Abstract:
:Micturition in the decerebrate cat is characterized by a coordinated bladder contraction and a simultaneous decrease in external urethral sphincter (EUS) efferent activity. Without the suppression of EUS activity, voiding is significantly impaired, resulting in a state sometimes referred to as bladder-sphincter dyssynergia. The aim of the present study was to determine whether glycinergic inhibition contributes to the suppression of EUS activity during micturition evoked by bladder distension or electrical stimulation of the pontine micturition center (PMC) in decerebrate cats. Using subconvulsive intravenous doses of strychnine (0.1-0.24 mg/kg), we examined changes in bladder and EUS electroneurographic (ENG) activity during micturition. Following subconvulsive doses of strychnine, tonic EUS ENG activity increased during bladder filling in five of six animals. In the presence of strychnine, it was possible to evoke reflex bladder contractions of similar duration and peak pressure to those observed before strychnine administration. However, there was an absence of suppression of EUS ENG activity during the bladder contractions in all the animals. To determine whether the changes in sphincter activity could be due to strychnine acting at glycine receptors on EUS motoneurons, sacral spinal tissue was processed for a structural protein (gephyrin) associated with the glycine receptor. Motoneurons in Onufs nucleus in S1 were identified using choline acetyltransferase immunohistochemistry and subsequently processed with a gephyrin monoclonal antibody. Abundant gephyrin labeling was evident throughout Onufs nucleus. Since Onufs nucleus is made up of EUS and other motoneuron populations, a sample of antidromically identified urethral and anal sphincter motoneurons were intracellularly labeled with tetramethylrhodamine dextran (TMR-D) and then processed with the gephyrin antibody. Using dual-beam confocal microscopy, gephyrin immunoreactivity was observed on the soma and proximal processes of individual EUS motoneurons in both male and female animals. It was concluded that a strychnine-sensitive mechanism contributes to the suppression of sphincter activity normally observed during voiding. Although glycinergic inhibition may affect several components of the circuitry responsible for micturition, it appears that the suppression of EUS motoneurons during micturition may be partly due to a direct glycinergic inhibition of the EUS motoneurons.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Shefchyk SJ,Espey MJ,Carr P,Nance D,Sawchuk M,Buss Rdoi
10.1007/s002210050345subject
Has Abstractpub_date
1998-04-01 00:00:00pages
297-306issue
3eissn
0014-4819issn
1432-1106journal_volume
119pub_type
杂志文章abstract::The present study was undertaken to investigate the effects of the alpha2 adrenergic agonist, clonidine, on the near complete cerebral ischemia (NCFI) evoked release of glutamate and aspartate from normo- and hyperglycemic rodent brain tissue using microdialysis tissue techniques. Hemodynamic variables, blood lactate,...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-005-0064-4
更新日期:2005-12-01 00:00:00
abstract::Recent anatomical and physiological studies have suggested that parts of the cingulate cortex are involved in the control of movement. These areas have been collectively termed the cingulate motor area (CMA). Currently almost nothing is known, however, about how neurons in the CMA actually participate in the control o...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210100807
更新日期:2001-09-01 00:00:00
abstract::Spike trains of long duration were recorded from concurrently active pairs of motor units in the human masseter and tibialis anterior muscles. An innovative analysis technique was used to investigate functional coupling between the motoneurons by plotting the discharge frequency of one motor unit with respect to the f...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/BF00228735
更新日期:1996-10-01 00:00:00
abstract::We investigated whether the control of movement of the left hand is more likely to involve the use of allocentric information than movements performed with the right hand. Previous studies (Gonzalez et al. in J Neurophys 95:3496-3501, 2006; De Grave et al. in Exp Br Res 193:421-427, 2009) have reported contradictory f...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-012-3007-x
更新日期:2012-04-01 00:00:00
abstract::Using different tracer substances the pathways connecting the superior colliculus with the diencephalon were studied in the Madagascan hedgehog tenrec (Echinops telfairi), a nocturnal insectivore with tiny eyes, a small and little differentiated superior colliculus and a visual cortex with no obvious fourth granular l...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00228725
更新日期:1996-10-01 00:00:00
abstract::A series of step-tracking experiments was conducted before, during, and after a 3-week space mission to assess the effects of prolonged microgravity on a non-postural motor-control task. In- and post-flight accuracy was affected only marginally. However, kinematic analyses revealed a considerable change in the underly...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050906
