Abstract:
:Scientific interest has increased the influence of temperature in neurodegenerative and psychiatric disorders, and according to the monoamine hypothesis, depression is a neurochemical disorder arising from hypofunctioning of brain monoamine systems. Here, in vivo flow-oxymetry is applied to verify relationships between cerebral oxygen tension (pO2), blood flow (CBF), that are markers of brain metabolism, and temperature (T), while in vivo voltammetry is concomitantly applied in the medial prefrontal cortex of anaesthetized rats to monitor monoamine levels such as dopamine (DA) and serotonin. An induced mild hypercapnia via increasing exogenous carbon dioxide (CO2) concentration resulted in increased pO2, CBF and T in discrete brain areas. Concomitant in situ voltammetric analysis of extracellular levels of serotonin and DA has revealed significant changes in the latter, only. Parallel treatment with antidepressant bupropion has confirmed its described central thermogenic properties and its positive influence on dopaminergic activity. CBF was also enhanced by such antidepressant. Altogether these data support direct relationships between markers of brain metabolism such as pO2, CBF, T and brain monoamine[s], indicating the coupled in vivo methodology: oxymetry-voltammetry as a rapid in vivo tool for analyses of such indicators in psychiatric disorders.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Crespi Fdoi
10.1007/s00221-013-3443-2subject
Has Abstractpub_date
2013-10-01 00:00:00pages
597-604issue
4eissn
0014-4819issn
1432-1106journal_volume
230pub_type
杂志文章abstract::Vibratory stimulation of the neck muscles can elicit illusory drift of a visual target; after vibration stops, motion in the opposite direction is perceived. This motion aftereffect (MAE) could be due to adaptation of proprioceptive mechanisms that encode head orientation, or at a stage where visual and proprioceptive...
journal_title:Experimental brain research
pub_type: 杂志文章
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journal_title:Experimental brain research
pub_type: 杂志文章
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journal_title:Experimental brain research
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journal_title:Experimental brain research
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-009-2030-z
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journal_title:Experimental brain research
pub_type: 杂志文章
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journal_title:Experimental brain research
pub_type: 杂志文章
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journal_title:Experimental brain research
pub_type: 杂志文章
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journal_title:Experimental brain research
pub_type: 杂志文章
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00240505
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journal_title:Experimental brain research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00221-012-3296-0
更新日期:2013-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-013-3491-7
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-005-0216-6
更新日期:2006-04-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/pl00005691
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00249792
更新日期:1987-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235920
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journal_title:Experimental brain research
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journal_title:Experimental brain research
pub_type: 杂志文章
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journal_title:Experimental brain research
pub_type: 杂志文章
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journal_title:Experimental brain research
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Experimental brain research
pub_type: 杂志文章
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更新日期:2012-02-01 00:00:00