Abstract:
:Antispastic effects of the noradrenaline and dopamine precursor l-3,4-dihydroxyphelanine (L-dopa) were investigated in 11 subjects in which exaggerated stretch reflexes developed after spinal cord injuries. The effects were evaluated from changes in the electromyographic (EMG) response of the quadriceps muscle during tendon jerks evoked by standardized taps over the patellar tendon, in clonus and in resistance to passive movements of the limb. After administration of L-dopa, EMG responses occurring 30-150 ms after the tendon tap decreased to about 50% of control, and clinical tests revealed a marked decrease in the resistance to muscle stretches and in the degree of clonus. The effects were maximal within about 1 h. The depressive actions of L-dopa are interpreted as being exerted primarily at the spinal level, since they were evoked in paraplegics and tetraplegics. The results support the previous hypothesis that group II muscle afferents contribute to.the exaggerated stretch reflex in spastic patients because L-dopa depresses transmission from group II but not from group I muscle afferents. They also indicate the possibility of using L-dopa in the treatment of spastic patients.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Eriksson J,Olausson B,Jankowska Edoi
10.1007/BF00227307subject
Has Abstractpub_date
1996-09-01 00:00:00pages
296-304issue
2eissn
0014-4819issn
1432-1106journal_volume
111pub_type
杂志文章abstract::The uptake of tritiated gamma-aminobutyric acid (3H-GABA) in the oculomotor nucleus of the cat was studied, using light and electron microscopic examination of radioautograms after intracerebral in vivo administration of the amino-acid. A glial uptake by oligodendrocytes was seen together with a neuronal uptake of the...
journal_title:Experimental brain research
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journal_title:Experimental brain research
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journal_title:Experimental brain research
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journal_title:Experimental brain research
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pub_type: 杂志文章,评审
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050802
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journal_title:Experimental brain research
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238970
更新日期:1985-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-005-0096-9
更新日期:2006-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
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更新日期:2010-04-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00239571
更新日期:1982-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00230435
更新日期:1993-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-011-2893-7
更新日期:2011-12-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-0879-2
更新日期:2007-07-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-008-1289-9
更新日期:2008-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-006-0536-1
更新日期:2006-10-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00234062
更新日期:1975-12-22 00:00:00
abstract::We have previously shown that sinusoidal galvanic vestibular stimulation (sGVS), delivered bilaterally at 0.2-2.0 Hz, evokes a potent entrainment of sympathetic outflow to muscle and skin. Most recently, we showed that stimulation at 0.08-0.18 Hz generates two bursts of modulation of muscle sympathetic nerve activity ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-012-3090-z
更新日期:2012-06-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237349
更新日期:1975-05-22 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF02423506
更新日期:1990-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章,评审
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更新日期:2008-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-05-01 00:00:00