更新日期:1999-12-01 00:00:00
abstract::This study examines the process of learning to walk from a functional perspective. To move forward, one must generate and control propulsive forces. To achieve this, it is necessary to create and tune a distance between the centre of mass (CoM) and the centre of pressure (CoP) along the antero-posterior axis. We hypot...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4378-6
更新日期:2015-10-01 00:00:00
abstract::The latencies of visually-evoked responses from X- and Y-type neurons of the cat's dorsal lateral geniculate nucleus were measured in a manner that takes account of the inherent variability of discharge in these cells. Latencies measured in this way vary from trial to trial in one cell (and also between cells) by tens...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235998
更新日期:1987-01-01 00:00:00
abstract::There are important developmental changes occurring during infancy in visual cortical structures that underlie higher-order perceptual abilities. Using high-density electrophysiological recording techniques, the present study aimed to examine the development of visual mechanisms, during the first year of life, associa...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-0854-y
更新日期:2007-06-01 00:00:00
abstract::Many vertebrates generate blinks as a component of saccadic gaze shifts. We investigated the nature of this linkage between saccades and blinking in normal humans. Activation of the orbicularis oculi, the lid closing muscle, EMG occurred with 97% of saccadic gaze shifts larger than 33 degrees. The blinks typically beg...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00227203
更新日期:1994-01-01 00:00:00
abstract::After injection of S35-methionine into cervical and lumbar dorsal root ganglia in turtle, a primary afferent projection was demonstrated on to the cerebellum. Few, but consistent patches of silver grains were found within the granular layer suggesting mossy fiber terminations. The projection was mainly ipsilateral and...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF01208609
更新日期:1982-01-01 00:00:00
abstract::The whisker-to-barrel pathway of the adult mouse was used in a study on the effects of peripheral sensory deprivation on GAD-immunoreactivity in the somatosensory cortex. At varying periods of time after removal of a set of vibrissal follicles, mice were processed for immunohistochemistry using an antibody against GAD...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00247346
更新日期:1989-01-01 00:00:00
abstract::We explored whether the synergic control of the hand during multi-finger force production tasks depends on the hand muscles involved. Healthy subjects performed accurate force production tasks and targeted force pulses while pressing against loops positioned at the level of fingertips, middle phalanges, and proximal p...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-018-5231-5
更新日期:2018-05-01 00:00:00
abstract::The descending projection of the hypothalamic paraventricular nucleus (PVN) to the sympathetic preganglionic neurons (SPNs) in the upper thoracic cord of the rat was studied. PVN-fibers were labeled by anterograde transport of Phaseolus vulgaris leucoagglutinin (PHA-L), while SPNs were retrogradely labeled with choler...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00229982
更新日期:1991-01-01 00:00:00
abstract::A recent study (Rossi et al. 2001) implied the absence of figure-ground based contextual modulation in macaque V1, in contrast to the study on which it was modelled (Zipser et al. 1996). We suggest that Rossi et al. may have underestimated the extent of modulation by considering only positive and not also negative mod...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-004-1847-8
更新日期:2004-05-01 00:00:00
abstract::Recent animal studies have found neuronal expression of major histocompatibility complex (MHC) class I in the central nervous system (CNS). However, the developmental expression profiles of MHC class I in human CNS remain unclear. Here, we systemically evaluate the expression and subcellular localization of MHC class ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4345-2
更新日期:2015-09-01 00:00:00
abstract::Goal-directed movements are commonly used to allow humans to interact with their environment. When making a goal-directed movement in a natural environment, there are many competing stimuli. It is therefore important to understand how making a goal-directed movement could be impacted by the need to divide attention be...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-014-3880-6
更新日期:2014-06-01 00:00:00
abstract::In a previous study we have demonstrated the existence of pulvinar (puv) cells which were optimally activated when a monkey executed reaching movements with his limbs (Acuña et al 1983). We now describe further observations in four Macaca nemestrina monkeys trained to perform goal directed reaching movements aimed at ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00230847
