Abstract:
:5-Hydroxytryptamine (5-HT) has the most diverse set of receptors in comparison with any other neurotransmitter or hormone in the body. To date, seven families of 5-HT receptors have been characterized. A great number of studies have been published regarding the role of 5-HT and its receptors in seizures. However, with a few exceptions, the net effect of activating or inhibiting each 5-HT receptor subtype on the development or severity of seizures remains controversial. Additionally, the results of studies, which have used knockout animals to investigate the role of 5-HT receptors in seizures, have sometimes been contradictory to those which have used pharmacological tools. The present study aims to review the available data regarding the influence of each receptor subtype on seizure development and, when possible, reconcile between the apparently different results obtained in these studies.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Gharedaghi MH,Seyedabadi M,Ghia JE,Dehpour AR,Rahimian Rdoi
10.1007/s00221-013-3757-0subject
Has Abstractpub_date
2014-02-01 00:00:00pages
347-67issue
2eissn
0014-4819issn
1432-1106journal_volume
232pub_type
杂志文章,评审abstract::Experiments were carried out on the in vitro preparation of the lamprey brainstem isolated together with the labyrinths. The brain orientation in space could be changed in steps of 45 degrees by rotation (360 degrees) around the longitudinal axis (roll) or the transverse axis (pitch). Vestibular afferents in the VIII ...
journal_title:Experimental brain research
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journal_title:Experimental brain research
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