experience of an illusory additional limb occurring after brain damage. Functional neuroimaging during SPL movements documented increased response in the ipsilesional supplementary motor area (SMA), premotor cortex (PMC), thalamus and caudate. This suggested that motor circuits are important for bodily related cognition, but anatomical evidence is sparse. Here, we tested this hypothesis by studying an extremely rare patient with chronic SPL, still present 3 years after a vascular stroke affecting cortical and subcortical right-hemisphere structures. Anatomical analysis included an advanced in vivo reconstruction of white matter tracts using diffusion-based spherical deconvolution. This reconstruction demonstrated a massive and relatively selective disconnection between anatomically preserved SMA/PMC and the thalamus. Our results provide strong anatomical support for the hypothesis that cortico-thalamic loops involving motor-related circuits are crucial to integrate sensorimotor processing with bodily self-awareness.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Bourlon C,Urbanski M,Quentin R,Duret C,Bardinet E,Bartolomeo P,Bourgeois Adoi
10.1007/s00221-017-5044-ysubject
Has Abstractpub_date
2017-10-01 00:00:00pages
3163-3174issue
10eissn
0014-4819issn
1432-1106pii
10.1007/s00221-017-5044-yjournal_volume
235pub_type
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