Plasticity in the barrel cortex of the adult mouse: effects of peripheral deprivation on GAD-immunoreactivity.

Abstract:

:The whisker-to-barrel pathway of the adult mouse was used in a study on the effects of peripheral sensory deprivation on GAD-immunoreactivity in the somatosensory cortex. At varying periods of time after removal of a set of vibrissal follicles, mice were processed for immunohistochemistry using an antibody against GAD. In sections tangential to the cortical surface we observed, in the barrels whose follicles were removed, decreased immunoreactivity as early as three days after surgery. The decrease was due to a lesser numerical density of stained puncta and to less intense staining of those remaining. GAD-positive somata were also less intensely stained, whereas their number did not seem to be changed. The changes, apparent at 3 days after the surgery, were restricted to the barrels corresponding to the removed follicles and were maximal at 2-4 weeks. At longer survival times (until 7 months) the immunoreactivity returned to normal, coincident with the regeneration of peripheral nerve fibres in the absence of their follicles. We conclude that GAD-immunoreactivity in the barrel cortex swiftly reacts to modifications of neuronal activity evoked in the periphery.

journal_name

Exp Brain Res

authors

Welker E,Soriano E,Van der Loos H

doi

10.1007/BF00247346

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

441-52

issue

3

eissn

0014-4819

issn

1432-1106

journal_volume

74

pub_type

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