更新日期:1990-01-01 00:00:00
abstract::The projection from the nucleus prepositus hypoglossi (PH) to the superior colliculus (SC) has been proposed to provide a feedback control of collicular saccadic activities. The present study aimed to identify the functional properties of PH neurones projecting to the SC relative to eye movement parameters. Preposito-...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00229141
更新日期:1996-08-01 00:00:00
abstract::Several studies have shown that people can catch a ball even if it is visible only during part of its flight. Here, we examine how well they can do so. We measured the movements of a ball and of the hands of both the thrower and the catcher during one-handed underarm throwing and catching. The catcher's sight was occl...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-010-2421-1
更新日期:2010-10-01 00:00:00
abstract::Nine participants performed a reciprocal precision aiming task under different experimental conditions. Due to the anisotropy of the work space, varying the direction of motion (from 0 degrees to 315 degrees in steps of 45 degrees ) allowed exploration of the effects of biomechanical constraints that were found to aff...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00221-004-1964-4
更新日期:2004-12-01 00:00:00
abstract::We recently demonstrated the existence of neurogenesis in the striatum of adult monkeys, but the number of striatal neurons generated under normal conditions was too small to establish their chemical phenotype. We therefore used brain-derived neurotrophic factor (BDNF), which promotes neuronal differentiation and surv...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-005-0233-5
更新日期:2006-04-01 00:00:00
abstract::Four rhesus monkeys with bilateral removals of SII and five unoperated monkeys were trained on tests of tactile equivalence, weight discrimination and generalization, tactile discrimination learning (including concurrent learning and serial reversal) and inter-manual transfer of tactile learning. Lesioned animals were...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00239806
更新日期:1978-04-14 00:00:00
abstract::The flow of information in the sensorimotor cortex may determine how somatic information modulates motor cortex neuronal activity during voluntary movement. Electrophysiological recordings and neuroanatomical tracing techniques were used to study the connections between the primary somatosensory cortex (SI) and the vi...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00229854
更新日期:1995-01-01 00:00:00
abstract::The aim of this study was to analyse the functional impairments caused by chronic median nerve compression at the wrist on hand sensation and manual skill. Hand function was assessed in 11 patients (8 women and 3 men) with severe carpal tunnel syndrome (CTS) and compared with that of an age- and sex-matched control gr...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050817
更新日期:1999-09-01 00:00:00
abstract::Under free-viewing conditions, the leftward stimulus features are frequently overestimated (pseudoneglect). This asymmetry could reflect the operation of: (a) spatial attention mechanisms in the right hemisphere (RH) or, (b) stimulus-specific activation. To test these propositions, we attempted to induce a stimulus-sp...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-005-0303-8
更新日期:2006-06-01 00:00:00
abstract::The study was conducted to investigate the difference between Han Chinese and Caucasians on various parameters measured from responses to transcranial magnetic brain stimulation (TMS). Sixteen subjects were studied in each group. A circular coil at the vertex was used for stimulation, whilst recording surface electrom...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-013-3763-2
更新日期:2014-02-01 00:00:00
abstract::Haptic perception is based on the integration of afferent proprioceptive and tactile signals. A further potential source of information during active touch is predicted sensory feedback (PSF) derived from a copy of efferent motor commands that give rise to the exploratory actions. There is substantial evidence that PS...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-009-1996-x
更新日期:2010-01-01 00:00:00
abstract::In order to further our understanding of action-blindsight, four hemianopic patients suffering from visual field loss contralateral to a unilateral occipital lesion were compared to six healthy controls during a double task of verbally reported target detection and saccadic responses toward the target. Three oculomoto...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-013-3803-y
更新日期:2014-03-01 00:00:00
abstract::Tone bursts produced bands of selective 2-[14C]-deoxyglucose labelling in the inferior colliculus (IC) of the awake monkey. Low tone frequencies produced labelling in dorsal regions and high tone frequencies produced labelling in ventral regions. The position of the bands coincided with the position of a single unit w...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237983
更新日期:1984-01-01 00:00:00