Abstract:
:The aim of this work was to study the neurochemical effects in the brain of GABA-transaminase inhibition by systemic administration of gabaculine (100 mg/kg, i.a.) in the rat. In order to investigate neurotransmitter and related amino-acid compartmentation and metabolism, we have developed an original tool: the coupling, in vivo, on the same animal, of 2D COSY 1H-NMR spectroscopy with intracerebral microdialysis. The main result is a continuous increase in GABA levels, both in the intracellular compartment (up to 3000+/-450%; P<0.001) and extracellular compartment (up to 808+/-82%; P<0.01) at the sixth hour. The intracellular increase in GABA level became significant at the first hour following gabaculine administration, whereas the extracellular level increased as of the second hour, probably indicating that accumulation of GABA in nerve endings precedes its release in synaptic clefts. Moreover, the levels of the excitatory amino acids, glutamate and aspartate, were decreased both in the intra- and extracellular compartments, thus enhancing sedative effects of the drug. We also observed a decrease in the global energetic creatine-phosphocreatine pool, which also could be related to the sedative properties of gabaculine, measurable by the diminution of cortical electrical activity and mean arterial blood pressure. Finally, the coupling between 2D 1H-NMR spectroscopy and intracerebral microdialysis appears to be an original tool for investigating the cerebral metabolic effects induced by pharmacological agents, in situ, in living animals.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Piérard C,Pérès M,Satabin P,Guezennec CY,Lagarde Ddoi
10.1007/s002210050802keywords:
subject
Has Abstractpub_date
1999-08-01 00:00:00pages
321-7issue
3eissn
0014-4819issn
1432-1106journal_volume
127pub_type
杂志文章abstract::5-Hydroxytryptamine (5-HT) has the most diverse set of receptors in comparison with any other neurotransmitter or hormone in the body. To date, seven families of 5-HT receptors have been characterized. A great number of studies have been published regarding the role of 5-HT and its receptors in seizures. However, with...
journal_title:Experimental brain research
pub_type: 杂志文章,评审
doi:10.1007/s00221-013-3757-0
更新日期:2014-02-01 00:00:00
abstract::Visual stimuli undetected by normal subjects as a result of masking procedures can nonetheless activate response preparation in motor areas and yield a motor response. An unanswered question is whether the same holds for undetected subliminal stimuli that are not responded to. To answer this question, in this study no...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-006-0825-8
更新日期:2007-06-01 00:00:00
abstract::A contrast reversal (alternating phase) stimulus was used to study the responses of 150 retinal ganglion cells from 15 adult cats. Because the majority of the cells did not show perfect linear spatial summation, a ratio of the firing rates at two time periods was used to express the degree of nonlinearity. Y-cells sho...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00236782
更新日期:1979-03-09 00:00:00
abstract::Movements of the dominant and nondominant hand have been claimed to differ with respect to how they take intersegmental dynamics into account. Consistent with this claim, movements of the dominant hand are hypothesized to better exploit the intrinsic limb dynamics, whereas movements of the nondominant hand are control...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-006-0747-5
更新日期:2007-04-01 00:00:00
abstract::The photothrombotic ring stroke model with sustained underperfusion followed by late spontaneous reperfusion (Gu et al. 1999) was employed to study its morphological consequences. The exposed crania of adult male Wistar rats were subjected to a ring-shaped laser irradiation beam simultaneously with intravenous erythro...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050672
更新日期:1999-03-01 00:00:00
abstract::In the context of an analysis concerning factors of importance for the relative contributions of recruitment and rate gradation of muscle force, the distribution of electrical excitability was analyzed for medial gastrocnemius (MG) motoneurones of rat and cat. The experimental data came from previously collected intra...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00232439
更新日期:1994-01-01 00:00:00
abstract::The effect of Coriolis, cross-coupled stimulation on the vestibuloocular reflex and the elicitation of motion sickness depends on background gravitoinertial force level (DiZio et al. 1986, 1987; Graybiel et al. 1977; Lackner and Graybiel 1984, 1986). We have explored whether this response dependency is related to the ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00247597
更新日期:1988-01-01 00:00:00
