The role of different serotonin receptor subtypes in seizure susceptibility.

Abstract:

:5-Hydroxytryptamine (5-HT) has the most diverse set of receptors in comparison with any other neurotransmitter or hormone in the body. To date, seven families of 5-HT receptors have been characterized. A great number of studies have been published regarding the role of 5-HT and its receptors in seizures. However, with a few exceptions, the net effect of activating or inhibiting each 5-HT receptor subtype on the development or severity of seizures remains controversial. Additionally, the results of studies, which have used knockout animals to investigate the role of 5-HT receptors in seizures, have sometimes been contradictory to those which have used pharmacological tools. The present study aims to review the available data regarding the influence of each receptor subtype on seizure development and, when possible, reconcile between the apparently different results obtained in these studies.

journal_name

Exp Brain Res

authors

Gharedaghi MH,Seyedabadi M,Ghia JE,Dehpour AR,Rahimian R

doi

10.1007/s00221-013-3757-0

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

347-67

issue

2

eissn

0014-4819

issn

1432-1106

journal_volume

232

pub_type

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