Abstract：
:We have reported previously that intracranial application of near-infrared light (NIr) reduces clinical signs and offers neuroprotection in a subacute MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) monkey model of Parkinson's disease. In this study, we explored whether NIr reduces the gliosis in this animal model. Sections of midbrain (containing the substantia nigra pars compacta; SNc) and striatum were processed for glial fibrillary acidic protein (to label astrocytes; GFAP) and ionised calcium-binding adaptor molecule 1 (to label microglia; IBA1) immunohistochemistry. Cell counts were undertaken using stereology, and cell body sizes were measured using ImageJ. Our results showed that NIr treatment reduced dramatically (~75 %) MPTP-induced astrogliosis in both the SNc and striatum. Among microglia, however, NIr had a more limited impact in both nuclei; although there was a reduction in overall cell size, there were no changes in the number of microglia in the MPTP-treated monkeys after NIr treatment. In summary, we showed that NIr treatment influenced the glial response, particularly that of the astrocytes, in our monkey MPTP model of Parkinson's disease. Our findings raise the possibility of glial cells as a future therapeutic target using NIr.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
El Massri N,Moro C,Torres N,Darlot F,Agay D,Chabrol C,Johnstone DM,Stone J,Benabid AL,Mitrofanis Jdoi
10.1007/s00221-016-4720-7subject
Has Abstractpub_date
2016-11-01 00:00:00pages
3225-3232issue
11eissn
0014-4819issn
1432-1106pii
10.1007/s00221-016-4720-7journal_volume
234pub_type
杂志文章abstract：:The present study assessed changes in perceived heaviness of weights lifted by the thumb, index, ring and little fingers during anaesthesia of the "lifting" digit. Subjects (n = 19) lifted weights solely by flexion of the distal joint of the digit, using a bilateral weight-matching paradigm. Changes in perceived heavi...
journal_title：Experimental brain research
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