abstract::This study aimed to examine the effect of explicit cuing on reactive stepping with the paretic limb during slip-like perturbations in stroke survivors and to identify differences in postural stability and fall-risk while stepping with either limb. Eleven chronic hemiparetic stroke survivors received slip-like stance p...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4367-9
更新日期:2015-11-01 00:00:00
abstract::Although postural control requires the integration of different sensory cues, little is known about the role of attentional artifacts on the individual's ability to properly respond to postural challenges. This study investigated the effects of concomitant tasks (cognitive and postural) on the relationship between vis...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-016-4762-x
更新日期:2016-12-01 00:00:00
abstract::In the present study, we report the sensitivity of utricular afferents to sinusoidal translational motion in the horizontal plane. The head orientation was altered relative to the direction of translational travel in 30 degrees increments to allow determination of the head orientation that elicited the maximal and min...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-003-1530-5
更新日期:2003-10-01 00:00:00
abstract::The present study assessed changes in perceived heaviness of weights lifted by the thumb, index, ring and little fingers during anaesthesia of the "lifting" digit. Subjects (n = 19) lifted weights solely by flexion of the distal joint of the digit, using a bilateral weight-matching paradigm. Changes in perceived heavi...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050247
更新日期:1997-12-01 00:00:00
abstract::We have studied the contribution of feedback signals originating from one of the "form-processing" extrastriate cortical areas, area 21a (A21a), to orientation selectivity of single neurons in the ipsilateral area 17 (A17). Consistent with previous findings, reversible inactivation (cooling to 5-10 degrees C) of area ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-1014-0
更新日期:2007-10-01 00:00:00
abstract::The coordination between eye and head movements during a rapid orienting gaze shift has been investigated mainly when subjects made horizontal movements towards visual targets with the eyes starting at the centre of the orbit. Under these conditions, it is difficult to identify the signals driving the two motor system...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/pl00005663
更新日期:1997-05-01 00:00:00
abstract::The aim of this study was to investigate the effects of self-reinnervation of the medial (MG) and lateral gastrocnemius (LG) muscles on joint kinematics of the whole hindlimb during overground walking on surfaces of varying slope in the cat. Hindlimb kinematics were assessed (1) with little or no activity in MG and LG...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-0938-8
更新日期:2007-08-01 00:00:00
abstract::In the present study, the sensitivity to sinusoidal linear accelerations in the plane of the utricular macula was tested in afferents. The head orientation relative to the translation axis was varied in order to determine the head position that elicited the maximal and minimal responses for each afferent. The response...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050219
更新日期:1997-11-01 00:00:00
abstract::We tested the hypothesis that geniculate X cells are the neural substrate of psychophysically identified pattern channels and that geniculate Y cells are the neural substrate of psychophysically identified flicker channels. The hypothesis was tested by measuring the relative sensitivity of isolated X and Y cells in th...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00240505
更新日期:1984-01-01 00:00:00
abstract::The evoked expression of the immediate early gene-encoded proteins c-Fos and Krox-24 was used to study activation of hindbrain neurons as a function of the development of cyclophosphamide (CP) cystitis in behaving rats. CP-injected animals received a single dose of 100 mg/kg i.p. under transient volatile anesthesia an...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00227263
更新日期:1996-03-01 00:00:00
abstract::Electrical stimulation over the cerebellum is known to transiently suppress the contralateral motor cortex in humans. However, projections from the cerebellar nuclei to the primary motor cortex are disynaptic excitatory pathways through the ventral thalamus. In the present investigation we studied facilitatory effects...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00221-004-1979-x
更新日期:2004-12-01 00:00:00
abstract::A compensatory stepping response (CSR) is a common strategy to restore dynamic stability in response to a postural disturbance. Currently, few studies have investigated the CSR to laterally directed disturbances delivered to subjects during quiet standing. The purpose of this study was to characterize the CSR of young...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-011-2854-1
更新日期:2011-10-01 00:00:00
abstract::The present experiment was designed to test the hypothesis that fatigue-induced impairment in movement accuracy is caused by a decrease in muscle cocontraction rather than a reduced ability to produce muscular force. Seven participants performed fast and accurate elbow extensions aimed at a target, before and after a ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-1264-x
更新日期:2008-02-01 00:00:00
abstract::It has recently been shown that spatially uninformative sounds can cause a visual stimulus to pop out from an array of similar distractor stimuli when that sound is presented in temporal proximity to a feature change in the visual stimulus. Until now, this effect has predominantly been demonstrated by using stationary...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-011-2797-6
更新日期:2011-09-01 00:00:00
abstract::Extracellular focal synaptic potentials (FSPs) were recorded in forelimb segments of cats in the region where corticospinal volleys (pyramidal stimulation) gave a maximal FSP. No FSP was recorded in this region on stimulation of the medial part of the lateral reticular nucleus (LRN), provided that ventral spinal pathw...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235897
更新日期:1982-01-01 00:00:00
abstract::When walking with a hand-held object, grip force is coupled in an anticipatory manner to changes in inertial force resulting from the accelerations and decelerations of gait. However, it is not known how grip and inertial forces are organized at the onset of gait, and if the two forces are coupled in the early phases ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-008-1476-8
更新日期:2008-09-01 00:00:00
abstract::The ability to control speed and accuracy of goal directed aiming tasks underpins many activities of daily living. Recent evidence has begun to suggest that obesity can affect the control of movement. This study evaluated perceptual motor control of 183 normal weight, overweight, and obese participants using a discret...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-018-5330-3
更新日期:2018-10-01 00:00:00
abstract::The present study characterizes expression of calbindin D28K (CB-D28K) and parvalbumin (PV) in ventral forebrain (VFB) grafts placed in the neocortex of adult rats bearing quisqualic acid lesions to the nucleus basalis magnocellularis. Three to nine months after transplantation surgery, rats were killed for in situ hy...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050311
更新日期:1998-02-01 00:00:00
abstract::The authors determined the effects of changes in task demands on interpersonal and intrapersonal coordination. Participants performed a joint task in which one participant held a stick to which a circle was attached at the top (holding role), while the other held a pointer through the circle without touching its borde...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-011-2653-8
更新日期:2011-06-01 00:00:00
abstract::In two experiments, we examined the effect of selective attention at encoding on repetition priming in normal aging and Alzheimer's disease (AD) patients for objects presented visually (experiment 1) or haptically (experiment 2). We used a repetition priming paradigm combined with a selective attention procedure at en...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-008-1441-6
更新日期:2008-08-01 00:00:00
abstract::Humans are known to show anticipatory adjustments in the grip force prior to a self-generated or predictable action or perturbation applied to a hand-held object. We investigated whether humans can also adjust covariation of individual finger forces (multi-finger synergies) prior to self-triggered perturbations. To ad...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-006-0583-7
更新日期:2006-11-01 00:00:00
abstract::Saccular and utricular organs are essential for postural stability and gaze control. Although saccular and utricular inputs are known to terminate on vestibular neurons, few previous studies have precisely elucidated the origin of these inputs. We investigated the saccular and utricular inputs to single vestibular neu...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002219900312
更新日期:2000-04-01 00:00:00
abstract::In an earlier report we found that when pairs of letters were physically transposed on the keyboard and typists were required to type letters in their new location, the disruptions in typing were reduced when the transpositions involved mirror movements of homologous fingers of the two hands compared with transpositio...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210000592
更新日期:2001-02-01 00:00:00